Ada Çayı (Salvia Officinalis)
Özet
Salvia officinalis (ada çayı) biyoaktif bileşenleri nedeniyle önemli bir tıbbi bitki olup Labiatae/Lamiaceae familyasına aittir. Salvia officinalis türünün anavatanı Akdeniz ve Ortadoğu olmak üzere günümüzde başta Avrupa ve Kuzey Amerika gelmekle birlikte tüm dünyaya yayılmıştır.
Halk hekimliğinde kullanılan diğer şifalı bitkiler gibi adaçayı ekstraktları ve uçucu yağları üzerinde de geniş kapsamlı tıbbi etkileri nedeniyle çeşitli çalışmalar yapılmıştır. Ada çayının potansiyel antitümör aktivitesi çeşitli kanserli hücre dizileri ve kanserli hayvan modellerinde incelenmiştir. Antiproliferatif etkisinin yanı sıra antimigratuvar ve antianjiyogenik etkileri de mevcuttur.
Bu bitkinin ekstraktları, serviks adeno karsinomu (HeLa), kolorektal kanser (HCT-116, HCT15, CO115, HT29), akciğer karsinomu (A549, H226), laringeal karsinom (Hep-2), melanom (A375, M14, A2058, B16), insülinoma (RINm5F), prostat adenokarsinomu ve ağız boşluğu skuamöz hücreli karsinomu gibi çeşitli kanserli hücre dizileri üzerinde yapılan çalışmalarda proapoptotik ve büyümeyi inhibe edici etkiler göstermiştir. Meme kanseri (MCF-7) hücre dizilerinde tam tersi proliferatif etki gösterdiği yönünde sonuçların olduğu çalışma da mevcuttur. Antiinflamatuar ve analjezik etkisi de olan ada çayı kemoterapötiklere bağlı nöropatik ağrının tedavisinde faydalı bulunmuştur. Geleneksel halk hekimliğinde de birçok tıbbi patolojide kullanılan ada çayı bitkisinin ekstraktlarına ilişkin farmakokinetik çalışma mevcut değildir.
Salvia officinalis is an important medicinal plant due to its bioactive components and belongs to the Labiatae/Lamiaceae family. The homeland of the Salvia officinalis species is the Mediterranean and the Middle East, and today, it has spread all over the world, especially Europe and North America. Like other medicinal plants used in folk medicine, various studies have been conducted on sage extracts and essential oils due to their wide-ranging medicinal effects.
The potential antitumor activity of sage has been studied in various cancer cell lines and cancer animal models. In addition to its antiproliferative effect, it also has antimigratory and antiangiogenic effects. Extracts of this plant performed on various cancerous cell lines such as cervix adenocarcinoma(HeLa), colorectal cancer(HCT-116, HCT15, CO115, HT29), lung carcinoma(A549, H226), laryngeal carcinoma(Hep-2), melanoma(A375, M14, A2058, B16), insulinoma(RINm5F), prostate adenocarcinoma and oral cavity squamous cell carcinoma have been found to be proapoptotic and growth inhibitory effects in studies on various cancer cell lines. There are also studies with the opposite results in breast cancer (MCF-7) cell lines.
Sage plant, which also has an anti-inflammatory and antinociceptive effect, has been found useful in the treatment of neuropathic pain due to chemotherapeutics. There are no pharmacokinetic studies on the extracts of the sage plant, which is used in many medical pathologies in traditional folk medicine.
Referanslar
Russo A, Formisano C, Rigano D, Senatore F, Delfine S, Cardile V, et al. Chemical composition and anticancer activity of essential oils of Mediterranean sage (Salvia officinalis L.) grown in different environmental conditions. Food Chem Toxicol. 2013;55:42-7.
NG. B, M. W. Herbal Drugs and Phytopharmaceuticals. 2nd edition ed2001.
Miura K, Kikuzaki H, Nakatani N. Apianane terpenoids from Salvia officinalis. Phytochemistry. 2001;58(8):1171-5.
