Graviola Meyvesi ve Yaprağı (Annona Muricata Leaf)
Synopsis
Annona muricata (A.muricata); Annonaceae ailesine ait olup, graviola ya da soursop (tarçın elması) olarak da bilinmektedir. Tropik bölgelerde yetişen bu bitki son zamanlarda anti-kanser etkisi ve kanser hastalarında kullanımı nedeniyle ön plana çıkmıştır. Özellikle asetogeninler olarak bilinen bileşenlerinin farmakolojik olarak oldukça aktif olduğu bilinmektedir. Birden fazla mekanizma ile apopitozisi indüklemekte ve özellikle kanser hücrelerine karşı sitotoksik özellik göstermektedir.
Annona muricata (A.muricata); belongs to the Annonaceae family and is also known as graviola or soursop. It grows in tropical regions and is prominent due to its anti-cancer effect and its use in cancer patients. Its components known as acetogenins are known to be very active pharmacologically. It induces apoptosis through multiple mechanisms and shows cytotoxic properties especially against cancer cells.
References
Mutakin, M., Fauziati, R., Fadhilah, F. N., et al (2022). Pharmacological activities of soursop (Annona muricata Lin.). Molecules, 27(4), 1201.
Pinto, A.D.Q.; Cordeiro, M.C.R.; de Andrade, S.R.M et al. (Annona Species; International Centre for Underutilised Crops: Southampton, UK, 2005.
Coria-Téllez, A.V.; Montalvo-Gónzalez, E.; Yahia, E.M.; et al. Annona muricata: A Comprehensive Review on Its Traditional Medicinal Uses, Phytochemicals, Pharmacological Activities, Mechanisms of Action and Toxicity. Arab. J. Chem. 2018, 11, 662–691. [CrossRef]
Gavamukulya, Y.; Abou-Elella, F.; Wamunyokoli, F.; et al. Phytochemical Screening, Anti-Oxidant Activity and in Vitro Anticancer Potential of Ethanolic and Water Leaves Extracts of Annona muricata (Graviola). Asian Pac. J. Trop. Med. 2014, 7, S355–S363. [CrossRef]
Nugraha, A.S.; Damayanti, Y.D.; Wangchuk, P.; et al. Anti-Infective and Anti-Cancer Properties of the Annona Species: Their Ethnomedicinal Uses, Alkaloid Diversity, and Pharmacological Activities. Molecules 2019, 24, 4419. [CrossRef]
Ferlay, J.; Colombet, M.; Soerjomataram, I.; et al. Cancer Statistics for the Year 2020: An Overview. Int. J. Cancer 2021, 149, 778–789. [CrossRef] [PubMed]
Global Cancer Facts & Figures|American Cancer Society. Available online: https://www.cancer.org/research/cancer-factsstatistics/ global.html (accessed on 31 August 2022).
Ilango, S., Sahoo, D. K., Paital, B., Kathirvel, K., et al. (2022). A review on annona muricata and its anticancer activity. Cancers, 14(18), 4539.
