Diabetes Mellitus ve Mineral İlişkisi
Synopsis
Diabetes mellitus, genetik ve çevresel birçok nedene bağlı olarak ortaya çıkabilen bir metabolik hastalıktır. Bu hastalık, yağ, protein ve karbonhidrat metabolizmasında dengesizliklere ve kronik yüksek kan glukoz düzeyine neden olan, insülin salımı ve/veya aktivitesindeki sorunlardan kaynaklanır. Son araştırmalar, azalmış insülin salımının diyabet gelişiminde en büyük faktör olduğunu açıkça ortaya koymaktadır. Bu nedenle, pankreatik beta hücrelerinin apoptozisinin önlenmesi ve insülin salınımının artırılması, diyabet tedavisinde önemli terapötik yaklaşımlardan biridir. Çinko, krom, selenyum, magnezyum, vanadyum, demir gibi bazı minerallerin yetersizliği veya aşırılığının pankreatik adacıkları olumsuz etkileyerek insülin salınımında veya insülin sinyal yolunda dengesizliklere ve diyabet gelişimine yol açabileceği bildirilmiştir.
References
American Diabetes Association. Diagnosis and classification of diabetes mellitus. Diabetes Care. 2014;37.
Saltiel AR. Insulin signaling in health and disease. J Clin Invest. 2021;131(1).
Rachdaoui N. Insulin: The friend and the foe in the development of type 2 diabetes mellitus. Int J Mol Sci. 2020;21(5):1–21.
Losada-Barragán M. Physiological effects of nutrients on insulin release by pancreatic beta cells. Mol Cell Biochem. 2021;476(8):3127–39.
Kolb H, Kempf K, Röhling M, Martin S. Insulin: Too much of a good thing is bad. BMC Med. 2020;18(1):1–12.
Vasiljević J, Torkko JM, Knoch KP, Solimena M. The making of insulin in health and disease. Diabetologia. 2020;63(10):1981–9.
Zhang Y, Ren C, Lu G, Mu Z, Cui W, Gao H, et al. Anti-diabetic effect of mulberry leaf polysaccharide by inhibiting pancreatic islet cell apoptosis and ameliorating insulin secretory capacity in diabetic rats. Int Immunopharmacol. 2014;22(1):248–57.
Khan AR, Awan FR. Metals in the pathogenesis of type 2 diabetes. J Diabetes Metab Disord. 2014;13(1):1–6.
Jansen J, Karges W, Rink L. Zinc and diabetes - clinical links and molecular mechanisms. J Nutr Biochem. 2009;20(6):399–417.
Bosco MD, Mohanasundaram DM, Drogemuller CJ, Lang CJ, Zalewski PD, Coates PT. Zinc and zinc transporter regulation in pancreatic islets and the potential role of zinc in islet transplantation. Rev Diabet Stud. 2010;7(4):263–74.
Dubey P, Thakur V, Chattopadhyay M. Role of minerals and trace elements in diabetes and insulin resistance. Nutrients. 2020;12(6):1–17.
Jayawardena R, Ranasinghe P, Galappatthy P, Malkanthi R, Constantine G, Katulanda P. Effects of zinc supplementation on diabetes mellitus: a systematic review and meta-analysis. Diabetol Metab Syndr. 2012;4(1):13.
Morais JBS, Severo JS, Beserra JB, de Oiveira ARS, Cruz KJC, de Sousa Melo SR, et al. Association between cortisol, insulin resistance and zinc in obesity: a mini-review. Biol Trace Elem Res. 2019;191(2):323–30.
Nygaard SB, Larsen A, Knuhtsen A, Rungby J, Smidt K. Effects of zinc supplementation and zinc chelation on in vitro β-cell function in INS-1E cells. BMC Res Notes. 2014;7:84.
Xu J, Zhou Q, Liu G, Tan Y, Cai L. Analysis of serum and urinal copper and zinc in chinese northeast population with the prediabetes or diabetes with and without complications. Oxid Med Cell Longev. 2013;2013.
Mackenzie S, Bergdahl A. Zinc homeostasis in diabetes mellitus and vascular complications. Biomedicines. 2022;10(1).
