Endometriozis ve Adenomyoziste IVF Yönetimi
Synopsis
Endometriozis ve adenomyozis, kadın infertilitesinin yaygın nedenlerinden biridir. Günümüzde bu hasta grubunun yaklaşık 1/4’ünde in vitro fertilizasyon ve intrasitoplazmik sperm enjeksiyonu gibi yardımcı üreme tekniklerine ihtiyaç duyulmaktadır. Sıklıkla birliktelik gösteren bu iki hastalığın kadınlarda fertilite üzerindeki etkileri iyi bilinmelidir. Hangi hastaya bekle gör, hangi hastaya fertilite tedavisi uygulanacağı hastaların yaşı, over rezervi, infertilite süresi, sistemik hastalıklar, eşlik eden diğer faktörler, hastalığın derecesi ve lokalizasyonu gibi birçok değişkene bağlıdır. Hala uygulanacak en optimal yardımcı üreme tekniği, tedavinin takibi ve embriyo transferi konusunda karar birliği yoktur. Bu yüzden endometriozis ve adenomyozisli hastalara uygulanacak fertilite tedavileri bireyselleştirilmelidir.
Endometriosis and adenomyosis are common causes of female infertility. Currently, approximately 1/4 of this patient group requires assisted reproductive techniques such as in vitro fertilisation and intracytoplasmic sperm injection. The effects of these two diseases, which often coexist, on fertility in women should be well known. Which patient should receive wait-and-see treatment and which patient should receive fertility treatment depends on many variables such as age, ovarian reserve, duration of infertility, systemic diseases, other accompanying factors, degree and localisation of the disease. There is still no consensus on the optimal assisted reproductive technique, follow-up of treatment and embryo transfer. Therefore, fertility treatments for patients with endometriosis and adenomyosis should be individualised.
References
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Taylor HS, Kotlyar AM and Flores VA. Endometriosis is a chronic systemic disease: clinical challenges and novel innovations. Lancet 2021; 397: 839–852.
Macer ML and Taylor HS. Endometriosis and infertility: a review of the pathogenesis and treatment of endometriosis-associated infertility. Obstet Gynecol Clin North Am 2012; 39: 535–549 / Bulletti C, Coccia ME, Battistoni S, et al. Endometriosis and infertility. J Assist Reprod Genet 2010; 27: 441–447
World Health Organization. Endometriosis. (12.08.2024 tarihinde https://www.who.int/news-room/fact-sheets/detail/endometriosis adresinden ulaşılmıştır)
Vassilopoulou L, Matalliotakis M, Zervou MI, et al. Endometriosis and in vitro fertilisation. Exp Ther Med 2018; 16: 1043–1051
Tanbo T, Fedorcsak P. Endometriosis-associated infertility: aspects of pathophysiological mechanisms and treatment options. Acta Obstet Gynecol Scand. 2017;96(6):659-667. doi:10.1111/aogs.13082
Aleksandrovych V., Basta P., Gil K. Current facts constituting an understanding of the nature of adenomyosis. Adv. Clin. Exp. Med. 2019;28:839–846. doi: 10.17219/acem/79176.
Martone S., Centini G., Exacoustos C., Zupi E., Afors K., Zullo F., Maneschi F., Habib N., Lazzeri L. Pathophysiologic mechanisms by which adenomyosis predisposes to postpartum haemorage and other obstetric complications. Med. Hypotheses. 2020;143:109833. doi: 10.1016/j.mehy.2020.109833.
Sharma S, Bathwal S, Agarwal N, Chattopadhyay R, Saha I, Chakravarty B. Does presence of adenomyosis affect reproductive outcome in IVF cycles? A retrospective analysis of 973 patients [published correction appears in Reprod Biomed Online. 2024 May;48(5):103911. doi: 10.1016/j.rbmo.2024.103911.
Tan J., Yong P., Bedaiwy M.A. A critical review of recent advances in the diagnosis, classification, and management of uterine adenomyosis. Curr. Opin. Obstet. Gynecol. 2019;31:212–221. doi: 10.1097/GCO.0000000000000555.
