Ayurveda
Özet
Ayurveda, “yaşam bilimi” anlamına gelmektedir. Ayurveda olarak da adlandırılan ayurvedik tıp, holistik (bütünsel) bir tıp sistemi olup, geçmişi 5000 yıl öncesine kadar dayanmaktadır.Ayurveda’da sağlık yaklaşımı doğal ve bütünsel olarak ele alınır. Bu nedenle dünyada ayurvedik tıbba olan ilgi zamanla artmaktadır. Ayurvedaya göre, doğal bitkisel kaynaklar vücut doşalarını (temel biyolojik enerjileri) dengede tutabildikleri için çok önemlidirler. Bu sebepten dolayı ayurvedik tıp tedavide herbal (bitkisel) kaynakları çok sık kullanmaktadır. Ayurvedik tedavide bu herbal kaynakların kombinasyonuna “rasayana” adı verilir. Rasayanaların terapötik etkinliğini araştıran bir çok bilimsel çalışma yapılmış ve ayurvedik tedavideki başarıları gösterilmiştir.Rasayanalar ile kanser alanında da çalışmalar yapılmış olup olumlu etkileri gösterilmiştir.
Ayurveda means “science of life.Ayurvedic medicine, also called Ayurveda, is a holistic medical system and dates back 5000 years.In Ayurveda, the health approach is considered natural and holistic.For this reason, interest in ayurvedic medicine in the world is increasing over time.According to Ayurveda, natural herbal sources are very important as they can keep the body's doshas (basic biological energies) in balance. For this reason, Ayurvedic medicine uses herbal sources very frequently in treatment. Many scientific studies have been conducted investigating the therapeutic effectiveness of rasayanas and their success in ayurvedic treatment has been demonstrated. Studies have also been conducted with Rasayanas in the field of cancer and their positive effects have been shown.
Referanslar
Pandey MM, Rastogi S, Rawat AK. Indian traditional ayurvedic system of medicine and nutritional supplementation. Evid Based Complement Alternat Med 2013;2013: 376327.
Subhose V, Srinivas P, Narayana A. Basic principles of pharmaceutical science in Ayurvĕda. Bull Indian Inst Hist Med Hyderabad 2005;35(2):83- 92.
Meduri K, Mullin G. Ayurvedic diets for wellness and disease intervention. Nutr Clin Pract 2010;25(6):685-6.
Kurup PNV. Ayurveda-a potential global medical system. In: Mishra LC, ed. Scientific Basis for AyurvedicTherapies. 1st ed. Washington: CRC Press; 2004. p.1-15.
Gujral ML, Sareen K, Tangri KK, Amma MK, Roy AK. Antiarthritic and anti-inflammatory activity of gum (Balsamodendrone mukul Hook). Indian J Physiol Pharmacol 1960;4:267-73.
Patel VK, Wang J, Shen RN, Sharma HM, Brahmi Z. Reduction of metastases of lewis lung carcinoma by an ayurvedic food supplement in mice. Nutr Res 1992;12(4-5):667-76.
Ballabh B, Chaurasia OP. Traditional medicinal plants of cold desert Ladakh--used in treatment of cold, cough and fever. J Ethnopharmacol 2007;112(2):341-9.
Narayana A, Subhose V. Standardization of Ayurvĕdic formulations: a scientific review. Bull Indian Inst Hist Med Hyderabad 2005;35(1):21-32.
Tan G., Gyllenhaal C., Soejarto D. Biodiversity as a source of anticancer drugs. Curr. Drug Targets. 2006;7:265–277. doi: 10.2174/138945006776054942.
De Mesquita M.L., de Paula J.E., Pessoa C., de Moraes M.O., Costa- Lotufo L.V., Grougnet R., Michel S., Tillequin F., Espindola L.S. Cytotoxic activity of Brazilian Cerrado plants used in traditional medicine against cancer cell lines. J. Ethnopharmacol. 2009;123:439–445. doi: 10.1016/j.jep.2009.03.018.
Chandra S. Endophytic fungi: Novel sources of anticancer lead molecules. Appl. Microbiol. Biotechnol. 2012;95:47–59. doi: 10.1007/s00253-012- 4128-7.
Srivastava V., Negi A.S., Kumar J., Gupta M., Khanuja S.P. Plant-based anticancer molecules: A chemical and biological profile of some important leads. Bioorg. Med. Chem. 2005;13:5892–5908. doi: 10.1016/j.bmc.2005.05.066.