Marreiro D do N, Cruz KJC, Morais JBS, Beserra JB, Severo JS, Soares de Oliveira AR. Zinc and oxidative stress: Current mechanisms. Antioxidants. 2017;6(2).
Adulcikas J, Sonda S, Norouzi S, Sohal SS, Myers S. Targeting the zinc transporter ZIP7 in the treatment of insulin resistance and type 2 diabetes. Nutrients. 2019;11(2).
Norouzi S, Adulcikas J, Sohal SS, Myers S. Zinc transporters and insulin resistance: Therapeutic implications for type 2 diabetes and metabolic disease. J Biomed Sci. 2017;24(1):1–10.
Olechnowicz J, Tinkov A, Skalny A, Suliburska J. Zinc status is associated with inflammation, oxidative stress, lipid, and glucose metabolism. J Physiol Sci. 2018;68(1):19–31.
Li X, Zhao J. The influence of zinc supplementation on metabolic status in gestational diabetes: a meta-analysis of randomized controlled studies. J Matern Neonatal Med. 2021;34(13):2140–5.
Ranasinghe P, Pigera S, Galappatthy P, Katulanda P, Constantine GR. Zinc and diabetes mellitus: Understanding molecular mechanisms and clinical implications. DARU, J Pharm Sci. 2015;23(1):1–13.
Bellomo E, Massarotti A, Hogstrand C, Maret W. Zinc ions modulate protein tyrosine phosphatase 1B activity. Metallomics. 2014;6(7):1229–39.
Vardatsikos G, Pandey NR, Srivastava AK. Insulino-mimetic and anti-diabetic effects of zinc. J Inorg Biochem. 2013;120:8–17.
Cruz KJC, De Oliveira ARS, Morais JBS, Severo JS, Mendes PMV, De Sousa Melo SR, et al. Zinc and insulin resistance: biochemical and molecular aspects. Biol Trace Elem Res. 2018;186(2):407–12.
Goldhaber SB. Trace element risk assessment: Essentiality vs. toxicity. Regul Toxicol Pharmacol. 2003;38(2):232–42.
Wallach S. Clinical and biochemical aspects of chromium deficiency. J Am Coll Nutr. 1985;4(1):107–20.
Scawarz, K. ; Mertz W. Chromium (III) and the glucose tolerance factor. Arch Biochem. 1959;85:292–5.
Mertz W, Roginski EE, Schwarz K. Effect of trivalent chromium complexes on glucose uptake by epididymal fat tissue of rats. J Biol Chem. 1961;236(2):318–22.
Anderson RA. Chromium and insulin resistance. Nutr Res Rev. 2003;16(2):267–75.
Vincent JB. Chromium: celebrating 50 years as an essential element? Dalt Trans. 2010;39(16):3787–94.
Jeejeebhoy KN, Chu RC, Marliss EB, Greenberg GR, Bruce-Robertson A. Chromium deficiency , glucose intolerance , and neuropathy reversed by chromium total parenteral. Am J Clin Nutr. 1977;30(March):531–8.
Sreekanth R, Pattabhi V, Rajan SS. Molecular basis of chromium insulin interactions. Biochem Biophys Res Commun. 2008;369(2):725–9.
Hua Y, Clark S, Ren J, Sreejayan N. Molecular mechanisms of chromium in alleviating insulin resistance. J Nutr Biochem. 2012;23(4):313–9.
Lipko M, Debski B. Mechanism of insulin-like effect of chromium(III) ions on glucose uptake in C2C12 mouse myotubes involves ROS formation. J Trace Elem Med Biol. 2018;45:171–5.
Kooshki F, Tutunchi H, Vajdi M, Karimi A, Niazkar HR, Shoorei H, et al. A Comprehensive insight into the effect of chromium supplementation on oxidative stress indices in diabetes mellitus: A systematic review. Clin Exp Pharmacol Physiol. 2021;48(3):291–309.
Sundaram B, Aggarwal A, Sandhir R. Chromium picolinate attenuates hyperglycemia-induced oxidative stress in streptozotocin-induced diabetic rats. J Trace Elem Med Biol. 2013;27(2):117–21.