Ghorbani A, Esmaeilizadeh M. Pharmacological properties of Salvia officinalis and its components. J Tradit Complement Med. 2017;7(4):433-40.
Jiang Y, Zhang L, Rupasinghe HP. Antiproliferative effects of extracts from Salvia officinalis L. and Saliva miltiorrhiza Bunge on hepatocellular carcinoma cells. Biomed Pharmacother. 2017;85:57-67.
Poulios E, Giaginis C, Vasios GK. Current Advances on the Extraction and Identification of Bioactive Components of Sage (Salvia spp.). Curr Pharm Biotechnol. 2019;20(10):845-57.
Slameňová D, Mašterová I, Lábaj J, Horváthová E, Kubala P, Jakubíková J, et al. Cytotoxic and DNA‐damaging effects of diterpenoid quinones from the roots of Salvia officinalis L. on colonic and hepatic human cells cultured in vitro. Basic & clinical pharmacology & toxicology. 2004;94(6):282-90.
Talib WH, Alsalahat I, Daoud S, Abutayeh RF, Mahmod AI. Plant-derived natural products in cancer research: extraction, mechanism of action, and drug formulation. Molecules. 2020;25(22):5319.
Pedro DF, Ramos AA, Lima CF, Baltazar F, Pereira-Wilson C. Colon Cancer Chemoprevention by Sage Tea Drinking: Decreased DNA Damage and Cell Proliferation. Phytother Res. 2016;30(2):298-305.
El Hadri A, del Rio MG, Sanz J, Coloma AG, Idaomar M, Ozonas BR, et al. Cytotoxic activity of α-humulene and transcaryophyllene from Salvia officinalis in animal and human tumor cells. An R Acad Nac Farm. 2010;76(3):343-56.
Garcia CS, Menti C, Lambert AP, Barcellos T, Moura S, Calloni C, et al. Pharmacological perspectives from Brazilian Salvia officinalis (Lamiaceae): antioxidant, and antitumor in mammalian cells. An Acad Bras Cienc. 2016;88(1):281-92.
Jedinák A, Mucková M, Kost'álová D, Maliar T, Masterova I. Antiprotease and antimetastatic activity of ursolic acid isolated from Salvia officinalis. Z Naturforsch C J Biosci. 2006;61(11-12):777-82.
Sertel S, Eichhorn T, Plinkert PK, Efferth T. [Anticancer activity of Salvia officinalis essential oil against HNSCC cell line (UMSCC1)]. Hno. 2011;59(12):1203-8.
Xavier CP, Lima CF, Fernandes-Ferreira M, Pereira-Wilson C. Salvia fruticosa, Salvia officinalis, and rosmarinic acid induce apoptosis and inhibit proliferation of human colorectal cell lines: the role in MAPK/ERK pathway. Nutr Cancer. 2009;61(4):564-71.
Kontogianni VG, Tomic G, Nikolic I, Nerantzaki AA, Sayyad N, Stosic-Grujicic S, et al. Phytochemical profile of Rosmarinus officinalis and Salvia officinalis extracts and correlation to their antioxidant and anti-proliferative activity. Food Chem. 2013;136(1):120-9.
Jantová S, Hudec R, Sekretár S, Kučerák J, Melušová M. Salvia officinalis L. extract and its new food antioxidant formulations induce apoptosis through mitochondrial/caspase pathway in leukemia L1210 cells. Interdiscip Toxicol. 2014;7(3):146-53.
Zare Shahneh F, Valiyari S, Baradaran B, Abdolalizadeh J, Bandehagh A, Azadmehr A, et al. Inhibitory and cytotoxic activities of salvia officinalis L. Extract on human lymphoma and leukemia cells by induction of apoptosis. Adv Pharm Bull. 2013;3(1):51-5.
EMA. Community herbal monograph on Salvia officinalis L., folium. European Medicines Agency London; 2009.
