Gebelikte Transplantasyon Cerrahisi ve Ebelik Bakımı
Özet
Organ transplantasyonu, geri dönüşü olmayan organ yetmezliğinin en önemli ve hayat kurtarıcı tedavisidir. Ancak, organ naklinin önünde alıcı kaynaklı immünolojik problemler olsa da organ bağışlarının yetersiz olması en önemli engeli oluşturmaktadır. Yeterli organ bağışı ve doku uyumu sonucunda başarılı nakillerin gerçekleşmesi mümkün olabilmektedir. Transplantasyon sonrası bakım ve izlem büyük öneme sahiptir. Özellikle doğurganlık çağındaki kadınların organ nakli süreçleri daha yakın takip ve dikkat gerektirmektedir. Gebeliğin uygun koşullar sağlandıktan sonra planlanması ve tercihen nakil sonrası 1-2 yıl gebeliğin ertelenmesi önerilmektedir. Bu süreçte prekonsepsiyonel bakım ve danışmanlık hizmeti ile sağlıklı gebeliğin oluşması ve sürdürülmesi mümkün olabilmektedir.
Referanslar
Grinyó JM. Why is organ transplantation clinically important? Cold Spring Harbor perspectives in medicine. 2013;3(6):a014985. doi: 10.1101/cshperspect.a014985.
DiMartini AF, Dew MA, and Trzepacz PT. Organ transplantation. Focus, 2005;3(2):280-303. doi: 10.1176/foc.3.2.280
Gülen H and Karaca A. Organ transplantasyonu sürecinde donör eğitimi ve hemşirelik bakımı. Düzce Üniversitesi Sağlık Bilimleri Enstitüsü Dergisi. 2018;8(2):83-88.
UNOS. Data and trends 2023. (cited 2023 20.10) (28.09.2024 tarihinde https://unos.org/ adresinden ulaşılmıştır).
Doku, Organ Nakli ve Diyaliz Hizmetleri Dairesi Başkanlığı. İstatistik OrganKDS 2023. (17.10.2024 tarihinden https://organkds.saglik.gov.tr/DSS/PUBLIC/PublicDefault2.aspx adresinden ulaşılmıştır).
Arıburnu Ö, Gül Ş, and Dinç L. Nurses’ perspectives and experiences regarding organ transplantation in Turkey: A qualitative study. Journal of Religion and Health. 2022;61(3):1936-1950. doi: 10.1007/s10943-022-01500-0.
Öden TN and Korkmaz FD. Kadavra Donörden Organ Nakli Oranlarını Arttırmada Hemşirenin Sorumlukları: Sahada Neler Yapabiliriz?. Celal Bayar Üniversitesi Sağlık Bilimleri Enstitüsü Dergisi. 2021;8(3):558-565. doi: 10.34087/cbusbed.889801
Arsava EM, Demirkaya Ş, Dora B, Giray S, et al. Beyin ölümü tanı kılavuzu. Türk Nöroloji Dergisi. 2014; 20:101-104. doi:10.1007/s10943-022-01500-0
Aydın, K., Ergan B, Tokur ME, et al. Current status of organ donation in a University Hospital in İzmir: identifying obstacles and possible future solutions. Turkish Journal of Intensive Care. 2019;17(3):154-160. doi:10.4274/tybd.galenos.2018.54366
Karasu D, Yılmaz C, Karaduman İ, vd. Beyin Ölümü Olgularının Retrospektif Analizi. Journal of Critical and Intensive Care. 2015;6(2):23-26. doi: 10.5152/dcbybd.2015.595
Al-Bar, M.A. and H. Chamsi-Pasha, Contemporary bioethics: Islamic perspective. London: Springer International Publishing; 2015.
Kotz D. University of Maryland School of Medicine Faculty Scientists and Clinicians perform historic first successful transplant of porcine heart into adult human with end-stage heart disease. 2022 (01.10.2024 tarihinde https://www.medschool.umaryland.edu/news/2022/University-of-Maryland-School-of-Medicine-Faculty-Scientists-and-Clinicians-Perform-Historic-First-Successful-Transplant-of-Porcine-Heart-into-Adult-Human-with-End-Stage-Heart-Disease.html adresinden ulaşılmıştır)
Demeestere I, Simon P, Emiliani S, et al. Orthotopic and heterotopic ovarian tissue transplantation. Human Reproduction Update. 2009;15(6):649-665. doi: 10.1093/humupd/dmp021
Emre S and Umman V. Split liver transplantation: an overview. Transplantation Proceedings. 2011;43(3):884-887. doi:10.1016/j.transproceed.2011.02.036.
