Isırgan Otu (Urtica Dioica)
Özet
Dünyanın birçok yerinde bitkisel ilaçlar çeşitli hastalıkların tedavisinde kullanılmakta olup ısırgan otu ekstraktı bu ilaçların önde gelenlerindendir. Antiinflamatuar özelliği nedeniyle karsinogenezi baskılayıp antikanser etkinlik sağladığı düşünülmektedir. Yapılan birçok çalışmada normal hücrelerde antikanser ve malign hücrelerde antimetastatik ve apopitotik etkisi gösterilmiştir. Bu etkilerinden dolayı prostat kanseri, akciğer ve meme kanseri gibi solid malignitelerde ve akut miyeloid lösemi gibi hematolojik malignitelerde kullanılır.
Karaciğerde sitokrom enzimlerinin fonksiyonlarını etkilediği için sık kullanılan birçok ilaç ile etkileşebilir. Dikkatli kullanılmaması durumunda ciddi ilaç etkileşimine sebep olup hayatı tehdit eden sağlık problemlerine yol açabilir.
Herbal medicines are used in many parts of the world to treat various diseases, and nettle extract is one of the leading ones. It is thought to suppress carcinogenesis and provide anticancer activity due to its anti-inflammatory properties. Many studies have shown its anticancer effect on normal cells and antimetastatic and apoptotic effects on malignant cells. Due to these effects, it is used in solid malignancies such as prostate cancer, lung and breast cancer, and hematological malignancies such as acute myeloid leukemia.
Since it affects the functions of cytochrome enzymes in the liver, it may interact with many frequently used drugs. If not used carefully, it may cause serious drug interactions and lead to life-threatening health problems.
Referanslar
Gozum S, Tezel A, Koc M. Complementary alternative treatments used by patients with cancer in eastern Turkey. Cancer Nurs. 2003; 26: 230–236.
Weber RW. Stinging nettle. Ann Allergy Asthma Immunol. 2003;90: A6.
Wetherit H:Isırgan otu yaprak ve tohumlarının Besleyici Özellikleri ve Antitümoral Etkileri.H.Ü. Sağlık Bilimleri Enstitüsü, Doktora Tezi, Ankara, 1989 (Danışman:Prof.Dr.A.Baysal).
Akbay P, Basaran AA, Undeger U, Basaran N. In vitro immunomodulatory activity of flavonoid glycosides from Urtica dioica L. Phytother Res. 2003;17: 34–37.
Fijalek Z, Soltyk K, Lozak A, Kominek A, Ostapczuk P. Determination of some micro- and macroelements in preparations made from peppermint and nettle leaves. Pharmazie. 2003; 58: 480–482.
Barlow R.b. ve Dixom R.O.D.: Cholinacetyl transferase in the nettle Urtica dioica.Biochem.J.,134:15-18,1973
Roschivina V.V. ve Mukhin E.N.: Acetylcholinesterase activity of chloroplasts of higher plants.Dokl. Akad. Nauk SSSR,278(3):754-7,1984.
Welander M.: Enzyme activities in Urtica dioica. Effects of saylight and leaf age on glutamat dehydrogenase, aspartate aminotransferase, and alanine aminotransferase. Physiol. Pant. ,30(3):192-9,1974
Walender M.: The effect of mercaptoethanol on activity of enzymes nitrogen metabolismin leaves from Urtica dioica and spinacia oleracea. Physiol. Plant., 43(3):242-6,1978.
Emmelin N. And Feldberg W.: The mechanism of sting of the common nettle .J.Physiol.,106:440,1948.
Atasu E. Ve Cihangir V.: Urtica L.türlerinin kimyasal içeriği ve tedavide kullanımı. FABAD Farmasotik Bilimler Dergisi,9(2):73-81,1984.
Beretz A, Steirle A, Anton R, Cazenave JP. 1982. Role of cyclic AMP in the inhibition of platelet aggregation by quercetin, a flavonoid that potentiates the effect of prostacyclin. Biochem Pharmacol 31: 3597– 3600.