Çebi A, Akgün E, Çelikler S, Firat M, Özel MZ, Ulukaya E, et al. Cytotoxic and genotoxic effects of an endemic plant of Turkey Salvia kronenburgii on breast cancer cell lines. Journal of cancer research and therapeutics. 2019;15(5):1080-6.
Camarillo IG, Xiao F, Madhivanan S, Salameh T, Nichols M, Reece LM, et al. Low and high voltage electrochemotherapy for breast cancer: An in vitro model study. Electroporation-Based Therapies for Cancer. 2014:55-102.
Ghoderao P, Sahare S, Kulkarni AA, Bhave T. Paclitaxel conjugated magnetic carbon nanotubes induce apoptosis in breast cancer cells and breast cancer stem cells in vitro. Paclitaxel: Elsevier; 2022. p. 309-31.
Luca SV, Skalicka-Woźniak K, Mihai C-T, Gradinaru AC, Mandici A, Ciocarlan N, et al. Chemical Profile and Bioactivity Evaluation of Salvia Species from Eastern Europe. Antioxidants. 2023;12(8):1514.
de Oliveira PF, Munari CC, Nicolella HD, Veneziani RC, Tavares DC. Manool, a Salvia officinalis diterpene, induces selective cytotoxicity in cancer cells. Cytotechnology. 2016;68(5):2139-43.
Yesil-Celiktas O, Sevimli C, Bedir E, Vardar-Sukan F. Inhibitory effects of rosemary extracts, carnosic acid and rosmarinic acid on the growth of various human cancer cell lines. Plant Foods Hum Nutr. 2010;65(2):158-63.
Moon DO, Kim MO, Lee JD, Choi YH, Kim GY. Rosmarinic acid sensitizes cell death through suppression of TNF-alpha-induced NF-kappaB activation and ROS generation in human leukemia U937 cells. Cancer Lett. 2010;288(2):183-91.
Scheckel KA, Degner SC, Romagnolo DF. Rosmarinic acid antagonizes activator protein-1-dependent activation of cyclooxygenase-2 expression in human cancer and nonmalignant cell lines. J Nutr. 2008;138(11):2098-105.
Zare H. The Effects of Salvia Officinalis Extract on Serum Level of Carcinoembryonic in Rat. Biomedical Journal of Scientific & Technical Research. 2020;28(1):21190-3.
Huang SS, Zheng RL. Rosmarinic acid inhibits angiogenesis and its mechanism of action in vitro. Cancer Lett. 2006;239(2):271-80.
YILDIRIM I, KUTLU T. Anticancer properties of different species of Salvia. Hacettepe Journal of Biology and Chemistry. 2015;43(2):91-7.
ALKAN FÜ, GÜRSEL FE, ATEŞ A, ÖZYÜREK M, GÜÇLÜ K, ALTUN M. Protective effects of Salvia officinalis extract against cyclophosphamide-induced genotoxicity and oxidative stress in rats. Turkish Journal of Veterinary & Animal Sciences. 2012;36(6):646-54.
Vuković-Gacić B, Nikcević S, Berić-Bjedov T, Knezević-Vukcević J, Simić D. Antimutagenic effect of essential oil of sage (Salvia officinalis L.) and its monoterpenes against UV-induced mutations in Escherichia coli and Saccharomyces cerevisiae. Food Chem Toxicol. 2006;44(10):1730-8.
Vujosević M, Blagojević J. Antimutagenic effects of extracts from sage (Salvia officinalis) in mammalian system in vivo. Acta Vet Hung. 2004;52(4):439-43.
Nikolić B, Mitić-Ćulafić D, Vuković-Gačić B, Knežević-Vukčević J. The antimutagenic effect of monoterpenes against UV-irradiation-, 4NQO-and t-BOOH-induced mutagenesis in coli. Archives of Biological Sciences. 2011;63(1):117-28.
Simíc D, Vuković-Gačić B, Knežević-Vukčević J. Detection of natural bioantimutagens and their mechanisms of action with bacterial assay-system. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. 1998;402(1-2):51-7.
