A Vitamini ve Karotenler
Synopsis
Kanser hastalarında A vitamini ve karotenlerin kullanımı karmaşık bir konudur. Bu besinlerin bilinen faydalarının yanında çeşitli riskleri de bulunmaktadır. Özellikle yüksek dozda A vitamini veya karoten kullanımı, kanser hastalarının tedaviye yanıtını olumsuz yönde etkileyebilir. Üstelik bu takviyeler bazı kanser ilaçlarının etkinliğini de azaltabilir. Bu nedenle kanser hastalarının bu takviyeleri kullanmadan önce mutlaka hekime danışması gerekmektedir.
Cancer patients' use of vitamin A and carotenoids is a complex issue. Alongside their known benefits, these nutrients come with various risks. Especially the use of high doses of vitamin A or carotenoids can adversely affect cancer patients' response to treatment. Moreover, these supplements can also reduce the effectiveness of certain cancer drugs. Therefore, it is essential for cancer patients to consult with a physician before using these supplements.
References
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Mandecka A, Czekajlo A, Gozdzik M, et al. The use of antioxidant vitamin supplements among oncological patients. Advances in Clinical and Experimental Medicine 2018;27(10):1365-9.
Retzlaff T, Dorfler J, Kutschan S, et al. The benefits of vitamin A as a complementary treatment for oncology patients: a systematic review. Journal of Cancer Research and Clinical Oncology 2023;149(5):2157-77.
Yamashita N, Aikawa T. Dutch Research on Beriberi: I. Christiaan Eijkman's Research and Evaluation of Kanehiro Takaki's Diet Reforms of the Japanese Navy. Nihon Ishigaku Zasshi. 2017;63(1):3-21.
Rajakumar K, Thomas SB. Reemerging nutritional rickets: a historical perspective. Archives of Pediatrics & Adolescent Medicine. 2005;159(4):335-41.
Lanska DJ. Chapter 29: historical aspects of the major neurological vitamin deficiency disorders: overview and fat-soluble vitamin A. Handbook of Clinical Neurology. 2010;95:435-44.
Giguere V, Evans RM. Chronicle of a discovery: the retinoic acid receptor. Journal of Molecular Endocrinology. 2022;69(4):T1-T11.
Grivard A, Goubet I, Duarte Filho LMS, et al. Archaea Carotenoids: Natural Pigments with Unexplored Innovative Potential. Marine Drugs. 2022;20(8).
Saini RK, Prasad P, Lokesh V, et al. Carotenoids: Dietary Sources, Extraction, Encapsulation, Bioavailability, and Health Benefits-A Review of Recent Advancements. Antioxidants (Basel). 2022;11(4).
Burri BJ. Beta-cryptoxanthin as a source of vitamin A. J Sci Food Agric. 2015;95(9):1786-94.
Sanusi RS. Outcome of Combined Neoadjuvant Chemotherapy and Vitamin A in Advanced Cervical Carcinoma: A Randomized Double-Blind Clinical Trial. Asian Pacific Journal of Cancer Prevention. 2019;20(7):2213-8.
Wang HY, Gong S, Li GH, et al. An effective and chemotherapy-free strategy of all-trans retinoic acid and arsenic trioxide for acute promyelocytic leukemia in all risk groups (APL15 trial). Blood Cancer Journal. 2022;12(11):158.
Lademann J, Meinke MC, Sterry W, et al. Carotenoids in human skin. Experimental Dermatology. 2011;20(5):377-82.
Middha P, Weinstein SJ, Mannisto S, et al. beta-Carotene Supplementation and Lung Cancer Incidence in the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study: The Role of Tar and Nicotine. Nicotine & Tobacco Research. 2019;21(8):1045-50.
Omenn GS. Chemoprevention of lung cancers: lessons from CARET, the beta-carotene and retinol efficacy trial, and prospects for the future. European Journal of Cancer Prevention. 2007;16(3):184-91.
Larsson SC, Bergkvist L, Naslund I, et al. Vitamin A, retinol, and carotenoids and the risk of gastric cancer: a prospective cohort study. American Journal of Clinical Nutrition. 2007;85(2):497-503.
