Endometriozis ve Beslenme
Synopsis
Endometriozis, uterus dışında yer alan endometrium benzeri dokunun varlığı ile karakterize edilen kronik inflamatuar bir hastalıktır. Kesin nedeni bilinmemekle birlikte, hormonal, genetik, immünolojik ve çevresel faktörler hastalığın gelişiminde rol oynayabilir. Kesin bir tedavi yöntemi yoktur ve mevcut medikal ile cerrahi tedaviler yan etkilerle ilişkilidir. Bu durum, beslenmeyi potansiyel bir tamamlayıcı tedavi seçeneği haline getirmiştir. Lif ve antioksidan açısından zengin bitki bazlı diyetler, inflamasyonu azaltabilir ve endometriozis riskini düşürebilir. Buna karşın, kırmızı ve işlenmiş et tüketimi riski artırabilir. Ancak, bu ilişkinin netleşmesi için daha fazla araştırmaya ihtiyaç vardır.
Endometriosis is a chronic inflammatory disease characterized by the presence of endometrium-like tissue outside the uterus. While its exact cause is unknown, hormonal, genetic, immunological, and environmental factors may contribute to its development. There is no definitive treatment, and current medical and surgical options often have side effects, making diet a potential complementary approach. Plant-based diets, rich in fiber and antioxidants, may reduce inflammation and lower the risk of endometriosis. Conversely, high consumption of red and processed meats may increase the risk. Although diet may influence symptoms, more research is needed to confirm these effects.
References
Taylor HS, Kotlyar AM, Flores VA. Endometriosis is a chronic systemic disease: clinical challenges and novel innovations. Lancet; 2021;397:839–52. doi: 10.1016/ S0140-6736(21)00389-5
Corte LD, Di Filippo C, Gabrielli O, Reppuccia S, Rosa VLL, Ragusa R, et al. The burden of endometriosis on women’s lifespan: a narrative overview on quality of life and psychosocial wellbeing. Int J Environ Res Public Health; 2020;17:4683. doi: 10.3390/ijerph17134683
Nap A, de Roos N. Endometriosis and the effects of dietary interventions: what are we looking for? Reprod Fertil; 2022;3:C14–22. doi: 10.1530/RAF-21-0110
Armour M, Sinclair J, Chalmers KJ, Smith CA. Self-management strategies amongst Australian women with endometriosis: a national online survey. BMC Complement Altern Med; 2019;19:17. doi: 10.1186/s12906-019-2431-x
Missmer SA, Chavarro JE, Malspeis S, Bertone-Johnson ER, Hornstein MD, Spiegelman D, et al. A prospective study of dietary fat consumption and endometriosis risk. Hum Reprod; 2010;25:1528–35. doi: 10.1093/humrep/deq044
Pundir J, Omanwa K, Kovoor E, Pundir V, Lancaster G, Barton-Smith P. Laparoscopic excision vs. ablation for endometriosis-associated pain: an updated systematic review and meta-analysis. J Minim Invasive Gynecol; 2017;24:747– 56. doi: 10.1016/j.jmig.2017.04.008
Rose DP, Goldman M, Connolly JM, Strong LE. High-fiber diet reduces serum estrogen concentrations in premenopausal women. Am J Clin Nutr; 1991;54:520– 5. doi: 10.1093/ajcn/54.3.520
Bagga D, Ashley JM, Geffrey SP, Wang HJ, Barnard RJ, Korenman S, et al. Effects of a very low fat, high fiber diet on serum hormones and menstrual function implications for breast cancer prevention. Cancer; 1995;76:2491–6. doi: 10.1002/1097-0142(19951215)76:12<2491::AIDCNCR2820761213>3.0.CO;2-R
Mehdizadehkashi A, Rokhgireh S, Tahermanesh K, Eslahi N, Minaeian S, Samimi M. The effect of vitamin D supplementation on clinical symptoms and metabolic profiles in patients with endometriosis. Gynecol Endocrinol; 2021;37:640– 5. doi: 10.1080/09513590.2021.1878138
Teas J, Hurley TG, Hebert JR, Franke AA, Sepkovic DW, Kurzer MS. Dietary seaweed modifies estrogen and phytoestrogen metabolism in healthy postmenopausal women. J Nutr; 2009;139:939–44. doi: 10.3945/jn.108.100834
Teas J, Hurley TG, Hebert JR, Franke AA, Sepkovic DW, Kurzer MS. Dietary seaweed modifies estrogen and phytoestrogen metabolism in healthy postmenopausal women. J Nutr; 2009;139:939–44. doi: 10.3945/jn.108.100834
Mier-Cabrera J, Aburto-Soto T, Burrola-Méndez S, Jiménez-Zamudio L, Tolentino MC, Casanueva E, et al. Women with endometriosis improved their peripheral antioxidant markers after the application of a high antioxidant diet. Reprod Biol Endocrinol;2009;7(1):54.