Rustnitschek-Schimmel I.: Seasonal Dynamics of nitrogenous compounds in a nitrophilic weed. Changes in inorganic and organic nitrogen fractions of the different plant parts of Urtica dioica. Plant Cell Physiol., 26(1):169-76,1985.
Rysin L.P. ve Antyukhina V.V.: Chemical composition of grass-underbush plants in pin forests of Moscow district. Lesovedenic, 1:36-47, 1977
Zulfagarly D. I., Alieva G.V., Arslanbekova M.A., Kazanbieva M.A. ve Lolua A.M.: Trace element level in medicanal plants. Azerb. Khim. Zh.,2:84-8,1982.
Lotti G., Paradossi C. Ve Marchini F.: Caratterizzazione analitica di nouovi olii di semi. Riv. Soc. Ital.Sci.Aliment., 14(4):263-70,1985.
Garnier G., Bezanger B.L., ve Debraux G.: Resources medicinales dela Flore Francaise: Tome I. Vigos Freres (ed), Paris.,1961.
Falkowskl M. Ve Kukulka I.: Choloropyhl content as an indicator of biological properties of meadow plants. Rocz. Nauk Ruln, Ser. F.,79(3): 105112, 1977.
Popova I.A., Maslova T.G., peum O.F., Miroslavov E.A. ve Tsarkova V.A.: Characteristics of the photosynthetic appratus of stinging nettle growing under various light conditions. Fiziol. Rast., 29(6):1102-8,1982.
Kudritskaya S.E., Fishman G.M., Zagorodskaya L.M. ve Chikovani D.M.: Carotenoids of Utrica dioica. Khim. Prir.Soedin. ,5:640-1,1986.
Bonetti M., Brunetti N., Caserta G., Framondino U., Marzetti P. ve Pacciaroni F.: Biogas prpduction from biomass. Com. Naz. Energ. Nucl.,CNEN-RT/B1081/6,48 s., 1981
Peumans W.J., De Ley M.,Broekaert W.F.:An unusual lection from stinging nettle(Urt
İca dioica) rhizomas. FEBA Lett., 177(1):99-103,1984.
Rovira P., Buckle M., Abastado J.P., Peumans W.J., Truffa B.P.: Major histocompability class I molecules present UDA, a superantigen of vegetal origin, to T lymphocytes. Eur. J. Immunol., 29(5):1571-1580, 1998.
Van Damme E.J.M., Broekaert W.F., Peumans W.J.:The Urtica dioica agglutinin is a complex mixture of isolectins. Plant Physiol., 86:598-601, 1998.
Wagner H., Wilier F., Krecher B.: Biologically active compounds from the aqueous extract of Urtica dioica. Plants Med., 55:452-454, 1989
Obertreis B, Giller K, Teucher T, Behnke B, Schmitz H. Anti-inflammatory effect of Urtica dioica folia extract in comparison to caffeic malic acid. Arzneimittelforschung. 1996; 46: 52–56.
Obertreis B, Ruttkowski T, Teucher T, Behnke B, Schmitz H. Ex-vivo in-vitro inhibition of lipopolysaccharide stimulated tumor necrosis factor-alpha and interleukin–1 beta secretion in human whole blood by extractum urticae dioicae foliorum. Arzneimittelforschung. 1996; 46: 389–394.
Balzarini J, Neyts J, Schols D, Hosoya M, Van Damme E, Peumans W, De Clercq E. The mannose-specific plant lectins from Cymbidium hybrid and Epipactis helleborine and the (N-acetylglucosamine)n-specific plant lectin from Urtica dioica are potent and selective inhibitors of human immunodeficiency virus and cytomegalovirus replication in vitro. Antiviral Res. 1992; 18.191–207.
