Gingko Biloba
Özet
Her geçen gün geleneksel ve tamamlayıcı tıp uygulamalarının kullanım sıklığının tüm dünyada ve ülkemizde giderek arttığı bilinmektedir. Birçok farklı rahatsızlıkta kullanıldığı gibi bu ürünler kanser hastalarında da yaygın bir şekilde kullanılmaktadır. Bunun en önemli nedenleri de antineoplastik ilaçların yan etki ve maliyetleridir. Gingko biloba da kanser hastalarında sık kullanılmakta olup kanser üzerine etkileri tartışmalıdır. Bu bölümde gingko bilobanın kullanıldığı hastalıklar, kanser hastalarında kullanımı, yan etkileri ve ilaç etkileşimleri tıbbi kanıtlara dayanarak özetlenmiştir.
It is known that the frequency of use of traditional and complementary medicine practices is increasing day by day all over the world and in our country. Just as they are used in many different diseases, these products are also widely used in cancer patients. The most important reasons for this are the side effects and costs of antineoplastic drugs. Gingko biloba is also frequently used in cancer patients, but its effects on cancer are controversial. In this section, the diseases in which gingko biloba is used, its use in cancer patients, side effects, and drug interactions are summarized based on medical evidence.
Referanslar
NIH/NCCIH. Ginkgo. 2022. Accessed May 10, 2022. https://www.nccih.nih.gov/health/ginkgo
van Beek TA, Montoro P. Chemical analysis and quality control of Ginkgo Biloba leaves, extracts, and phytopharmaceuticals. J Chromatogr A. 2009;1216(11):2002–32.
Chan, P.-C., Xia, Q., Fu, P.P., 2007. Ginkgo biloba leave extract: biological, medicinal, and toxicological effects. J. Environ. Sci. Health. C. Environ. Carcinog. Ecotoxicol. Rev. 25, 211e244.
Isaac Duah Boateng. A critical review of ginkgolic acids in Ginkgo biloba leaf extract (EGb): toxicity and technologies to remove ginkgolic acids and their promising bioactivities. Food Funct 2022 Sep 22;13(18):9226-9242.
Jin-Peng Zhu, Hao Gong, Faiza Labreche, Xiao-Hong Kou, Cai-E Wu, Gong-Jian Fan, Ting-Ting Li, Jia-Hong Wang. In vivo toxicity assessment of 4'-O-methylpyridoxine from Ginkgo biloba seeds: Growth, hematology, metabolism, and oxidative parameters. Toxicon. 2021 Oct 15:201:66-73.
Lixia Yan, Qiping Wei, Ying Gao. Treating Severe Adverse Drug Reactions Caused by Ischemic Optic Neuropathy with Ginkgo Biloba Extract Injection: A Case Report. Altern Ther Health Med. 2023 Jul;29(5):78-81.
Xiangji Dang, Rui Wang, Yan Liu. Disulfiram-like Reaction With Ginaton: A Case Report and Literature Review. Clin Ther. 2023 Nov;45(11):1151-1154.
Jin-Peng Zhu, Hao Gong, Cai-E Wu, Gong-Jian Fan, Ting-Ting Li, Jia-Hong Wang. 4'- O-methylpyridoxine: Preparation from Ginkgo biloba Seeds and Cytotoxicity in GES-1 Cells. Toxins (Basel). 2021 Jan 26;13(2):95.
Qun Wang, Zhi Li Wu, Xing Yuan, Hong Yuan Dong, Xin Xu, Hong Xin ve ark. Bilobetin induces kidney injury by influencing cGMP-mediated AQP-2 trafficking and podocyte cell cycle arrest. Phytomedicine. 2019 Nov:64:153073.
Yun-Ying Li, Xiao-Yan Lu, Jia-Li Sun, Qing-Qing Wang, Yao-Dan Zhang, Jian-Bing Zhang, Xiao-Hui Fan. Potential hepatic and renal toxicity induced by the biflavonoids from Ginkgo biloba. Chin J Nat Med. 2019 Sep;17(9):672-681.