Santanam N, Kavtaradze N, Dominguez C, Rock JA, Parthasarathy S, Murphy AA. Antioxidant supplementation reduces total chemokines and inflammatory cytokines in women with endometriosis. Fertil Steril; 2003;80:32–3. https://doi.org/10.1016/S0015- 0282(03)01887-9.
Parazzini F, Chiaffarino F, Surace M, Chatenoud L, Cipriani S, Chiantera V, et al. Selected food intake and risk of endometriosis. Hum Reprod; 2004;19(8):1755–9. https://doi.org/10.1093/humrep/ deh395
Yamamoto A, Harris HR, Vitonis AF, Chavarro JE, Missmer SA. A prospective cohort study of meat and fish consumption and endometriosis risk. Am J Obstet Gynecol;2018;219(2):178.e1–e10. https://doi.org/10.1016/j.ajog.2018.05.034.
Handa Y, Fujita H, Watanabe Y, Honma S, Kaneuchi M, Minakami H, et al. Does dietary estrogen intake from meat relate to the incidence of hormone dependent cancers? JCO; 2010;28(15_suppl):1553. doi: 10.1200/jco.2010.28.15_suppl. 1553
8. Shah B, Newman JD, Woolf K, Ganguzza L, Guo Y, Allen N, et al. Anti-inflammatory effects of a vegan diet vs. the American heart association–recommended diet in coronary artery disease trial. JAHA; 2018;7:e011367. doi: 10.1161/JAHA.118.011367
Trabert B, Peters U, De Roos AJ, Scholes D, Holt VL. Diet and risk of endometriosis in a population-based case-control study. Br J Nutr; 2011;105(3):459–67. https://doi.org/10.1017/ S0007114510003661.
Alizadeh M, Safaeiyan A, Ostadrahimi A, Estakhri R, Daneghian S, Ghafari A, et al. Efect of L−arginine and selenium added to a hypocaloric diet enriched with legumes on cardiovascular disease risk factors in women with central obesity: a randomized, double-blind, placebo controlled trial. Ann Nutr Metab; 2012;60(2):157–68.
Saraf-Bank S, Esmaillzadeh A, Faghihimani E, Azadbakht L. Efect of nonsoy legume consumption on infammation and serum adiponectin levels among frst-degree relatives of patients with diabetes: a randomized, crossover study. Nutrition; 2015;31(3):459–65
Harris HR, Eke AC, Chavarro JE, Missmer SA. Fruit and vegetable consumption and risk of endometriosis. Hum Reprod; 2018) 33:715–27. doi: 10.1093/humrep/dey014
Youseflu S, Sadatmahalleh SJ, Mottaghi A, Kazemnejad A. Dietary phytoestrogen intake and the risk of endometriosis in iranian women: a case-control study. International Journal of Fertility and Sterility; 2020;13(4):296–300. https://doi.org/10.22074/ijfs.2020. 5806.