Galelli A, Delcourt M, Wagner MC, Peumans W, Truffa-Bachi P. Selective expansion followed by profound deletion of mature V beta 8,3+ T cells in vivo after exposure to the superantigenic lectin Urtica dioica agglutinin. J Immunol. 1995; 154: 2600–2611
Musette P, Galelli A, Chabre H, Callard P, Peumans W, Truffa-Bachi P, Kourilsky P, Gachelin G. Urtica dioica agglutinin, a V beta 8,3-specific superantigen, prevents the development of the systemic lupus erythematosus-like pathology of MRL lpr/lpr mice. Eur J Immunol. 1996; 26: 1707–1711.
Cetinus E, Kilinc M, Inanc F, Kurutas EB, Buzkan N. The role of urtica dioica (urticaceae) in the prevention of oxidative stress caused by tourniquet application in rats. Tohoku J Exp Med. 2005; 205: 215–221.
Tanakol R.. Antioksidan vitaminler: Hastalıkta ve sağlıkta önemleri. Klinik gelişim. 1998; 11: 347–356.
Gulcin I, Kufrevioglu OI, Oktay M, Buyukokuroglu ME. Antioxidant, antimicrobial, antiulcer and analgesic activities of nettle (Urtica dioica L.). J Ethnopharmacol. 2004; 90: 205–215.
Riehemann K, Behnke B, Schulze-Osthoff K. Plant extracts from stinging nettle (Urtica dioica), an antirheumatic remedy, inhibit the proinflammatory transcription factor NFkappaB. FEBS Lett. 1999; 442: 89–94.
Lichius JJ Renneberg H, Blaschek W, Aumuller G, Muth C. The inhibiting effects of components of stinging nettle roots on experimentally induced prostatic hyperplasia in mice. Planta Med. 1999, 65: 666–668.
Lindemann P, Muller HH, Aumuller G, Konrad L. Antiproliferative effect of a polysaccharide fraction of a 20% methanolic extract of stinging nettle roots upon epithelial cells of the human prostate (LNCaP). Pharmazie. 1999; 54: 768–771.
Ezeome ER, Anarado AN. Use of complementary and alternative medicine by cancer patients at the University of Nigeria Teaching Hospital, Enugu, Nigeria. BMC Complement Altern Med. 2007 ;7(1):28
Portakal O, Ozkaya O, Erden Inal M, Bozan B, Kosan M, Sayek I. Coenzyme Q10 concentrations and antioxidant status in tissues of breast cancer patients. Clin Biochem. 2000; 33: 279–284.
Huang YL, Sheu JY, Lin TH. Association between oxidative stress and changes of trace elements in patients with breast cancer. Clin. Biochem. 1999; 32: 131–136.
Gerber M, Richardson S, Salkeld R, Chappuis P. Antioxidants in female breast cancer patients. Cancer Invest. 1991; 9: 421–428.
Ching S, Ingram D, Hahnel R, Beilby J, Rossi E. Serum levels of micronutrients, antioxidants and total antioxidant status predict risk of breast cancer in a case control study. J Nutr. 2002; 132: 303–306.
Ghiselli A, Serafini M, Natella F, Scaccini C. Total antioxidant capacity as a tool to assess redox status: critical view and experimental data. Free Radic Biol Med. 2000; 29: 1106–1114.
Kanter M.,Coşkun Ö.,Budancamank M.Hepatoprotective effects of Nigella sativa L and Urtica dioica L on lipid peroxidation, antioxidant enzym systems and liver enzymsin carbon tetracloride-treated rats World J Gastroenterol,14;11(42):6684-6688,2005
Özmen R.: Isırgan Otu Yaprağı ile beslenen Sıçanlarda akut karbontatraklorür uygulamasının plazma ve karaciğer lipid peroksidasyonu ile glutatyon seviyelerinde etkisi. M.Ü.. Sağlık Bilimleri Enstitüsü, Yüksek Lisans Tezi, İstanbul,2001(Danışman: Yrd.Doç.Dr.B.Göker).