Panchal SK, Wanyonyi S, Brown L. Selenium, vanadium, and chromium as micronutrients to improve metabolic syndrome. Curr Hypertens Rep. 2017;19(3).
Kangalgi̇l M, Yardımcı H. Selenyumun insan sağlığı üzerine etkileri ve diyabetes mellitusla ilişkisi. Bozok Tıp Derg. 2017;7(4):66–71.
Steinbrenner H, Duntas LH, Rayman MP. The role of selenium in type-2 diabetes mellitus and its metabolic comorbidities. Redox Biol. 2022;50:102236.
Fontenelle LC, Feitosa MM, Morais JBS, Severo JS, de Freitas TEC, Beserra JB, et al. The role of selenium in insulin resistance. Brazilian J Pharm Sci. 2018;54(1):1–11.
González de Vega R, Fernández-Sánchez ML, Fernández JC, Álvarez Menéndez FV, Sanz-Medel A. Selenium levels and Glutathione peroxidase activity in the plasma of patients with type II diabetes mellitus. J Trace Elem Med Biol. 2016;37:44–9.
Steinbrenner H. Interference of selenium and selenoproteins with the insulin-regulated carbohydrate and lipid metabolism. Free Radic Biol Med. 2013;65:1538–47.
Steinbrenner H, Hotze AL, Speckmann B, Pinto A, Sies H, Schott M, et al. Localization and regulation of pancreatic selenoprotein P. J Mol Endocrinol. 2013;50(1):31–42.
Wang X, Zhang W, Chen H, Liao N, Wang Z, Zhang X, et al. High selenium impairs hepatic insulin sensitivity through opposite regulation of ROS. Toxicol Lett. 2014;224(1):16–23.
Zhou J, Huang K, Lei XG. Selenium and diabetes - Evidence from animal studies. Free Radic Biol Med. 2013;65:1548–56.
de Sousa Melo SR, dos Santos LR, da Cunha Soares T, Cardoso BEP, da Silva Dias TM, Morais JBS, et al. Participation of magnesium in the secretion and signaling pathways of insulin: an updated review. Biol Trace Elem Res. 2022;200(8):3545–53.
Glasdam SM, Glasdam S, Peters GH. The importance of magnesium in the human body: A systematic literature review. Adv Clin Chem. 2016;73:169–93.
Bo S, Pisu E. Role of dietary magnesium in cardiovascular disease prevention, insulin sensitivity and diabetes. Curr Opin Lipidol. 2008;19(1):50–6.
Hruby A, McKeown NM, Song Y, Djoussé L. Dietary magnesium and genetic interactions in diabetes and related risk factors: A brief overview of current knowledge. Nutrients. 2013;5(12):4990–5011.
Kokot T, Malczyk E, Wilemska-Kucharzewska K, Muc-Wierzgoń M, Fatyga E. Serum magnesium and abdominal obesity and its consequences. Nutr Prev Treat Abdom Obes. 2019;383–91.
De Oliveira ARS, Cruz KJC, Severo JS, Morais JBS, De Freitas TEC, Araújo RS, et al. Hypomagnesemia and its relation with chronic low-grade inflammation in obesity. Rev Assoc Med Bras. 2017;63(2):156–63.
Gommers LMM, Hoenderop JGJ, Bindels RJM, De Baaij JHF. Hypomagnesemia in type 2 diabetes: A vicious circle? Diabetes. 2016;65(1):3–13.
Gröber U, Schmidt J, Kisters K. Magnesium in prevention and therapy. Nutrients. 2015;7(9):8199–226.
Kostov K. Effects of magnesium deficiency on mechanisms of insulin resistance in type 2 diabetes: focusing on the processes of insulin secretion and signaling. Int J Mol Sci. 2019;20(6).
Thompson KH, Orvig C. Vanadium in diabetes: 100 years from Phase 0 to Phase I. J Inorg Biochem. 2006;100(12):1925–35.
Heyliger CE, Tahılıanı AG, Mcneill JH. Effect of vanadate on elevated blood glucose and depressed cardiac performance of diabetic rats. Science (80- ). 1985;227:1474–7.
Korbecki J, Baranowska-Bosiacka I, Gutowska I, Chlubek D. Insulin-mimetic property of vanadium compounds. Postepy Biochem. 2016;62(1):60–5.
