Vitamin D
Özet
Bu bölüm, Vitamin D ve kanser gelişimi arasındaki karmaşık ilişkiyi incelemekte, Vitamin D'nin biyokimyasal özelliklerini ve kanser hücreleri üzerindeki etkilerini vurgulamaktadır. Vitamin D, özgül protein reseptörü olan Vitamin D Reseptörü (VDR) ile etkileşerek, gen ifadesini ve hücre büyümesi, farklılaşması ve apoptozis gibi temel kanser süreçlerini düzenleyen bir sinyal iletim dizisini tetikler. Bu etkiler, genetik ve epigenetik mekanizmalar aracılığıyla gerçekleşir ve Vitamin D'nin hücre döngüsü düzenleyicileri, büyüme faktörleri ve apoptotik yollar üzerindeki etkilerini kanser araştırmalarının ön saflarına taşır. Bölüm, kanser biyolojisinde Vitamin D ve VDR'nin rolünü derinlemesine ele almakta, onları kanser önleme ve tedavisinde yeni stratejiler geliştirmede kilit olarak sunmaktadır. Yapılan çalışmalar, özellikle meme ve kolon kanseri modellerinde, Vitamin D ve analoglarının antikarsinojenik etkiler gösterdiğini ortaya koymuştur. Bölüm ayrıca, Vitamin D eksikliğinin kanser gelişimindeki rolünü incelemekte, kanserle ilgili hücresel süreçler üzerindeki düzenleyici etkilerini vurgulamaktadır. Vitamin D'nin, özellikle aktif formu olan kalsitriolün, mevcut ve gelecekteki kanser tedavi stratejilerindeki potansiyelini tartışmakta, antiproliferatif, apoptotik, anti-anjiyojenik etkilerine ve transkripsiyon faktörlerinin modülasyonuna odaklanmaktadır. Bölüm, Vitamin D'nin kanser tedavisinde önemli bir potansiyele sahip olduğunu sonuçlandırmakta, ancak kanser tedavi ve önlemedeki tam potansiyelini anlamak için daha fazla araştırmaya ihtiyaç olduğunu belirtmektedir.
This chapter explores the intricate relationship between Vitamin D and cancer development, highlighting its biochemical properties and effects on cancer cells. Vitamin D functions through interaction with its specific protein receptor, Vitamin D Receptor (VDR), triggering a series of signal transductions that regulate gene expression and fundamental cancer processes such as cell growth, differentiation, and apoptosis. These effects, mediated through genetic and epigenetic mechanisms, place Vitamin D's influence on cell cycle regulators, growth factors, and apoptotic pathways at the forefront of cancer research. The chapter delves into the role of Vitamin D and VDR in cancer biology, presenting them as pivotal in developing new strategies for cancer prevention and treatment. Studies have shown that Vitamin D and its analogs, particularly in breast and colon cancer models, exhibit anticarcinogenic effects. The chapter also examines the role of Vitamin D deficiency in cancer development, emphasizing its regulatory effects on cellular processes related to cancer. It discusses the potential of Vitamin D, especially its active form calcitriol, in current and future cancer treatment strategies, focusing on its antiproliferative, apoptotic, anti-angiogenic effects, and modulation of transcription factors. The chapter concludes that while Vitamin D holds significant promise in cancer therapy, further research is essential to fully understand its potential in cancer treatment and prevention.
Referanslar
Brenza HL, DeLuca HF. Regulation of 25-hydroxyvitamin D3 1α-hydroxylase gene expression by parathyroid hormone and 1,25-dihydroxyvitamin D3. Arch Biochem Biophys. 2000 Sep 1;381(1):143–52.
Mehta RG, Moriarty RM, Mehta RR, Penmasta R, Lazzaro G, Constantinou A, et al. Prevention of Preneoplastic Mammary Lesion Development by a Novel Vitamin D Analogue, 1α-Hydroxyvitamin D5 [Internet]. 1997. Available from: http://jnci.oxfordjournals.org/
Mehta RG, Moriarty RM, Mehta RR, et al. Prevention of preneoplastic mammary lesion development by a novel vitamin D analogue, 1alpha-hydroxyvitamin D5. J Natl Cancer Inst. 1997;89(3):212-218. doi:10.1093/jnci/89.3.212.