Hodroj, M. H., Al Bast, N. H. Taleb. Nettle Tea Inhibits Growth of Acute Myeloid Leukemia Cells In Vitro by Promoting Apoptosis. Nutrients, 2020; 12(9): 10.3390/nu12092629
Yin S.-Y., Wei W.-C., Jian F.-Y., Yang N.-S. Bitkisel ilaçların kanser hastalarına yönelik terapötik uygulamaları. Kanıt. Tabanlı Tamamlayıcı. Alternatif. Med. 2013; 2013:302426.
Kregiel D., Pawlikowska E., Antolak H. Urtica spp.: Olağanüstü Özelliklere Sahip Sıradan Bitkiler. Moleküller. 2018; 23:1664.
Weber RW. Stinging nettle. Ann Allergy Asthma Immunol. 2003;90: A6.
Wetherit H:Isırgan otu yaprak ve tohumlarının Besleyici Özellikleri ve Antitümoral Etkileri.H.Ü. Sağlık Bilimleri Enstitüsü, Doktora Tezi, Ankara, 1989 (Danışman:Prof.Dr.A.Baysal).
Akbay P, Basaran AA, Undeger U, Basaran N. In vitro immunomodulatory activity of flavonoid glycosides from Urtica dioica L. Phytother Res. 2003;17: 34–37.
Fijalek Z, Soltyk K, Lozak A, Kominek A, Ostapczuk P. Determination of some micro- and macroelements in preparations made from peppermint and nettle leaves. Pharmazie. 2003; 58: 480–482.
Barlow R.b. ve Dixom R.O.D.: Cholinacetyl transferase in the nettle Urtica dioica.Biochem.J.,134:15-18,1973
Roschivina V.V. ve Mukhin E.N.: Acetylcholinesterase activity of chloroplasts of higher plants.Dokl. Akad. Nauk SSSR,278(3):754-7,1984.
Welander M.: Enzyme activities in Urtica dioica. Effects of saylight and leaf age on glutamat dehydrogenase, aspartate aminotransferase, and alanine aminotransferase. Physiol. Pant. ,30(3):192-9,1974
Walender M.: The effect of mercaptoethanol on activity of enzymes nitrogen metabolismin leaves from Urtica dioica and spinacia oleracea. Physiol. Plant., 43(3):242-6,1978.
Emmelin N. And Feldberg W.: The mechanism of sting of the common nettle .J.Physiol.,106:440,1948.
Atasu E. Ve Cihangir V.: Urtica L.türlerinin kimyasal içeriği ve tedavide kullanımı. FABAD Farmasotik Bilimler Dergisi,9(2):73-81,1984.
Beretz A, Steirle A, Anton R, Cazenave JP. 1982. Role of cyclic AMP in the inhibition of platelet aggregation by quercetin, a flavonoid that potentiates the effect of prostacyclin. Biochem Pharmacol 31: 3597– 3600.
Rustnitschek-Schimmel I.: Seasonal Dynamics of nitrogenous compounds in a nitrophilic weed. Changes in inorganic and organic nitrogen fractions of the different plant parts of Urtica dioica. Plant Cell Physiol., 26(1):169-76,1985.
Rysin L.P. ve Antyukhina V.V.: Chemical composition of grass-underbush plants in pin forests of Moscow district. Lesovedenic, 1:36-47, 1977
Zulfagarly D. I., Alieva G.V., Arslanbekova M.A., Kazanbieva M.A. ve Lolua A.M.: Trace element level in medicanal plants. Azerb. Khim. Zh.,2:84-8,1982.
Lotti G., Paradossi C. Ve Marchini F.: Caratterizzazione analitica di nouovi olii di semi. Riv. Soc. Ital.Sci.Aliment., 14(4):263-70,1985.
Garnier G., Bezanger B.L., ve Debraux G.: Resources medicinales dela Flore Francaise: Tome I. Vigos Freres (ed), Paris.,1961.
Falkowskl M. Ve Kukulka I.: Choloropyhl content as an indicator of biological properties of meadow plants. Rocz. Nauk Ruln, Ser. F.,79(3): 105112, 1977.
