Erkek İnfertilitesinde Ampirik Tedavi Yöntemleri
References
Al Khayal AM, Balaraj FK, Alferayan TA, Al Sait MA, Abumelha SM, Alrabeeah KA. Empirical therapy for male factor infertility: Survey of the current practice. Urology Annals. 2021;13(4):346.
Jung JH, Seo JT. Empirical medical therapy in idiopathic male infertility: promise or panacea? Clinical and experimental reproductive medicine. 2014;41(3):108.
Buhling KJ, Chan P, Kathrins M, Showell M, Vij SC, Sigman M. Should empiric therapies be used for male factor infertility? Fertility and Sterility. 2020;113(6):1121-30.
Garg H, Kumar R. Empirical drug therapy for idiopathic male infertility: what is the new evidence? Urology. 2015;86(6):1065-75.
Turgut H. Early Period Evaluations after Varicocelectomy: Semen Analysis and Spontaneous Pregnancy Rates. Journal of Urological Surgery. 2020;7(3).
Shah T, Shin D. Empiric medical therapy for idiopathic male infertility. Male Infertility: Contemporary Clinical Approaches, Andrology, ART and Antioxidants. 2020:873-82.
Badenoch D, Waxman J, Boorman L, Sidhu B, Moore H, Holt W, Blandy J. Administration of a gonadotropin releasing hormone analogue in oligozoospermic infertile males. European Journal of Endocrinology. 1988;117(2):265-7.
Pitteloud N, Hayes FJ, Dwyer A, Boepple PA, Lee H, Crowley Jr WF. Predictors of outcome of long-term GnRH therapy in men with idiopathic hypogonadotropic hypogonadism. The Journal of Clinical Endocrinology & Metabolism. 2002;87(9):4128-36.
Kobori Y, Suzuki K, Iwahata T, Shin T, Sato R, Nishio K, et al. Hormonal therapy (hCG and rhFSH) for infertile men with adult-onset idiopathic hypogonadotropic hypogonadism. Systems biology in reproductive medicine. 2015;61(2):110-2.
Christiansen P, Skakkebæk NE. Pulsatile gonadotropin-releasing hormone treatment of men with idiopathic hypogonadotropic hypogonadism. Hormone research. 2002;57(1-2):32-6.
Li Y-F, Zhu T, Zhang Y, Luo Y, Li K, Liu X-D, et al. AB029. The beneficial effects of pulsatile gonadotropin-releasing hormone pumps in the treatment of adult male idiopathic hypogonadotropic hypogonadism. Translational Andrology and Urology. 2018;7(Suppl 5).
Schill WB, Jüngst D, Unterburger P, Braun S. Combined hMG/hCG treatment in subfertile men with idiopathic normogonadotrophic oligozoospermia. International journal of andrology. 1982;5(5):467-77.
Ahmadi-Asrbadr Y, Hemmati-Ghavshough M, Khanzadeh N, Ansari F, Mohammad-Rahimi M. Comparison of the effect of combined therapy of HCG ampule and letrozole tablet with each method separately on the spermogram parameters in the obese men with idiopathic infertility: a clinical trial. American Journal of Clinical and Experimental Urology. 2022;10(4):258.
Paradisi R, Busacchi P, Seracchioli R, Porcu E, Venturoli S. Effects of high doses of recombinant human follicle-stimulating hormone in the treatment of male factor infertility: results of a pilot study. Fertility and sterility. 2006;86(3):728-31.
La Vignera S, Condorelli RA, Duca Y, Mongioi LM, Cannarella R, Giacone F, Calogero AE. FSH therapy for idiopathic male infertility: four schemes are better than one. The Aging Male. 2019.
Al-Inany H, Abou-Setta A, Aboulghar M. Gonadotrophin-releasing hormone antagonists for assisted conception: a Cochrane review. Reproductive biomedicine online. 2007;14(5):640-9.
Colacurci N, De Leo V, Ruvolo G, Piomboni P, Caprio F, Pivonello R, et al. Recombinant FSH improves sperm DNA damage in male infertility: a phase II clinical trial. Frontiers in endocrinology. 2018;9:383.
