Papatya (Chammomilla Recutita)
Synopsis
Papatya, Asteraceae ailesinden batı Asya ve Avrupada yetişmekte olan bir bitkidir(1).Avustralya ve Amerika da da üretilmektedir. Papatya çayı , çok sık tüketilen bitki çaylarından olup tıp biliminde de kullanılmıştır ve uzun yıllardır tüketilmiş olmasına rağmen, sağlık üzerine etkileri netlik kazanmamıştır. Farklı ülkelerde başta gargara, pomad, krem,buhar inhalasyonu olmak üzere değişik tüketim formları da mevcuttur. Çalışmalarda papatyadan elde edilen apigenin ve luteolin gibi flavonoidlerin anti-kanserojenik etkisi olabileceği vurgulanmıştır(2). Amacımız kanser hastalarında papatya kullanımının kanser üzerine olumlu ve olumsuz etkilerini ve onkolojik ilaçlar ile etkileşimini incelemektir.
Daisy is a plant from the Asteraceae family that grows in western Asia and Europe (1). It is also produced in Australia and America. Chamomile is one of the most frequently consumed herbal teas and has also been used in medical science. Although chamomile tea has been consumed for many years, its effects on health are not clear. Different consumption forms are available in different countries, including mouthwash, pomade, cream and steam inhalation. Current studies have emphasized that flavonoids such as apigenin and luteolin obtained from chamomile may have anti-carcinogenic effects(2). Our aim is to examine the positive and negative effects of chamomile use on cancer patients and its interaction with oncological drugs.
References
European Pharmacopeia, 5th edition, Council Europe,Strasbourg (2005)
Janmejai K. Srivastava ,Sanjay Gupta Antiproliferative and Apoptotic Effects of Chamomile Extract in Various Human Cancer cells 2007 Nov 14,55(23):9470-80
Baytop T. Türkiye’de Bitkilerle Tedavi. 2.baskı. İstanbul: Nobel Tıp Kitabevleri; 1999.
Redaelli C, Formentini L, Santaniello E. Reversed-Phase HighPerformance Liquid Chromatography Analysis of Apigenin and its Glucosides in Flowers of Matricaria chamomilla and Chamomile Extracts. Planta Med. 1981 Jul;42(7)288-292
Parker S. Pediatric Herb Compendium [internette]. 2002 [9.11.2005 okundu]. www.naturallyhealthy.org/pedherbs.php
Lucassen PL, Assedelft WJ, vn Ejk JT,Gubbels JW, Douwes AC, van Geldrop WJ. Systematic Review of the occurence of infantile colic in the community. Arc Dis Child. 2001 May; 84(5): 398- 403.
Clifford TJ, Campell MK, Speechly KN, Gorozinsky F. Evidence of Transient Infant Distress And Absence of Lasting Effects on Maternal Mental Health. Arch Pedatr Adolesc Med. 2002; 156: 1183-1188. 123
Brazelton T.B. Crying in infancy. Pediatrics. 1962 April; 29(4): 579- 588.
Geertsma MA, Jeffrey SH.Colic-A Pain Syndrome of Infancy? Pediatric Clinics of North America. 1989 November; 36(4): 905-919
Nabavi SF, Khan H, D'onofrio G, Šamec D, Shirooie S, Dehpour AR et al. Apigenin as neuroprotective agent: Of mice and men. Pharmacological Research. 2018;128:359-65.
Arts, I.C. and P.C. Hollman, Polyphenols and disease risk in epidemiologic studies. Am J Clin Nutr, 2005. 81(1 Suppl): p. 317S-325S.---reaktif
Cazarolli LH, Zanatta L, Alberton EH, Figueiredo MS, Folador P, Damazio RG, Pizzolatti MG, Silva FR (2008). "Flavonoids: Prospective Drug Candidates". Mini-Reviews in Medicinal Chemistry. 8 (13). ss. 1429-1440.
Blumenthal M, Goldberg A, Brinckmann J. Herbal Medicine Expanded Commission E Monographs [online] 2000.