Tetik S. and Cebesoy ÜB. Ortaokul Öğrencilerinin Organ Bağışı ve Organ Nakline Yönelik Görüşlerinin İncelenmesi: Bingöl Örneği. Cumhuriyet Uluslararası Eğitim Dergisi. 2019; 8(4):983-1004. doi:10.30703/cije.544020
Özbaş A. Organ Naklinde (Transplantasyonda) Bakım. In: Akyolcu N, Kanan N ve Aksoy G (Eds.). Cerrahi Hemşireliği II. İstanbul: Nobel Tıp Kitabevleri; 2018. p. 603-709.
Costanzo MR, Dipchand A, Starling R, et al. The International Society of Heart and Lung Transplantation Guidelines for the care of heart transplant recipients. The Journal of Heart and Lung Transplantation. 2010; 29(8): 914-956. doi:10.1016/j.healun.2010.05.034
World Health Organization, SEA/RC57/10-Regional implications of the decisions and resolutions of the fifty-seventh World Health Assembly and the 113th and 114th sessions of the executive board (No. SEA/RC57/10). WHO Regional Office for South-East Asia: 2004.
Matesanz R, Mahillo B, Alvarez M, et al. Global observatory and database on donation and transplantation: world overview on transplantation activities. Transplantation Proceedings. 2009;41(6):2297-2301 doi:10.1016/j.transproceed.2009.05.004
Manla Y, AlSindi F, Attallah N, et al. Temporal trends in brain-death organ donation in Asia: results from the global observatory on donation and transplantation. Transplantation Proceedings. 2022;54(2):233-236. doi:10.1016/j.transproceed.2021.12.031
Resmi Gazete. Organ ve Doku Alınması, Saklanması, Aşılanması ve Nakli Hakkında Kanun. (10.09.2024 tarihinde https://www.mevzuat.gov.tr/mevzuatmetin/1.5.2238.pdf adresinden ulaşılmıştır).
Goila AK, Pawar M. The diagnosis of brain death. Indian journal of critical care medicine. 2009;13(1):7-11. doi: 10.4103/0972-5229.53108
Yılmaz M and Karakoç A. Böbrek naklinde alıcı ve donörlerin değerlendirilmesi. Nefroloji Hemşireliği Dergisi. 2015;10(2):31-38.
Yılmaz M. Doku uygunluk antijenleri. Arşiv Kaynak Tarama Dergisi. 2014;23(1):8-13. doi:10.17827/aktd.79536
Morris PJ, Johnson RJ. Fuggle, S. V., et al. Analysis of factors that affect outcome of primary cadaveric renal transplantation in the UK. Lancet. 1999;354(9185):1147-1152. doi: 10.1016/S0140-6736(99)01104-6
Emmanouilidis N, Hashem AAB, Stiegler P, et al. Transplanting a left or right donor kidney into the left or right iliac fossa: importance of laterality and site of venous anastomosis. Updates in Surgery. 2023;75(5):1243-1257. doi: 10.1007/s13304-023-01512-9
Ogasawara K, Sano R, Kominato Y. Review of ABO expression and variations based on transcriptional regulation of the ABO blood group gene. Transfusion Medicine and Hemotherapy. 2024;51(4):210-224. doi:10.1159/000536556
Mir S, Yılmaz E. İmmünolojik Yüksek Riskli Hastaya Yaklaşım. Çağdaş Tıp Dergisi. 2016;6:121-130. doi:10.16899/ctd.85663
Eng HS, Bennett G, Bardy P, et al. Clinical significance of anti-HLA antibodies detected by Luminex®: Enhancing the interpretation of CDC-BXM and important post-transplantation monitoring tools. Human Immunology. 2009;70(8):595-599. doi:10.1016/j.humimm.2009.06.010
Shah S. Verma P. Overview of pregnancy in renal transplant patients. International Journal of Nephrology. 2016;(1):4539342. doi:10.1155/2016/4539342
Nwakanma LU, Williams JA, Weiss ES, et al. Influence of pretransplant panel-reactive antibody on outcomes in 8,160 heart transplant recipients in recent era. The Annals of Thoracic Surgery. 2007;84(5):1556-1563. doi:10.1016/j.athoracsur.2007.05.095
Premasathian N, Panorchan K, Vongwiwatana A, et al. The effect of peak and current serum panel-reactive antibody on graft survival. In Transplantation Proceedings. 2008;40(7):2200-2201. doi: 10.1016/j.transproceed.2008.07.073
Fine RN, Becker Y, De Geest S, et al. Nonadherence consensus conference summary report. American Journal of Transplantation. 2009;9(1):35-41. doi:10.1111/j.1600-6143.2008.02495.x
Ayna TK, Çiftçi HŞ, Tozkır H, et al. İmmunsupresif ilaçların etki mekanizmaları. Gaziantep Medical Journal. 2009;15(3):42-47.