Drishya, G.; Nambiar, J.; Shaji, S.K.; et al. RECK and TIMP-2 Mediate Inhibition of MMP-2 and MMP-9 by Annona muricata. J. Biosci. 2020, 45, 1. [CrossRef]
Pieme, A.A.; Kumar, G.G.; Dongmo, S.S.; et al. Antiproliferative Activity and Induction of Apoptosis by Annona muricata (Annonaceae) Extract on Human Cancer Cells. BMC Complement. Altern. Med.2014, 14, 1–10. [CrossRef]
Moghadamtousi, S.Z.; Kadir, H.A.; Paydar, M.; et al. Annona muricata Leaves Induced Apoptosis in A549 Cells through Mitochondrial-Mediated Pathway and Involvement of NF-_B. BMC Complement. Altern. Med. 2014, 14, 1–13. [CrossRef]
Kim, J.Y.; Dao, T.T.P.; Song, K et al. Annona muricata Leaf Extract Triggered Intrinsic Apoptotic Pathway to Attenuate Cancerous Features of Triple Negative Breast Cancer MDA-MB-231 Cells. Evid.-Based Complement. Altern. Med. 2018, 2018, 916. [CrossRef]
Hadisaputri, Y.E.; Habibah, U.; Abdullah, F.F.; et al. Antiproliferation Activity and Apoptotic Mechanism of Soursop ( Annona muricata L.) Leaves Extract and Fractions on MCF7 Breast Cancer Cells. Breast Cancer Targets Ther. 2021, 13, 447–457. [CrossRef]
Yang, C.; Gundala, S.R.; Mukkavilli, R.; et al. Synergistic Interactions among Flavonoids and Acetogenins in Graviola (Annona muricata) Leaves Confer Protection against Prostate Cancer. Carcinogenesis 2015, 36, 656–665. [CrossRef]
Son, Y.R.; Choi, E.H.; Kim, G.T.; et al. Bioefficacy of Graviola Leaf Extracts in Scavenging Free Radicals and Upregulating Antioxidant Genes. Food Funct. 2016, 7, 861–871. [CrossRef] [PubMed]
Indrawati, L.; Ascobat, P.; Bela, B.; et al. The Effect of an Annona muricata Leaf Extract on Nutritional Status and Cytotoxicity in Colorectal Cancer: A Randomized Controlled Trial. Asia Pac. J. Clin. Nutr. 2017, 26, 606–612. [CrossRef]
Jaradat, N. A., Al-Ramahi, R., Zaid, A. N., et al. (2016). Ethnopharmacological survey of herbal remedies used for treatment of various types of cancer and their methods of preparations in the West Bank-Palestine. BMC complementary and alternative medicine, 16(1), 1-12.
Manoharan, J. P., Palanisamy, H., & Vidyalakshmi, S. (2023). Overcoming multi drug resistance mediated by ABC transporters by a novel acetogenin-annonacin from Annona muricata L. Journal of Ethnopharmacology, 117598.
Hansra, D. M., Silva, O., Mehta, A, et al. Patient with metastatic breast cancer achieves stable disease for 5 years on graviola and xeloda after progressing on multiple lines of therapy. Advances in Breast Cancer Research, 2014.
Torres, M. P., Rachagani, S., Purohit, V., et al. (2012). Graviola: a novel promising natural-derived drug that inhibits tumorigenicity and metastasis of pancreatic cancer cells in vitro and in vivo through altering cell metabolism. Cancer letters, 323(1), 29-40.
Buskermolen, A. B. (2021). Tablet Formulation of The Ethyl Acetate Soluble Extract of Soursop (Annona muricata L.) Leaves. American Journal of Applied Sciences (ISSN: 2321–089X), 11(02).
Gomes de Melo J, de Sousa Araújo TA, Thijan Nobre de Almeida e Castro V, et al. Antiproliferative activity, antioxidant capacity and tannin content in plants of semi-arid northeastern Brazil. Molecules. 2010;15(12):8534–8542. https://doi. org/10.3390/molecules15128534
Rachmani EPN, Suhesti TS, Widiastuti R, et al. Cytotoxic effects of methanol extracts of soursop leaves (Annona muricata) on MCF-7 cell line and its effect on expression of BCL-2. ASEAN/Asian Academic Society International Conference Proceeding Series; 2013.
Yajid, A. I., Ab Rahman, H. S., Wong, M. P. K., et al. (2018). Potential benefits of Annona muricata in combating cancer: A review. The Malaysian journal of medical sciences: MJMS, 25(1), 5.
Zorofchian Moghadamtousi S, Karimian H, Rouhollahi Eet al. Annona muricata leaves induce G(1) cell cycle arrest and apoptosis through mitochondria-mediated pathway in human HCT-116 and HT-29 colon cancer cells. J Ethnopharmacol. 2014;156:277–289. https://doi.org/10.1016/j. jep.2014.08.011. PubMed PMID: 25195082.
