Bal ve Propolis
Synopsis
Kanser günümüzde en önemli halk sağlığı problemlerinden birtanesidir. Kanser görülme sıklığı ve kansere bağlı ölümler artmaktadır. Bu da; hem kanser tedavisi için hem de kanser tedavisi esnasında destekleyici tedavi arayışlarını beraberinde getirmektedir. Bal ve propolis eski çağlardan bu yana alternatif ve destekleyici tıbbın en önemli unsurlarından iki tanesidir. Bal ve propolisin; anti-mikrobiyal, anti-inflamatuar, anti-oksidan ve anti-kanser etkilerinin olması onkoloji alanında sık kullanılan iki ürün olmasına sebep olmuştur. Bu yazıda bal ve propolisin onkoloji alanındaki kullanımı derlenmiştir.
Cancer is currently one of the most significant public health problems. The incidence of cancer and cancer-related deaths is on the rise, prompting the exploration of both cancer treatment and supportive therapies during cancer treatment. Honey and propolis have been essential components of alternative and supportive medicine since ancient times. The antimicrobial, anti-inflammatory, antioxidant, and anticancer effects of honey and propolis have made them widely used in the field of oncology. This article compiles the use of honey and propolis in the field of oncology.
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Ranneh Y, Akim AM, Hamid HA, Khazaai H, Fadel A, Zakaria ZA, et al. Honey and its nutritional and anti-inflammatory value. Vol. 21, BMC Complementary Medicine and Therapies. BioMed Central Ltd; 2021.
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Afrin S, Haneefa SM, Fernandez-Cabezudo MJ, Giampieri F, Al-Ramadi BK, Battino M. Therapeutic and preventive properties of honey and its bioactive compounds in cancer: An evidence-based review. Vol. 33, Nutrition Research Reviews. Cambridge University Press; 2020. p. 50–76.
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Mato I, Huidobro JF, Simal-Lozano J, Sancho MT. Significance of Nonaromatic Organic Acids in Honey. Vol. 66, Journal of Food Protection. IAMFES; 2003. p. 2371–6.
Porcza L, Simms C, Chopra M. Honey and Cancer: Current Status and Future Directions. Diseases. 2016 Sep 30;4(4):30.
Münstedt K, Männle H. Bee products and their role in cancer prevention and treatment. Complement Ther Med. 2020 Jun 1;51.
Canini. Acacia honey and chrysin reduce proliferation of melanoma cells through alterations in cell cycle progression. Int J Oncol. 2010 Sep 1;37(4).
Aliyu M, Odunola OA, Farooq AD, Rasheed H, Mesaik AM, Choudhary MI, et al. Molecular mechanism of antiproliferation potential of Acacia honey on NCI-H460 cell line. Nutr Cancer. 2013;65(2):296–304.
Swellam T, Miyanaga N, Onozawa M, Hattori K, Kawai K, Shimazui T, et al. Antineoplastic activity of honey in an experimental bladder cancer implantation model: in vivo and in vitro studies. Int J Urol. 2003 Apr;10(4):213–9.
Vidya Priyadarsini R, Senthil Murugan R, Maitreyi S, Ramalingam K, Karunagaran D, Nagini S. The flavonoid quercetin induces cell cycle arrest and mitochondria-mediated apoptosis in human cervical cancer (HeLa) cells through p53 induction and NF-κB inhibition. Eur J Pharmacol. 2010 Dec 15;649(1–3):84–91.
Zhang Q, Zhao XH, Wang ZJ. Flavones and flavonols exert cytotoxic effects on a human oesophageal adenocarcinoma cell line (OE33) by causing G2/M arrest and inducing apoptosis. Food Chem Toxicol. 2008 Jun;46(6):2042–53.
Mu C, Jia P, Yan Z, Liu X, Li X, Liu H. Quercetin induces cell cycle G1 arrest through elevating Cdk inhibitors p21 and p27 in human hepatoma cell line (HepG2). Methods Find Exp Clin Pharmacol. 2007 Apr;29(3):179–83.
Song W, Dang Q, Xu D, Chen Y, Zhu G, Wu K, et al. Kaempferol induces cell cycle arrest and apoptosis in renal cell carcinoma through EGFR/p38 signaling. Oncol Rep. 2014 Mar;31(3):1350–6.
Afrin S, Giampieri F, Gasparrini M, Forbes-Hernández TY, Cianciosi D, Reboredo-Rodriguez P, et al. The inhibitory effect of Manuka honey on human colon cancer HCT-116 and LoVo cell growth. Part 2: Induction of oxidative stress, alteration of mitochondrial respiration and glycolysis, and suppression of metastatic ability. Food Funct. 2018 Apr 25;9(4):2158–70.