CLARK RV, SHERINS RJ. Treatment of men with idiopathic oligozoospermic infertility using the aromatase inhibitor, testolactone results of a double‐blinded, randomized, placebo‐controlled trial with crossover. Journal of andrology. 1989;10(3):240-7.
Pavlovich CP, King P, Goldstein M, Schlegel PN. Evidence of a treatable endocrinopathy in infertile men. The Journal of urology. 2001;165(3):837-41.
Saylam B, Efesoy O, Çayan S. The effect of aromatase inhibitor letrozole on body mass index, serum hormones, and sperm parameters in infertile men. Fertility and sterility. 2011;95(2):809-11.
Gregoriou O, Bakas P, Grigoriadis C, Creatsa M, Hassiakos D, Creatsas G. Changes in hormonal profile and seminal parameters with use of aromatase inhibitors in management of infertile men with low testosterone to estradiol ratios. Fertility and sterility. 2012;98(1):48-51.
Schlegel PN. Aromatase inhibitors for male infertility. Fertility and sterility. 2012;98(6):1359-62.
Giagulli V, Carbone M, De Pergola G, Guastamacchia E, Resta F, Licchelli B, et al. Could androgen receptor gene CAG tract polymorphism affect spermatogenesis in men with idiopathic infertility? Journal of assisted reproduction and genetics. 2014;31:689-97.
Dohle G, Smit M, Weber R. Androgens and male fertility. World journal of urology. 2003;21(5):341-5.
Liu PY, Handelsman DJ. The present and future state of hormonal treatment for male infertility. Human reproduction update. 2003;9(1):9-23.
Mobasseri N, Babaei F, Karimian M, Nikzad H. Androgen receptor (AR)-CAG trinucleotide repeat length and idiopathic male infertility: A case-control trial and a meta-analysis. EXCLI journal. 2018;17:1167.
Kumar R, Gautam G, Gupta NP. Drug therapy for idiopathic male infertility: rationale versus evidence. The Journal of urology. 2006;176(4):1307-12.
Chua M, Escusa K, Luna S, Tapia L, Dofitas B, Morales M. Revisiting oestrogen antagonists (clomiphene or tamoxifen) as medical empiric therapy for idiopathic male infertility: a meta‐analysis. Andrology. 2013;1(5):749-57.
Çakan M, Aldemir M, Topcuoglu M, Altuğ U. Role of testosterone/estradiol ratio in predicting the efficacy of tamoxifen citrate treatment in idiopathic oligoasthenoteratozoospermic men. Urologia internationalis. 2009;83(4):446-51.
Ko EY, Siddiqi K, Brannigan RE, Sabanegh Jr ES. Empirical medical therapy for idiopathic male infertility: a survey of the American Urological Association. The Journal of urology. 2012;187(3):973-8.
Moradi M, Moradi A, Alemi M, Ahmadnia H, Abdi H, Ahmadi A, Bazargan-Hejazi S. Safety and efficacy of clomiphene citrate and L-carnitine in idiopathic male infertility: a comparative study. Urology journal. 2010;7(3):188.
Bozhedomov V, Lipatova N, Bozhedomova G, Rokhlikov I, Shcherbakova E, Komarina R. Using L-and acetyl-L-carnintines in combination with clomiphene citrate and antioxidant complex for treating idiopathic male infertility: a prospective randomized trial. Urologiia. 2017(3):22-32.
Huijben MM, Lock M, de Kemp V, de Kort L, van Breda H. Clomiphene Citrate a First Step to Improve Idiopathic Male Infertility: A Retrospective Analysis. Andrologia. 2023;2023.
Cannarella R, Condorelli RA, Mongioi LM, Barbagallo F, Calogero AE, La Vignera S. Effects of the selective estrogen receptor modulators for the treatment of male infertility: a systematic review and meta-analysis. Expert Opinion on Pharmacotherapy. 2019;20(12):1517-25.
Dutta S, Majzoub A, Agarwal A. Oxidative stress and sperm function: A systematic review on evaluation and management. Arab journal of urology. 2019;17(2):87-97.