Hansen CM, Hamberg KJ, Binderup E, Binderup L. Seocalcitol (EB 1089): A Vitamin D Analogue of Anti-cancer Potential. Background, Design, Synthesis, Pre-clinical and Clinical Evaluation. Vol. 6, Current Pharmaceutical Design. 2000.
Muñoz A, Grant WB. Vitamin D and Cancer: An Historical Overview of the Epidemiology and Mechanisms. Vol. 14, Nutrients. MDPI; 2022.
Feskanich D, Ma J, Fuchs CS, et al. Plasma vitamin D metabolites and risk of colorectal cancer in women. Cancer Epidemiol Biomarkers Prev. 2004;13(9):1502-1508.
Tong WM, Âllay EK, Hofer H, Hulla W, Manhardt T, Peterlik M, et al. Original Paper Growth Regulation of Human Colon Cancer Cells by Epidermal Growth Factor and 1,25-Dihydroxyvitamin D 3 is Mediated by Mutual Modulation of Receptor Expression. Vol. 34, Eur J Cancer. 1998.
Fleet JC, Desmet M, Johnson R, Li Y. Vitamin D and cancer: A review of molecular mechanisms. Vol. 441, Biochemical Journal. 2012. p. 61–76.
Pálmer HG, González-Sancho JM, Espada J, Berciano MT, Puig I, Baulida J, et al. Vitamin D3 promotes the differentiation of colon carcinoma cells by the induction of E-cadherin and the inhibition of β-catenin signaling. Journal of Cell Biology. 2001 Jul 23;154(2):369–87.
Liu M, Lee MH, Cohen M, Bommakanti M, Freedman LP. Transcriptional activation of the Cdk inhibit.or p21 b vitamin D3 leads to the induced ifferentiation of the myelomonocytic cell line U937. 1996.
Narvaez CJ, Welsh JE. Role of Mitochondria and Caspases in Vitamin D-mediated Apoptosis of MCF-7 Breast Cancer Cells. Journal of Biological Chemistry. 2001 Mar 23;276(12):9101–7.
Ylikomi T, Laaksi I, Lou YR, Martikainen, *’~ P, Miettinen S, Pennanen P, et al. Antiproliferative Action of Vitamin D. Vol. 64, VITAMINS AND HORMONES. 2002.
Krishnan A V., Trump DL, Johnson CS, Feldman D. The role of vitamin D in cancer prevention and treatment. Vol. 39, Endocrinology and Metabolism Clinics of North America. 2010. p. 401–18.
Bao BY, Yao J, Lee YF. 1α, 25-dihydroxyvitamin D3 suppresses interleukin-8-mediated prostate cancer cell angiogenesis. Carcinogenesis. 2006 Sep;27(9):1883–93.
Ben-Shoshan M, Amir S, Dang DT, Dang LH, Weisman Y, Mabjeesh NJ. 1α,25-dihydroxyvitamin D3 (Calcitriol) inhibits hypoxia-inducible factor-1/vascular endothelial growth factor pathway in human cancer cells. Mol Cancer Ther. 2007 Apr;6(4):1433–9.
Beer TM, Ryan CW, Venner PM, Petrylak DP, Chatta GS, Ruether JD, et al. Double-blinded randomized study of high-dose calcitriol plus docetaxel compared with placebo plus docetaxel in androgen-independent prostate cancer: A report from the ASCENT investigators. Journal of Clinical Oncology. 2007 Feb 20;25(6):669–74.
Scaglione-Sewell BA, Bissonnette M, Skarosi S, Abraham C, Brasitus TA. A Vitamin D 3 Analog Induces a G1-Phase Arrest in CaCo-2 Cells by Inhibiting Cdk2 and Cdk6: Roles of Cyclin E, p21 Waf1 , and p27 Kip1 *. 2000.