Abdullah, M.; Syam, A.F.; Meilany, S.; et al. The Value of Caspase-3 after the Application of Annona muricata Leaf Extract in COLO-205 Colorectal Cancer Cell Line. Gastroenterol. Res. Pr. 2017, 4357165. [CrossRef] [PubMed]
Kim, G.S.; Zeng, L.; Alali, F.; et al. Two New Mono-Tetrahydrofuran Ring Acetogenins, Annomuricin E and Muricapentocin, from the Leaves of Annona muricata. J. Nat. Prod. 1998, 61, 432–436. [CrossRef] [PubMed]
Zafra-Polo MC, Figadère B, Gallardo T, et al. Natural acetogenins from Annonaceae, synthesis and mechanisms of action. Phytochemistry. 1998;48(7):1087–1117. https:// doi.org/10.1016/S0031-9422(97)00917-5
Yang H, Liu N, Lee S. Ethanol extract of Annona muricata L induces liver cancer cell apoptosis through ROS pathway. Biomedical and Pharmacology Journal. 2016;9(3):919–925. https://doi.org/10.13005/bpj/1030
Indrawati, L.; Purwantyastuti, P.; Abdullah, M.; et al. Safety of Annona muricata Extract Supplementation for Colorectal Cancer Patients. Indones. J. Gastroenterol. Hepatol. Dig. Endosc. 2017, 17, 170–175. [CrossRef]
Surono, I.S.; Lienggonegoro, L.A.; Indrawati, L.; et al. Inflammatory Response of Annona muricata Linn Leaves Extract in Colorectal Cancer Patients. J. Global. Pharma. Technol. 2017, 9 (Suppl. 7), 150–157.
Knüpfer, H.; Preiss, R. Serum Interleukin-6 Levels in Colorectal Cancer Patients-a Summary of Published Results. Int. J. Colorectal. Dis. 2010, 25, 135–140. [CrossRef]
Yap, S. Colon Cancer Reversed by Phyto-Nutritional Therapy: A Case Study. Int. J. Biotechnol. Wellness Ind. 2013, 2, 132–139. [CrossRef]
Shahid, F.; Farooqui, Z.; Khan, F. Cisplatin-Induced Gastrointestinal Toxicity: An Update on Possible Mechanisms and on Available Gastroprotective Strategies. Eur. J. Pharm. 2018, 827, 49–57. [CrossRef] [PubMed]
Pinto, A.D.Q.; Cordeiro, M.C.R.; de Andrade, S.R.M et al. (Annona Species; International Centre for Underutilised Crops: Southampton, UK, 2005.
Coria-Téllez, A.V.; Montalvo-Gónzalez, E.; Yahia, E.M.; et al. Annona muricata: A Comprehensive Review on Its Traditional Medicinal Uses, Phytochemicals, Pharmacological Activities, Mechanisms of Action and Toxicity. Arab. J. Chem. 2018, 11, 662–691. [CrossRef]
Gavamukulya, Y.; Abou-Elella, F.; Wamunyokoli, F.; et al. Phytochemical Screening, Anti-Oxidant Activity and in Vitro Anticancer Potential of Ethanolic and Water Leaves Extracts of Annona muricata (Graviola). Asian Pac. J. Trop. Med. 2014, 7, S355–S363. [CrossRef]
Nugraha, A.S.; Damayanti, Y.D.; Wangchuk, P.; et al. Anti-Infective and Anti-Cancer Properties of the Annona Species: Their Ethnomedicinal Uses, Alkaloid Diversity, and Pharmacological Activities. Molecules 2019, 24, 4419. [CrossRef]
Ferlay, J.; Colombet, M.; Soerjomataram, I.; et al. Cancer Statistics for the Year 2020: An Overview. Int. J. Cancer 2021, 149, 778–789. [CrossRef] [PubMed]
Global Cancer Facts & Figures|American Cancer Society. Available online: https://www.cancer.org/research/cancer-factsstatistics/ global.html (accessed on 31 August 2022).
Ilango, S., Sahoo, D. K., Paital, B., Kathirvel, K., et al. (2022). A review on annona muricata and its anticancer activity. Cancers, 14(18), 4539.