Botterweck AA, van den Brandt PA, Goldbohm RA. Vitamins, carotenoids, dietary fiber, and the risk of gastric carcinoma: results from a prospective study after 6.3 years of follow‐up. Cancer. 2000;88(4):737-48.
Leenders M, Leufkens AM, Siersema PD, et al. Plasma and dietary carotenoids and vitamins A, C and E and risk of colon and rectal cancer in the European Prospective Investigation into Cancer and Nutrition. International Journal of Cancer. 2014;135(12):2930-9.
Park Y, Spiegelman D, Hunter DJ, et al. Intakes of vitamins A, C, and E and use of multiple vitamin supplements and risk of colon cancer: a pooled analysis of prospective cohort studies. Cancer Causes Control. 2010;21(11):1745-57.
Huang X, Gao Y, Zhi X, et al. Association between vitamin A, retinol and carotenoid intake and pancreatic cancer risk: Evidence from epidemiologic studies. Scientific Reports. 2016;6:38936.
Kabat GC, Kim M, Adams-Campbell LL, et al. Longitudinal study of serum carotenoid, retinol, and tocopherol concentrations in relation to breast cancer risk among postmenopausal women. American Journal of Clinical Nutrition. 2009;90(1):162-9.
Han X, Zhao R, Wang Y, et al. Dietary Vitamin A Intake and Circulating Vitamin A Concentrations and the Risk of Three Common Cancers in Women: A Meta-Analysis. Oxidative Medicine and Cellular Longevity. 2022;2022:7686405.
C Ritenbaugh KS, and M Helfand. Routine vitamin supplementation to prevent cancer: a summary of the evidence from randomized controlled trials for the U.S. Preventive Services Task Force National Institutes of Health. Available from: https://www.ncbi.nlm.nih.gov/books/NBK71064/.
Frieling UM, Schaumberg DA, Kupper TS, et al. A randomized, 12-year primary-prevention trial of beta carotene supplementation for nonmelanoma skin cancer in the physician's health study. Archives of Dermatological. 2000;136(2):179-84.
Fung TT, Spiegelman D, Egan KM, et al. Vitamin and carotenoid intake and risk of squamous cell carcinoma of the skin. International Journal of Cancer. 2003;103(1):110-5.
Vitamin A. LiverTox: Clinical and Research Information on Drug-Induced Liver Injury. Bethesda (MD) 2012.
Zhang H, Zhang J, Dong H. Fatal Hepatotoxicity Due to Viaminate. American Journal of the Medical Sciences. 2018;356(1):84-6.
Wright ME, Groshong SD, Husgafvel-Pursiainen K, et al. Effects of beta-carotene supplementation on molecular markers of lung carcinogenesis in male smokers. Cancer prevention research (Philadelphia). 2010;3(6):745-52.
Duriancik DM, Lackey DE, Hoag KA. Vitamin A as a regulator of antigen presenting cells. Journal of Nutrition. 2010;140(8):1395-9.
Cantorna MT, Snyder L, Arora J. Vitamin A and vitamin D regulate the microbial complexity, barrier function, and the mucosal immune responses to ensure intestinal homeostasis. Critical Reviews in Biochemistry and Molecular Biology. 2019;54(2):184-92.
Lee H, Ko G. Antiviral effect of vitamin A on norovirus infection via modulation of the gut microbiome. Scientific Reports. 2016;6:25835.
Stinchfield PA, Orenstein WA. Vitamin A for the Management of Measles in the United States. Infectious Diseases in Clinical Practice. 2020;28(4):181-7.
Szlagatys-Sidorkiewicz A, Zagierski M, Jankowska A, et al. Longitudinal study of vitamins A, E and lipid oxidative damage in human milk throughout lactation. Early Human Development. 2012;88(6):421-4.
Bhende B. Vitamin A: A Review Article. Asian Journal of Nursing Education and Research. 2021:582-4.
Milani A, Basirnejad M, Shahbazi S, et al. Carotenoids: biochemistry, pharmacology and treatment. British Journal of Pharmacology. 2017;174(11):1290-324.
Britton G. Carotenoid research: History and new perspectives for chemistry in biological systems. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids. 2020;1865(11):158699.