Larkin T. Herbs are often more toxic than magical. FDA Consumers. 1983;17:4–10.
Bhishagratha KL. Sushruta samhita. Sushruta samhita. Varanasi: Choukhamba Orientalia; 1991.
Smit HF, Woerdenbag HJ, Singh RH, Meulenbeld GJ, Labadie RP, Zwaving JH. Ayurvedic herbal drugs with possible cytostatic activity. J Ethnopharmacol. 1995;47:75–84.
Cragg G.M., Newman D.J. Plants as a source of anticancer agents. J. Ethnopharmacol. 2005;100:72–79. doi: 10.1016/j.jep.2005.05.011.
Song N., Ma J., Zhang X., Qu D., Hui L., Sang C., Li H. Lappaconitine hydrochloride induces apoptosis and S phase cell cycle arrest through MAPK signaling pathway in human liver cancer HepG2 cells. Pharmacogn. Mag. 2021;17:334–341. doi: 10.4103/pm.pm_251_20.
Lai K.-C., Huang A.-C., Hsu S.-C., Kuo C.-L., Yang J.-S., Wu S.-H., Chung J.-G. Benzyl isothiocyanate (BITC) inhibits migration and invasion of human colon cancer HT29 cells by inhibiting matrix metalloproteinase-2/-9 and urokinase plasminogen (uPA) through PKC and MAPK signaling pathway. J. Agric. Food Chem. 2010;58:2935–2942. doi: 10.1021/jf9036694.
Hong Y., Lee J., Moon H., Ryu C.H., Seok J., Jung Y.-S., Ryu J., Baek S.J. Quercetin induces anticancer activity by upregulating pro-NAG- 1/GDF15 in differentiated thyroid cancer cells. Cancers. 2021;13:3022. doi: 10.3390/cancers13123022.
Guan X., Guan Y. Artemisinin induces selective and potent anticancer effects in drug resistant breast cancer cells by inducing cellular apoptosis and autophagy and G2/M cell cycle arrest. JBUON. 2020;25:1330–1336.
Tsai Y.-J., Chen B.-H. Preparation of catechin extracts and nanoemulsions from green tea leaf waste and their inhibition effect on prostate cancer cell PC-3. Int. J. Nanomed. 2016;11:1907–1926. doi: 10.2147/IJN.S103759.
Hussein N.A.E.M., El-Toukhy M.A.E.-F., Kazem A.H., Ali M.E.-S., Ahmad M.A.E.-R., Ghazy H.M.R., El-Din A.M.G. Protective and therapeutic effects of cannabis plant extract on liver cancer induced by dimethylnitrosamine in mice. Alex. J. Med. 2014;50:241–251. doi: 10.1016/j.ajme.2014.02.003.
Kandelous H.M., Salimi M., Khori V., Rastkari N., Amanzadeh A.,Salimi M. Mitochondrial apoptosis induced by Chamaemelum nobile extract in breast cancer cells. Iranian J. Pharm. Res. 2016;15:197–204
Xu Y., Fang R., Shao J., Cai Z. Erianin induces triple-negative breast cancer cells apoptosis by activating PI3K/Akt pathway. Biosci. Rep. 2021;41:BSR20210093. doi: 10.1042/BSR20210093.
Arya R.K., Singh A., Yadav N.K., Cheruvu S.H., Hossain Z., Meena S., Maheshwari S., Singh A.K., Shahab U., Sharma C. Anti-breast tumor activity of Eclipta extract in-vitro and in-vivo: Novel evidence of endoplasmic reticulum specific localization of Hsp60 during apoptosis. Sci. Rep. 2015;5:18457. doi: 10.1038/srep18457.
Li J., Guo Q., Lei X., Zhang L., Su C., Liu Y., Zhou W., Chen H., Wang H., Wang F. Pristimerin induces apoptosis and inhibits proliferation, migration in H1299 lung cancer cells. J. Cancer. 2020;11:6348–6355. doi: 10.7150/jca.44431.
Zhang D.-F., Yang Z.-C., Chen J.-Q., Jin X.-X., Qiu Y.-D., Chen X.-J., Shi H.-Y., Liu Z.-G., Wang M.-S., Liang G. Piperlongumine inhibits migration and proliferation of castration-resistant prostate cancer cells via triggering persistent DNA damage. BMC Complement. Med. Ther. 2021;21:195. doi: 10.1186/s12906-021-03369-0.
