Strategies to Increase Solubility and Bioavailability of Drugs
References
Holford NG. Pharmacokinetics & pharmacodynamics: Rational dosing & the time course of drug action. In: Katzung BG. eds. Basic & Clinical Pharmacology; 14e. McGraw-Hill Education; 2017.
Kumar R, Thakur AK, Chaudhari P, et al. Particle size reduction techniques of pharmaceutical compounds for the enhancement of their dissolution rate and bioavailability. Journal of Pharmaceutical Innovation; 2022;17(2): 333-352. doi:10.1007/s12247-020-09530-5
Grogan S, Preuss CV. Pharmacokinetics. StatPearls. Treasure Island (FL): StatPearls Publishing Copyright © 2024, StatPearls Publishing LLC.; 2024.
Bhalani DV, Nutan B, Kumar A, et al. Bioavailability enhancement techniques for poorly aqueous soluble drugs and therapeutics. Biomedicines; 2022;10(9): 2055. doi: 10.3390/biomedicines10092055
Doogue MP, Polasek TM. The ABCD of clinical pharmacokinetics. Sage Publications Sage UK: London, England; 2013. p.5-7. doi: 10.1177/2042098612469335
Verma P, Thakur A, Deshmukh K, et al. Routes of drug administration. International Journal of Pharmaceutical Studies and Research; 2010;1(1): 54-59.
Allam AN, El Gamal S, Naggar V. Bioavailability: A pharmaceutical review. International Journal of Drug Delivery Technology; 2011;1(1): 77-93.
Eisenmann ED, Talebi Z, Sparreboom A, et al. Boosting the oral bioavailability of anticancer drugs through intentional drug–drug interactions. Basic & Clinical Pharmacology & Toxicology; 2022;130: 23-35. doi: 10.1111/bcpt.13623
Chan LN. Drug‐nutrient interactions. Journal of Parenteral and Enteral Nutrition; 2013;37(4): 450-459. doi: 10.1177/0148607113488799
Schmidt LE, Dalhoff K. Food-drug interactions. Drugs; 2002;62: 1481-1502. doi: 10.2165/00003495-200262100-00005.
Çelik G, Birdane YO. Bioavailability and bioequivalence. Kocatepe Veterinary Journal; 2015;8(1): 85-94. doi: 10.5578/kvj.8621
Bardal SK, Waechter JE, Martin DS. Applied Pharmacology: Elsevier/Saunders; 2011.
Jain KK. An overview of drug delivery systems. Drug Delivery Systems; 2020;2020: 1-54. doi: 10.1007/978-1-4939-9798-5_1.
Lou J, Duan H, Qin Q, et al. Advances in oral drug delivery systems: Challenges and opportunities. Pharmaceutics; 2023;15(2): 484. doi: 10.3390/pharmaceutics15020484
Amidon GL, Lennernäs H, Shah VP, et al. A theoretical basis for a biopharmaceutic drug classification: the correlation of in vitro drug product dissolution and in vivo bioavailability. Pharmaceutical Research; 1995;12: 413-420. doi: 10.1023/a:1016212804288
Stevens CW. Brenner and Stevens’ Pharmacology E-Book: Elsevier Health Sciences; 2022.
Howland RD. Lippincott´s Illustrated Reviews. Pharmacology; 2006.
Gulati N, Gupta H. Parenteral drug delivery: A review. Recent Patents on Drug Delivery & Formulation; 2011;5(2): 133-145. doi: 10.2174/187221111795471391.
Kayaalp SO. Akılcı Tedavi Yönünden Tıbbi Farmakoloji: Pelikan Yayıncılık; 2012.
Borghardt JM, Kloft C, Sharma A. Inhaled therapy in respiratory disease: the complex interplay of pulmonary kinetic processes. Canadian Respiratory Journal; 2018;2018. doi: 10.1155/2018/2732017
Ibrahim M, Verma R, Garcia-Contreras L. Inhalation drug delivery devices: Technology update. Medical Devices: Evidence and Research; 2015:131-139. doi: 10.2147/MDER.S48888.