Privitera G, Napoli E, Luca T, Ruberto G, Castorina S. In vitro anti-proliferative effect of Salvia officinalis essential oil and its three main components on human lung cancer cells. Am J Phytomed Clin Ther. 2014;2:1159-68.
Yanagimichi M, Nishino K, Sakamoto A, Kurodai R, Kojima K, Eto N, et al. Analyses of putative anti-cancer potential of three STAT3 signaling inhibitory compounds derived from Salvia officinalis. Biochemistry and Biophysics Reports. 2021;25:100882.
Federica C, Cristina N, Anna C, Nunziatina DT, Antonella L, Lucia M. In vitro binding studies of methanolic extracts from different Salvia species. 2006.
Avato P, Fortunato IM, Ruta C, D’Elia R. Glandular hairs and essential oils in micropropagated plants of Salvia officinalis L. Plant Science. 2005;169(1):29-36.
Russo A, Formisano C, Rigano D, Senatore F, Delfine S, Cardile V, et al. Chemical composition and anticancer activity of essential oils of Mediterranean sage (Salvia officinalis L.) grown in different environmental conditions. Food and Chemical Toxicology. 2013;55:42-7.
Poulios E, Giaginis C, Vasios GK. Current state of the art on the antioxidant activity of sage (Salvia spp.) and its bioactive components. Planta Medica. 2020;86(04):224-38.
Horváthová E, Srančíková A, Regendová-Sedláčková E, Melušová M, Meluš V, Netriová J, et al. Enriching the drinking water of rats with extracts of Salvia officinalis and Thymus vulgaris increases their resistance to oxidative stress. Mutagenesis. 2016;31(1):51-9.
Bahri S, Ben Ali R, Nahdi A, Mlika M, Abdennabi R, Jameleddine S. Salvia officinalis attenuates bleomycin-induced oxidative stress and lung fibrosis in rats. Nutrition and cancer. 2020;72(7):1135-45.
Guerriero G, Berni R, Muñoz-Sanchez JA, Apone F, Abdel-Salam EM, Qahtan AA, et al. Production of plant secondary metabolites: Examples, tips and suggestions for biotechnologists. Genes. 2018;9(6):309.
Ghorbani A, Esmaeilizadeh M. Pharmacological properties of Salvia officinalis and its components. Journal of traditional and complementary medicine. 2017;7(4):433-40.
Cuvelier ME, Richard H, Berset C. Antioxidative activity and phenolic composition of pilot‐plant and commercial extracts of sage and rosemary. Journal of the American Oil Chemists' Society. 1996;73(5):645-52.
Dianat M, Esmaeilizadeh M, Badavi M, Samarbafzadeh A, Naghizadeh B. Protective effects of crocin on hemodynamic parameters and infarct size in comparison with vitamin E after ischemia reperfusion in isolated rat hearts. Planta medica. 2014;80(05):393-8.
Govindaraj J, Sorimuthu Pillai S. Rosmarinic acid modulates the antioxidant status and protects pancreatic tissues from glucolipotoxicity mediated oxidative stress in high-fat diet: streptozotocin-induced diabetic rats. Molecular and cellular biochemistry. 2015;404:143-59.
Xu R. Salvia officinalis-based green-mediated vanadium nanoparticles: Describing a modern chemotherapeutic drug for the treatment of colorectal carcinoma. Authorea Preprints. 2022.
Brune K, Patrignani P. New insights into the use of currently available non-steroidal anti-inflammatory drugs. J Pain Res. 2015;8:105-18.
Baricevic D, Sosa S, Della Loggia R, Tubaro A, Simonovska B, Krasna A, et al. Topical anti-inflammatory activity of Salvia officinalis L. leaves: the relevance of ursolic acid. J Ethnopharmacol. 2001;75(2-3):125-32.
Azevedo MI, Pereira AF, Nogueira RB, Rolim FE, Brito GA, Wong DV, et al. The antioxidant effects of the flavonoids rutin and quercetin inhibit oxaliplatin-induced chronic painful peripheral neuropathy. Mol Pain. 2013;9:53.