De Almeida G.C., Oliveira L.F., Predes D., Fokoue H.H., Kuster R.M., Oliveira F.L., Mendes F.A., Abreu J.G. Piperine suppresses the Wnt/β- catenin pathway and has anticancer effects on colorectal cancer cells. Sci. Rep. 2020;10:1161. doi: 10.1038/s41598-020-68574-2.
Harinantenaina L., Brodie P.J., Slebodnick C., Callmander M.W., Rakotobe E., Randrianasolo S., Randrianaivo R., Rasamison V.E., TenDyke K., Shen Y. Antiproliferative compounds from Pongamiopsis pervilleana from the Madagascar dry forest. J. Nat. Prod. 2010;73:1559–1562. doi: 10.1021/np100430r.
Fadlalla K., Watson A., Yehualaeshet T., Turner T., Samuel T. Ruta graveolens extract induces DNA damage pathways and blocks Akt activation to inhibit cancer cell proliferation and survival. Anticancer Res. 2011;31:233–241.
Jordan M.A., Thrower D., Wilson L. Mechanism of inhibition of cell proliferation by Vinca alkaloids. Cancer Res. 1991;51:2212–2222.
Mamtani R., Vaughn D.J. Vinflunine in the treatment of advanced bladder cancer. Expert Rev. Anticancer Ther. 2011;11:13–20. doi: 10.1586/era.10.196
Kinghorn A.D., Seo E.-K. Plants as sources of drugs. In: Fuller G., McKeon T.A., Bills D.D., editors. Agricultural Materials as Renewable Resources. Volume 647. ACS Publications; Washington, DC, USA: 1996. pp. 179–193
Gelmon K. The taxoids: Paclitaxel and docetaxel. The Lancet. 1994;344:1267–1272. doi: 10.1016/S0140-6736(94)90754-4.
Paller C.J., Antonarakis E.S. Cabazitaxel: A novel second-line treatment for metastatic castration-resistant prostate cancer. Drug Des. Dev. Ther. 2011;5:117–124. doi: 10.2147/DDDT.S13029.
Einhorn LH, Donohue J. Cis-diaminodichloroplatinum, vinblastine, and bleomycin in combination chemotherapy in disseminated testicular cancer. Ann Intern Med 1977;87(3): 293-8
Drasga RE, Einhorn LH, Williams SD, Patel DN, Stevens EE. Fertility after chemotherapy for testicular cancer. J Clin Oncol 1983;1(3): 179-83.
Casey EB, Jellife AM, Le Quesne PM, Millett YL. Vincristine neuropathy. Clinical and electrophysiological observations. Brain 1973; 96:69.
Legha SS. Vincristine neurotoxicity. Pathophysiology and management. Med Toxicol 1986; 1:421.
Grisold W, Cavaletti G, Windebank AJ. Peripheral neuropathies from chemotherapeutics and targeted agents: diagnosis, treatment, and prevention. Neuro Oncol 2012; 14 Suppl 4:iv45.
Subhose V, Srinivas P, Narayana A. Basic principles of pharmaceutical science in Ayurvĕda. Bull Indian Inst Hist Med Hyderabad 2005;35(2):83- 92.
Meduri K, Mullin G. Ayurvedic diets for wellness and disease intervention. Nutr Clin Pract 2010;25(6):685-6.
Kurup PNV. Ayurveda-a potential global medical system. In: Mishra LC, ed. Scientific Basis for AyurvedicTherapies. 1st ed. Washington: CRC Press; 2004. p.1-15.
Gujral ML, Sareen K, Tangri KK, Amma MK, Roy AK. Antiarthritic and anti-inflammatory activity of gum (Balsamodendrone mukul Hook). Indian J Physiol Pharmacol 1960;4:267-73.
Patel VK, Wang J, Shen RN, Sharma HM, Brahmi Z. Reduction of metastases of lewis lung carcinoma by an ayurvedic food supplement in mice. Nutr Res 1992;12(4-5):667-76.
Ballabh B, Chaurasia OP. Traditional medicinal plants of cold desert Ladakh--used in treatment of cold, cough and fever. J Ethnopharmacol 2007;112(2):341-9.
Narayana A, Subhose V. Standardization of Ayurvĕdic formulations: a scientific review. Bull Indian Inst Hist Med Hyderabad 2005;35(1):21-32.
Tan G., Gyllenhaal C., Soejarto D. Biodiversity as a source of anticancer drugs. Curr. Drug Targets. 2006;7:265–277. doi: 10.2174/138945006776054942.