Jie Bai, Chao Zhang. Metabolic interaction between biflavonoids in Ginkgo biloba leaves and tacrolimus. Biopharm Drug Dispos. 2023 Apr;44(2):157-164.
Xueting Xing, Mengzhu Kong, Qiaoyu Hou, Jiaqi Li, Wen Qian, Xijing Chen, Hanhan Li, Changqing Yang. Effects of ginkgo leaf tablet on the pharmacokinetics of rosiglitazone in rats and its potential mechanism. Pharm Biol. 2022 Dec;60(1):1190-1197.
Milan Trabert, Roland Seifert. Critical analysis of ginkgo preparations: comparison of approved drugs and dietary supplements marketed in Germany. Naunyn Schmiedebergs Arch Pharmacol. 2023 Jul 20.
Tian-Ran Chen, Ling-Hua Wei, Xiao-Qing Guan, Chao Huang, Zhe-Yi Liu ve ark. Biflavones from Ginkgo biloba as inhibitors of human thrombin. Bioorg Chem. 2019 Nov:92:103199.
Ewald Pretner, Hakıma Amrı, Wenpıng Lı, Rachel Brown, Chın-Shoou Lın, Erını Makarıou. Cancer-related Overexpression of the Peripheral-type Benzodiazepine Receptor and Cytostatic Anticancer Effects of Ginkgo biloba Extract. ANTICANCER RESEARCH 26: 9-22 (2006).
Jian-Shu Lou, Li-Ping Zhao, Zhi-Hui Huang, Xia-Yin Chen, Jing-Ting Xu, William Chi-Shing TAI ve ark. Ginkgetin derived from Ginkgo biloba leaves enhances the therapeutic effect of cisplatin via ferroptosis-mediated disruption of the Nrf2/HO-1 axis in EGFR wild-type non-small-cell lung cancer. Phytomedicine (2020), doi:https://doi.org/10.1016/j.phymed.2020.153370
Ping Chen, Tao Wang, Qi Chen. Ginkgo biloba Golden Leaf Extract (GGLE) Inhibits Melanoma Cell Invasion and Angiogenesis Through Inhibition of Angiogenin. Integrative Cancer Therapies Volume 22: 1–11.
Huan Wang, Xia Wu, Stephane Lezmi, Qian Li, William G. Helferich, Yueqing Xu and Hong Chen. Extract of Ginkgo biloba exacerbates liver metastasis in a mouse colon cancer Xenograft model. BMC Complementary and Alternative Medicine (2017) 17:516.
Qiong Liu, Lingying Chen, Wenjun Yin, Yuehua Nie, Penghui Zeng, Xin Yang. Anti-Tumor Effect Of Ginkgetin On Human Hepatocellular Carcinoma Cell Lines By İnducing Cell Cycle Arrest And Promoting Cell Apoptosis. Cell Cycle 2022, Vol. 21, No. 1, 74–85.
Kyung-Su Kim, Kwang-Hyeon Rhee, Joo-Heon Yoon, Jeung Gweon Lee, Joo-Hwan Lee, Jong-Bum Yoo. Ginkgo biloba extract (EGb 761) induces apoptosis by the activation of caspase-3 in oral cavity cancer cells. Oral Oncology (2005) 41, 383–389.
Ai-Hua Xu, Hua-Sheng Chen, Bu-Chan Sun, Xiao-Ren Xiang, Yun-Fei Chu, Fan Zhai, Ling-Chang Jia. Therapeutic mechanism of ginkgo biloba exocarp polysaccharides on gastric cancer. World J Gastroenterol 2003;9(11):2424-2427.
Ok Heui You, Sun-Hee Kim, Bonglee Kim, Eun Jung Sohn, Hyo-Jeong Lee, Bum-Sang Shim, Miyong Yun, Byung-Mog Kwon, Sung-Hoon Kim. Ginkgetin induces apoptosis via activation of caspase and inhibition of survival genes in PC-3 prostate cancer cells. Bioorganic & Medicinal Chemistry Letters 23 (2013) 2692–2695.