Drishya, G.; Nambiar, J.; Shaji, S.K.; et al. RECK and TIMP-2 Mediate Inhibition of MMP-2 and MMP-9 by Annona muricata. J. Biosci. 2020, 45, 1. [CrossRef]
Pieme, A.A.; Kumar, G.G.; Dongmo, S.S.; et al. Antiproliferative Activity and Induction of Apoptosis by Annona muricata (Annonaceae) Extract on Human Cancer Cells. BMC Complement. Altern. Med.2014, 14, 1–10. [CrossRef]
Moghadamtousi, S.Z.; Kadir, H.A.; Paydar, M.; et al. Annona muricata Leaves Induced Apoptosis in A549 Cells through Mitochondrial-Mediated Pathway and Involvement of NF-_B. BMC Complement. Altern. Med. 2014, 14, 1–13. [CrossRef]
Kim, J.Y.; Dao, T.T.P.; Song, K et al. Annona muricata Leaf Extract Triggered Intrinsic Apoptotic Pathway to Attenuate Cancerous Features of Triple Negative Breast Cancer MDA-MB-231 Cells. Evid.-Based Complement. Altern. Med. 2018, 2018, 916. [CrossRef]
Hadisaputri, Y.E.; Habibah, U.; Abdullah, F.F.; et al. Antiproliferation Activity and Apoptotic Mechanism of Soursop ( Annona muricata L.) Leaves Extract and Fractions on MCF7 Breast Cancer Cells. Breast Cancer Targets Ther. 2021, 13, 447–457. [CrossRef]
Yang, C.; Gundala, S.R.; Mukkavilli, R.; et al. Synergistic Interactions among Flavonoids and Acetogenins in Graviola (Annona muricata) Leaves Confer Protection against Prostate Cancer. Carcinogenesis 2015, 36, 656–665. [CrossRef]
Son, Y.R.; Choi, E.H.; Kim, G.T.; et al. Bioefficacy of Graviola Leaf Extracts in Scavenging Free Radicals and Upregulating Antioxidant Genes. Food Funct. 2016, 7, 861–871. [CrossRef] [PubMed]
Indrawati, L.; Ascobat, P.; Bela, B.; et al. The Effect of an Annona muricata Leaf Extract on Nutritional Status and Cytotoxicity in Colorectal Cancer: A Randomized Controlled Trial. Asia Pac. J. Clin. Nutr. 2017, 26, 606–612. [CrossRef]
Jaradat, N. A., Al-Ramahi, R., Zaid, A. N., et al. (2016). Ethnopharmacological survey of herbal remedies used for treatment of various types of cancer and their methods of preparations in the West Bank-Palestine. BMC complementary and alternative medicine, 16(1), 1-12.
Manoharan, J. P., Palanisamy, H., & Vidyalakshmi, S. (2023). Overcoming multi drug resistance mediated by ABC transporters by a novel acetogenin-annonacin from Annona muricata L. Journal of Ethnopharmacology, 117598.
Hansra, D. M., Silva, O., Mehta, A, et al. Patient with metastatic breast cancer achieves stable disease for 5 years on graviola and xeloda after progressing on multiple lines of therapy. Advances in Breast Cancer Research, 2014.
Torres, M. P., Rachagani, S., Purohit, V., et al. (2012). Graviola: a novel promising natural-derived drug that inhibits tumorigenicity and metastasis of pancreatic cancer cells in vitro and in vivo through altering cell metabolism. Cancer letters, 323(1), 29-40.
Buskermolen, A. B. (2021). Tablet Formulation of The Ethyl Acetate Soluble Extract of Soursop (Annona muricata L.) Leaves. American Journal of Applied Sciences (ISSN: 2321–089X), 11(02).