Qiu Y, Yuan S, Wang H. Vitamin D status in endometriosis: a systematic review and meta-analysis. Arch Gynecol Obstet; 2020;302:141–52. doi: 10.1007/s00404-020-05576-5
Nirgianakis K, Egger K, Kalaitzopoulos DR, Lanz S, Bally L, Mueller MD. Effectiveness of dietary interventions in the treatment of endometriosis: a systematic review. Reprod Sci; 2022;29:26–42. doi: 10.1007/s43032-020- 00418-w
Skibola CF. The effect of Fucus vesiculosus, an edible brown seaweed, upon menstrual cycle length and hormonal status in three pre-menopausal women: a case report. BMC Compl Altern Med; 2004;4:10. doi: 10.1186/1472-6882-4-10
Craig WJ, Mangels AR, Fresán U, Marsh K, Miles FL, Saunders AV, et al. The safe and effective use of plant-based diets with guidelines for health professionals. Nutrients; 2021;13:4144. doi: 10.3390/nu13114144
Mazza E, Troiano E, Mazza S, Ferro Y, Abbinante A, Agneta MT, Montalcini T and Pujia A (2023) The impact of endometriosis on dietary choices and activities of everyday life: a cross-sectional study. Front. Nutr.10:1273976. doi: 10.3389/fnut.2023.1273976
Brinkman M, Baglietto L, Krishnan K, English D, Severi G, Morris H, et al. Consumption of animal products, their nutrient components and postmenopausal circulating steroid hormone concentrations. Eur J Clin Nutr; 2010;64(2):176–83
Bartram H.-P, Gostner A, Scheppach W, Reddy BS., Rao CV, Dusel G, at al. Effects of fish oil on rectal cell proliferation, mucosal fatty acids, and prostaglandin E2 release in healthy subjects. Gastroenterology; 1993;105(5), 1317–1322.doi:10.1016/0016-5085(93)90135-y
Hurrell R, Egli I. Iron bioavailability and dietary reference values. Am J Clin Nutr; 2010;91(5):1461s–7s
Donnez J, Binda MM, Donnez O, Dolmans MM. Oxidative stress in the pelvic cavity and its role in the pathogenesis of endometriosis. Fertil Steril; 2016;106(5):1011–7
Blank MM, Wentzensen N, Murphy MA, Hollenbeck A, Park Y. Dietary fat intake and risk of ovarian cancer in the NIH-AARP Diet and Health Study. Br J Cancer; 2012;106:596–602. doi: 10.1038/bjc.2011.572
Arab A , Karimi E, Vingrys K, Kelishadi MR , Mehrabani S, Askari G. Food groups and nutrients consumption and risk of endometriosis: a systematic review and meta-analysis of observational studies. Nutrition Journal; 2022;21:58.
Barnard N. Diet and sex-hormone binding globulin, dysmenorrhea, and premenstrual symptoms. Obstet Gynecol; 2000;95:245– 50. doi: 10.1016/S0029-7844(99)00525-6
George ES, Marshall S, Mayr HL, Trakman GL, Tatucu-Babet OA, Lassemillante AM, et al. The effect of high-polyphenol extra virgin olive oil on cardiovascular risk factors: a systematic review and meta-analysis. Crit Rev Food Sci Nutr; 2019;59:2772–95. doi: 10.1080/10408398.2018.1470491
Nodler JL, Harris HR, Chavarro JE, Frazier AL, Missmer SA. Dairy consumption during adolescence and endometriosis risk. Am J Obstet Gynecol; 2020;222:–257.e16. doi: 10.1016/j.ajog.2019.09.010
Harris HR, Chavarro JE, Malspeis S, Willett WC, Missmer SA. Dairy-food, calcium, magnesium, and vitamin D intake and endometriosis: a prospective cohort study. Am J Epidemiol; 2013;177(5):420–30.
Youseflu S, Jahanian Sadatmahalleh S, Mottaghi A, Kazemnejad A. The association of food consumption and nutrient intake with endometriosis risk in iranian women: a case-control study. International Journal of Reproductive BioMedicine; 2019;17(9): 661–70.
Corte LD, Di Filippo C, Gabrielli O, Reppuccia S, Rosa VLL, Ragusa R, et al. The burden of endometriosis on women’s lifespan: a narrative overview on quality of life and psychosocial wellbeing. Int J Environ Res Public Health; 2020;17:4683. doi: 10.3390/ijerph17134683
Nap A, de Roos N. Endometriosis and the effects of dietary interventions: what are we looking for? Reprod Fertil; 2022;3:C14–22. doi: 10.1530/RAF-21-0110
Armour M, Sinclair J, Chalmers KJ, Smith CA. Self-management strategies amongst Australian women with endometriosis: a national online survey. BMC Complement Altern Med; 2019;19:17. doi: 10.1186/s12906-019-2431-x
Missmer SA, Chavarro JE, Malspeis S, Bertone-Johnson ER, Hornstein MD, Spiegelman D, et al. A prospective study of dietary fat consumption and endometriosis risk. Hum Reprod; 2010;25:1528–35. doi: 10.1093/humrep/deq044