Ritchie C, Ko EY. Oxidative stress in the pathophysiology of male infertility. Andrologia. 2021;53(1):e13581.
Agarwal A, Parekh N, Selvam MKP, Henkel R, Shah R, Homa ST, et al. Male oxidative stress infertility (MOSI): proposed terminology and clinical practice guidelines for management of idiopathic male infertility. The world journal of men's health. 2019;37(3):296-312.
Kefer JC, Agarwal A, Sabanegh E. Role of antioxidants in the treatment of male infertility. International journal of Urology. 2009;16(5):449-57.
Steiner AZ, Hansen KR, Barnhart KT, Cedars MI, Legro RS, Diamond MP, et al. The effect of antioxidants on male factor infertility: the Males, Antioxidants, and Infertility (MOXI) randomized clinical trial. Fertility and sterility. 2020;113(3):552-60. e3.
Kessopoulou E, Powers HJ, Sharma KK, Pearson MJ, Russell JM, Cooke ID, Barratt CL. A double-blind randomized placebo cross-over controlled trial using the antioxidant vitamin E to treat reactive oxygen species associated male infertility. Fertility and sterility. 1995;64(4):825-31.
Ebisch I, Thomas C, Peters W, Braat D, Steegers-Theunissen R. The importance of folate, zinc and antioxidants in the pathogenesis and prevention of subfertility. Human reproduction update. 2007;13(2):163-74.
Fallah A, Mohammad-Hasani A, Colagar AH. Zinc is an essential element for male fertility: a review of Zn roles in men’s health, germination, sperm quality, and fertilization. Journal of reproduction & infertility. 2018;19(2):69.
Wong WY, Thomas CM, Merkus JM, Zielhuis GA, Steegers-Theunissen RP. Male factor subfertility: possible causes and the impact of nutritional factors. Fertility and sterility. 2000;73(3):435-42.
Wei G, Zhou Z, Cui Y, Huang Y, Wan Z, Che X, et al. A meta-analysis of the efficacy of L-carnitine/L-acetyl-carnitine or N-acetyl-cysteine in men with idiopathic asthenozoospermia. American Journal of Men's Health. 2021;15(2):15579883211011371.
Khaw SC, Wong ZZ, Anderson R, Da Silva SM. l-carnitine and l-acetylcarnitine supplementation for idiopathic male infertility. Reproduction and Fertility. 2020;1(1):67-81.
Lenzi A, Sgro P, Salacone P, Paoli D, Gilio B, Lombardo F, et al. A placebo-controlled double-blind randomized trial of the use of combined l-carnitine and l-acetyl-carnitine treatment in men with asthenozoospermia. Fertility and sterility. 2004;81(6):1578-84.
Ma L, Sun Y. Comparison of L-Carnitine vs. Coq10 and Vitamin E for idiopathic male infertility: a randomized controlled trial. European Review for Medical & Pharmacological Sciences. 2022;26(13).
Shang X, Wang L, Mo D, Cai H, Zheng D, Zhou Y. Effect and safety of L-carnitine in the treatment of idiopathic oligoasthenozoospermia: a systemic review. Zhonghua nan ke xue= National Journal of Andrology. 2015;21(1):65-73.
Kopets R, Kuibida I, Chernyavska I, Cherepanyn V, Mazo R, Fedevych V, Gerasymov S. Dietary supplementation with a novel l‐carnitine multi‐micronutrient in idiopathic male subfertility involving oligo‐, astheno‐, teratozoospermia: a randomized clinical study. Andrology. 2020;8(5):1184-93.
Alahmar AT, Calogero AE, Singh R, Cannarella R, Sengupta P, Dutta S. Coenzyme Q10, oxidative stress, and male infertility: A review. Clinical and experimental reproductive medicine. 2021;48(2):97.
Özdemir Y. Pentoksifilin ve platelet aktive edici faktör uygulama sonrası spermatozoada meydana gelen ultrastrüktürel değişikliklerin kıyaslanması: İstanbul Bilim Üniversitesi, Sağlık Bilimleri Enstitüsü.; 2014.