De Mesquita M.L., de Paula J.E., Pessoa C., de Moraes M.O., Costa- Lotufo L.V., Grougnet R., Michel S., Tillequin F., Espindola L.S. Cytotoxic activity of Brazilian Cerrado plants used in traditional medicine against cancer cell lines. J. Ethnopharmacol. 2009;123:439–445. doi: 10.1016/j.jep.2009.03.018.
Chandra S. Endophytic fungi: Novel sources of anticancer lead molecules. Appl. Microbiol. Biotechnol. 2012;95:47–59. doi: 10.1007/s00253-012- 4128-7.
Srivastava V., Negi A.S., Kumar J., Gupta M., Khanuja S.P. Plant-based anticancer molecules: A chemical and biological profile of some important leads. Bioorg. Med. Chem. 2005;13:5892–5908. doi: 10.1016/j.bmc.2005.05.066.
Larkin T. Herbs are often more toxic than magical. FDA Consumers. 1983;17:4–10.
Bhishagratha KL. Sushruta samhita. Sushruta samhita. Varanasi: Choukhamba Orientalia; 1991.
Smit HF, Woerdenbag HJ, Singh RH, Meulenbeld GJ, Labadie RP, Zwaving JH. Ayurvedic herbal drugs with possible cytostatic activity. J Ethnopharmacol. 1995;47:75–84.
Cragg G.M., Newman D.J. Plants as a source of anticancer agents. J. Ethnopharmacol. 2005;100:72–79. doi: 10.1016/j.jep.2005.05.011.
Song N., Ma J., Zhang X., Qu D., Hui L., Sang C., Li H. Lappaconitine hydrochloride induces apoptosis and S phase cell cycle arrest through MAPK signaling pathway in human liver cancer HepG2 cells. Pharmacogn. Mag. 2021;17:334–341. doi: 10.4103/pm.pm_251_20.
Lai K.-C., Huang A.-C., Hsu S.-C., Kuo C.-L., Yang J.-S., Wu S.-H., Chung J.-G. Benzyl isothiocyanate (BITC) inhibits migration and invasion of human colon cancer HT29 cells by inhibiting matrix metalloproteinase-2/-9 and urokinase plasminogen (uPA) through PKC and MAPK signaling pathway. J. Agric. Food Chem. 2010;58:2935–2942. doi: 10.1021/jf9036694.
Hong Y., Lee J., Moon H., Ryu C.H., Seok J., Jung Y.-S., Ryu J., Baek S.J. Quercetin induces anticancer activity by upregulating pro-NAG- 1/GDF15 in differentiated thyroid cancer cells. Cancers. 2021;13:3022. doi: 10.3390/cancers13123022.
Guan X., Guan Y. Artemisinin induces selective and potent anticancer effects in drug resistant breast cancer cells by inducing cellular apoptosis and autophagy and G2/M cell cycle arrest. JBUON. 2020;25:1330–1336.
Tsai Y.-J., Chen B.-H. Preparation of catechin extracts and nanoemulsions from green tea leaf waste and their inhibition effect on prostate cancer cell PC-3. Int. J. Nanomed. 2016;11:1907–1926. doi: 10.2147/IJN.S103759.
Hussein N.A.E.M., El-Toukhy M.A.E.-F., Kazem A.H., Ali M.E.-S., Ahmad M.A.E.-R., Ghazy H.M.R., El-Din A.M.G. Protective and therapeutic effects of cannabis plant extract on liver cancer induced by dimethylnitrosamine in mice. Alex. J. Med. 2014;50:241–251. doi: 10.1016/j.ajme.2014.02.003.
Kandelous H.M., Salimi M., Khori V., Rastkari N., Amanzadeh A.,Salimi M. Mitochondrial apoptosis induced by Chamaemelum nobile extract in breast cancer cells. Iranian J. Pharm. Res. 2016;15:197–204
Xu Y., Fang R., Shao J., Cai Z. Erianin induces triple-negative breast cancer cells apoptosis by activating PI3K/Akt pathway. Biosci. Rep. 2021;41:BSR20210093. doi: 10.1042/BSR20210093.
Arya R.K., Singh A., Yadav N.K., Cheruvu S.H., Hossain Z., Meena S., Maheshwari S., Singh A.K., Shahab U., Sharma C. Anti-breast tumor activity of Eclipta extract in-vitro and in-vivo: Novel evidence of endoplasmic reticulum specific localization of Hsp60 during apoptosis. Sci. Rep. 2015;5:18457. doi: 10.1038/srep18457.