Liqiang Chang, Tingting Liu, Zhongqiu Chai, Song Jie, Zhongyun Li, Meilian Liu, Wenhai Dong, Xixing Wang, Bing Zhou. lincRNA-p21 Mediates the Anti-Cancer Effect of Ginkgo Biloba Extract EGb 761 by Stabilizing E-Cadherin Protein in Colon Cancer. Med Sci Monit, 2018; 24: 9488-9496.
Zhenhua Fu, Lan Lin, Shiquan Liu, Mengbin Qin, Siwei He, Liye Zhu, Jiean Huang. Ginkgo Biloba Extract Inhibits Metastasis and ERK/Nuclear Factor kappa B (NF-kB) Signaling Pathway in Gastric Cancer. Med Sci Monit, 2019; 25: 6836-6845.
Wei J, Weiliang Q, Yisheng W. 2011. Ginkgo may prevent genetic-associated ovarian cancer risk: multiple biomarkers and anticancer pathways induced by ginkgolide B in BRCA1-mutant ovarian epithelial cells. Eur J Cancer Prev.20:508–517.
Jiguang Ma, Wanxing Duan, Suxia Han, Jianjun Lei, Qinhong Xu, Xin Chen, Zhengdong Jiang, Ligang Nan, Jiahui Li, Ke Chen, Liang Han, Zheng Wang, Xuqi Li, Erxi Wu, Xiongwei Huo. Ginkgolic acid suppresses the development of pancreatic cancer by inhibiting pathways driving lipogenesis. Oncotarget, Vol. 6, No. 25.
Jong-Rung Tsai, Po-Len Liu, Yung-Hsiang Chen, Shah-Hwa Chou, Ming-Chan Yang, Yu-Jen Cheng, Jhi-Jhu Hwang, Wei-Hsian Yin, Inn-Wen Chong. Ginkgo biloba Extract Decreases Non-Small Cell Lung Cancer Cell Migration by Downregulating Metastasis-Associated Factor Heat-Shock Protein 27. PLOSONE Volume 9, Issue 3.
van Beek TA, Montoro P. Chemical analysis and quality control of Ginkgo Biloba leaves, extracts, and phytopharmaceuticals. J Chromatogr A. 2009;1216(11):2002–32.
Chan, P.-C., Xia, Q., Fu, P.P., 2007. Ginkgo biloba leave extract: biological, medicinal, and toxicological effects. J. Environ. Sci. Health. C. Environ. Carcinog. Ecotoxicol. Rev. 25, 211e244.
Isaac Duah Boateng. A critical review of ginkgolic acids in Ginkgo biloba leaf extract (EGb): toxicity and technologies to remove ginkgolic acids and their promising bioactivities. Food Funct 2022 Sep 22;13(18):9226-9242.
Jin-Peng Zhu, Hao Gong, Faiza Labreche, Xiao-Hong Kou, Cai-E Wu, Gong-Jian Fan, Ting-Ting Li, Jia-Hong Wang. In vivo toxicity assessment of 4'-O-methylpyridoxine from Ginkgo biloba seeds: Growth, hematology, metabolism, and oxidative parameters. Toxicon. 2021 Oct 15:201:66-73.
Lixia Yan, Qiping Wei, Ying Gao. Treating Severe Adverse Drug Reactions Caused by Ischemic Optic Neuropathy with Ginkgo Biloba Extract Injection: A Case Report. Altern Ther Health Med. 2023 Jul;29(5):78-81.
Xiangji Dang, Rui Wang, Yan Liu. Disulfiram-like Reaction With Ginaton: A Case Report and Literature Review. Clin Ther. 2023 Nov;45(11):1151-1154.