Babikli ZG. Pentoksifilin uygulama sonrası maruziyet süresi dikkate alınarak spermatozoada meydana gelen ultrastrüktürel değişiklikler: İstanbul Bilim Üniversitesi, Sağlık Bilimleri Enstitüsü.; 2014.
Omar MI, Pal RP, Kelly BD, Bruins HM, Yuan Y, Diemer T, et al. Benefits of empiric nutritional and medical therapy for semen parameters and pregnancy and live birth rates in couples with idiopathic infertility: a systematic review and meta-analysis. European urology. 2019;75(4):615-25.
Nieschlag E, Kamischke A. Empirical therapies for idiopathic male infertility. Andrology: male reproductive health and dysfunction. 2010:457-67.
Dohle G, Colpi G, Hargreave T, Papp G, Jungwirth A, Weidner W, Infertility EWGoM. EAU guidelines on male infertility. European urology. 2005;48(5):703-11.
Minhas S, Bettocchi C, Boeri L, Capogrosso P, Carvalho J, Cilesiz NC, et al. European association of urology guidelines on male sexual and reproductive health: 2021 update on male infertility. European urology. 2021;80(5):603-20.
Thaker H, Ko EY, Sabanegh ES, Brannigan RE, Alukal JP, Samplaski MK. Empirical medical therapy for idiopathic male infertility. F&S Reports. 2020;1(1):15-20.
Tadros NN, Sabanegh ES. Empiric medical therapy with hormonal agents for idiopathic male infertility. Indian journal of urology: IJU: journal of the Urological Society of India. 2017;33(3):194.
Del Giudice F, Busetto GM, De Berardinis E, Sperduti I, Ferro M, Maggi M, et al. A systematic review and meta-analysis of clinical trials implementing aromatase inhibitors to treat male infertility. Asian journal of andrology. 2020;22(4):360.
Tan RB, Guay AT, Hellstrom WJ. Clinical use of aromatase inhibitors in adult males. Sexual Medicine Reviews. 2014;2(2):79-90.
Jung JH, Seo JT. Empirical medical therapy in idiopathic male infertility: promise or panacea? Clinical and experimental reproductive medicine. 2014;41(3):108.
Buhling KJ, Chan P, Kathrins M, Showell M, Vij SC, Sigman M. Should empiric therapies be used for male factor infertility? Fertility and Sterility. 2020;113(6):1121-30.
Garg H, Kumar R. Empirical drug therapy for idiopathic male infertility: what is the new evidence? Urology. 2015;86(6):1065-75.
Turgut H. Early Period Evaluations after Varicocelectomy: Semen Analysis and Spontaneous Pregnancy Rates. Journal of Urological Surgery. 2020;7(3).
Shah T, Shin D. Empiric medical therapy for idiopathic male infertility. Male Infertility: Contemporary Clinical Approaches, Andrology, ART and Antioxidants. 2020:873-82.
Badenoch D, Waxman J, Boorman L, Sidhu B, Moore H, Holt W, Blandy J. Administration of a gonadotropin releasing hormone analogue in oligozoospermic infertile males. European Journal of Endocrinology. 1988;117(2):265-7.
Pitteloud N, Hayes FJ, Dwyer A, Boepple PA, Lee H, Crowley Jr WF. Predictors of outcome of long-term GnRH therapy in men with idiopathic hypogonadotropic hypogonadism. The Journal of Clinical Endocrinology & Metabolism. 2002;87(9):4128-36.
Kobori Y, Suzuki K, Iwahata T, Shin T, Sato R, Nishio K, et al. Hormonal therapy (hCG and rhFSH) for infertile men with adult-onset idiopathic hypogonadotropic hypogonadism. Systems biology in reproductive medicine. 2015;61(2):110-2.
Christiansen P, Skakkebæk NE. Pulsatile gonadotropin-releasing hormone treatment of men with idiopathic hypogonadotropic hypogonadism. Hormone research. 2002;57(1-2):32-6.
Li Y-F, Zhu T, Zhang Y, Luo Y, Li K, Liu X-D, et al. AB029. The beneficial effects of pulsatile gonadotropin-releasing hormone pumps in the treatment of adult male idiopathic hypogonadotropic hypogonadism. Translational Andrology and Urology. 2018;7(Suppl 5).