Squillace ALA, Simonian DS, Allegro MC, Borges E Júnior, Bianchi PHM, Bibancos M. Adenomyosis and in vitro fertilization impacts - A literature review. JBRA Assist Reprod. Published online April 27, 2021. doi:10.5935/1518-0557.20200104
Tamura H., Kishi H., Kitade M., Asai-Sato M., Tanaka A., Murakami T., Minegishi T., Sugino N. Clinical outcomes of infertility treatment for women with adenomyosis in Japan. Reprod. Med. Biol. 2017;16:276–282. doi: 10.1002/rmb2.12036
Guo, S. W. (2020). The pathogenesis of adenomyosis vis-à-vis endometriosis. Journal of clinical medicine, 9(2), 485.
Mijatovic, V., Florijn, E., Halim, N., Schats, R., & Hompes, P. (2010). Adenomyosis has no adverse effects on IVF/ICSI outcomes in women with endometriosis treated with long-term pituitary down-regulation before IVF/ICSI. European Journal of Obstetrics & Gynecology and Reproductive Biology, 151(1), 62-65
Becker CM, Bokor A, Heikinheimo O, et al. ESHRE guideline: endometriosis. Hum Reprod Open. 2022;2022(2):hoac009. Published 2022 Feb 26. doi:10.1093/hropen/hoac009
Harb HM, Gallos ID, Chu J, Harb M, Coomarasamy A. The effect of endometriosis on in vitro fertilisation outcome: a systematic review and meta-analysis. Bjog 2013;120: 1308-1320
Johnson NP, Hummelshoj L, Adamson GD, et al. World Endometriosis Society consensus on the classification of endometriosis. Hum Reprod. 2017;32(2):315-324. doi:10.1093/humrep/dew293
Garbhagudi IVF Centre, ART in endometriosis. (12.08.2024 tarihinde https://www.garbhagudi.com/blogs/art-in-endometriosis adresinden ulaşılmıştır)
Cozzolino M, Alsbjerg B, Pellicer A, Garcia-Velasco JA, Humaidan P. The adenomyosis/endometriosis IVF patient - call for clinical focus. Reprod Biomed Online. 2024;48(4):103737. doi:10.1016/j.rbmo.2023.103737
Zhang Y, Zhao W, Han Y, et al. The follicular-phase depot GnRH agonist protocol results in a higher live birth rate without discernible differences in luteal function and child health versus the daily mid-luteal GnRH agonist protocol: a single-centre, retrospective, propensity score matched cohort study. Reprod Biol Endocrinol. 2022;20(1):140.
Rozati R, Tabasum W,Azimi SS, Syedani Z, Wnnamaneni S. Stimulation protocols for Severe Endometriosis-is there any difference? Brazilian Journal of Development, Curitiba, 2024;10(1):282-303 doi:10.34117/bjdv10n1-019
Kolanska K, Cohen J, Bendifallah S, et al. Pregnancy outcomes after controlled ovarian hyperstimulation in women with endometriosis-associated infertility: GnRH-agonist versus GnRH-antagonist. J Gynecol Obstet Hum Reprod. 2017;46(9):681-686. doi:10.1016/j.jogoh.2017.09.007
Kuan KKW, Omoseni S, Tello JA. Comparing ART outcomes in women with endometriosis after GnRH agonist versus GnRH antagonist ovarian stimulation: a systematic review. Ther Adv Endocrinol Metab. 2023;14:20420188231173325. doi:10.1177/20420188231173325
Georgiou EX, Melo P, Baker PE, et al. Long-term GnRH agonist therapy before in vitro fertilisation (IVF) for improving fertility outcomes in women with endometriosis. Cochrane Database Syst Rev. 2019;2019(11):CD013240. doi:10.1002/14651858.CD013240.pub2
Rocha TP, Andres MP, Borrelli GM, Abrão MS. Fertility-Sparing Treatment of Adenomyosis in Patients With Infertility: A Systematic Review of Current Options. Reprod Sci. 2018;25(4):480-486. doi:10.1177/1933719118756754
Han B, Liang T, Zhang W, Ma C, Qiao J. The effect of adenomyosis types on clinical outcomes of IVF embryo transfer after ultra-long GnRH agonist protocol. Reprod Biomed Online. 2023;46(2):346-351. doi:10.1016/j.rbmo.2022.09.021
Lan J, Wu Y, Wu Z, et al. Ultra-Long GnRH Agonist Protocol During IVF/ICSI Improves Pregnancy Outcomes in Women With Adenomyosis: A Retrospective Cohort Study. Front Endocrinol (Lausanne). 2021;12:609771. doi:10.3389/fendo.2021.609771
Thalluri V, Tremellen KP. Ultrasound diagnosed adenomyosis has a negative impact on successful implantation following GnRH antagonist IVF treatment. Hum Reprod. 2012;27(12):3487-3492. doi:10.1093/humrep/des305
Zhang, L., Cai, H., Liu, X., Xiong, Y., Liang, X., & Shi, J. (2022). Comparison of pregnancy outcomes between GnRH antagonist protocol with freeze-all strategy and long-acting GnRH agonist protocol in women with adenomyosis undergoing IVF/ICSI: a propensity-score matching analysis. BMC Pregnancy and Childbirth, 22(1), 946..