Fritz H, Kennedy D, Fergusson D, et al. Vitamin A and retinoid derivatives for lung cancer: a systematic review and meta analysis. PLoS One. 2011;6(6):e21107.
Mandecka A, Czekajlo A, Gozdzik M, et al. The use of antioxidant vitamin supplements among oncological patients. Advances in Clinical and Experimental Medicine 2018;27(10):1365-9.
Retzlaff T, Dorfler J, Kutschan S, et al. The benefits of vitamin A as a complementary treatment for oncology patients: a systematic review. Journal of Cancer Research and Clinical Oncology 2023;149(5):2157-77.
Yamashita N, Aikawa T. Dutch Research on Beriberi: I. Christiaan Eijkman's Research and Evaluation of Kanehiro Takaki's Diet Reforms of the Japanese Navy. Nihon Ishigaku Zasshi. 2017;63(1):3-21.
Rajakumar K, Thomas SB. Reemerging nutritional rickets: a historical perspective. Archives of Pediatrics & Adolescent Medicine. 2005;159(4):335-41.
Lanska DJ. Chapter 29: historical aspects of the major neurological vitamin deficiency disorders: overview and fat-soluble vitamin A. Handbook of Clinical Neurology. 2010;95:435-44.
Giguere V, Evans RM. Chronicle of a discovery: the retinoic acid receptor. Journal of Molecular Endocrinology. 2022;69(4):T1-T11.
Grivard A, Goubet I, Duarte Filho LMS, et al. Archaea Carotenoids: Natural Pigments with Unexplored Innovative Potential. Marine Drugs. 2022;20(8).
Saini RK, Prasad P, Lokesh V, et al. Carotenoids: Dietary Sources, Extraction, Encapsulation, Bioavailability, and Health Benefits-A Review of Recent Advancements. Antioxidants (Basel). 2022;11(4).
Burri BJ. Beta-cryptoxanthin as a source of vitamin A. J Sci Food Agric. 2015;95(9):1786-94.
Sanusi RS. Outcome of Combined Neoadjuvant Chemotherapy and Vitamin A in Advanced Cervical Carcinoma: A Randomized Double-Blind Clinical Trial. Asian Pacific Journal of Cancer Prevention. 2019;20(7):2213-8.
Wang HY, Gong S, Li GH, et al. An effective and chemotherapy-free strategy of all-trans retinoic acid and arsenic trioxide for acute promyelocytic leukemia in all risk groups (APL15 trial). Blood Cancer Journal. 2022;12(11):158.
Lademann J, Meinke MC, Sterry W, et al. Carotenoids in human skin. Experimental Dermatology. 2011;20(5):377-82.
Middha P, Weinstein SJ, Mannisto S, et al. beta-Carotene Supplementation and Lung Cancer Incidence in the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study: The Role of Tar and Nicotine. Nicotine & Tobacco Research. 2019;21(8):1045-50.
Omenn GS. Chemoprevention of lung cancers: lessons from CARET, the beta-carotene and retinol efficacy trial, and prospects for the future. European Journal of Cancer Prevention. 2007;16(3):184-91.
Larsson SC, Bergkvist L, Naslund I, et al. Vitamin A, retinol, and carotenoids and the risk of gastric cancer: a prospective cohort study. American Journal of Clinical Nutrition. 2007;85(2):497-503.
Botterweck AA, van den Brandt PA, Goldbohm RA. Vitamins, carotenoids, dietary fiber, and the risk of gastric carcinoma: results from a prospective study after 6.3 years of follow‐up. Cancer. 2000;88(4):737-48.
Leenders M, Leufkens AM, Siersema PD, et al. Plasma and dietary carotenoids and vitamins A, C and E and risk of colon and rectal cancer in the European Prospective Investigation into Cancer and Nutrition. International Journal of Cancer. 2014;135(12):2930-9.
Park Y, Spiegelman D, Hunter DJ, et al. Intakes of vitamins A, C, and E and use of multiple vitamin supplements and risk of colon cancer: a pooled analysis of prospective cohort studies. Cancer Causes Control. 2010;21(11):1745-57.