Starzl TE, Marchioro TL, Von Kaulla KN, et al. Homotransplantation of the liver in humans. Surgery, Gynecology & Obstetric. 1963. 117: 659.
Barnard CN. A human cardiac transplant: An interim report of a successful operation performed at Groote Schuur Hospital, Cape Town. SAMJ South African Medical Journal. 2017;107(12):1271-1275.
Cooley DA, Frazier OH, Macris MP, et al. Heterotopic heart-single lung transplantation: report of a new technique. The Journal of Heart Transplantation. 1987;6(2):112-115.
Toledo-Pereyra LH, Sutherland DE. Richard Carlton Lillehei transplant and shock surgical pioneer. Journal of Investigative Surgery. 2011;24(2):49-52. doi:10.3109/08941939.2011.558433
Hart A, Lentine KL, Smith JM, et al. OPTN/SRTR 2019 annual data report: kidney. American Journal of Transplantation. 2021;21:21-137. doi:10.1111/ajt.16502
Kandaswamy R, Stock PG, Miller J, et al. OPTN/SRTR 2019 annual data report: pancreas. American Journal of Transplantation. 2021;21:138-207. doi: 10.1111/ajt.16979
Nelson J, Alvey N, Bowman L, et al. Consensus recommendations for use of maintenance immunosuppression in solid organ transplantation: Endorsed by the American College of Clinical Pharmacy, American Society of Transplantation, and the International Society for Heart and Lung Transplantation. Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy. 2022;42(8):599-633. doi:10.1002/phar.2716
Kwong AJ, Ebel NH, Kim WR, et al. OPTN/SRTR 2019 annual data report: liver. American journal of transplantation. 2021;21:208-315. doi:10.1016/j.ajt.2023.02.006
Black CK, Termanini KM, Aguirre O, et al. Solid organ transplantation in the 21st century. Annals of Translational Medicine. 2018;6(20):409. doi: 10.21037/atm.2018.09.68
Witt CA, Hachem RR. Immunosuppression: what's standard and what's new? in Seminars in respiratory and critical care medicine. 2013;35(3):405-413. doi: 10.1055/s-0033-1348465
Hartono C, Muthukumar T, Suthanthiran M. Immunosuppressive drug therapy. Cold Spring Harbor perspectives in medicine. 2013;3(9):015487. doi: 10.1101/cshperspect.a015487
Van Sandwijk M, Bemelman F, Ten Berge I. Immunosuppressive drugs after solid organ transplantation. Neth J Med, 2013;71(6): 281-289.
Yıldız İ, Sabuncuoğlu MZ, Koca YS, et al. Süleyman Demirel Üniversitesi Tıp Fakültesi böbrek nakli: birinci yıl sonuçlarımız. SDÜ Tıp Fakültesi Dergisi. 2016;23(4):112-116.
Uc PE, Sağol S. Transplantation and Pregnancy. Obstetrics & Reproductive Medicine. 2024;30(1):62-74. doi: 10.21613/GORM.2023.1488
Kallapur A, Jang C, Yin O, et al. Pregnancy care in solid organ transplant recipients. International Journal of Gynecology & Obstetrics. 2022;157(3):502-513. doi:10.1002/ijgo.13819
Wiles KS, Tillett AL, Harding KR. Solid organ transplantation in pregnancy. Obstetrician & Gynaecologist. 2016;18(3):189-197. doi: 10.1111/tog.12263
Vega J, Videla C, Santis O, et al. Kidney transplantation during a twin pregnancy. Case report and review of the literature. CEN case reports. 2012;1:43-49. doi: 10.1007/s13730-012-0011-8
Pham PTT, Pham PMT, Pham SV, et al. New onset diabetes after transplantation (NODAT): An overview. Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy. 2011;4:175-186.