Mansourabadi AH, Sadeghi HM, Razavi N, Rezvani E. Anti-inflammatory and analgesic properties of salvigenin, Salvia officinalis flavonoid extracted. Advanced Herbal Medicine. 2016;2(1):31-41.
Rodrigues MR, Kanazawa LK, das Neves TL, da Silva CF, Horst H, Pizzolatti MG, et al. Antinociceptive and anti-inflammatory potential of extract and isolated compounds from the leaves of Salvia officinalis in mice. J Ethnopharmacol. 2012;139(2):519-26.
Osakabe N, Yasuda A, Natsume M, Yoshikawa T. Rosmarinic acid inhibits epidermal inflammatory responses: anticarcinogenic effect of Perilla frutescens extract in the murine two-stage skin model. Carcinogenesis. 2004;25(4):549-57.
Abad ANA, Nouri MHK, Tavakkoli F. Effect of Salvia officinalis hydroalcoholic extract on vincristine-induced neuropathy in mice. Chinese Journal of Natural Medicines. 2011;9(5):354-8.
Abad M, Moreno A, Palacios A, Narita M, Blanco F, Moreno‐Bueno G, et al. The tumor suppressor ING1 contributes to epigenetic control of cellular senescence. Aging cell. 2011;10(1):158-71.
Qnais EY, Abu-Dieyeh M, Abdulla FA, Abdalla SS. The antinociceptive and anti-inflammatory effects of Salvia officinalis leaf aqueous and butanol extracts. Pharmaceutical Biology. 2010;48(10):1149-56.
Wichtl M. Herbal drugs and phytopharmaceuticals: a handbook for practice on a scientific basis: CRC press; 2004.
Mills SY, Bone K. The essential guide to herbal safety: Elsevier Health Sciences; 2004.
Products EMACoHM. Assessment report on Salvia Officinalis L., Folium and Salvia Officinalis L., Aetheroleum. 2008.
NG. B, M. W. Herbal Drugs and Phytopharmaceuticals. 2nd edition ed2001.
Miura K, Kikuzaki H, Nakatani N. Apianane terpenoids from Salvia officinalis. Phytochemistry. 2001;58(8):1171-5.
Ghorbani A, Esmaeilizadeh M. Pharmacological properties of Salvia officinalis and its components. J Tradit Complement Med. 2017;7(4):433-40.
Jiang Y, Zhang L, Rupasinghe HP. Antiproliferative effects of extracts from Salvia officinalis L. and Saliva miltiorrhiza Bunge on hepatocellular carcinoma cells. Biomed Pharmacother. 2017;85:57-67.
Poulios E, Giaginis C, Vasios GK. Current Advances on the Extraction and Identification of Bioactive Components of Sage (Salvia spp.). Curr Pharm Biotechnol. 2019;20(10):845-57.
Slameňová D, Mašterová I, Lábaj J, Horváthová E, Kubala P, Jakubíková J, et al. Cytotoxic and DNA‐damaging effects of diterpenoid quinones from the roots of Salvia officinalis L. on colonic and hepatic human cells cultured in vitro. Basic & clinical pharmacology & toxicology. 2004;94(6):282-90.
Talib WH, Alsalahat I, Daoud S, Abutayeh RF, Mahmod AI. Plant-derived natural products in cancer research: extraction, mechanism of action, and drug formulation. Molecules. 2020;25(22):5319.
Pedro DF, Ramos AA, Lima CF, Baltazar F, Pereira-Wilson C. Colon Cancer Chemoprevention by Sage Tea Drinking: Decreased DNA Damage and Cell Proliferation. Phytother Res. 2016;30(2):298-305.
El Hadri A, del Rio MG, Sanz J, Coloma AG, Idaomar M, Ozonas BR, et al. Cytotoxic activity of α-humulene and transcaryophyllene from Salvia officinalis in animal and human tumor cells. An R Acad Nac Farm. 2010;76(3):343-56.