Avallone, R .; Zanoli, P .; Corsi, L.;Matricaria chamomilla Phytother'in çiçek başlarındaki benzodiazepin benzeri bileşikler ve GABA . Res. 1996 10 S177 S179
Svehlikova, V .; Bennett, RN ; Mellon, FA ; İhtiyaçlar, PW ; Piacente, S .; Kroon, Pensilvanya ; Bao, Y. Papatyadan ( Chamomilla recutita [L.] Rauschert) apigenin 7-O-glukozitin asile edilmiş türevlerinin izolasyonu, tanımlanması ve stabilitesi Fitokimya 2004 65 2323 2332
Apigenin'in potansiyel 16.farmakolojik etkileri üzerine bir derleme Yıl 2023.Cilt:32 Sayı:2,113-119, 30.06.2023
Yin F, Giuliano AE,Law RE, Van Herle AJ. 2001 Antikanser Arş. 21:413-420
Wang W, Heideman L, chung CS, Pelling JC, Koehler KJ, Birt DF, 2000 Mol. Kansorejen. 28:102-110
Caltagirone S, Rossi C, Poggi A, Ranelletti FO, Natali PG, Brunetti M, Aiello FB, Piantelli M . 2000 Uluslararası J. Kanser 87: 595–600
Yin F, Giuliano AE, Van Herle AJ.1999 Tiroid 9:369-376
Iran J Pharm Res Mitochondrial Apoptosis Induced by Chamaemelum Nobile Extract in Breast Cancer Cells 2016 Winter; 15(Sunnl):197-204.
Liang YC,Huang YT,Tsai SH,Lim-Shiau SY,Chen CFR,Lin JK.1999 Karsinogenez 20:1945-1952
Ishidate M Jr, Sofuni T, Yoshikawa K, Hayashi M, Nohmi T, Sawada M, Matsuoka A. Primary mutagenicity screening of food additives currently used in Japan. Food Chem Toxicol. 1984 Aug;22(8).623-636.
Involvement of nuclear factor-kappa B, Bax and Bcl-2 in induction of cell cycle arrest and apoptosis by apigenin in human prostate carcinoma cells.Saniay Gupta,Farrukh Afag
Wu K, Yuan LH and Xia W (2005). Inhibitory effects of apigenin on the growth of gastric carcinoma SGC-7901 cells. World J Gastroenterol 11: 4461-4464,.
Antigenotoxicity, Cytotoxicity, and Apoptosis Induction by Apigenin, Bisabolol, and Protocatechuic Acid Jaouad Anter,1 Magdalena Romero-Jime´nez,1 Zahira Ferna´ndez-Bedmar,1 Myriam Villatoro-Pulido,2 Mohamed Analla,3 A´ ngeles Alonso-Moraga,1 and Andre´s Mun˜oz-Serrano
Cavalieri E, Mariotto S, Fabrizi C, de Patri AC, Gottardo R, Leone S, Berra LV, Lauro GM, Ciampa AR, Suzuki H: Alphabisabolol, a nontoxic natural compound, strongly induces apoptosis in glioma cells. Biochem Biophys Res Commun 2004;315:
Ostad SN, Soodi M, Shariffzadeh M, Khorshidi N, Marzban H. The effect of essential oil on uterine contraction as a model for dysmenorrhea, pharmacology and toxicology study. J. Ethnopharmacol. 2001 Aug; 76839: 299-304.
ESCOP Monographs The Scientific Foundation For Herbal Medicinal Products, second edition, New York, USA,Thieme; 2003.
Matricaria Flower. British Herbal Pharmacopoeia (BHP). 1996. Exeter, U.K. British Herbal Medicine, p.131.
http://www.otrehberi.com/dizin_bitkisel_droglar
Subiza J, Subiza JL, Alonso M, Hinojosa M, Garcia R, Jerz M, Subiza E. Allergic conjunctivitis to Chamomile tea. Ann Allergy. 1990 Aug;65(2):127-132.
Paulsen E, Andersen KE, Hausen BM. Compositae dermatitis in a Danish dermatology department in one year (1). Results of routine patch testing with the sesquiterpene lactone mix supplemented with aimed patch testing with extracts and sesquiterpene lactones of Compositae plants. Contact Dermatitis. 1993 Jul;29(1):6-10.
de Jong NW, Vermuelen AM, Gerth van Wijk R, de Groot H. Occupational allergy caused by flowers. Allergy.1998 Feb;53(2):204-209. 132
Andres C, Chen WC, Ollert M, Mempel M, Darsow U, Ring J. Anaphylactic reaction to Chamomile tea. Allergol Int. 2009 Mar;58(1):135-136.