Popova I.A., Maslova T.G., peum O.F., Miroslavov E.A. ve Tsarkova V.A.: Characteristics of the photosynthetic appratus of stinging nettle growing under various light conditions. Fiziol. Rast., 29(6):1102-8,1982.
Kudritskaya S.E., Fishman G.M., Zagorodskaya L.M. ve Chikovani D.M.: Carotenoids of Utrica dioica. Khim. Prir.Soedin. ,5:640-1,1986.
Bonetti M., Brunetti N., Caserta G., Framondino U., Marzetti P. ve Pacciaroni F.: Biogas prpduction from biomass. Com. Naz. Energ. Nucl.,CNEN-RT/B1081/6,48 s., 1981
Peumans W.J., De Ley M.,Broekaert W.F.:An unusual lection from stinging nettle(Urt
İca dioica) rhizomas. FEBA Lett., 177(1):99-103,1984.
Rovira P., Buckle M., Abastado J.P., Peumans W.J., Truffa B.P.: Major histocompability class I molecules present UDA, a superantigen of vegetal origin, to T lymphocytes. Eur. J. Immunol., 29(5):1571-1580, 1998.
Van Damme E.J.M., Broekaert W.F., Peumans W.J.:The Urtica dioica agglutinin is a complex mixture of isolectins. Plant Physiol., 86:598-601, 1998.
Wagner H., Wilier F., Krecher B.: Biologically active compounds from the aqueous extract of Urtica dioica. Plants Med., 55:452-454, 1989
Obertreis B, Giller K, Teucher T, Behnke B, Schmitz H. Anti-inflammatory effect of Urtica dioica folia extract in comparison to caffeic malic acid. Arzneimittelforschung. 1996; 46: 52–56.
Obertreis B, Ruttkowski T, Teucher T, Behnke B, Schmitz H. Ex-vivo in-vitro inhibition of lipopolysaccharide stimulated tumor necrosis factor-alpha and interleukin–1 beta secretion in human whole blood by extractum urticae dioicae foliorum. Arzneimittelforschung. 1996; 46: 389–394.
Balzarini J, Neyts J, Schols D, Hosoya M, Van Damme E, Peumans W, De Clercq E. The mannose-specific plant lectins from Cymbidium hybrid and Epipactis helleborine and the (N-acetylglucosamine)n-specific plant lectin from Urtica dioica are potent and selective inhibitors of human immunodeficiency virus and cytomegalovirus replication in vitro. Antiviral Res. 1992; 18.191–207.
Galelli A, Delcourt M, Wagner MC, Peumans W, Truffa-Bachi P. Selective expansion followed by profound deletion of mature V beta 8,3+ T cells in vivo after exposure to the superantigenic lectin Urtica dioica agglutinin. J Immunol. 1995; 154: 2600–2611
Musette P, Galelli A, Chabre H, Callard P, Peumans W, Truffa-Bachi P, Kourilsky P, Gachelin G. Urtica dioica agglutinin, a V beta 8,3-specific superantigen, prevents the development of the systemic lupus erythematosus-like pathology of MRL lpr/lpr mice. Eur J Immunol. 1996; 26: 1707–1711.
Cetinus E, Kilinc M, Inanc F, Kurutas EB, Buzkan N. The role of urtica dioica (urticaceae) in the prevention of oxidative stress caused by tourniquet application in rats. Tohoku J Exp Med. 2005; 205: 215–221.
Tanakol R.. Antioksidan vitaminler: Hastalıkta ve sağlıkta önemleri. Klinik gelişim. 1998; 11: 347–356.
Gulcin I, Kufrevioglu OI, Oktay M, Buyukokuroglu ME. Antioxidant, antimicrobial, antiulcer and analgesic activities of nettle (Urtica dioica L.). J Ethnopharmacol. 2004; 90: 205–215.
Riehemann K, Behnke B, Schulze-Osthoff K. Plant extracts from stinging nettle (Urtica dioica), an antirheumatic remedy, inhibit the proinflammatory transcription factor NFkappaB. FEBS Lett. 1999; 442: 89–94.
