Sarkopenik Obezite
Özet
Sarkopenik obezite; kas kütlesinde azalmayla birlikte kas gücü veya fiziksel performansta azalma olarak tanımlanmaktadır. Yaşlanma dışında başka bir neden olmadığında birincil; kullanmama, hastalık veya yetersiz beslenme gibi bir veya daha fazla nedenle ilişkilendirildiğinde ise ikincil olarak kabul edilir. Sarkopenik obezite, aşırı yağ kütlesi artışının sarkopeni ile birlikteliğini ifade eden, olumsuz klinik ve fonksiyonel sonuçları olan bir durumdur. Vücuttaki yaşa bağlı değişiklikler (visseral yağlanma ve kas yağında artış, kas kitlesinde azalma), sistemik kronik inflamasyon, insülin direnci, yaşam tarzı değişiklikleri (diyet, fiziksel aktivite vb.), moleküler mekanizmalar (leptin, adiponektin, interlökin 6, interlökin 10, miyostatin vb.) ile birlikte bu faktörler arasındaki ilişkiler sarkopenik obezitenin etiyolojisinde yer alır. Tedavisi farmakolojik ve farmakolojik olmayan yöntemleri (diyet, egzersiz, yaşam tarzı değişiklikleri) içerir.
Referanslar
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Bahat G, Yilmaz O, Kılıç C, Oren MM, Karan MA. Performance of SARC-F in Regard to Sarcopenia Definitions, Muscle Mass and Functional Measures. J Nutr Health Aging. 2018;22(8):898-903. doi: 10.1007/s12603-018-1067-8. PMID: 30272090.
Hong SH, Choi KM. Sarcopenic Obesity, Insulin Resistance, and Their Implications in Cardiovascular and Metabolic Consequences. Int J Mol Sci. 2020 Jan 13;21(2):494. doi: 10.3390/ijms21020494. PMID: 31941015; PMCID: PMC7013734.
Johnson Stoklossa CA, Sharma AM, Forhan M, Siervo M, Padwal RS, Prado CM. Prevalence of Sarcopenic Obesity in Adults with Class II/III Obesity Using Different Diagnostic Criteria. J Nutr Metab. 2017;2017:7307618. doi: 10.1155/2017/7307618. Epub 2017 Mar 22. PMID: 28421144; PMCID: PMC5380855.
Donini LM, Busetto L, Bauer JM, et al. Critical appraisal of definitions and diagnostic criteria for sarcopenic obesity based on a systematic review. Clin Nutr. 2020 Aug;39(8):2368-2388. doi: 10.1016/j.clnu.2019.11.024. Epub 2019 Nov 27. PMID: 31813698.
Gao Q, Mei F, Shang Y, et al. Global prevalence of sarcopenic obesity in older adults: A systematic review and meta-analysis. Clin Nutr. 2021 Jul;40(7):4633-4641. doi: 10.1016/j.clnu.2021.06.009. Epub 2021 Jun 21. PMID: 34229269.
Batsis JA, Villareal DT. Sarcopenic obesity in older adults: aetiology, epidemiology and treatment strategies. Nat Rev Endocrinol. 2018 Sep;14(9):513-537. doi: 10.1038/s41574-018-0062-9. PMID: 30065268; PMCID: PMC6241236.
Koliaki C, Liatis S, Dalamaga M, Kokkinos A. Sarcopenic Obesity: Epidemiologic Evidence, Pathophysiology, and Therapeutic Perspectives. Curr Obes Rep. 2019 Dec;8(4):458-471. doi: 10.1007/s13679-019-00359-9. PMID: 31654335.
El Bizri I, Batsis JA. Linking epidemiology and molecular mechanisms in sarcopenic obesity in populations. Proc Nutr Soc. 2020 Feb 14:1-9. doi: 10.1017/S0029665120000075. Epub ahead of print. PMID: 32054546; PMCID: PMC7426243.
Simsek H, Meseri R, Sahin S, et al. Prevalence of sarcopenia and related factors in community-dwelling elderly individuals. Saudi Med J. 2019 May;40(6):568-574. doi: 10.15537/smj.2019.6.23917. PMID: 31219491; PMCID: PMC6778764.
Janssen I. Evolution of sarcopenia research. Appl Physiol Nutr Metab. 2010;35:707–712.
Stenholm S, Harris TB, Rantanen T, Visser M, Kritchevsky SB, Ferrucci L. Sarcopenic obesity: definition, cause and consequences. Curr Opin Clin Nutr Metab Care. 2008 Nov;11(6):693-700. doi: 10.1097/MCO.0b013e328312c37d. PMID: 18827572; PMCID: PMC2633408.
XU, D. F.; SUN, J. Q. Research progress of sarcopenic obesity in older adults. Chin J Geriatr, 2013, 32.9: 1017-1020.
Santos, C. M., Dias, J. M. D., Samora, G. A. R., Perracini, M. R., Guerra, R. O., Dias, R. C. Prevalence of obesity, sarcopenic obesity and associated factors: A FIBRA Network study. Fisioterapia em Movimento, 2017, 30: 161-169.
Guillet C, Masgrau A, Walrand S, Boirie Y. Impaired protein metabolism: interlinks between obesity, insulin resistance and inflammation. Obes Rev. 2012 Dec;13 Suppl 2:51-7. doi: 10.1111/j.1467-789X.2012.01037.x. PMID: 23107259.
Baumgartner RN. Body composition in healthy aging. Ann N Y Acad Sci. 2000 May;904:437-48. doi: 10.1111/j.1749-6632.2000.tb06498.x. PMID: 10865787.
Flegal KM, Carroll MD, Ogden CL, Johnson CL. Prevalence and trends in obesity among US adults, 1999-2000. JAMA. 2002 Oct 9;288(14):1723-7. doi: 10.1001/jama.288.14.1723. PMID: 12365955.
Rolland Y, Lauwers-Cances V, Cristini C, Abellan van Kan G, Janssen I, Morley JE, Vellas B. Difficulties with physical function associated with obesity, sarcopenia, and sarcopenic-obesity in community-dwelling elderly women: the EPIDOS (EPIDemiologie de l'OSteoporose) Study. Am J Clin Nutr. 2009 Jun;89(6):1895-900. doi: 10.3945/ajcn.2008.26950. Epub 2009 Apr 15. PMID: 19369381.
Bauer JM, Cruz-Jentoft AJ, Fielding RA, et al. Is There Enough Evidence for Osteosarcopenic Obesity as a Distinct Entity? A Critical Literature Review. Calcif Tissue Int. 2019 Aug;105(2):109-124. doi: 10.1007/s00223-019-00561-w. Epub 2019 May 16. Erratum in: Calcif Tissue Int. 2019 Jul 23; PMID: 31098729.
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Sayfalar
71-84
Yayınlanan
3 Nisan 2023
Telif Hakkı (c) 2023 Akademisyen Kitap Portalı
Lisans
LisansNasıl Atıf Yapılır
1.
Kılıç Z. Sarkopenik Obezite. Içinde: Kelle B, editör. Fizik Tedavi ve Rehabilitasyonda Güncel Konular [Internet]. Türkiye: Akademisyen Yayınevi Kitap DOI Portalı; 2023 [a.yer 16 Temmuz 2026]. ss. 71-84. Erişim adresi: https://omp35.books.akademisyen.net/index.php/akya/catalog/book/2533/chapter/13793
