Vitamin E
Özet
E vitamini kanserin gelişmesinde ve korunmasında araştırılan besinlerden biridir. Antioksidan özellikleri dokulardaki hücrelerin oksidatif stresten korunmasında rol oynar. Oksidatif stresin kanserdeki rolü nedeniyle diyetle alınan E vitamini tüketiminin kanseri önleme ve kanser tedavisindeki rolü üzerine birçok çalışma bulunmaktadır. Çalışmaların netliği ve sonuçlarının merkezinde, E vitamininin kanser üzerindeki olumlu etkisi belirsizliğini korumaktadır.
Vitamin E is one of the nutrients researched in the development and protection of cancer. Its antioxidant properties play a role in protecting cells in tissues from oxidative stress. Due to the role of oxidative stress in cancer, there are many studies on the role of dietary vitamin E consumption in cancer prevention and cancer treatment. Central to the clarity and results of the studies, the positive effect of vitamin E on cancer remains unclear.
Referanslar
Burton GW, Traber MG. Vitamin E: antioxidant activity, biokinetics, and bioavailability. Annu Rev Nutr 1990;10:357–82.
Ozer KN, Azzi A. In: Papas A, ed. Antioxidant status, diet, nutrition and health. Boca Raton: CRC Press, 1998.449–60
Kamal-Eldin A, Appelqvist LA. The chemistry and antioxidant properties of tocopherols and tocotrienols. Lipids 1996;31:671–701.
Abraham A, Kattoor AJ, Saldeen T, Mehta JL. Vitamin E and its anticancer effects. Crit Rev Food Sci Nutr. 2019;59(17):2831–8.
Traber MG. Vitamin E regulatory mechanisms. Annu Rev Nutr. 2007;27:347–62.
Yang CS, Suh N, Kong AN. Does vitamin E prevent or promote cancer? Cancer Prev Res (Phila). 2012;5(5):701–5.
Hu F, Wu Z, Li G, Teng C, Liu Y, Wang F, et al. The plasma level of retinol, vitamins A, C and alpha-tocopherol could reduce breast cancer risk? A meta-analysis and meta-regression. J Cancer Res Clin Oncol. 2015;141(4):601–14
de Munter L, Maasland DH, van den Brandt PA, Kremer B, Schouten LJ. Vitamin and carotenoid intake and risk of head-neck cancer subtypes in the Netherlands Cohort Study. Am J Clin Nutr. 2015;102(2):420–32.
Crane TE, Khulpateea BR, Alberts DS, Basen-Engquist K, Thomson CA. Dietary intake and ovarian cancer risk: a systematic review. Cancer Epidemiol Biomarkers Prev. 2014;23(2):255–73
Koushik A, Wang M, Anderson KE, van den Brandt P, Clendenen TV, Eliassen AH, et al. Intake of vitamins A, C, and E and folate and the risk of ovarian cancer in a pooled analysis of 10 cohort studies. Cancer Causes Control. 2015;26(9):1315–27.
Huang J, Weinstein SJ, Yu K, Mannisto S, Albanes D. A prospective study of serum vitamin E and 28-year risk of lung cancer. J Natl Cancer Inst. 2020;112:191–9.
Cui L, Li L, Tian Y, Xu F, Qiao T. Association between dietary vitamin E intake and esophageal cancer risk: an updated meta-analysis. Nutrients. 2018;10(7):801.
Shang Y, Yi S, Cui D, Han G, Liu C. Vitamin E intake and risk of renal cell carcinoma: a meta-analysis of 7 case-control studies. J Ren Nutr. 2015;25(4):339–44.
Lin JH, Chen SJ, Liu H, Yan Y, Zheng JH. Vitamin E consumption and the risk of bladder cancer. Int J Vitam Nutr Res. 2019;89(3–4):168–75.
Chen F, Li Q, Yu Y, Yang W, Shi F, Qu Y. Association of vitamin C, vitamin D, vitamin E and risk of bladder cancer: a dose-response meta-analysis. Sci Rep. 2015;5:9599.
Klein, E. A., Thompson, I. M., Jr, Tangen, C. M., Crowley, J. J., Lucia, M. S., Goodman, P. J., Minasian, L. M., Ford, L. G., Parnes, H. L., Gaziano, J. M., Karp, D. D., Lieber, M. M., Walther, P. J., Klotz, L., Parsons, J. K., Chin, J. L., Darke, A. K., Lippman, S. M., Goodman, G. E., Meyskens, F. L., Jr, … Baker, L. H. (2011). Vitamin E and the risk of prostate cancer: the Selenium and Vitamin E Cancer Prevention Trial (SELECT). JAMA, 306(14), 1549–1556. https://doi.org/10.1001/jama.2011.1437
Loh, W. Q., Youn, J., & Seow, W. J. (2022). Vitamin E Intake and Risk of Prostate Cancer: A Meta-Analysis. Nutrients, 15(1), 14. https://doi.org/10.3390/nu15010014
Xin, J., Jiang, X., Ben, S., Yuan, Q., Su, L., Zhang, Z., Christiani, D. C., Du, M., & Wang, M. (2022). Association between circulating vitamin E and ten common cancers: evidence from large-scale Mendelian randomization analysis and a longitudinal cohort study. BMC medicine, 20(1), 168. https://doi.org/10.1186/s12916-022-02366-5
Argyriou AA, Chroni E, Koutras A, et al. A randomized controlled trial evaluating the effıcacy and safety of vitamin E supplementation for protection against cisplatin-induced peripheral neuropathy: fınal results. Support Care Cancer. 2006;14:1134-1140.