Jin-Peng Zhu, Hao Gong, Cai-E Wu, Gong-Jian Fan, Ting-Ting Li, Jia-Hong Wang. 4'- O-methylpyridoxine: Preparation from Ginkgo biloba Seeds and Cytotoxicity in GES-1 Cells. Toxins (Basel). 2021 Jan 26;13(2):95.
Qun Wang, Zhi Li Wu, Xing Yuan, Hong Yuan Dong, Xin Xu, Hong Xin ve ark. Bilobetin induces kidney injury by influencing cGMP-mediated AQP-2 trafficking and podocyte cell cycle arrest. Phytomedicine. 2019 Nov:64:153073.
Yun-Ying Li, Xiao-Yan Lu, Jia-Li Sun, Qing-Qing Wang, Yao-Dan Zhang, Jian-Bing Zhang, Xiao-Hui Fan. Potential hepatic and renal toxicity induced by the biflavonoids from Ginkgo biloba. Chin J Nat Med. 2019 Sep;17(9):672-681.
Jie Bai, Chao Zhang. Metabolic interaction between biflavonoids in Ginkgo biloba leaves and tacrolimus. Biopharm Drug Dispos. 2023 Apr;44(2):157-164.
Xueting Xing, Mengzhu Kong, Qiaoyu Hou, Jiaqi Li, Wen Qian, Xijing Chen, Hanhan Li, Changqing Yang. Effects of ginkgo leaf tablet on the pharmacokinetics of rosiglitazone in rats and its potential mechanism. Pharm Biol. 2022 Dec;60(1):1190-1197.
Milan Trabert, Roland Seifert. Critical analysis of ginkgo preparations: comparison of approved drugs and dietary supplements marketed in Germany. Naunyn Schmiedebergs Arch Pharmacol. 2023 Jul 20.
Tian-Ran Chen, Ling-Hua Wei, Xiao-Qing Guan, Chao Huang, Zhe-Yi Liu ve ark. Biflavones from Ginkgo biloba as inhibitors of human thrombin. Bioorg Chem. 2019 Nov:92:103199.
Ewald Pretner, Hakıma Amrı, Wenpıng Lı, Rachel Brown, Chın-Shoou Lın, Erını Makarıou. Cancer-related Overexpression of the Peripheral-type Benzodiazepine Receptor and Cytostatic Anticancer Effects of Ginkgo biloba Extract. ANTICANCER RESEARCH 26: 9-22 (2006).
Jian-Shu Lou, Li-Ping Zhao, Zhi-Hui Huang, Xia-Yin Chen, Jing-Ting Xu, William Chi-Shing TAI ve ark. Ginkgetin derived from Ginkgo biloba leaves enhances the therapeutic effect of cisplatin via ferroptosis-mediated disruption of the Nrf2/HO-1 axis in EGFR wild-type non-small-cell lung cancer. Phytomedicine (2020), doi:https://doi.org/10.1016/j.phymed.2020.153370
Ping Chen, Tao Wang, Qi Chen. Ginkgo biloba Golden Leaf Extract (GGLE) Inhibits Melanoma Cell Invasion and Angiogenesis Through Inhibition of Angiogenin. Integrative Cancer Therapies Volume 22: 1–11.
Huan Wang, Xia Wu, Stephane Lezmi, Qian Li, William G. Helferich, Yueqing Xu and Hong Chen. Extract of Ginkgo biloba exacerbates liver metastasis in a mouse colon cancer Xenograft model. BMC Complementary and Alternative Medicine (2017) 17:516.
Qiong Liu, Lingying Chen, Wenjun Yin, Yuehua Nie, Penghui Zeng, Xin Yang. Anti-Tumor Effect Of Ginkgetin On Human Hepatocellular Carcinoma Cell Lines By İnducing Cell Cycle Arrest And Promoting Cell Apoptosis. Cell Cycle 2022, Vol. 21, No. 1, 74–85.
