Trombositten Zengin Fibrinle Ağız, Diş ve Çene Cerrahisinde Başarı: Güncel Yaklaşımlar
Synopsis
Yara iyileşmesinin biyolojisinin daha iyi anlaşılmasıyla birlikte, trombositlerin içerdikleri büyüme faktörleri sayesinde hemostaz ve iyileşme süreçlerinde temel bir rol oynadığı ortaya konmuştur. Yapılan araştırmalar, trombositten zengin fibrinin yara iyileşmesini hızlandırdığını göstermektedir. Trombositten Zengin Fibrin (TZF), otojen kan dokusundan elde edilen, trombositler ve büyüme faktörleri içeren bir plazma bileşenidir. TZF, ağız diş ve çene cerrahisinde yumuşak ve sert doku iyileşmesini hızlandırmak ve düzenlemek amacıyla tek başına kullanılabildiği gibi, greft materyalleriyle karıştırılarak veya doğrudan enjeksiyon yöntemiyle de uygulanmaktadır. Trombositten Zengin Fibrin (TZF) Choukroun tarafından 2006 yılında tanımlanmıştır. TZF, kan dokusundan elde edilen ve fibrin matriks yapısında bol miktarda trombosit ve lökosit barındıran bir materyaldir. TZF, içerdiği yüksek büyüme faktörleri sayesinde, greft materyali veya membran olarak kullanılabilmektedir. Klinik uygulamalarda kullanım alanları giderek genişlerken, özellikle son dönemde doku rejenerasyonu üzerindeki etkileri tartışılmakta ve değerlendirilmektedir.
With a better understanding of the biology of wound healing, it has been revealed that platelets play a fundamental role in hemostasis and healing processes thanks to the growth factors they contain. Studies show that platelet-rich fibrin accelerates wound healing. Platelet Rich Fibrin (PRF) is a plasma component obtained from autogenous blood tissue, containing platelets and growth factors. PRF can be used alone to accelerate and regulate soft and hard tissue healing in oral and maxillofacial surgery, or it can be mixed with graft materials or applied by direct injection. Platelet Rich Fibrin (PRF) was described by Choukroun in 2006. PRF is a material obtained from blood tissue and contains abundant platelets and leukocytes in its fibrin matrix structure. PRF can be used as graft material or membrane. While its areas of use in clinical applications are gradually expanding, its effects on tissue regeneration have been discussed and evaluated, especially recently.
References
Goss JR. Goss JR. Rejeneration versusu repair. In. Cohen IK, Diegelman Lindblad WJ, Editors. Wound healing, biochemical and clinical aspects. Philadelphia: WB Saunders; 1992 ; 40-62. 1992.
Dohan DM, Choukroun J, Diss A, Dohan SL, Dohan AJJ, Mouhyi J, vd. Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part I: technological concepts and evolution. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. Mart 2006;101(3):e37-44.
Altuntaş, Z., Gündeşlioğlu, A. Ö., İnce, B., Dadacı, M., vd. (2014). Trombositten Zengin Plazma, Trombositten Fakir Plazma, Trombositten Zengin Fibrin Kavramları, Yara İyileşmesindeki Biyolojik Rolleri ve Plastik Cerrahide Kullanım Alanları. Türk Plastik Rekonstrüktif ve Estetik Cerrahi Dergisi, 22(2), 49-53.
Conley CL. Conley CL. Hemostasis. In V. B. Mountcastle (Ed.), Medical Physiology. St. Louis: Mosby, 2004; 1137–46. 2004.
Bithell T. Bithell T. Wintrobe’s Clinical Hematology: Disorders of hemostasis and coagulation. Lea & Febiger; 1993. 1138 s. 1993.
Heldin CH, Westermark B. Mechanism of Action and In Vivo Role of Platelet-Derived Growth Factor. Physiol Rev. 10 Ocak 1999;79(4):1283-316.
Ghanaati S, Herrera-Vizcaino C, Al-Maawi S, Lorenz J, Miron RJ, Nelson K, vd. Fifteen Years of Platelet Rich Fibrin in Dentistry and Oromaxillofacial Surgery: How High is the Level of Scientific Evidence? J Oral Implantol. Aralık 2018;44(6):471-92.
Fujioka-Kobayashi M, Miron RJ, Hernandez M, Kandalam U, Zhang Y, Choukroun J. Optimized Platelet-Rich Fibrin With the Low-Speed Concept: Growth Factor Release, Biocompatibility, and Cellular Response. J Periodontol. Ocak 2017;88(1):112-21.