Pundir J, Omanwa K, Kovoor E, Pundir V, Lancaster G, Barton-Smith P. Laparoscopic excision vs. ablation for endometriosis-associated pain: an updated systematic review and meta-analysis. J Minim Invasive Gynecol; 2017;24:747– 56. doi: 10.1016/j.jmig.2017.04.008
Rose DP, Goldman M, Connolly JM, Strong LE. High-fiber diet reduces serum estrogen concentrations in premenopausal women. Am J Clin Nutr; 1991;54:520– 5. doi: 10.1093/ajcn/54.3.520
Bagga D, Ashley JM, Geffrey SP, Wang HJ, Barnard RJ, Korenman S, et al. Effects of a very low fat, high fiber diet on serum hormones and menstrual function implications for breast cancer prevention. Cancer; 1995;76:2491–6. doi: 10.1002/1097-0142(19951215)76:12<2491::AIDCNCR2820761213>3.0.CO;2-R
Mehdizadehkashi A, Rokhgireh S, Tahermanesh K, Eslahi N, Minaeian S, Samimi M. The effect of vitamin D supplementation on clinical symptoms and metabolic profiles in patients with endometriosis. Gynecol Endocrinol; 2021;37:640– 5. doi: 10.1080/09513590.2021.1878138
Teas J, Hurley TG, Hebert JR, Franke AA, Sepkovic DW, Kurzer MS. Dietary seaweed modifies estrogen and phytoestrogen metabolism in healthy postmenopausal women. J Nutr; 2009;139:939–44. doi: 10.3945/jn.108.100834
Teas J, Hurley TG, Hebert JR, Franke AA, Sepkovic DW, Kurzer MS. Dietary seaweed modifies estrogen and phytoestrogen metabolism in healthy postmenopausal women. J Nutr; 2009;139:939–44. doi: 10.3945/jn.108.100834
Mier-Cabrera J, Aburto-Soto T, Burrola-Méndez S, Jiménez-Zamudio L, Tolentino MC, Casanueva E, et al. Women with endometriosis improved their peripheral antioxidant markers after the application of a high antioxidant diet. Reprod Biol Endocrinol;2009;7(1):54.
Santanam N, Kavtaradze N, Dominguez C, Rock JA, Parthasarathy S, Murphy AA. Antioxidant supplementation reduces total chemokines and inflammatory cytokines in women with endometriosis. Fertil Steril; 2003;80:32–3. https://doi.org/10.1016/S0015- 0282(03)01887-9.
Parazzini F, Chiaffarino F, Surace M, Chatenoud L, Cipriani S, Chiantera V, et al. Selected food intake and risk of endometriosis. Hum Reprod; 2004;19(8):1755–9. https://doi.org/10.1093/humrep/ deh395
Yamamoto A, Harris HR, Vitonis AF, Chavarro JE, Missmer SA. A prospective cohort study of meat and fish consumption and endometriosis risk. Am J Obstet Gynecol;2018;219(2):178.e1–e10. https://doi.org/10.1016/j.ajog.2018.05.034.
Handa Y, Fujita H, Watanabe Y, Honma S, Kaneuchi M, Minakami H, et al. Does dietary estrogen intake from meat relate to the incidence of hormone dependent cancers? JCO; 2010;28(15_suppl):1553. doi: 10.1200/jco.2010.28.15_suppl. 1553
8. Shah B, Newman JD, Woolf K, Ganguzza L, Guo Y, Allen N, et al. Anti-inflammatory effects of a vegan diet vs. the American heart association–recommended diet in coronary artery disease trial. JAHA; 2018;7:e011367. doi: 10.1161/JAHA.118.011367
Trabert B, Peters U, De Roos AJ, Scholes D, Holt VL. Diet and risk of endometriosis in a population-based case-control study. Br J Nutr; 2011;105(3):459–67. https://doi.org/10.1017/ S0007114510003661.
Alizadeh M, Safaeiyan A, Ostadrahimi A, Estakhri R, Daneghian S, Ghafari A, et al. Efect of L−arginine and selenium added to a hypocaloric diet enriched with legumes on cardiovascular disease risk factors in women with central obesity: a randomized, double-blind, placebo controlled trial. Ann Nutr Metab; 2012;60(2):157–68.
Saraf-Bank S, Esmaillzadeh A, Faghihimani E, Azadbakht L. Efect of nonsoy legume consumption on infammation and serum adiponectin levels among frst-degree relatives of patients with diabetes: a randomized, crossover study. Nutrition; 2015;31(3):459–65
Harris HR, Eke AC, Chavarro JE, Missmer SA. Fruit and vegetable consumption and risk of endometriosis. Hum Reprod; 2018) 33:715–27. doi: 10.1093/humrep/dey014
Youseflu S, Sadatmahalleh SJ, Mottaghi A, Kazemnejad A. Dietary phytoestrogen intake and the risk of endometriosis in iranian women: a case-control study. International Journal of Fertility and Sterility; 2020;13(4):296–300. https://doi.org/10.22074/ijfs.2020. 5806.