Gowda BJ, Ahmed MG, Husain A. Transferosomal in situ gel administered through umbilical skin tissues for improved systemic bioavailability of drugs: A novel strategy to replace conventional transdermal route. Medical Hypotheses; 2022;161: 110805. doi:10.1016/j.mehy.2022.110805
Shah NV, Seth AK, Balaraman R, et al. Nanostructured lipid carriers for oral bioavailability enhancement of raloxifene: Design and in vivo study. Journal of Advanced Research; 2016;7(3): 423-434. doi: 10.1016/j.jare.2016.03.002
Junyaprasert VB, Morakul B. Nanocrystals for enhancement of oral bioavailability of poorly water-soluble drugs. Asian Journal of Pharmaceutical Sciences; 2015;10(1): 13-23. doi.org/10.1016/j.ajps.2014.08.005
Haq MMU, Razzak M, Uddin M, et al. Rectal drug delivery system: An overview, Clinical Pharmacology & Biopharmaceutics; 2021.
Ahire E, Thakkar S, Darshanwad M, et al. Parenteral nanosuspensions: A brief review from solubility enhancement to more novel and specific applications. Acta Pharmaceutica Sinica B; 2018;8(5): 733-755. doi.org/10.1016/j.apsb.2018.07.011
Ghadiri M, Young PM, Traini D. Strategies to enhance drug absorption via nasal and pulmonary routes. Pharmaceutics; 2019;11(3): 113. doi: 10.3390/pharmaceutics11030113
Marwah H, Garg T, Goyal AK, et al. Permeation enhancer strategies in transdermal drug delivery. Drug delivery; 2016;23(2): 564-578. doi: 10.3109/10717544.2014.935532
Gupta B, Mishra V, Gharat S, et al. Cellulosic polymers for enhancing drug bioavailability in ocular drug delivery systems. Pharmaceuticals; 2021;14(11): 1201. doi: 10.3390/ph14111201
Mandal A, Bisht R, Rupenthal ID, et al. Polymeric micelles for ocular drug delivery: From structural frameworks to recent preclinical studies. Journal of Controlled Release; 2017;248: 96-116. doi: 10.1016/j.jconrel.2017.01.012
Mohammed MA, Syeda JT, Wasan KM, et al. An overview of chitosan nanoparticles and its application in non-parenteral drug delivery. Pharmaceutics; 2017;9(4): 53. doi: 10.3390/pharmaceutics9040053
Gupta S, Kesarla R, Omri A. Formulation strategies to improve the bioavailability of poorly absorbed drugs with special emphasis on self-emulsifying systems. International Scholarly Research Notices; 2013;2013. doi: 10.1155/2013/848043
Müller CE. Prodrug approaches for enhancing the bioavailability of drugs with low solubility. Chemistry & Biodiversity; 2009;6(11): 2071-2083. doi: 10.1002/cbdv.200900114
Sanches BM, Ferreira EI. Is prodrug design an approach to increase water solubility? International Journal of Pharmaceutics. 2019;568: 118498. doi: 10.1016/j.ijpharm.2019.118498
Gupta D, Bhatia D, Dave V, et al. Salts of therapeutic agents: chemical, physicochemical, and biological considerations. Molecules; 2018;23(7): 1719. doi: 10.3390/molecules23071719
Sathisaran I, Dalvi SV. Engineering cocrystals of poorly water-soluble drugs to enhance dissolution in aqueous medium. Pharmaceutics; 2018;10(3): 108. doi: 10.3390/pharmaceutics10030108
Vioglio PC, Chierotti MR, Gobetto R. Pharmaceutical aspects of salt and cocrystal forms of APIs and characterization challenges. Advanced Drug Delivery Reviews; 2017;117: 86-110. doi: 10.1016/j.addr.2017.07.001
Almotairy A, Almutairi M, Althobaiti A, et al. Effect of pH modifiers on the solubility, dissolution rate, and stability of telmisartan solid dispersions produced by hot-melt extrusion technology. Journal of Drug Delivery Science and Technology. 2021;65: 102674. doi:10.1016/j.jddst.2021.102674
Jagtap S, Magdum C, Jadge D, et al. Solubility enhancement technique: A review. Journal of Pharmaceutical Sciences and Research. 2018;10(9): 2205-2211. doi:10.56726/irjmets43891
Deshmukh AS, Tiwari KJ, Mahajan VR. Solubility enhancement techniques for poorly water-soluble drugs. International Journal of Pharmaceutical Sciences and Nanotechnology; 2017;10(8). doi: 10.37285/ijpsn.2017.10.3.1
Nazli H, Mesut B, Özsoy Y. Çözünürlüğü düşük olan etken maddeler için farmasötik yaklaşımlar ve aprepitantın çözünürlüğü. Fabad Journal of Pharmaceutical Sciences; 2021;46(3): 325-344.