Fuchs-Tarlovsky V, Bejarano-Rosales M, Gutierrez-Salmean G, et al. Effect of antioxidant supplementation over oxidative stress and quality of life in cervical cancer. Nutr Hosp. 2011;26:819-826.
Kottschade LA, Sloan JA, Mazurczak MA, et al. The use of vitamin E for the prevention of chemotherapy-induced peripheral neuropathy: results of a randomized phase III clinical trial. Support Care Cancer. 2011; 19:1769-1777
Afonseca SO, Cruz FM, Cubero D, et al. Vitamin E for prevention of oxaliplatin-induced peripheral neuropathy: a pilot randomized clinical trial. Sao Paulo Med J. 2013;131:35-38.
Whittaker JA, Al-Ismail SA. Effect of digoxin and vitamin E in preventing cardiac damage caused by doxorubicin in acute myeloid leukaemia. BMJ (Clin Res Ed). 1984;288:283-284.
Koselugo (selumetinib) [prescribing information]. Wilmington, DE: AstraZeneca Pharmaceuticals LP; April 2020.
Imbruvica (ibrutinib) [product monograph]. Toronto, Ontario, Canada: Janssen Inc; November 2014.
Imbruvica (ibrutinib) [prescribing information]. Horsham, PA: Janssen Biotech Inc; July 2014
Podszun, M., & Frank, J. (2014). Vitamin E-drug interactions: molecular basis and clinical relevance. Nutrition research reviews, 27(2), 215–231. https://doi.org/10.1017/S0954422414000146
Peralta, E. A., Viegas, M. L., Louis, S., Engle, D. L., & Dunnington, G. L. (2006). Effect of vitamin E on tamoxifen-treated breast cancer cells. Surgery, 140(4), 607-615.
Peralta, E. A., Brewer, A. T., Louis, S., & Dunnington, G. L. (2009). Vitamin E increases biomarkers of estrogen stimulation when taken with tamoxifen. Journal of Surgical Research, 153(1), 143-147.
Ozer KN, Azzi A. In: Papas A, ed. Antioxidant status, diet, nutrition and health. Boca Raton: CRC Press, 1998.449–60
Kamal-Eldin A, Appelqvist LA. The chemistry and antioxidant properties of tocopherols and tocotrienols. Lipids 1996;31:671–701.
Abraham A, Kattoor AJ, Saldeen T, Mehta JL. Vitamin E and its anticancer effects. Crit Rev Food Sci Nutr. 2019;59(17):2831–8.
Traber MG. Vitamin E regulatory mechanisms. Annu Rev Nutr. 2007;27:347–62.
Yang CS, Suh N, Kong AN. Does vitamin E prevent or promote cancer? Cancer Prev Res (Phila). 2012;5(5):701–5.
Hu F, Wu Z, Li G, Teng C, Liu Y, Wang F, et al. The plasma level of retinol, vitamins A, C and alpha-tocopherol could reduce breast cancer risk? A meta-analysis and meta-regression. J Cancer Res Clin Oncol. 2015;141(4):601–14
de Munter L, Maasland DH, van den Brandt PA, Kremer B, Schouten LJ. Vitamin and carotenoid intake and risk of head-neck cancer subtypes in the Netherlands Cohort Study. Am J Clin Nutr. 2015;102(2):420–32.
Crane TE, Khulpateea BR, Alberts DS, Basen-Engquist K, Thomson CA. Dietary intake and ovarian cancer risk: a systematic review. Cancer Epidemiol Biomarkers Prev. 2014;23(2):255–73
Koushik A, Wang M, Anderson KE, van den Brandt P, Clendenen TV, Eliassen AH, et al. Intake of vitamins A, C, and E and folate and the risk of ovarian cancer in a pooled analysis of 10 cohort studies. Cancer Causes Control. 2015;26(9):1315–27.
Huang J, Weinstein SJ, Yu K, Mannisto S, Albanes D. A prospective study of serum vitamin E and 28-year risk of lung cancer. J Natl Cancer Inst. 2020;112:191–9.
Cui L, Li L, Tian Y, Xu F, Qiao T. Association between dietary vitamin E intake and esophageal cancer risk: an updated meta-analysis. Nutrients. 2018;10(7):801.