Schill WB, Jüngst D, Unterburger P, Braun S. Combined hMG/hCG treatment in subfertile men with idiopathic normogonadotrophic oligozoospermia. International journal of andrology. 1982;5(5):467-77.
Ahmadi-Asrbadr Y, Hemmati-Ghavshough M, Khanzadeh N, Ansari F, Mohammad-Rahimi M. Comparison of the effect of combined therapy of HCG ampule and letrozole tablet with each method separately on the spermogram parameters in the obese men with idiopathic infertility: a clinical trial. American Journal of Clinical and Experimental Urology. 2022;10(4):258.
Paradisi R, Busacchi P, Seracchioli R, Porcu E, Venturoli S. Effects of high doses of recombinant human follicle-stimulating hormone in the treatment of male factor infertility: results of a pilot study. Fertility and sterility. 2006;86(3):728-31.
La Vignera S, Condorelli RA, Duca Y, Mongioi LM, Cannarella R, Giacone F, Calogero AE. FSH therapy for idiopathic male infertility: four schemes are better than one. The Aging Male. 2019.
Al-Inany H, Abou-Setta A, Aboulghar M. Gonadotrophin-releasing hormone antagonists for assisted conception: a Cochrane review. Reproductive biomedicine online. 2007;14(5):640-9.
Colacurci N, De Leo V, Ruvolo G, Piomboni P, Caprio F, Pivonello R, et al. Recombinant FSH improves sperm DNA damage in male infertility: a phase II clinical trial. Frontiers in endocrinology. 2018;9:383.
CLARK RV, SHERINS RJ. Treatment of men with idiopathic oligozoospermic infertility using the aromatase inhibitor, testolactone results of a double‐blinded, randomized, placebo‐controlled trial with crossover. Journal of andrology. 1989;10(3):240-7.
Pavlovich CP, King P, Goldstein M, Schlegel PN. Evidence of a treatable endocrinopathy in infertile men. The Journal of urology. 2001;165(3):837-41.
Saylam B, Efesoy O, Çayan S. The effect of aromatase inhibitor letrozole on body mass index, serum hormones, and sperm parameters in infertile men. Fertility and sterility. 2011;95(2):809-11.
Gregoriou O, Bakas P, Grigoriadis C, Creatsa M, Hassiakos D, Creatsas G. Changes in hormonal profile and seminal parameters with use of aromatase inhibitors in management of infertile men with low testosterone to estradiol ratios. Fertility and sterility. 2012;98(1):48-51.
Schlegel PN. Aromatase inhibitors for male infertility. Fertility and sterility. 2012;98(6):1359-62.
Giagulli V, Carbone M, De Pergola G, Guastamacchia E, Resta F, Licchelli B, et al. Could androgen receptor gene CAG tract polymorphism affect spermatogenesis in men with idiopathic infertility? Journal of assisted reproduction and genetics. 2014;31:689-97.
Dohle G, Smit M, Weber R. Androgens and male fertility. World journal of urology. 2003;21(5):341-5.
Liu PY, Handelsman DJ. The present and future state of hormonal treatment for male infertility. Human reproduction update. 2003;9(1):9-23.
Mobasseri N, Babaei F, Karimian M, Nikzad H. Androgen receptor (AR)-CAG trinucleotide repeat length and idiopathic male infertility: A case-control trial and a meta-analysis. EXCLI journal. 2018;17:1167.
Kumar R, Gautam G, Gupta NP. Drug therapy for idiopathic male infertility: rationale versus evidence. The Journal of urology. 2006;176(4):1307-12.
Chua M, Escusa K, Luna S, Tapia L, Dofitas B, Morales M. Revisiting oestrogen antagonists (clomiphene or tamoxifen) as medical empiric therapy for idiopathic male infertility: a meta‐analysis. Andrology. 2013;1(5):749-57.