Singh J, Walia M, Harikumar S. Solubility enhancement by solid dispersion method: A review. Journal of Drug Delivery and Therapeutics; 2013;3(5): 148-155. doi: 10.22270/jddt.v3i5.632
Saokham P, Muankaew C, Jansook P, et al. Solubility of cyclodextrins and drug/cyclodextrin complexes. Molecules; 2018;23(5): 1161. doi: 10.3390/molecules23051161
Al-Kassas R, Bansal M, Shaw J. Nanosizing techniques for improving bioavailability of drugs. Journal of Controlled Release; 2017;260: 202-212. doi: 10.1016/j.jconrel.2017.06.003
Salazar J, Müller RH, Möschwitzer JP. Combinative particle size reduction technologies for the production of drug nanocrystals. Journal of Pharmaceutics; 2014;2014. doi: 10.1155/2014/265754
Lakshmi P, Kumar GA. Nanosuspension technology: A review. International Journal of Pharmacy and Pharmaceutical Sciences; 2010;2(4): 35-40. doi: 10.52711/2231-5713.2021.00042
Harwansh RK, Deshmukh R, Rahman MA. Nanoemulsion: Promising nanocarrier system for delivery of herbal bioactives. Journal of Drug Delivery Science and Technology; 2019;51: 224-233. doi: 10.1016/j.jddst.2019.03.006
Kumar RS, Mukherjee J. Microemulsions: Platform for improvement of solubility and dissolution of poorly soluble drugs. Journal of Drug Delivery and Therapeutics; 2019;9(4-A): 908-910. doi: 10.22270/jddt.v9i4-A.3789
Kumar R, Singh A, Garg N, et al. Solid lipid nanoparticles for the controlled delivery of poorly water soluble non-steroidal anti-inflammatory drugs. Ultrasonics Sonochemistry; 2018;40: 686-696. doi: 10.1016/j.ultsonch.2017.08.018
Wang Y, Pi C, Feng X, et al. The influence of nanoparticle properties on oral bioavailability of drugs. International journal of Nanomedicine; 2020: 6295-6310. doi: 10.2147/IJN.S257269
Kumar R, Thakur AK, Chaudhari P, et al. Particle size reduction techniques of pharmaceutical compounds for the enhancement of their dissolution rate and bioavailability. Journal of Pharmaceutical Innovation; 2022;17(2): 333-352. doi:10.1007/s12247-020-09530-5
Grogan S, Preuss CV. Pharmacokinetics. StatPearls. Treasure Island (FL): StatPearls Publishing Copyright © 2024, StatPearls Publishing LLC.; 2024.
Bhalani DV, Nutan B, Kumar A, et al. Bioavailability enhancement techniques for poorly aqueous soluble drugs and therapeutics. Biomedicines; 2022;10(9): 2055. doi: 10.3390/biomedicines10092055
Doogue MP, Polasek TM. The ABCD of clinical pharmacokinetics. Sage Publications Sage UK: London, England; 2013. p.5-7. doi: 10.1177/2042098612469335
Verma P, Thakur A, Deshmukh K, et al. Routes of drug administration. International Journal of Pharmaceutical Studies and Research; 2010;1(1): 54-59.
Allam AN, El Gamal S, Naggar V. Bioavailability: A pharmaceutical review. International Journal of Drug Delivery Technology; 2011;1(1): 77-93.
Eisenmann ED, Talebi Z, Sparreboom A, et al. Boosting the oral bioavailability of anticancer drugs through intentional drug–drug interactions. Basic & Clinical Pharmacology & Toxicology; 2022;130: 23-35. doi: 10.1111/bcpt.13623
Chan LN. Drug‐nutrient interactions. Journal of Parenteral and Enteral Nutrition; 2013;37(4): 450-459. doi: 10.1177/0148607113488799
Schmidt LE, Dalhoff K. Food-drug interactions. Drugs; 2002;62: 1481-1502. doi: 10.2165/00003495-200262100-00005.
Çelik G, Birdane YO. Bioavailability and bioequivalence. Kocatepe Veterinary Journal; 2015;8(1): 85-94. doi: 10.5578/kvj.8621
Bardal SK, Waechter JE, Martin DS. Applied Pharmacology: Elsevier/Saunders; 2011.
Jain KK. An overview of drug delivery systems. Drug Delivery Systems; 2020;2020: 1-54. doi: 10.1007/978-1-4939-9798-5_1.