Lichius JJ Renneberg H, Blaschek W, Aumuller G, Muth C. The inhibiting effects of components of stinging nettle roots on experimentally induced prostatic hyperplasia in mice. Planta Med. 1999, 65: 666–668.
Lindemann P, Muller HH, Aumuller G, Konrad L. Antiproliferative effect of a polysaccharide fraction of a 20% methanolic extract of stinging nettle roots upon epithelial cells of the human prostate (LNCaP). Pharmazie. 1999; 54: 768–771.
Ezeome ER, Anarado AN. Use of complementary and alternative medicine by cancer patients at the University of Nigeria Teaching Hospital, Enugu, Nigeria. BMC Complement Altern Med. 2007 ;7(1):28
Portakal O, Ozkaya O, Erden Inal M, Bozan B, Kosan M, Sayek I. Coenzyme Q10 concentrations and antioxidant status in tissues of breast cancer patients. Clin Biochem. 2000; 33: 279–284.
Huang YL, Sheu JY, Lin TH. Association between oxidative stress and changes of trace elements in patients with breast cancer. Clin. Biochem. 1999; 32: 131–136.
Gerber M, Richardson S, Salkeld R, Chappuis P. Antioxidants in female breast cancer patients. Cancer Invest. 1991; 9: 421–428.
Ching S, Ingram D, Hahnel R, Beilby J, Rossi E. Serum levels of micronutrients, antioxidants and total antioxidant status predict risk of breast cancer in a case control study. J Nutr. 2002; 132: 303–306.
Ghiselli A, Serafini M, Natella F, Scaccini C. Total antioxidant capacity as a tool to assess redox status: critical view and experimental data. Free Radic Biol Med. 2000; 29: 1106–1114.
Kanter M.,Coşkun Ö.,Budancamank M.Hepatoprotective effects of Nigella sativa L and Urtica dioica L on lipid peroxidation, antioxidant enzym systems and liver enzymsin carbon tetracloride-treated rats World J Gastroenterol,14;11(42):6684-6688,2005
Özmen R.: Isırgan Otu Yaprağı ile beslenen Sıçanlarda akut karbontatraklorür uygulamasının plazma ve karaciğer lipid peroksidasyonu ile glutatyon seviyelerinde etkisi. M.Ü.. Sağlık Bilimleri Enstitüsü, Yüksek Lisans Tezi, İstanbul,2001(Danışman: Yrd.Doç.Dr.B.Göker).
Hodroj, M. H., Al Bast, N. H. Taleb. Nettle Tea Inhibits Growth of Acute Myeloid Leukemia Cells In Vitro by Promoting Apoptosis. Nutrients, 2020; 12(9): 10.3390/nu12092629
Yin S.-Y., Wei W.-C., Jian F.-Y., Yang N.-S. Bitkisel ilaçların kanser hastalarına yönelik terapötik uygulamaları. Kanıt. Tabanlı Tamamlayıcı. Alternatif. Med. 2013; 2013:302426.
Kregiel D., Pawlikowska E., Antolak H. Urtica spp.: Olağanüstü Özelliklere Sahip Sıradan Bitkiler. Moleküller. 2018; 23:1664.
Sayfalar
85-92
Yayınlanan
11 Mart 2024
Telif Hakkı (c) 2024 Akademisyen Yayınevi Kitap Portalı
Lisans
LisansNasıl Atıf Yapılır
1.
Dinç G. Isırgan Otu (Urtica Dioica). Içinde: Sakin A, editör. Kanser Hastalarının Başvurduğu Geleneksel ve Tamamlayıcı Tedaviler - Tıbbi Onkolog Gözü ile Bakış ve Onkolojik İlaçlarla Etkileşim [Internet]. Türkiye: Akademisyen Yayınevi Kitap DOI Portalı; 2024 [a.yer 13 Temmuz 2026]. ss. 85-92. Erişim adresi: https://omp35.books.akademisyen.net/index.php/akya/catalog/book/2380/chapter/13893