Srivastava AK, Mehdi MZ. Insulino-mimetic and anti-diabetic effects of vanadium compounds. Diabet Med. 2005;22(1):2–13.
Emerit J, Beaumont C, Trivin F. Iron metabolism, free radicals, and oxidative injury. Biomed Pharmacother. 2001;55(6):333–9.
Targher G, Franchini M, Montagnana M, Lippi G. The role of iron in diabetes and its complications: Reponse to Swaminathan et . Diabetes Care. 2007;30(12).
Adams PC, Kertesz AE, Valberg LS. Clinical presentation of hemochromatosis: A changing scene. Am J Med. 1991;90(1):445–9.
Fernández-Real JM, López-Bermejo A, Ricart W. Iron stores, blood donation, and insulin sensitivity and secretion. Clin Chem. 2005;51(7):1201–5.
Jiang R, Ma J, Ascherio A, Stampfer MJ, Willett WC, Hu FB. Dietary iron intake and blood donations in relation to risk of type 2 diabetes in men: a prospective cohort study. Am J Clin Nutr. 2004;79(1):70–5.
Cooksey RC, Jouihan HA, Ajioka RS, Hazel MW, Jones DL, Kushner JP, et al. Oxidative stress, β-cell apoptosis, and decreased insulin secretory capacity in mouse models of hemochromatosis. Endocrinology. 2004;145(11):5305–12.
Fernandez-Rea, Jose Manuel, Lopez-Bermejo A, Ricart W. Cross-talk between iron metabolism and diabetes. Diabetes. 2002 Jul;51(8):2348-2354.
Ferńandez-Real JM, Mcclain D, Review MM. Mechanisms linking glucose homeostasis and iron metabolism toward the onset and progression of type 2 diabetes. Diabetes Care. 2015;38(11):2169–76.
Liu J, Li Q, Yang Y, Ma L. Iron metabolism and type 2 diabetes mellitus: A meta-analysis and systematic review. J Diabetes Investig. 2020;11(4):946–55.
Bertelsen M, Änggård EE, Carrier MJ. Oxidative stress impairs insulin internalization in endothelial cells in vitro. Diabetologia. 2001;44(5):605–13.
Davis RJ, Corvera S, Czech MP. Insulin stimulates cellular iron uptake and causes the redistribution of intracellular transferrin receptors to the plasma membrane. J Biol Chem. 1986;261(19):8708–11.
Saltiel AR. Insulin signaling in health and disease. J Clin Invest. 2021;131(1).
Rachdaoui N. Insulin: The friend and the foe in the development of type 2 diabetes mellitus. Int J Mol Sci. 2020;21(5):1–21.
Losada-Barragán M. Physiological effects of nutrients on insulin release by pancreatic beta cells. Mol Cell Biochem. 2021;476(8):3127–39.
Kolb H, Kempf K, Röhling M, Martin S. Insulin: Too much of a good thing is bad. BMC Med. 2020;18(1):1–12.
Vasiljević J, Torkko JM, Knoch KP, Solimena M. The making of insulin in health and disease. Diabetologia. 2020;63(10):1981–9.
Zhang Y, Ren C, Lu G, Mu Z, Cui W, Gao H, et al. Anti-diabetic effect of mulberry leaf polysaccharide by inhibiting pancreatic islet cell apoptosis and ameliorating insulin secretory capacity in diabetic rats. Int Immunopharmacol. 2014;22(1):248–57.
Khan AR, Awan FR. Metals in the pathogenesis of type 2 diabetes. J Diabetes Metab Disord. 2014;13(1):1–6.
Jansen J, Karges W, Rink L. Zinc and diabetes - clinical links and molecular mechanisms. J Nutr Biochem. 2009;20(6):399–417.
Bosco MD, Mohanasundaram DM, Drogemuller CJ, Lang CJ, Zalewski PD, Coates PT. Zinc and zinc transporter regulation in pancreatic islets and the potential role of zinc in islet transplantation. Rev Diabet Stud. 2010;7(4):263–74.