Chang Y, Shen M, Wang S, Li X, Duan H. Association of embryo transfer type with infertility in endometriosis: a systematic review and meta-analysis. J Assist Reprod Genet. 2022;39(5):1033-1043. doi:10.1007/s10815-022-02460-w
Taylor HS, Kotlyar AM and Flores VA. Endometriosis is a chronic systemic disease: clinical challenges and novel innovations. Lancet 2021; 397: 839–852.
Macer ML and Taylor HS. Endometriosis and infertility: a review of the pathogenesis and treatment of endometriosis-associated infertility. Obstet Gynecol Clin North Am 2012; 39: 535–549 / Bulletti C, Coccia ME, Battistoni S, et al. Endometriosis and infertility. J Assist Reprod Genet 2010; 27: 441–447
World Health Organization. Endometriosis. (12.08.2024 tarihinde https://www.who.int/news-room/fact-sheets/detail/endometriosis adresinden ulaşılmıştır)
Vassilopoulou L, Matalliotakis M, Zervou MI, et al. Endometriosis and in vitro fertilisation. Exp Ther Med 2018; 16: 1043–1051
Tanbo T, Fedorcsak P. Endometriosis-associated infertility: aspects of pathophysiological mechanisms and treatment options. Acta Obstet Gynecol Scand. 2017;96(6):659-667. doi:10.1111/aogs.13082
Aleksandrovych V., Basta P., Gil K. Current facts constituting an understanding of the nature of adenomyosis. Adv. Clin. Exp. Med. 2019;28:839–846. doi: 10.17219/acem/79176.
Martone S., Centini G., Exacoustos C., Zupi E., Afors K., Zullo F., Maneschi F., Habib N., Lazzeri L. Pathophysiologic mechanisms by which adenomyosis predisposes to postpartum haemorage and other obstetric complications. Med. Hypotheses. 2020;143:109833. doi: 10.1016/j.mehy.2020.109833.
Sharma S, Bathwal S, Agarwal N, Chattopadhyay R, Saha I, Chakravarty B. Does presence of adenomyosis affect reproductive outcome in IVF cycles? A retrospective analysis of 973 patients [published correction appears in Reprod Biomed Online. 2024 May;48(5):103911. doi: 10.1016/j.rbmo.2024.103911.
Tan J., Yong P., Bedaiwy M.A. A critical review of recent advances in the diagnosis, classification, and management of uterine adenomyosis. Curr. Opin. Obstet. Gynecol. 2019;31:212–221. doi: 10.1097/GCO.0000000000000555.
Squillace ALA, Simonian DS, Allegro MC, Borges E Júnior, Bianchi PHM, Bibancos M. Adenomyosis and in vitro fertilization impacts - A literature review. JBRA Assist Reprod. Published online April 27, 2021. doi:10.5935/1518-0557.20200104
Tamura H., Kishi H., Kitade M., Asai-Sato M., Tanaka A., Murakami T., Minegishi T., Sugino N. Clinical outcomes of infertility treatment for women with adenomyosis in Japan. Reprod. Med. Biol. 2017;16:276–282. doi: 10.1002/rmb2.12036
Guo, S. W. (2020). The pathogenesis of adenomyosis vis-à-vis endometriosis. Journal of clinical medicine, 9(2), 485.