Huang X, Gao Y, Zhi X, et al. Association between vitamin A, retinol and carotenoid intake and pancreatic cancer risk: Evidence from epidemiologic studies. Scientific Reports. 2016;6:38936.
Kabat GC, Kim M, Adams-Campbell LL, et al. Longitudinal study of serum carotenoid, retinol, and tocopherol concentrations in relation to breast cancer risk among postmenopausal women. American Journal of Clinical Nutrition. 2009;90(1):162-9.
Han X, Zhao R, Wang Y, et al. Dietary Vitamin A Intake and Circulating Vitamin A Concentrations and the Risk of Three Common Cancers in Women: A Meta-Analysis. Oxidative Medicine and Cellular Longevity. 2022;2022:7686405.
C Ritenbaugh KS, and M Helfand. Routine vitamin supplementation to prevent cancer: a summary of the evidence from randomized controlled trials for the U.S. Preventive Services Task Force National Institutes of Health. Available from: https://www.ncbi.nlm.nih.gov/books/NBK71064/.
Frieling UM, Schaumberg DA, Kupper TS, et al. A randomized, 12-year primary-prevention trial of beta carotene supplementation for nonmelanoma skin cancer in the physician's health study. Archives of Dermatological. 2000;136(2):179-84.
Fung TT, Spiegelman D, Egan KM, et al. Vitamin and carotenoid intake and risk of squamous cell carcinoma of the skin. International Journal of Cancer. 2003;103(1):110-5.
Vitamin A. LiverTox: Clinical and Research Information on Drug-Induced Liver Injury. Bethesda (MD) 2012.
Zhang H, Zhang J, Dong H. Fatal Hepatotoxicity Due to Viaminate. American Journal of the Medical Sciences. 2018;356(1):84-6.
Wright ME, Groshong SD, Husgafvel-Pursiainen K, et al. Effects of beta-carotene supplementation on molecular markers of lung carcinogenesis in male smokers. Cancer prevention research (Philadelphia). 2010;3(6):745-52.
Duriancik DM, Lackey DE, Hoag KA. Vitamin A as a regulator of antigen presenting cells. Journal of Nutrition. 2010;140(8):1395-9.
Cantorna MT, Snyder L, Arora J. Vitamin A and vitamin D regulate the microbial complexity, barrier function, and the mucosal immune responses to ensure intestinal homeostasis. Critical Reviews in Biochemistry and Molecular Biology. 2019;54(2):184-92.
Lee H, Ko G. Antiviral effect of vitamin A on norovirus infection via modulation of the gut microbiome. Scientific Reports. 2016;6:25835.
Stinchfield PA, Orenstein WA. Vitamin A for the Management of Measles in the United States. Infectious Diseases in Clinical Practice. 2020;28(4):181-7.
Szlagatys-Sidorkiewicz A, Zagierski M, Jankowska A, et al. Longitudinal study of vitamins A, E and lipid oxidative damage in human milk throughout lactation. Early Human Development. 2012;88(6):421-4.
Bhende B. Vitamin A: A Review Article. Asian Journal of Nursing Education and Research. 2021:582-4.
Milani A, Basirnejad M, Shahbazi S, et al. Carotenoids: biochemistry, pharmacology and treatment. British Journal of Pharmacology. 2017;174(11):1290-324.
Britton G. Carotenoid research: History and new perspectives for chemistry in biological systems. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids. 2020;1865(11):158699.
Fritz H, Kennedy D, Fergusson D, et al. Vitamin A and retinoid derivatives for lung cancer: a systematic review and meta analysis. PLoS One. 2011;6(6):e21107.
Pages
409-414
Published
March 11, 2024
Copyright (c) 2024 Academician Publishing Book Portal
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1.
Kapağan T. A Vitamini ve Karotenler. In: Sakin A, editor. Kanser Hastalarının Başvurduğu Geleneksel ve Tamamlayıcı Tedaviler - Tıbbi Onkolog Gözü ile Bakış ve Onkolojik İlaçlarla Etkileşim [Internet]. Türkiye: Academician Publishing Book DOI Portal; 2024 [cited 2026 Jul. 13]. pp. 409-14. Available from: https://omp35.books.akademisyen.net/index.php/akya/catalog/book/2380/chapter/13989