Garcia CS, Menti C, Lambert AP, Barcellos T, Moura S, Calloni C, et al. Pharmacological perspectives from Brazilian Salvia officinalis (Lamiaceae): antioxidant, and antitumor in mammalian cells. An Acad Bras Cienc. 2016;88(1):281-92.
Jedinák A, Mucková M, Kost'álová D, Maliar T, Masterova I. Antiprotease and antimetastatic activity of ursolic acid isolated from Salvia officinalis. Z Naturforsch C J Biosci. 2006;61(11-12):777-82.
Sertel S, Eichhorn T, Plinkert PK, Efferth T. [Anticancer activity of Salvia officinalis essential oil against HNSCC cell line (UMSCC1)]. Hno. 2011;59(12):1203-8.
Xavier CP, Lima CF, Fernandes-Ferreira M, Pereira-Wilson C. Salvia fruticosa, Salvia officinalis, and rosmarinic acid induce apoptosis and inhibit proliferation of human colorectal cell lines: the role in MAPK/ERK pathway. Nutr Cancer. 2009;61(4):564-71.
Kontogianni VG, Tomic G, Nikolic I, Nerantzaki AA, Sayyad N, Stosic-Grujicic S, et al. Phytochemical profile of Rosmarinus officinalis and Salvia officinalis extracts and correlation to their antioxidant and anti-proliferative activity. Food Chem. 2013;136(1):120-9.
Jantová S, Hudec R, Sekretár S, Kučerák J, Melušová M. Salvia officinalis L. extract and its new food antioxidant formulations induce apoptosis through mitochondrial/caspase pathway in leukemia L1210 cells. Interdiscip Toxicol. 2014;7(3):146-53.
Zare Shahneh F, Valiyari S, Baradaran B, Abdolalizadeh J, Bandehagh A, Azadmehr A, et al. Inhibitory and cytotoxic activities of salvia officinalis L. Extract on human lymphoma and leukemia cells by induction of apoptosis. Adv Pharm Bull. 2013;3(1):51-5.
EMA. Community herbal monograph on Salvia officinalis L., folium. European Medicines Agency London; 2009.
Çebi A, Akgün E, Çelikler S, Firat M, Özel MZ, Ulukaya E, et al. Cytotoxic and genotoxic effects of an endemic plant of Turkey Salvia kronenburgii on breast cancer cell lines. Journal of cancer research and therapeutics. 2019;15(5):1080-6.
Camarillo IG, Xiao F, Madhivanan S, Salameh T, Nichols M, Reece LM, et al. Low and high voltage electrochemotherapy for breast cancer: An in vitro model study. Electroporation-Based Therapies for Cancer. 2014:55-102.
Ghoderao P, Sahare S, Kulkarni AA, Bhave T. Paclitaxel conjugated magnetic carbon nanotubes induce apoptosis in breast cancer cells and breast cancer stem cells in vitro. Paclitaxel: Elsevier; 2022. p. 309-31.
Luca SV, Skalicka-Woźniak K, Mihai C-T, Gradinaru AC, Mandici A, Ciocarlan N, et al. Chemical Profile and Bioactivity Evaluation of Salvia Species from Eastern Europe. Antioxidants. 2023;12(8):1514.
de Oliveira PF, Munari CC, Nicolella HD, Veneziani RC, Tavares DC. Manool, a Salvia officinalis diterpene, induces selective cytotoxicity in cancer cells. Cytotechnology. 2016;68(5):2139-43.
Yesil-Celiktas O, Sevimli C, Bedir E, Vardar-Sukan F. Inhibitory effects of rosemary extracts, carnosic acid and rosmarinic acid on the growth of various human cancer cell lines. Plant Foods Hum Nutr. 2010;65(2):158-63.
Moon DO, Kim MO, Lee JD, Choi YH, Kim GY. Rosmarinic acid sensitizes cell death through suppression of TNF-alpha-induced NF-kappaB activation and ROS generation in human leukemia U937 cells. Cancer Lett. 2010;288(2):183-91.