Qiu Y, Yuan S, Wang H. Vitamin D status in endometriosis: a systematic review and meta-analysis. Arch Gynecol Obstet; 2020;302:141–52. doi: 10.1007/s00404-020-05576-5
Nirgianakis K, Egger K, Kalaitzopoulos DR, Lanz S, Bally L, Mueller MD. Effectiveness of dietary interventions in the treatment of endometriosis: a systematic review. Reprod Sci; 2022;29:26–42. doi: 10.1007/s43032-020- 00418-w
Skibola CF. The effect of Fucus vesiculosus, an edible brown seaweed, upon menstrual cycle length and hormonal status in three pre-menopausal women: a case report. BMC Compl Altern Med; 2004;4:10. doi: 10.1186/1472-6882-4-10
Craig WJ, Mangels AR, Fresán U, Marsh K, Miles FL, Saunders AV, et al. The safe and effective use of plant-based diets with guidelines for health professionals. Nutrients; 2021;13:4144. doi: 10.3390/nu13114144
Mazza E, Troiano E, Mazza S, Ferro Y, Abbinante A, Agneta MT, Montalcini T and Pujia A (2023) The impact of endometriosis on dietary choices and activities of everyday life: a cross-sectional study. Front. Nutr.10:1273976. doi: 10.3389/fnut.2023.1273976
Brinkman M, Baglietto L, Krishnan K, English D, Severi G, Morris H, et al. Consumption of animal products, their nutrient components and postmenopausal circulating steroid hormone concentrations. Eur J Clin Nutr; 2010;64(2):176–83
Bartram H.-P, Gostner A, Scheppach W, Reddy BS., Rao CV, Dusel G, at al. Effects of fish oil on rectal cell proliferation, mucosal fatty acids, and prostaglandin E2 release in healthy subjects. Gastroenterology; 1993;105(5), 1317–1322.doi:10.1016/0016-5085(93)90135-y
Hurrell R, Egli I. Iron bioavailability and dietary reference values. Am J Clin Nutr; 2010;91(5):1461s–7s
Donnez J, Binda MM, Donnez O, Dolmans MM. Oxidative stress in the pelvic cavity and its role in the pathogenesis of endometriosis. Fertil Steril; 2016;106(5):1011–7
Blank MM, Wentzensen N, Murphy MA, Hollenbeck A, Park Y. Dietary fat intake and risk of ovarian cancer in the NIH-AARP Diet and Health Study. Br J Cancer; 2012;106:596–602. doi: 10.1038/bjc.2011.572
Arab A , Karimi E, Vingrys K, Kelishadi MR , Mehrabani S, Askari G. Food groups and nutrients consumption and risk of endometriosis: a systematic review and meta-analysis of observational studies. Nutrition Journal; 2022;21:58.
Barnard N. Diet and sex-hormone binding globulin, dysmenorrhea, and premenstrual symptoms. Obstet Gynecol; 2000;95:245– 50. doi: 10.1016/S0029-7844(99)00525-6
George ES, Marshall S, Mayr HL, Trakman GL, Tatucu-Babet OA, Lassemillante AM, et al. The effect of high-polyphenol extra virgin olive oil on cardiovascular risk factors: a systematic review and meta-analysis. Crit Rev Food Sci Nutr; 2019;59:2772–95. doi: 10.1080/10408398.2018.1470491
Nodler JL, Harris HR, Chavarro JE, Frazier AL, Missmer SA. Dairy consumption during adolescence and endometriosis risk. Am J Obstet Gynecol; 2020;222:–257.e16. doi: 10.1016/j.ajog.2019.09.010
Harris HR, Chavarro JE, Malspeis S, Willett WC, Missmer SA. Dairy-food, calcium, magnesium, and vitamin D intake and endometriosis: a prospective cohort study. Am J Epidemiol; 2013;177(5):420–30.
Youseflu S, Jahanian Sadatmahalleh S, Mottaghi A, Kazemnejad A. The association of food consumption and nutrient intake with endometriosis risk in iranian women: a case-control study. International Journal of Reproductive BioMedicine; 2019;17(9): 661–70.
Pages
157-162
Published
January 21, 2025
Copyright (c) 2025 Academician Publishing Book Portal