Mijatovic, V., Florijn, E., Halim, N., Schats, R., & Hompes, P. (2010). Adenomyosis has no adverse effects on IVF/ICSI outcomes in women with endometriosis treated with long-term pituitary down-regulation before IVF/ICSI. European Journal of Obstetrics & Gynecology and Reproductive Biology, 151(1), 62-65
Becker CM, Bokor A, Heikinheimo O, et al. ESHRE guideline: endometriosis. Hum Reprod Open. 2022;2022(2):hoac009. Published 2022 Feb 26. doi:10.1093/hropen/hoac009
Harb HM, Gallos ID, Chu J, Harb M, Coomarasamy A. The effect of endometriosis on in vitro fertilisation outcome: a systematic review and meta-analysis. Bjog 2013;120: 1308-1320
Johnson NP, Hummelshoj L, Adamson GD, et al. World Endometriosis Society consensus on the classification of endometriosis. Hum Reprod. 2017;32(2):315-324. doi:10.1093/humrep/dew293
Garbhagudi IVF Centre, ART in endometriosis. (12.08.2024 tarihinde https://www.garbhagudi.com/blogs/art-in-endometriosis adresinden ulaşılmıştır)
Cozzolino M, Alsbjerg B, Pellicer A, Garcia-Velasco JA, Humaidan P. The adenomyosis/endometriosis IVF patient - call for clinical focus. Reprod Biomed Online. 2024;48(4):103737. doi:10.1016/j.rbmo.2023.103737
Zhang Y, Zhao W, Han Y, et al. The follicular-phase depot GnRH agonist protocol results in a higher live birth rate without discernible differences in luteal function and child health versus the daily mid-luteal GnRH agonist protocol: a single-centre, retrospective, propensity score matched cohort study. Reprod Biol Endocrinol. 2022;20(1):140.
Rozati R, Tabasum W,Azimi SS, Syedani Z, Wnnamaneni S. Stimulation protocols for Severe Endometriosis-is there any difference? Brazilian Journal of Development, Curitiba, 2024;10(1):282-303 doi:10.34117/bjdv10n1-019
Kolanska K, Cohen J, Bendifallah S, et al. Pregnancy outcomes after controlled ovarian hyperstimulation in women with endometriosis-associated infertility: GnRH-agonist versus GnRH-antagonist. J Gynecol Obstet Hum Reprod. 2017;46(9):681-686. doi:10.1016/j.jogoh.2017.09.007
Kuan KKW, Omoseni S, Tello JA. Comparing ART outcomes in women with endometriosis after GnRH agonist versus GnRH antagonist ovarian stimulation: a systematic review. Ther Adv Endocrinol Metab. 2023;14:20420188231173325. doi:10.1177/20420188231173325
Georgiou EX, Melo P, Baker PE, et al. Long-term GnRH agonist therapy before in vitro fertilisation (IVF) for improving fertility outcomes in women with endometriosis. Cochrane Database Syst Rev. 2019;2019(11):CD013240. doi:10.1002/14651858.CD013240.pub2
Rocha TP, Andres MP, Borrelli GM, Abrão MS. Fertility-Sparing Treatment of Adenomyosis in Patients With Infertility: A Systematic Review of Current Options. Reprod Sci. 2018;25(4):480-486. doi:10.1177/1933719118756754
Han B, Liang T, Zhang W, Ma C, Qiao J. The effect of adenomyosis types on clinical outcomes of IVF embryo transfer after ultra-long GnRH agonist protocol. Reprod Biomed Online. 2023;46(2):346-351. doi:10.1016/j.rbmo.2022.09.021
Lan J, Wu Y, Wu Z, et al. Ultra-Long GnRH Agonist Protocol During IVF/ICSI Improves Pregnancy Outcomes in Women With Adenomyosis: A Retrospective Cohort Study. Front Endocrinol (Lausanne). 2021;12:609771. doi:10.3389/fendo.2021.609771
Thalluri V, Tremellen KP. Ultrasound diagnosed adenomyosis has a negative impact on successful implantation following GnRH antagonist IVF treatment. Hum Reprod. 2012;27(12):3487-3492. doi:10.1093/humrep/des305
Zhang, L., Cai, H., Liu, X., Xiong, Y., Liang, X., & Shi, J. (2022). Comparison of pregnancy outcomes between GnRH antagonist protocol with freeze-all strategy and long-acting GnRH agonist protocol in women with adenomyosis undergoing IVF/ICSI: a propensity-score matching analysis. BMC Pregnancy and Childbirth, 22(1), 946..
Chang Y, Shen M, Wang S, Li X, Duan H. Association of embryo transfer type with infertility in endometriosis: a systematic review and meta-analysis. J Assist Reprod Genet. 2022;39(5):1033-1043. doi:10.1007/s10815-022-02460-w
Pages
231-236
Published
January 21, 2025
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