Scheckel KA, Degner SC, Romagnolo DF. Rosmarinic acid antagonizes activator protein-1-dependent activation of cyclooxygenase-2 expression in human cancer and nonmalignant cell lines. J Nutr. 2008;138(11):2098-105.
Zare H. The Effects of Salvia Officinalis Extract on Serum Level of Carcinoembryonic in Rat. Biomedical Journal of Scientific & Technical Research. 2020;28(1):21190-3.
Huang SS, Zheng RL. Rosmarinic acid inhibits angiogenesis and its mechanism of action in vitro. Cancer Lett. 2006;239(2):271-80.
YILDIRIM I, KUTLU T. Anticancer properties of different species of Salvia. Hacettepe Journal of Biology and Chemistry. 2015;43(2):91-7.
ALKAN FÜ, GÜRSEL FE, ATEŞ A, ÖZYÜREK M, GÜÇLÜ K, ALTUN M. Protective effects of Salvia officinalis extract against cyclophosphamide-induced genotoxicity and oxidative stress in rats. Turkish Journal of Veterinary & Animal Sciences. 2012;36(6):646-54.
Vuković-Gacić B, Nikcević S, Berić-Bjedov T, Knezević-Vukcević J, Simić D. Antimutagenic effect of essential oil of sage (Salvia officinalis L.) and its monoterpenes against UV-induced mutations in Escherichia coli and Saccharomyces cerevisiae. Food Chem Toxicol. 2006;44(10):1730-8.
Vujosević M, Blagojević J. Antimutagenic effects of extracts from sage (Salvia officinalis) in mammalian system in vivo. Acta Vet Hung. 2004;52(4):439-43.
Nikolić B, Mitić-Ćulafić D, Vuković-Gačić B, Knežević-Vukčević J. The antimutagenic effect of monoterpenes against UV-irradiation-, 4NQO-and t-BOOH-induced mutagenesis in coli. Archives of Biological Sciences. 2011;63(1):117-28.
Simíc D, Vuković-Gačić B, Knežević-Vukčević J. Detection of natural bioantimutagens and their mechanisms of action with bacterial assay-system. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. 1998;402(1-2):51-7.
Privitera G, Napoli E, Luca T, Ruberto G, Castorina S. In vitro anti-proliferative effect of Salvia officinalis essential oil and its three main components on human lung cancer cells. Am J Phytomed Clin Ther. 2014;2:1159-68.
Yanagimichi M, Nishino K, Sakamoto A, Kurodai R, Kojima K, Eto N, et al. Analyses of putative anti-cancer potential of three STAT3 signaling inhibitory compounds derived from Salvia officinalis. Biochemistry and Biophysics Reports. 2021;25:100882.
Federica C, Cristina N, Anna C, Nunziatina DT, Antonella L, Lucia M. In vitro binding studies of methanolic extracts from different Salvia species. 2006.
Avato P, Fortunato IM, Ruta C, D’Elia R. Glandular hairs and essential oils in micropropagated plants of Salvia officinalis L. Plant Science. 2005;169(1):29-36.
Russo A, Formisano C, Rigano D, Senatore F, Delfine S, Cardile V, et al. Chemical composition and anticancer activity of essential oils of Mediterranean sage (Salvia officinalis L.) grown in different environmental conditions. Food and Chemical Toxicology. 2013;55:42-7.
Poulios E, Giaginis C, Vasios GK. Current state of the art on the antioxidant activity of sage (Salvia spp.) and its bioactive components. Planta Medica. 2020;86(04):224-38.
Horváthová E, Srančíková A, Regendová-Sedláčková E, Melušová M, Meluš V, Netriová J, et al. Enriching the drinking water of rats with extracts of Salvia officinalis and Thymus vulgaris increases their resistance to oxidative stress. Mutagenesis. 2016;31(1):51-9.