Dubey P, Thakur V, Chattopadhyay M. Role of minerals and trace elements in diabetes and insulin resistance. Nutrients. 2020;12(6):1–17.
Jayawardena R, Ranasinghe P, Galappatthy P, Malkanthi R, Constantine G, Katulanda P. Effects of zinc supplementation on diabetes mellitus: a systematic review and meta-analysis. Diabetol Metab Syndr. 2012;4(1):13.
Morais JBS, Severo JS, Beserra JB, de Oiveira ARS, Cruz KJC, de Sousa Melo SR, et al. Association between cortisol, insulin resistance and zinc in obesity: a mini-review. Biol Trace Elem Res. 2019;191(2):323–30.
Nygaard SB, Larsen A, Knuhtsen A, Rungby J, Smidt K. Effects of zinc supplementation and zinc chelation on in vitro β-cell function in INS-1E cells. BMC Res Notes. 2014;7:84.
Xu J, Zhou Q, Liu G, Tan Y, Cai L. Analysis of serum and urinal copper and zinc in chinese northeast population with the prediabetes or diabetes with and without complications. Oxid Med Cell Longev. 2013;2013.
Mackenzie S, Bergdahl A. Zinc homeostasis in diabetes mellitus and vascular complications. Biomedicines. 2022;10(1).
Marreiro D do N, Cruz KJC, Morais JBS, Beserra JB, Severo JS, Soares de Oliveira AR. Zinc and oxidative stress: Current mechanisms. Antioxidants. 2017;6(2).
Adulcikas J, Sonda S, Norouzi S, Sohal SS, Myers S. Targeting the zinc transporter ZIP7 in the treatment of insulin resistance and type 2 diabetes. Nutrients. 2019;11(2).
Norouzi S, Adulcikas J, Sohal SS, Myers S. Zinc transporters and insulin resistance: Therapeutic implications for type 2 diabetes and metabolic disease. J Biomed Sci. 2017;24(1):1–10.
Olechnowicz J, Tinkov A, Skalny A, Suliburska J. Zinc status is associated with inflammation, oxidative stress, lipid, and glucose metabolism. J Physiol Sci. 2018;68(1):19–31.
Li X, Zhao J. The influence of zinc supplementation on metabolic status in gestational diabetes: a meta-analysis of randomized controlled studies. J Matern Neonatal Med. 2021;34(13):2140–5.
Ranasinghe P, Pigera S, Galappatthy P, Katulanda P, Constantine GR. Zinc and diabetes mellitus: Understanding molecular mechanisms and clinical implications. DARU, J Pharm Sci. 2015;23(1):1–13.
Bellomo E, Massarotti A, Hogstrand C, Maret W. Zinc ions modulate protein tyrosine phosphatase 1B activity. Metallomics. 2014;6(7):1229–39.
Vardatsikos G, Pandey NR, Srivastava AK. Insulino-mimetic and anti-diabetic effects of zinc. J Inorg Biochem. 2013;120:8–17.
Cruz KJC, De Oliveira ARS, Morais JBS, Severo JS, Mendes PMV, De Sousa Melo SR, et al. Zinc and insulin resistance: biochemical and molecular aspects. Biol Trace Elem Res. 2018;186(2):407–12.
Goldhaber SB. Trace element risk assessment: Essentiality vs. toxicity. Regul Toxicol Pharmacol. 2003;38(2):232–42.
Wallach S. Clinical and biochemical aspects of chromium deficiency. J Am Coll Nutr. 1985;4(1):107–20.
Scawarz, K. ; Mertz W. Chromium (III) and the glucose tolerance factor. Arch Biochem. 1959;85:292–5.
Mertz W, Roginski EE, Schwarz K. Effect of trivalent chromium complexes on glucose uptake by epididymal fat tissue of rats. J Biol Chem. 1961;236(2):318–22.
Anderson RA. Chromium and insulin resistance. Nutr Res Rev. 2003;16(2):267–75.
Vincent JB. Chromium: celebrating 50 years as an essential element? Dalt Trans. 2010;39(16):3787–94.
Jeejeebhoy KN, Chu RC, Marliss EB, Greenberg GR, Bruce-Robertson A. Chromium deficiency , glucose intolerance , and neuropathy reversed by chromium total parenteral. Am J Clin Nutr. 1977;30(March):531–8.