Kyung-Su Kim, Kwang-Hyeon Rhee, Joo-Heon Yoon, Jeung Gweon Lee, Joo-Hwan Lee, Jong-Bum Yoo. Ginkgo biloba extract (EGb 761) induces apoptosis by the activation of caspase-3 in oral cavity cancer cells. Oral Oncology (2005) 41, 383–389.
Ai-Hua Xu, Hua-Sheng Chen, Bu-Chan Sun, Xiao-Ren Xiang, Yun-Fei Chu, Fan Zhai, Ling-Chang Jia. Therapeutic mechanism of ginkgo biloba exocarp polysaccharides on gastric cancer. World J Gastroenterol 2003;9(11):2424-2427.
Ok Heui You, Sun-Hee Kim, Bonglee Kim, Eun Jung Sohn, Hyo-Jeong Lee, Bum-Sang Shim, Miyong Yun, Byung-Mog Kwon, Sung-Hoon Kim. Ginkgetin induces apoptosis via activation of caspase and inhibition of survival genes in PC-3 prostate cancer cells. Bioorganic & Medicinal Chemistry Letters 23 (2013) 2692–2695.
Liqiang Chang, Tingting Liu, Zhongqiu Chai, Song Jie, Zhongyun Li, Meilian Liu, Wenhai Dong, Xixing Wang, Bing Zhou. lincRNA-p21 Mediates the Anti-Cancer Effect of Ginkgo Biloba Extract EGb 761 by Stabilizing E-Cadherin Protein in Colon Cancer. Med Sci Monit, 2018; 24: 9488-9496.
Zhenhua Fu, Lan Lin, Shiquan Liu, Mengbin Qin, Siwei He, Liye Zhu, Jiean Huang. Ginkgo Biloba Extract Inhibits Metastasis and ERK/Nuclear Factor kappa B (NF-kB) Signaling Pathway in Gastric Cancer. Med Sci Monit, 2019; 25: 6836-6845.
Wei J, Weiliang Q, Yisheng W. 2011. Ginkgo may prevent genetic-associated ovarian cancer risk: multiple biomarkers and anticancer pathways induced by ginkgolide B in BRCA1-mutant ovarian epithelial cells. Eur J Cancer Prev.20:508–517.
Jiguang Ma, Wanxing Duan, Suxia Han, Jianjun Lei, Qinhong Xu, Xin Chen, Zhengdong Jiang, Ligang Nan, Jiahui Li, Ke Chen, Liang Han, Zheng Wang, Xuqi Li, Erxi Wu, Xiongwei Huo. Ginkgolic acid suppresses the development of pancreatic cancer by inhibiting pathways driving lipogenesis. Oncotarget, Vol. 6, No. 25.
Jong-Rung Tsai, Po-Len Liu, Yung-Hsiang Chen, Shah-Hwa Chou, Ming-Chan Yang, Yu-Jen Cheng, Jhi-Jhu Hwang, Wei-Hsian Yin, Inn-Wen Chong. Ginkgo biloba Extract Decreases Non-Small Cell Lung Cancer Cell Migration by Downregulating Metastasis-Associated Factor Heat-Shock Protein 27. PLOSONE Volume 9, Issue 3.
Sayfalar
35-38
Yayınlanan
11 Mart 2024
Telif Hakkı (c) 2024 Akademisyen Yayınevi Kitap Portalı
Lisans
LisansNasıl Atıf Yapılır
1.
Erciyestepe M. Gingko Biloba. Içinde: Sakin A, editör. Kanser Hastalarının Başvurduğu Geleneksel ve Tamamlayıcı Tedaviler - Tıbbi Onkolog Gözü ile Bakış ve Onkolojik İlaçlarla Etkileşim [Internet]. Türkiye: Akademisyen Yayınevi Kitap DOI Portalı; 2024 [a.yer 13 Temmuz 2026]. ss. 35-8. Erişim adresi: https://omp35.books.akademisyen.net/index.php/akya/catalog/book/2380/chapter/13886