Coscia L, Daly T, Nathan H, et al. Transplant pregnancy registry international. Transplantation. 2017;101:64. doi: 10.1097/01.tp.0000525078.35784.d3
Saha MT, Saha HH, Niskanen LK, et al. Time course of serum prolactin and sex hormones following successful renal transplantation. Nephron. 2002;92(3):735-737. doi:10.1159/000064079
McKay DB, Josephson MA. Reproduction and transplantation: report on the AST Consensus Conference on Reproductive Issues and Transplantation. American Journal of Transplntation. 2005;5(7):1592-1599. doi:10.1111/j.1600-6143.2005.00969.x
Bramham K, Hall M, Nelson-Piercy C. Renal disease in pregnancy. 2nd ed. UK: Cambridge University Press; 2018.
Deshpande NA, Coscia LA, Gomez-Lobo V, et al. Pregnancy after solid organ transplantation: a guide for obstetric management. Reviews in Obstetrics and Gynecology. 2013;6(3-4):116-125. doı:10.3909/riog0230
Roman AS. Pregnancy After Transplant-Addressing mode of obstetrical delivery among solid organ transplant recipients. JAMA Network Open. 2021;4(10):e2127414-e2127414. doi:10.1001/jamanetworkopen.2021.27414
Thiagarajan K, Arakali SR, Mealey KJ, et al. Safety considerations: breastfeeding after transplant. Progress in Transplantation. 2013;23(2):137-146. doi:10.7182/pit2013803
Wiles KS. Contraception in women with renal disease. In: Renal Disease in Pregnancy. Cambridge: Cambridge University Press; 2008.
Sarkar M, Brady CW, Fleckenstein J, et al. Reproductive health and liver disease: practice guidance by the American Association for the Study of Liver Diseases. Hepatology. 2021;73(1):318-365. doi:10.1002/hep.31559
Dei Malatesta MF, Rossi M, Rocca B, et al. Pregnancy after liver transplantation: report of 8 new cases and review of the literature. Transplant Immunology. 2006;15(4):297-302. doi:10.1016/j.trim.2006.01.001
Rahim MN, Long L, Penna L, et al., Pregnancy in liver transplantation. Liver Transplantation. 2020;26(4):564-581. doi: 10.1002/lt.25717
Macera F, Occhi L, Masciocco G, et al. A new life: motherhood after heart transplantation. A single-center experience and review of literature. Transplantation. 2018;102(9):1538-1544. doi: 10.1097/TP.0000000000002281
McKay DB, Josephson MA. Women’s Health Committee of the American Society of Transplantation. Reproduction and transplantation: report on the AST consensus conference on reproductive issues and transplantation. American Journal of Transplant. 2005;5(7):1592-1599. doi:10.1111/j.1600-6143.2005.00969.x
Lyu DM, Zamora MR. Medical complications of lung transplantation. Proceedings of the American Thoracic Society. 2009;6(1):101-107. doi: 10.1513/pats.200808-077GO
Acuna S, Zaffar N, Dong S, et al. Pregnancy outcomes in women with cardiothoracic transplants: a systematic review and meta-analysis. The Journal of Heart and Lung Transplantation. 2020;39(2):93-102. doi:10.1016/j.healun.2019.11.018
Gadre S, Gadre SK. Pregnancy and lung transplantation. Current Pulmonology Reports. 2021;10(2):62-70. doi:10.1007/s13665-021-00274-2
Richards EG, Farrell RM, Ricci S, et al. Uterus transplantation: state of the art in 2021. Journal of Assisted Reproduction and Genetics. 2021;38(9):2251-2259. doi:10.1007/s10815-021-02245-7
Robertson JA. Impact of uterus transplant on fetuses and resulting children: a response to Daar and Klipstein. Journal of Law and the Biosciences. 2016;3(3):710-717. doi:10.1093/jlb/lsw036
Fishman JA. Infection in organ transplantation. American Journal of Transplantation. 2017;17(4):856-879. doi:10.1111/ajt.14208
Robson SE, Waugh J. Gebelikte tıbbi problemler: Ebeler için el kitabı içinde. Soğukpınar N. (Ed) Ankara: Nobel akademik yayıncılık; 2016.
Williams L, Wilkins A. Hemşirelik Bakımını Planlama, Hemşirelik Bakımını Planlama içinde. Çiçek H, Özdemir L (Ed). Ankara: Nobel Akademik Yayıncılık; 2016.
Josephson MA, McKay DB. Women and transplantation: fertility, sexuality, pregnancy, contraception. Advances in Chronic Kidney Disease. 2013;20(5):433-440. doi:10.1053/j.ackd.2013.06.005