Çakan M, Aldemir M, Topcuoglu M, Altuğ U. Role of testosterone/estradiol ratio in predicting the efficacy of tamoxifen citrate treatment in idiopathic oligoasthenoteratozoospermic men. Urologia internationalis. 2009;83(4):446-51.
Ko EY, Siddiqi K, Brannigan RE, Sabanegh Jr ES. Empirical medical therapy for idiopathic male infertility: a survey of the American Urological Association. The Journal of urology. 2012;187(3):973-8.
Moradi M, Moradi A, Alemi M, Ahmadnia H, Abdi H, Ahmadi A, Bazargan-Hejazi S. Safety and efficacy of clomiphene citrate and L-carnitine in idiopathic male infertility: a comparative study. Urology journal. 2010;7(3):188.
Bozhedomov V, Lipatova N, Bozhedomova G, Rokhlikov I, Shcherbakova E, Komarina R. Using L-and acetyl-L-carnintines in combination with clomiphene citrate and antioxidant complex for treating idiopathic male infertility: a prospective randomized trial. Urologiia. 2017(3):22-32.
Huijben MM, Lock M, de Kemp V, de Kort L, van Breda H. Clomiphene Citrate a First Step to Improve Idiopathic Male Infertility: A Retrospective Analysis. Andrologia. 2023;2023.
Cannarella R, Condorelli RA, Mongioi LM, Barbagallo F, Calogero AE, La Vignera S. Effects of the selective estrogen receptor modulators for the treatment of male infertility: a systematic review and meta-analysis. Expert Opinion on Pharmacotherapy. 2019;20(12):1517-25.
Dutta S, Majzoub A, Agarwal A. Oxidative stress and sperm function: A systematic review on evaluation and management. Arab journal of urology. 2019;17(2):87-97.
Ritchie C, Ko EY. Oxidative stress in the pathophysiology of male infertility. Andrologia. 2021;53(1):e13581.
Agarwal A, Parekh N, Selvam MKP, Henkel R, Shah R, Homa ST, et al. Male oxidative stress infertility (MOSI): proposed terminology and clinical practice guidelines for management of idiopathic male infertility. The world journal of men's health. 2019;37(3):296-312.
Kefer JC, Agarwal A, Sabanegh E. Role of antioxidants in the treatment of male infertility. International journal of Urology. 2009;16(5):449-57.
Steiner AZ, Hansen KR, Barnhart KT, Cedars MI, Legro RS, Diamond MP, et al. The effect of antioxidants on male factor infertility: the Males, Antioxidants, and Infertility (MOXI) randomized clinical trial. Fertility and sterility. 2020;113(3):552-60. e3.
Kessopoulou E, Powers HJ, Sharma KK, Pearson MJ, Russell JM, Cooke ID, Barratt CL. A double-blind randomized placebo cross-over controlled trial using the antioxidant vitamin E to treat reactive oxygen species associated male infertility. Fertility and sterility. 1995;64(4):825-31.
Ebisch I, Thomas C, Peters W, Braat D, Steegers-Theunissen R. The importance of folate, zinc and antioxidants in the pathogenesis and prevention of subfertility. Human reproduction update. 2007;13(2):163-74.
Fallah A, Mohammad-Hasani A, Colagar AH. Zinc is an essential element for male fertility: a review of Zn roles in men’s health, germination, sperm quality, and fertilization. Journal of reproduction & infertility. 2018;19(2):69.
Wong WY, Thomas CM, Merkus JM, Zielhuis GA, Steegers-Theunissen RP. Male factor subfertility: possible causes and the impact of nutritional factors. Fertility and sterility. 2000;73(3):435-42.
Wei G, Zhou Z, Cui Y, Huang Y, Wan Z, Che X, et al. A meta-analysis of the efficacy of L-carnitine/L-acetyl-carnitine or N-acetyl-cysteine in men with idiopathic asthenozoospermia. American Journal of Men's Health. 2021;15(2):15579883211011371.
Khaw SC, Wong ZZ, Anderson R, Da Silva SM. l-carnitine and l-acetylcarnitine supplementation for idiopathic male infertility. Reproduction and Fertility. 2020;1(1):67-81.