Gomes de Melo J, de Sousa Araújo TA, Thijan Nobre de Almeida e Castro V, et al. Antiproliferative activity, antioxidant capacity and tannin content in plants of semi-arid northeastern Brazil. Molecules. 2010;15(12):8534–8542. https://doi. org/10.3390/molecules15128534
Rachmani EPN, Suhesti TS, Widiastuti R, et al. Cytotoxic effects of methanol extracts of soursop leaves (Annona muricata) on MCF-7 cell line and its effect on expression of BCL-2. ASEAN/Asian Academic Society International Conference Proceeding Series; 2013.
Yajid, A. I., Ab Rahman, H. S., Wong, M. P. K., et al. (2018). Potential benefits of Annona muricata in combating cancer: A review. The Malaysian journal of medical sciences: MJMS, 25(1), 5.
Zorofchian Moghadamtousi S, Karimian H, Rouhollahi Eet al. Annona muricata leaves induce G(1) cell cycle arrest and apoptosis through mitochondria-mediated pathway in human HCT-116 and HT-29 colon cancer cells. J Ethnopharmacol. 2014;156:277–289. https://doi.org/10.1016/j. jep.2014.08.011. PubMed PMID: 25195082.
Abdullah, M.; Syam, A.F.; Meilany, S.; et al. The Value of Caspase-3 after the Application of Annona muricata Leaf Extract in COLO-205 Colorectal Cancer Cell Line. Gastroenterol. Res. Pr. 2017, 4357165. [CrossRef] [PubMed]
Kim, G.S.; Zeng, L.; Alali, F.; et al. Two New Mono-Tetrahydrofuran Ring Acetogenins, Annomuricin E and Muricapentocin, from the Leaves of Annona muricata. J. Nat. Prod. 1998, 61, 432–436. [CrossRef] [PubMed]
Zafra-Polo MC, Figadère B, Gallardo T, et al. Natural acetogenins from Annonaceae, synthesis and mechanisms of action. Phytochemistry. 1998;48(7):1087–1117. https:// doi.org/10.1016/S0031-9422(97)00917-5
Yang H, Liu N, Lee S. Ethanol extract of Annona muricata L induces liver cancer cell apoptosis through ROS pathway. Biomedical and Pharmacology Journal. 2016;9(3):919–925. https://doi.org/10.13005/bpj/1030
Indrawati, L.; Purwantyastuti, P.; Abdullah, M.; et al. Safety of Annona muricata Extract Supplementation for Colorectal Cancer Patients. Indones. J. Gastroenterol. Hepatol. Dig. Endosc. 2017, 17, 170–175. [CrossRef]
Surono, I.S.; Lienggonegoro, L.A.; Indrawati, L.; et al. Inflammatory Response of Annona muricata Linn Leaves Extract in Colorectal Cancer Patients. J. Global. Pharma. Technol. 2017, 9 (Suppl. 7), 150–157.
Knüpfer, H.; Preiss, R. Serum Interleukin-6 Levels in Colorectal Cancer Patients-a Summary of Published Results. Int. J. Colorectal. Dis. 2010, 25, 135–140. [CrossRef]
Yap, S. Colon Cancer Reversed by Phyto-Nutritional Therapy: A Case Study. Int. J. Biotechnol. Wellness Ind. 2013, 2, 132–139. [CrossRef]
Shahid, F.; Farooqui, Z.; Khan, F. Cisplatin-Induced Gastrointestinal Toxicity: An Update on Possible Mechanisms and on Available Gastroprotective Strategies. Eur. J. Pharm. 2018, 827, 49–57. [CrossRef] [PubMed]
Pages
245-250
Published
March 11, 2024
Copyright (c) 2024 Academician Publishing Book Portal
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1.
Sali S. Graviola Meyvesi ve Yaprağı (Annona Muricata Leaf). In: Sakin A, editor. Kanser Hastalarının Başvurduğu Geleneksel ve Tamamlayıcı Tedaviler - Tıbbi Onkolog Gözü ile Bakış ve Onkolojik İlaçlarla Etkileşim [Internet]. Türkiye: Academician Publishing Book DOI Portal; 2024 [cited 2026 Jul. 13]. pp. 245-50. Available from: https://omp35.books.akademisyen.net/index.php/akya/catalog/book/2380/chapter/13924