Lou J, Duan H, Qin Q, et al. Advances in oral drug delivery systems: Challenges and opportunities. Pharmaceutics; 2023;15(2): 484. doi: 10.3390/pharmaceutics15020484
Amidon GL, Lennernäs H, Shah VP, et al. A theoretical basis for a biopharmaceutic drug classification: the correlation of in vitro drug product dissolution and in vivo bioavailability. Pharmaceutical Research; 1995;12: 413-420. doi: 10.1023/a:1016212804288
Stevens CW. Brenner and Stevens’ Pharmacology E-Book: Elsevier Health Sciences; 2022.
Howland RD. Lippincott´s Illustrated Reviews. Pharmacology; 2006.
Gulati N, Gupta H. Parenteral drug delivery: A review. Recent Patents on Drug Delivery & Formulation; 2011;5(2): 133-145. doi: 10.2174/187221111795471391.
Kayaalp SO. Akılcı Tedavi Yönünden Tıbbi Farmakoloji: Pelikan Yayıncılık; 2012.
Borghardt JM, Kloft C, Sharma A. Inhaled therapy in respiratory disease: the complex interplay of pulmonary kinetic processes. Canadian Respiratory Journal; 2018;2018. doi: 10.1155/2018/2732017
Ibrahim M, Verma R, Garcia-Contreras L. Inhalation drug delivery devices: Technology update. Medical Devices: Evidence and Research; 2015:131-139. doi: 10.2147/MDER.S48888.
Gowda BJ, Ahmed MG, Husain A. Transferosomal in situ gel administered through umbilical skin tissues for improved systemic bioavailability of drugs: A novel strategy to replace conventional transdermal route. Medical Hypotheses; 2022;161: 110805. doi:10.1016/j.mehy.2022.110805
Shah NV, Seth AK, Balaraman R, et al. Nanostructured lipid carriers for oral bioavailability enhancement of raloxifene: Design and in vivo study. Journal of Advanced Research; 2016;7(3): 423-434. doi: 10.1016/j.jare.2016.03.002
Junyaprasert VB, Morakul B. Nanocrystals for enhancement of oral bioavailability of poorly water-soluble drugs. Asian Journal of Pharmaceutical Sciences; 2015;10(1): 13-23. doi.org/10.1016/j.ajps.2014.08.005
Haq MMU, Razzak M, Uddin M, et al. Rectal drug delivery system: An overview, Clinical Pharmacology & Biopharmaceutics; 2021.
Ahire E, Thakkar S, Darshanwad M, et al. Parenteral nanosuspensions: A brief review from solubility enhancement to more novel and specific applications. Acta Pharmaceutica Sinica B; 2018;8(5): 733-755. doi.org/10.1016/j.apsb.2018.07.011
Ghadiri M, Young PM, Traini D. Strategies to enhance drug absorption via nasal and pulmonary routes. Pharmaceutics; 2019;11(3): 113. doi: 10.3390/pharmaceutics11030113
Marwah H, Garg T, Goyal AK, et al. Permeation enhancer strategies in transdermal drug delivery. Drug delivery; 2016;23(2): 564-578. doi: 10.3109/10717544.2014.935532
Gupta B, Mishra V, Gharat S, et al. Cellulosic polymers for enhancing drug bioavailability in ocular drug delivery systems. Pharmaceuticals; 2021;14(11): 1201. doi: 10.3390/ph14111201
Mandal A, Bisht R, Rupenthal ID, et al. Polymeric micelles for ocular drug delivery: From structural frameworks to recent preclinical studies. Journal of Controlled Release; 2017;248: 96-116. doi: 10.1016/j.jconrel.2017.01.012
Mohammed MA, Syeda JT, Wasan KM, et al. An overview of chitosan nanoparticles and its application in non-parenteral drug delivery. Pharmaceutics; 2017;9(4): 53. doi: 10.3390/pharmaceutics9040053
Gupta S, Kesarla R, Omri A. Formulation strategies to improve the bioavailability of poorly absorbed drugs with special emphasis on self-emulsifying systems. International Scholarly Research Notices; 2013;2013. doi: 10.1155/2013/848043
Müller CE. Prodrug approaches for enhancing the bioavailability of drugs with low solubility. Chemistry & Biodiversity; 2009;6(11): 2071-2083. doi: 10.1002/cbdv.200900114
Sanches BM, Ferreira EI. Is prodrug design an approach to increase water solubility? International Journal of Pharmaceutics. 2019;568: 118498. doi: 10.1016/j.ijpharm.2019.118498