Sreekanth R, Pattabhi V, Rajan SS. Molecular basis of chromium insulin interactions. Biochem Biophys Res Commun. 2008;369(2):725–9.
Hua Y, Clark S, Ren J, Sreejayan N. Molecular mechanisms of chromium in alleviating insulin resistance. J Nutr Biochem. 2012;23(4):313–9.
Lipko M, Debski B. Mechanism of insulin-like effect of chromium(III) ions on glucose uptake in C2C12 mouse myotubes involves ROS formation. J Trace Elem Med Biol. 2018;45:171–5.
Kooshki F, Tutunchi H, Vajdi M, Karimi A, Niazkar HR, Shoorei H, et al. A Comprehensive insight into the effect of chromium supplementation on oxidative stress indices in diabetes mellitus: A systematic review. Clin Exp Pharmacol Physiol. 2021;48(3):291–309.
Sundaram B, Aggarwal A, Sandhir R. Chromium picolinate attenuates hyperglycemia-induced oxidative stress in streptozotocin-induced diabetic rats. J Trace Elem Med Biol. 2013;27(2):117–21.
Panchal SK, Wanyonyi S, Brown L. Selenium, vanadium, and chromium as micronutrients to improve metabolic syndrome. Curr Hypertens Rep. 2017;19(3).
Kangalgi̇l M, Yardımcı H. Selenyumun insan sağlığı üzerine etkileri ve diyabetes mellitusla ilişkisi. Bozok Tıp Derg. 2017;7(4):66–71.
Steinbrenner H, Duntas LH, Rayman MP. The role of selenium in type-2 diabetes mellitus and its metabolic comorbidities. Redox Biol. 2022;50:102236.
Fontenelle LC, Feitosa MM, Morais JBS, Severo JS, de Freitas TEC, Beserra JB, et al. The role of selenium in insulin resistance. Brazilian J Pharm Sci. 2018;54(1):1–11.
González de Vega R, Fernández-Sánchez ML, Fernández JC, Álvarez Menéndez FV, Sanz-Medel A. Selenium levels and Glutathione peroxidase activity in the plasma of patients with type II diabetes mellitus. J Trace Elem Med Biol. 2016;37:44–9.
Steinbrenner H. Interference of selenium and selenoproteins with the insulin-regulated carbohydrate and lipid metabolism. Free Radic Biol Med. 2013;65:1538–47.
Steinbrenner H, Hotze AL, Speckmann B, Pinto A, Sies H, Schott M, et al. Localization and regulation of pancreatic selenoprotein P. J Mol Endocrinol. 2013;50(1):31–42.
Wang X, Zhang W, Chen H, Liao N, Wang Z, Zhang X, et al. High selenium impairs hepatic insulin sensitivity through opposite regulation of ROS. Toxicol Lett. 2014;224(1):16–23.
Zhou J, Huang K, Lei XG. Selenium and diabetes - Evidence from animal studies. Free Radic Biol Med. 2013;65:1548–56.
de Sousa Melo SR, dos Santos LR, da Cunha Soares T, Cardoso BEP, da Silva Dias TM, Morais JBS, et al. Participation of magnesium in the secretion and signaling pathways of insulin: an updated review. Biol Trace Elem Res. 2022;200(8):3545–53.
Glasdam SM, Glasdam S, Peters GH. The importance of magnesium in the human body: A systematic literature review. Adv Clin Chem. 2016;73:169–93.
Bo S, Pisu E. Role of dietary magnesium in cardiovascular disease prevention, insulin sensitivity and diabetes. Curr Opin Lipidol. 2008;19(1):50–6.
Hruby A, McKeown NM, Song Y, Djoussé L. Dietary magnesium and genetic interactions in diabetes and related risk factors: A brief overview of current knowledge. Nutrients. 2013;5(12):4990–5011.
Kokot T, Malczyk E, Wilemska-Kucharzewska K, Muc-Wierzgoń M, Fatyga E. Serum magnesium and abdominal obesity and its consequences. Nutr Prev Treat Abdom Obes. 2019;383–91.