Li J., Guo Q., Lei X., Zhang L., Su C., Liu Y., Zhou W., Chen H., Wang H., Wang F. Pristimerin induces apoptosis and inhibits proliferation, migration in H1299 lung cancer cells. J. Cancer. 2020;11:6348–6355. doi: 10.7150/jca.44431.
Zhang D.-F., Yang Z.-C., Chen J.-Q., Jin X.-X., Qiu Y.-D., Chen X.-J., Shi H.-Y., Liu Z.-G., Wang M.-S., Liang G. Piperlongumine inhibits migration and proliferation of castration-resistant prostate cancer cells via triggering persistent DNA damage. BMC Complement. Med. Ther. 2021;21:195. doi: 10.1186/s12906-021-03369-0.
De Almeida G.C., Oliveira L.F., Predes D., Fokoue H.H., Kuster R.M., Oliveira F.L., Mendes F.A., Abreu J.G. Piperine suppresses the Wnt/β- catenin pathway and has anticancer effects on colorectal cancer cells. Sci. Rep. 2020;10:1161. doi: 10.1038/s41598-020-68574-2.
Harinantenaina L., Brodie P.J., Slebodnick C., Callmander M.W., Rakotobe E., Randrianasolo S., Randrianaivo R., Rasamison V.E., TenDyke K., Shen Y. Antiproliferative compounds from Pongamiopsis pervilleana from the Madagascar dry forest. J. Nat. Prod. 2010;73:1559–1562. doi: 10.1021/np100430r.
Fadlalla K., Watson A., Yehualaeshet T., Turner T., Samuel T. Ruta graveolens extract induces DNA damage pathways and blocks Akt activation to inhibit cancer cell proliferation and survival. Anticancer Res. 2011;31:233–241.
Jordan M.A., Thrower D., Wilson L. Mechanism of inhibition of cell proliferation by Vinca alkaloids. Cancer Res. 1991;51:2212–2222.
Mamtani R., Vaughn D.J. Vinflunine in the treatment of advanced bladder cancer. Expert Rev. Anticancer Ther. 2011;11:13–20. doi: 10.1586/era.10.196
Kinghorn A.D., Seo E.-K. Plants as sources of drugs. In: Fuller G., McKeon T.A., Bills D.D., editors. Agricultural Materials as Renewable Resources. Volume 647. ACS Publications; Washington, DC, USA: 1996. pp. 179–193
Gelmon K. The taxoids: Paclitaxel and docetaxel. The Lancet. 1994;344:1267–1272. doi: 10.1016/S0140-6736(94)90754-4.
Paller C.J., Antonarakis E.S. Cabazitaxel: A novel second-line treatment for metastatic castration-resistant prostate cancer. Drug Des. Dev. Ther. 2011;5:117–124. doi: 10.2147/DDDT.S13029.
Einhorn LH, Donohue J. Cis-diaminodichloroplatinum, vinblastine, and bleomycin in combination chemotherapy in disseminated testicular cancer. Ann Intern Med 1977;87(3): 293-8
Drasga RE, Einhorn LH, Williams SD, Patel DN, Stevens EE. Fertility after chemotherapy for testicular cancer. J Clin Oncol 1983;1(3): 179-83.
Casey EB, Jellife AM, Le Quesne PM, Millett YL. Vincristine neuropathy. Clinical and electrophysiological observations. Brain 1973; 96:69.
Legha SS. Vincristine neurotoxicity. Pathophysiology and management. Med Toxicol 1986; 1:421.
Grisold W, Cavaletti G, Windebank AJ. Peripheral neuropathies from chemotherapeutics and targeted agents: diagnosis, treatment, and prevention. Neuro Oncol 2012; 14 Suppl 4:iv45.
Sayfalar
505-510
Yayınlanan
11 Mart 2024
Telif Hakkı (c) 2024 Akademisyen Yayınevi Kitap Portalı
Lisans
LisansNasıl Atıf Yapılır
1.
Tünbekici S. Ayurveda. Içinde: Sakin A, editör. Kanser Hastalarının Başvurduğu Geleneksel ve Tamamlayıcı Tedaviler - Tıbbi Onkolog Gözü ile Bakış ve Onkolojik İlaçlarla Etkileşim [Internet]. Türkiye: Akademisyen Yayınevi Kitap DOI Portalı; 2024 [a.yer 13 Temmuz 2026]. ss. 505-10. Erişim adresi: https://omp35.books.akademisyen.net/index.php/akya/catalog/book/2380/chapter/14023