Aryappalli P, Al-Qubaisi SS, Attoub S, George JA, Arafat K, Ramadi KB, et al. The IL-6/STAT3 Signaling Pathway Is an Early Target of Manuka Honey-Induced Suppression of Human Breast Cancer Cells. Front Oncol. 2017;7:167.
Seyhan MF, Yılmaz E, Timirci-Kahraman Ö, Saygılı N, Kısakesen Hİ, Eronat AP, et al. Anatolian honey is not only sweet but can also protect from breast cancer: Elixir for women from artemis to present. IUBMB Life. 2017 Sep;69(9):677–88.
Fauzi AN, Norazmi MN, Yaacob NS. Tualang honey induces apoptosis and disrupts the mitochondrial membrane potential of human breast and cervical cancer cell lines. Food Chem Toxicol. 2011 Apr;49(4):871–8.
Fernandez-Cabezudo MJ, El-Kharrag R, Torab F, Bashir G, George JA, El-Taji H, et al. Intravenous Administration of Manuka Honey Inhibits Tumor Growth and Improves Host Survival When Used in Combination with Chemotherapy in a Melanoma Mouse Model. PLoS One. 2013 Feb 7;8(2).
Jaganathan SK, Mandal M. Involvement of non-protein thiols, mitochondrial dysfunction, reactive oxygen species and p53 in honey-induced apoptosis. Invest New Drugs. 2010 Oct;28(5):624–33.
Afrin S, Forbes-Hernández TY, Cianciosi D, Pistollato F, Zhang J, Pacetti M, et al. Strawberry tree honey as a new potential functional food. Part 2: Strawberry tree honey increases ROS generation by suppressing Nrf2-ARE and NF-кB signaling pathways and decreases metabolic phenotypes and metastatic activity in colon cancer cells. J Funct Foods. 2019 Jun;57:477–87.
Afrin S, Giampieri F, Forbes-Hernández TY, Gasparrini M, Amici A, Cianciosi D, et al. Manuka honey synergistically enhances the chemopreventive effect of 5-fluorouracil on human colon cancer cells by inducing oxidative stress and apoptosis, altering metabolic phenotypes and suppressing metastasis ability. Free Radic Biol Med. 2018 Oct;126:41–54.
Reuter S, Gupta SC, Chaturvedi MM, Aggarwal BB. Oxidative stress, inflammation, and cancer: how are they linked? Free Radic Biol Med. 2010 Dec 1;49(11):1603–16.
Wang H, Cho CH. Effect of NF-κB signaling on apoptosis in chronic inflammation-associated carcinogenesis. Curr Cancer Drug Targets. 2010 Sep;10(6):593–9.
Naldini A, Carraro F. Role of inflammatory mediators in angiogenesis. Curr Drug Targets Inflamm Allergy. 2005 Feb;4(1):3–8.
Goldberg JE, Schwertfeger KL. Proinflammatory cytokines in breast cancer: mechanisms of action and potential targets for therapeutics. Curr Drug Targets. 2010 Sep;11(9):1133–46.
Batumalaie K, Zaman Safi S, Mohd Yusof K, Shah Ismail I, Devi Sekaran S, Qvist R. Effect of gelam honey on the oxidative stress-induced signaling pathways in pancreatic hamster cells. Int J Endocrinol. 2013;2013:367312.
Pichichero E, Cicconi R, Mattei M, Canini A. Chrysin-induced apoptosis is mediated through p38 and Bax activation in B16-F1 and A375 melanoma cells. Int J Oncol. 2011 Feb;38(2):473–83.
Candiracci M, Piatti E, Dominguez-Barragán M, García-Antrás D, Morgado B, Ruano D, et al. Anti-inflammatory activity of a honey flavonoid extract on lipopolysaccharide-activated N13 microglial cells. J Agric Food Chem. 2012 Dec 19;60(50):12304–11.
Erejuwa OO, Sulaiman SA, Ab Wahab MS. Effects of honey and its mechanisms of action on the development and progression of cancer. Vol. 19, Molecules. 2014. p. 2497–522.
Sauer H, Wartenberg M, Hescheler J. Reactive oxygen species as intracellular messengers during cell growth and differentiation. Cell Physiol Biochem. 2001;11(4):173–86.
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Pages
339-348
Published
March 11, 2024
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Çoban E. Bal ve Propolis. In: Sakin A, editor. Kanser Hastalarının Başvurduğu Geleneksel ve Tamamlayıcı Tedaviler - Tıbbi Onkolog Gözü ile Bakış ve Onkolojik İlaçlarla Etkileşim [Internet]. Türkiye: Academician Publishing Book DOI Portal; 2024 [cited 2026 Jul. 13]. pp. 339-48. Available from: https://omp35.books.akademisyen.net/index.php/akya/catalog/book/2380/chapter/13937