De Oliveira ARS, Cruz KJC, Severo JS, Morais JBS, De Freitas TEC, Araújo RS, et al. Hypomagnesemia and its relation with chronic low-grade inflammation in obesity. Rev Assoc Med Bras. 2017;63(2):156–63.
Gommers LMM, Hoenderop JGJ, Bindels RJM, De Baaij JHF. Hypomagnesemia in type 2 diabetes: A vicious circle? Diabetes. 2016;65(1):3–13.
Gröber U, Schmidt J, Kisters K. Magnesium in prevention and therapy. Nutrients. 2015;7(9):8199–226.
Kostov K. Effects of magnesium deficiency on mechanisms of insulin resistance in type 2 diabetes: focusing on the processes of insulin secretion and signaling. Int J Mol Sci. 2019;20(6).
Thompson KH, Orvig C. Vanadium in diabetes: 100 years from Phase 0 to Phase I. J Inorg Biochem. 2006;100(12):1925–35.
Heyliger CE, Tahılıanı AG, Mcneill JH. Effect of vanadate on elevated blood glucose and depressed cardiac performance of diabetic rats. Science (80- ). 1985;227:1474–7.
Korbecki J, Baranowska-Bosiacka I, Gutowska I, Chlubek D. Insulin-mimetic property of vanadium compounds. Postepy Biochem. 2016;62(1):60–5.
Srivastava AK, Mehdi MZ. Insulino-mimetic and anti-diabetic effects of vanadium compounds. Diabet Med. 2005;22(1):2–13.
Emerit J, Beaumont C, Trivin F. Iron metabolism, free radicals, and oxidative injury. Biomed Pharmacother. 2001;55(6):333–9.
Targher G, Franchini M, Montagnana M, Lippi G. The role of iron in diabetes and its complications: Reponse to Swaminathan et . Diabetes Care. 2007;30(12).
Adams PC, Kertesz AE, Valberg LS. Clinical presentation of hemochromatosis: A changing scene. Am J Med. 1991;90(1):445–9.
Fernández-Real JM, López-Bermejo A, Ricart W. Iron stores, blood donation, and insulin sensitivity and secretion. Clin Chem. 2005;51(7):1201–5.
Jiang R, Ma J, Ascherio A, Stampfer MJ, Willett WC, Hu FB. Dietary iron intake and blood donations in relation to risk of type 2 diabetes in men: a prospective cohort study. Am J Clin Nutr. 2004;79(1):70–5.
Cooksey RC, Jouihan HA, Ajioka RS, Hazel MW, Jones DL, Kushner JP, et al. Oxidative stress, β-cell apoptosis, and decreased insulin secretory capacity in mouse models of hemochromatosis. Endocrinology. 2004;145(11):5305–12.
Fernandez-Rea, Jose Manuel, Lopez-Bermejo A, Ricart W. Cross-talk between iron metabolism and diabetes. Diabetes. 2002 Jul;51(8):2348-2354.
Ferńandez-Real JM, Mcclain D, Review MM. Mechanisms linking glucose homeostasis and iron metabolism toward the onset and progression of type 2 diabetes. Diabetes Care. 2015;38(11):2169–76.
Liu J, Li Q, Yang Y, Ma L. Iron metabolism and type 2 diabetes mellitus: A meta-analysis and systematic review. J Diabetes Investig. 2020;11(4):946–55.
Bertelsen M, Änggård EE, Carrier MJ. Oxidative stress impairs insulin internalization in endothelial cells in vitro. Diabetologia. 2001;44(5):605–13.
Davis RJ, Corvera S, Czech MP. Insulin stimulates cellular iron uptake and causes the redistribution of intracellular transferrin receptors to the plasma membrane. J Biol Chem. 1986;261(19):8708–11.
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101-115
Published
September 29, 2023
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Ekici M. Diabetes Mellitus ve Mineral İlişkisi. In: Dege G, Yıldırım MS, editors. Beslenme ve Hemşirelik [Internet]. Türkiye: Academician Publishing Book DOI Portal; 2023 [cited 2026 Jul. 15]. pp. 101-15. Available from: https://omp35.books.akademisyen.net/index.php/akya/catalog/book/2738/chapter/13023