Subiza J, Subiza JL, Hinojosa M, Garcia R, Jerez M, Valdivieso R, Subiza E. Anaphlactic reaction after the ingestion of Chamomile tea: a study of cross-reactivity with other compositae pollens. J. Allergy Clin Immunol. 1989 Sep;84(3):353-358.
Segal R, Pilote L. Warfarin interaction with Matricaria chamomilla. CMAJ. 2006 Apr 25;174(9):1281-1282.
Shukla S. ve Gupta S. (2010).Apigenin: A Promising Molecule for Cancer Prevention Pharm Res. ; 27(6): 962–978
Janmejai K. Srivastava ,Sanjay Gupta Antiproliferative and Apoptotic Effects of Chamomile Extract in Various Human Cancer cells 2007 Nov 14,55(23):9470-80
Baytop T. Türkiye’de Bitkilerle Tedavi. 2.baskı. İstanbul: Nobel Tıp Kitabevleri; 1999.
Redaelli C, Formentini L, Santaniello E. Reversed-Phase HighPerformance Liquid Chromatography Analysis of Apigenin and its Glucosides in Flowers of Matricaria chamomilla and Chamomile Extracts. Planta Med. 1981 Jul;42(7)288-292
Parker S. Pediatric Herb Compendium [internette]. 2002 [9.11.2005 okundu]. www.naturallyhealthy.org/pedherbs.php
Lucassen PL, Assedelft WJ, vn Ejk JT,Gubbels JW, Douwes AC, van Geldrop WJ. Systematic Review of the occurence of infantile colic in the community. Arc Dis Child. 2001 May; 84(5): 398- 403.
Clifford TJ, Campell MK, Speechly KN, Gorozinsky F. Evidence of Transient Infant Distress And Absence of Lasting Effects on Maternal Mental Health. Arch Pedatr Adolesc Med. 2002; 156: 1183-1188. 123
Brazelton T.B. Crying in infancy. Pediatrics. 1962 April; 29(4): 579- 588.
Geertsma MA, Jeffrey SH.Colic-A Pain Syndrome of Infancy? Pediatric Clinics of North America. 1989 November; 36(4): 905-919
Nabavi SF, Khan H, D'onofrio G, Šamec D, Shirooie S, Dehpour AR et al. Apigenin as neuroprotective agent: Of mice and men. Pharmacological Research. 2018;128:359-65.
Arts, I.C. and P.C. Hollman, Polyphenols and disease risk in epidemiologic studies. Am J Clin Nutr, 2005. 81(1 Suppl): p. 317S-325S.---reaktif
Cazarolli LH, Zanatta L, Alberton EH, Figueiredo MS, Folador P, Damazio RG, Pizzolatti MG, Silva FR (2008). "Flavonoids: Prospective Drug Candidates". Mini-Reviews in Medicinal Chemistry. 8 (13). ss. 1429-1440.
Blumenthal M, Goldberg A, Brinckmann J. Herbal Medicine Expanded Commission E Monographs [online] 2000.
Avallone, R .; Zanoli, P .; Corsi, L.;Matricaria chamomilla Phytother'in çiçek başlarındaki benzodiazepin benzeri bileşikler ve GABA . Res. 1996 10 S177 S179
Svehlikova, V .; Bennett, RN ; Mellon, FA ; İhtiyaçlar, PW ; Piacente, S .; Kroon, Pensilvanya ; Bao, Y. Papatyadan ( Chamomilla recutita [L.] Rauschert) apigenin 7-O-glukozitin asile edilmiş türevlerinin izolasyonu, tanımlanması ve stabilitesi Fitokimya 2004 65 2323 2332
Apigenin'in potansiyel 16.farmakolojik etkileri üzerine bir derleme Yıl 2023.Cilt:32 Sayı:2,113-119, 30.06.2023
Yin F, Giuliano AE,Law RE, Van Herle AJ. 2001 Antikanser Arş. 21:413-420
Wang W, Heideman L, chung CS, Pelling JC, Koehler KJ, Birt DF, 2000 Mol. Kansorejen. 28:102-110
Caltagirone S, Rossi C, Poggi A, Ranelletti FO, Natali PG, Brunetti M, Aiello FB, Piantelli M . 2000 Uluslararası J. Kanser 87: 595–600
Yin F, Giuliano AE, Van Herle AJ.1999 Tiroid 9:369-376
Iran J Pharm Res Mitochondrial Apoptosis Induced by Chamaemelum Nobile Extract in Breast Cancer Cells 2016 Winter; 15(Sunnl):197-204.