Gupta D, Bhatia D, Dave V, et al. Salts of therapeutic agents: chemical, physicochemical, and biological considerations. Molecules; 2018;23(7): 1719. doi: 10.3390/molecules23071719
Sathisaran I, Dalvi SV. Engineering cocrystals of poorly water-soluble drugs to enhance dissolution in aqueous medium. Pharmaceutics; 2018;10(3): 108. doi: 10.3390/pharmaceutics10030108
Vioglio PC, Chierotti MR, Gobetto R. Pharmaceutical aspects of salt and cocrystal forms of APIs and characterization challenges. Advanced Drug Delivery Reviews; 2017;117: 86-110. doi: 10.1016/j.addr.2017.07.001
Almotairy A, Almutairi M, Althobaiti A, et al. Effect of pH modifiers on the solubility, dissolution rate, and stability of telmisartan solid dispersions produced by hot-melt extrusion technology. Journal of Drug Delivery Science and Technology. 2021;65: 102674. doi:10.1016/j.jddst.2021.102674
Jagtap S, Magdum C, Jadge D, et al. Solubility enhancement technique: A review. Journal of Pharmaceutical Sciences and Research. 2018;10(9): 2205-2211. doi:10.56726/irjmets43891
Deshmukh AS, Tiwari KJ, Mahajan VR. Solubility enhancement techniques for poorly water-soluble drugs. International Journal of Pharmaceutical Sciences and Nanotechnology; 2017;10(8). doi: 10.37285/ijpsn.2017.10.3.1
Nazli H, Mesut B, Özsoy Y. Çözünürlüğü düşük olan etken maddeler için farmasötik yaklaşımlar ve aprepitantın çözünürlüğü. Fabad Journal of Pharmaceutical Sciences; 2021;46(3): 325-344.
Singh J, Walia M, Harikumar S. Solubility enhancement by solid dispersion method: A review. Journal of Drug Delivery and Therapeutics; 2013;3(5): 148-155. doi: 10.22270/jddt.v3i5.632
Saokham P, Muankaew C, Jansook P, et al. Solubility of cyclodextrins and drug/cyclodextrin complexes. Molecules; 2018;23(5): 1161. doi: 10.3390/molecules23051161
Al-Kassas R, Bansal M, Shaw J. Nanosizing techniques for improving bioavailability of drugs. Journal of Controlled Release; 2017;260: 202-212. doi: 10.1016/j.jconrel.2017.06.003
Salazar J, Müller RH, Möschwitzer JP. Combinative particle size reduction technologies for the production of drug nanocrystals. Journal of Pharmaceutics; 2014;2014. doi: 10.1155/2014/265754
Lakshmi P, Kumar GA. Nanosuspension technology: A review. International Journal of Pharmacy and Pharmaceutical Sciences; 2010;2(4): 35-40. doi: 10.52711/2231-5713.2021.00042
Harwansh RK, Deshmukh R, Rahman MA. Nanoemulsion: Promising nanocarrier system for delivery of herbal bioactives. Journal of Drug Delivery Science and Technology; 2019;51: 224-233. doi: 10.1016/j.jddst.2019.03.006
Kumar RS, Mukherjee J. Microemulsions: Platform for improvement of solubility and dissolution of poorly soluble drugs. Journal of Drug Delivery and Therapeutics; 2019;9(4-A): 908-910. doi: 10.22270/jddt.v9i4-A.3789
Kumar R, Singh A, Garg N, et al. Solid lipid nanoparticles for the controlled delivery of poorly water soluble non-steroidal anti-inflammatory drugs. Ultrasonics Sonochemistry; 2018;40: 686-696. doi: 10.1016/j.ultsonch.2017.08.018
Wang Y, Pi C, Feng X, et al. The influence of nanoparticle properties on oral bioavailability of drugs. International journal of Nanomedicine; 2020: 6295-6310. doi: 10.2147/IJN.S257269
Pages
95-108
Published
April 16, 2024
Copyright (c) 2024 Academician Publishing Book Portal
License
LicenseHow to Cite
1.
Çinar İ, Özakar E, Sevinç Özakar R. Strategies to Increase Solubility and Bioavailability of Drugs. In: Yamalı C, editor. Current Research in Pharmacy and Pharmaceutical Sciences II-2024 [Internet]. Türkiye: Academician Publishing Book DOI Portal; 2024 [cited 2026 Jul. 13]. pp. 95-108. Available from: https://omp35.books.akademisyen.net/index.php/akya/catalog/book/3054/chapter/13722