Lenzi A, Sgro P, Salacone P, Paoli D, Gilio B, Lombardo F, et al. A placebo-controlled double-blind randomized trial of the use of combined l-carnitine and l-acetyl-carnitine treatment in men with asthenozoospermia. Fertility and sterility. 2004;81(6):1578-84.
Ma L, Sun Y. Comparison of L-Carnitine vs. Coq10 and Vitamin E for idiopathic male infertility: a randomized controlled trial. European Review for Medical & Pharmacological Sciences. 2022;26(13).
Shang X, Wang L, Mo D, Cai H, Zheng D, Zhou Y. Effect and safety of L-carnitine in the treatment of idiopathic oligoasthenozoospermia: a systemic review. Zhonghua nan ke xue= National Journal of Andrology. 2015;21(1):65-73.
Kopets R, Kuibida I, Chernyavska I, Cherepanyn V, Mazo R, Fedevych V, Gerasymov S. Dietary supplementation with a novel l‐carnitine multi‐micronutrient in idiopathic male subfertility involving oligo‐, astheno‐, teratozoospermia: a randomized clinical study. Andrology. 2020;8(5):1184-93.
Alahmar AT, Calogero AE, Singh R, Cannarella R, Sengupta P, Dutta S. Coenzyme Q10, oxidative stress, and male infertility: A review. Clinical and experimental reproductive medicine. 2021;48(2):97.
Özdemir Y. Pentoksifilin ve platelet aktive edici faktör uygulama sonrası spermatozoada meydana gelen ultrastrüktürel değişikliklerin kıyaslanması: İstanbul Bilim Üniversitesi, Sağlık Bilimleri Enstitüsü.; 2014.
Babikli ZG. Pentoksifilin uygulama sonrası maruziyet süresi dikkate alınarak spermatozoada meydana gelen ultrastrüktürel değişiklikler: İstanbul Bilim Üniversitesi, Sağlık Bilimleri Enstitüsü.; 2014.
Omar MI, Pal RP, Kelly BD, Bruins HM, Yuan Y, Diemer T, et al. Benefits of empiric nutritional and medical therapy for semen parameters and pregnancy and live birth rates in couples with idiopathic infertility: a systematic review and meta-analysis. European urology. 2019;75(4):615-25.
Nieschlag E, Kamischke A. Empirical therapies for idiopathic male infertility. Andrology: male reproductive health and dysfunction. 2010:457-67.
Dohle G, Colpi G, Hargreave T, Papp G, Jungwirth A, Weidner W, Infertility EWGoM. EAU guidelines on male infertility. European urology. 2005;48(5):703-11.
Minhas S, Bettocchi C, Boeri L, Capogrosso P, Carvalho J, Cilesiz NC, et al. European association of urology guidelines on male sexual and reproductive health: 2021 update on male infertility. European urology. 2021;80(5):603-20.
Thaker H, Ko EY, Sabanegh ES, Brannigan RE, Alukal JP, Samplaski MK. Empirical medical therapy for idiopathic male infertility. F&S Reports. 2020;1(1):15-20.
Tadros NN, Sabanegh ES. Empiric medical therapy with hormonal agents for idiopathic male infertility. Indian journal of urology: IJU: journal of the Urological Society of India. 2017;33(3):194.
Del Giudice F, Busetto GM, De Berardinis E, Sperduti I, Ferro M, Maggi M, et al. A systematic review and meta-analysis of clinical trials implementing aromatase inhibitors to treat male infertility. Asian journal of andrology. 2020;22(4):360.
Tan RB, Guay AT, Hellstrom WJ. Clinical use of aromatase inhibitors in adult males. Sexual Medicine Reviews. 2014;2(2):79-90.
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41-62
Published
April 30, 2024
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Atkın MS. Erkek İnfertilitesinde Ampirik Tedavi Yöntemleri. In: Turgut H, editor. Güncel Üroloji Çalışmaları V (Bahar) [Internet]. Türkiye: Academician Publishing Book DOI Portal; 2024 [cited 2026 Jul. 13]. pp. 41-62. Available from: https://omp35.books.akademisyen.net/index.php/akya/catalog/book/3059/chapter/13460