Bahri S, Ben Ali R, Nahdi A, Mlika M, Abdennabi R, Jameleddine S. Salvia officinalis attenuates bleomycin-induced oxidative stress and lung fibrosis in rats. Nutrition and cancer. 2020;72(7):1135-45.
Guerriero G, Berni R, Muñoz-Sanchez JA, Apone F, Abdel-Salam EM, Qahtan AA, et al. Production of plant secondary metabolites: Examples, tips and suggestions for biotechnologists. Genes. 2018;9(6):309.
Ghorbani A, Esmaeilizadeh M. Pharmacological properties of Salvia officinalis and its components. Journal of traditional and complementary medicine. 2017;7(4):433-40.
Cuvelier ME, Richard H, Berset C. Antioxidative activity and phenolic composition of pilot‐plant and commercial extracts of sage and rosemary. Journal of the American Oil Chemists' Society. 1996;73(5):645-52.
Dianat M, Esmaeilizadeh M, Badavi M, Samarbafzadeh A, Naghizadeh B. Protective effects of crocin on hemodynamic parameters and infarct size in comparison with vitamin E after ischemia reperfusion in isolated rat hearts. Planta medica. 2014;80(05):393-8.
Govindaraj J, Sorimuthu Pillai S. Rosmarinic acid modulates the antioxidant status and protects pancreatic tissues from glucolipotoxicity mediated oxidative stress in high-fat diet: streptozotocin-induced diabetic rats. Molecular and cellular biochemistry. 2015;404:143-59.
Xu R. Salvia officinalis-based green-mediated vanadium nanoparticles: Describing a modern chemotherapeutic drug for the treatment of colorectal carcinoma. Authorea Preprints. 2022.
Brune K, Patrignani P. New insights into the use of currently available non-steroidal anti-inflammatory drugs. J Pain Res. 2015;8:105-18.
Baricevic D, Sosa S, Della Loggia R, Tubaro A, Simonovska B, Krasna A, et al. Topical anti-inflammatory activity of Salvia officinalis L. leaves: the relevance of ursolic acid. J Ethnopharmacol. 2001;75(2-3):125-32.
Azevedo MI, Pereira AF, Nogueira RB, Rolim FE, Brito GA, Wong DV, et al. The antioxidant effects of the flavonoids rutin and quercetin inhibit oxaliplatin-induced chronic painful peripheral neuropathy. Mol Pain. 2013;9:53.
Mansourabadi AH, Sadeghi HM, Razavi N, Rezvani E. Anti-inflammatory and analgesic properties of salvigenin, Salvia officinalis flavonoid extracted. Advanced Herbal Medicine. 2016;2(1):31-41.
Rodrigues MR, Kanazawa LK, das Neves TL, da Silva CF, Horst H, Pizzolatti MG, et al. Antinociceptive and anti-inflammatory potential of extract and isolated compounds from the leaves of Salvia officinalis in mice. J Ethnopharmacol. 2012;139(2):519-26.
Osakabe N, Yasuda A, Natsume M, Yoshikawa T. Rosmarinic acid inhibits epidermal inflammatory responses: anticarcinogenic effect of Perilla frutescens extract in the murine two-stage skin model. Carcinogenesis. 2004;25(4):549-57.
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Sayfalar
55-62
Yayınlanan
11 Mart 2024
Telif Hakkı (c) 2024 Akademisyen Yayınevi Kitap Portalı
Lisans
LisansNasıl Atıf Yapılır
1.
Orman S. Ada Çayı (Salvia Officinalis). Içinde: Sakin A, editör. Kanser Hastalarının Başvurduğu Geleneksel ve Tamamlayıcı Tedaviler - Tıbbi Onkolog Gözü ile Bakış ve Onkolojik İlaçlarla Etkileşim [Internet]. Türkiye: Akademisyen Yayınevi Kitap DOI Portalı; 2024 [a.yer 13 Temmuz 2026]. ss. 55-62. Erişim adresi: https://omp35.books.akademisyen.net/index.php/akya/catalog/book/2380/chapter/13889