Liang YC,Huang YT,Tsai SH,Lim-Shiau SY,Chen CFR,Lin JK.1999 Karsinogenez 20:1945-1952
Ishidate M Jr, Sofuni T, Yoshikawa K, Hayashi M, Nohmi T, Sawada M, Matsuoka A. Primary mutagenicity screening of food additives currently used in Japan. Food Chem Toxicol. 1984 Aug;22(8).623-636.
Involvement of nuclear factor-kappa B, Bax and Bcl-2 in induction of cell cycle arrest and apoptosis by apigenin in human prostate carcinoma cells.Saniay Gupta,Farrukh Afag
Wu K, Yuan LH and Xia W (2005). Inhibitory effects of apigenin on the growth of gastric carcinoma SGC-7901 cells. World J Gastroenterol 11: 4461-4464,.
Antigenotoxicity, Cytotoxicity, and Apoptosis Induction by Apigenin, Bisabolol, and Protocatechuic Acid Jaouad Anter,1 Magdalena Romero-Jime´nez,1 Zahira Ferna´ndez-Bedmar,1 Myriam Villatoro-Pulido,2 Mohamed Analla,3 A´ ngeles Alonso-Moraga,1 and Andre´s Mun˜oz-Serrano
Cavalieri E, Mariotto S, Fabrizi C, de Patri AC, Gottardo R, Leone S, Berra LV, Lauro GM, Ciampa AR, Suzuki H: Alphabisabolol, a nontoxic natural compound, strongly induces apoptosis in glioma cells. Biochem Biophys Res Commun 2004;315:
Ostad SN, Soodi M, Shariffzadeh M, Khorshidi N, Marzban H. The effect of essential oil on uterine contraction as a model for dysmenorrhea, pharmacology and toxicology study. J. Ethnopharmacol. 2001 Aug; 76839: 299-304.
ESCOP Monographs The Scientific Foundation For Herbal Medicinal Products, second edition, New York, USA,Thieme; 2003.
Matricaria Flower. British Herbal Pharmacopoeia (BHP). 1996. Exeter, U.K. British Herbal Medicine, p.131.
http://www.otrehberi.com/dizin_bitkisel_droglar
Subiza J, Subiza JL, Alonso M, Hinojosa M, Garcia R, Jerz M, Subiza E. Allergic conjunctivitis to Chamomile tea. Ann Allergy. 1990 Aug;65(2):127-132.
Paulsen E, Andersen KE, Hausen BM. Compositae dermatitis in a Danish dermatology department in one year (1). Results of routine patch testing with the sesquiterpene lactone mix supplemented with aimed patch testing with extracts and sesquiterpene lactones of Compositae plants. Contact Dermatitis. 1993 Jul;29(1):6-10.
de Jong NW, Vermuelen AM, Gerth van Wijk R, de Groot H. Occupational allergy caused by flowers. Allergy.1998 Feb;53(2):204-209. 132
Andres C, Chen WC, Ollert M, Mempel M, Darsow U, Ring J. Anaphylactic reaction to Chamomile tea. Allergol Int. 2009 Mar;58(1):135-136.
Subiza J, Subiza JL, Hinojosa M, Garcia R, Jerez M, Valdivieso R, Subiza E. Anaphlactic reaction after the ingestion of Chamomile tea: a study of cross-reactivity with other compositae pollens. J. Allergy Clin Immunol. 1989 Sep;84(3):353-358.
Segal R, Pilote L. Warfarin interaction with Matricaria chamomilla. CMAJ. 2006 Apr 25;174(9):1281-1282.
Shukla S. ve Gupta S. (2010).Apigenin: A Promising Molecule for Cancer Prevention Pharm Res. ; 27(6): 962–978
Pages
145-150
Published
March 11, 2024
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LicenseHow to Cite
1.
Şahin Çelik B. Papatya (Chammomilla Recutita). In: Sakin A, editor. Kanser Hastalarının Başvurduğu Geleneksel ve Tamamlayıcı Tedaviler - Tıbbi Onkolog Gözü ile Bakış ve Onkolojik İlaçlarla Etkileşim [Internet]. Türkiye: Academician Publishing Book DOI Portal; 2024 [cited 2026 Jul. 13]. pp. 145-50. Available from: https://omp35.books.akademisyen.net/index.php/akya/catalog/book/2380/chapter/13901