Shang Y, Yi S, Cui D, Han G, Liu C. Vitamin E intake and risk of renal cell carcinoma: a meta-analysis of 7 case-control studies. J Ren Nutr. 2015;25(4):339–44.
Lin JH, Chen SJ, Liu H, Yan Y, Zheng JH. Vitamin E consumption and the risk of bladder cancer. Int J Vitam Nutr Res. 2019;89(3–4):168–75.
Chen F, Li Q, Yu Y, Yang W, Shi F, Qu Y. Association of vitamin C, vitamin D, vitamin E and risk of bladder cancer: a dose-response meta-analysis. Sci Rep. 2015;5:9599.
Klein, E. A., Thompson, I. M., Jr, Tangen, C. M., Crowley, J. J., Lucia, M. S., Goodman, P. J., Minasian, L. M., Ford, L. G., Parnes, H. L., Gaziano, J. M., Karp, D. D., Lieber, M. M., Walther, P. J., Klotz, L., Parsons, J. K., Chin, J. L., Darke, A. K., Lippman, S. M., Goodman, G. E., Meyskens, F. L., Jr, … Baker, L. H. (2011). Vitamin E and the risk of prostate cancer: the Selenium and Vitamin E Cancer Prevention Trial (SELECT). JAMA, 306(14), 1549–1556. https://doi.org/10.1001/jama.2011.1437
Loh, W. Q., Youn, J., & Seow, W. J. (2022). Vitamin E Intake and Risk of Prostate Cancer: A Meta-Analysis. Nutrients, 15(1), 14. https://doi.org/10.3390/nu15010014
Xin, J., Jiang, X., Ben, S., Yuan, Q., Su, L., Zhang, Z., Christiani, D. C., Du, M., & Wang, M. (2022). Association between circulating vitamin E and ten common cancers: evidence from large-scale Mendelian randomization analysis and a longitudinal cohort study. BMC medicine, 20(1), 168. https://doi.org/10.1186/s12916-022-02366-5
Argyriou AA, Chroni E, Koutras A, et al. A randomized controlled trial evaluating the effıcacy and safety of vitamin E supplementation for protection against cisplatin-induced peripheral neuropathy: fınal results. Support Care Cancer. 2006;14:1134-1140.
Fuchs-Tarlovsky V, Bejarano-Rosales M, Gutierrez-Salmean G, et al. Effect of antioxidant supplementation over oxidative stress and quality of life in cervical cancer. Nutr Hosp. 2011;26:819-826.
Kottschade LA, Sloan JA, Mazurczak MA, et al. The use of vitamin E for the prevention of chemotherapy-induced peripheral neuropathy: results of a randomized phase III clinical trial. Support Care Cancer. 2011; 19:1769-1777
Afonseca SO, Cruz FM, Cubero D, et al. Vitamin E for prevention of oxaliplatin-induced peripheral neuropathy: a pilot randomized clinical trial. Sao Paulo Med J. 2013;131:35-38.
Whittaker JA, Al-Ismail SA. Effect of digoxin and vitamin E in preventing cardiac damage caused by doxorubicin in acute myeloid leukaemia. BMJ (Clin Res Ed). 1984;288:283-284.
Koselugo (selumetinib) [prescribing information]. Wilmington, DE: AstraZeneca Pharmaceuticals LP; April 2020.
Imbruvica (ibrutinib) [product monograph]. Toronto, Ontario, Canada: Janssen Inc; November 2014.
Imbruvica (ibrutinib) [prescribing information]. Horsham, PA: Janssen Biotech Inc; July 2014
Podszun, M., & Frank, J. (2014). Vitamin E-drug interactions: molecular basis and clinical relevance. Nutrition research reviews, 27(2), 215–231. https://doi.org/10.1017/S0954422414000146
Peralta, E. A., Viegas, M. L., Louis, S., Engle, D. L., & Dunnington, G. L. (2006). Effect of vitamin E on tamoxifen-treated breast cancer cells. Surgery, 140(4), 607-615.
Peralta, E. A., Brewer, A. T., Louis, S., & Dunnington, G. L. (2009). Vitamin E increases biomarkers of estrogen stimulation when taken with tamoxifen. Journal of Surgical Research, 153(1), 143-147.
Sayfalar
415-418
Yayınlanan
11 Mart 2024
Telif Hakkı (c) 2024 Akademisyen Yayınevi Kitap Portalı
Lisans
LisansNasıl Atıf Yapılır
1.
Akgüner G. Vitamin E. Içinde: Sakin A, editör. Kanser Hastalarının Başvurduğu Geleneksel ve Tamamlayıcı Tedaviler - Tıbbi Onkolog Gözü ile Bakış ve Onkolojik İlaçlarla Etkileşim [Internet]. Türkiye: Akademisyen Yayınevi Kitap DOI Portalı; 2024 [a.yer 13 Temmuz 2026]. ss. 415-8. Erişim adresi: https://omp35.books.akademisyen.net/index.php/akya/catalog/book/2380/chapter/13991