Toffler M. Toffler M, Toscano N, Holtzclaw D, Corso M, Dohan D (2009) Introducing Choukroun’s platelet rich fibrin (PRF) to the reconstructive surgery milieu. J Implant Adv Clin Dent 1:22–31. 2009;
Choukroun J. Choukroun J, Adda F, Schoeffler C, Vervelle A (2001) Une opportunité en paro-implantologie: le PRF. Implantodontie 42:e62. 2001.
Sammartino G, Tia M, Marenzi G, Espedito Di Lauro A, D’Agostino E, Claudio PP. Use of Autologous Platelet-Rich Plasma (PRP) in Periodontal Defect Treatment After Extraction of Impacted Mandibular Third Molars. J Oral Maxillofac Surg. Haziran 2005;63(6):766-70.
Taşkaldıran A, Koçyiğit İD, Tüz H, Tekin U, Atıl F. ve Trombositten Zengin Fibrinin Ağız, Çene ve Yüz Cerrahisinde Kullanım Alanı. J Clin. 2011;
Choukroun J, Diss A, Simonpieri A, Girard MO, Schoeffler C, Dohan SL, vd. Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part IV: clinical effects on tissue healing. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. Mart 2006;101(3):e56-60.
Choukroun J, Ghanaati S. Reduction of relative centrifugation force within injectable platelet-rich-fibrin (PRF) concentrates advances patients’ own inflammatory cells, platelets and growth factors: the first introduction to the low speed centrifugation concept. Eur J Trauma Emerg Surg Off Publ Eur Trauma Soc. Şubat 2018;44(1):87-95.
Kumar RV, Shubhashini N. Platelet rich fibrin: a new paradigm in periodontal regeneration. Cell Tissue Bank. Eylül 2013;14(3):453-63.
Pavlovic V, Ciric M, Jovanovic V, Trandafilovic M, Stojanovic P. Platelet-rich fibrin: Basics of biological actions and protocol modifications. Open Med. 22 Mart 2021;16(1):446-54.
Miron RJ, Chai J, Fujioka-Kobayashi M, Sculean A, Zhang Y. Evaluation of 24 protocols for the production of platelet-rich fibrin. BMC Oral Health. 07 Kasım 2020;20(1):310.
Pinto N, Quirynen M, et al. Letter to the editor regarding Fujioka- Kobayashi et al. 2017 (JOP-16-0443.R1). J Periodontol. 2018. 2017;
Miron RJ, Choukroun J, Ghanaati S. Reply from authors: RE: Optimized platelet-rich fibrin with the low-speed concept: Growth factor release, biocompatibility, and cellular response: Necessity for standardization of relative centrifugal force values in studies on platelet-rich fibrin. J Periodontol. Şubat 2019;90(2):122-5.
Choukroun J, Diss A, Simonpieri A, Girard MO, Schoeffler C, Dohan SL, vd. Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part V: histologic evaluations of PRF effects on bone allograft maturation in sinus lift. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. Mart 2006;101(3):299-303.
Dohan DM, Choukroun J, Diss A, Dohan SL, Dohan AJJ, Mouhyi J, vd. Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part III: leucocyte activation: a new feature for platelet concentrates? Oral Surg Oral Med Oral Pathol Oral Radiol Endod. Mart 2006;101(3):e51-55.
Dohan Ehrenfest DM, De Peppo GM, Doglioli P, Sammartino G. Slow release of growth factors and thrombospondin-1 in Choukroun’s platelet-rich fibrin (PRF): a gold standard to achieve for all surgical platelet concentrates technologies. Growth Factors. Ocak 2009;27(1):63-9.
Miron RJ, Chai J, Zheng S, Feng M, Sculean A, Zhang Y. A novel method for evaluating and quantifying cell types in platelet rich fibrin and an introduction to horizontal centrifugation. J Biomed Mater Res A. Ekim 2019;107(10):2257-71.
Kubesch A, Barbeck M, Al-Maawi S, Orlowska A, Booms PF, Sader RA, vd. A low-speed centrifugation concept leads to cell accumulation and vascularization of solid platelet-rich fibrin: an experimental study in vivo. Platelets. 03 Nisan 2019;30(3):329-40.
Feng M, Wang Y, Zhang P, Zhao Q, Yu S, Shen K, vd. Antibacterial effects of platelet-rich fibrin produced by horizontal centrifugation. Int J Oral Sci. 26 Kasım 2020;12(1):1-8.
Fujioka-Kobayashi M, Kono M, Katagiri H, Schaller B, Zhang Y, Sculean A, vd. Histological comparison of Platelet rich fibrin clots prepared by fixed-angle versus horizontal centrifugation. Platelets. 03 Nisan 2021;32(3):413-9.
Caruana A, Savina D, Macedo JP, Soares SC. From Platelet-Rich Plasma to Advanced Platelet-Rich Fibrin: Biological Achievements and Clinical Advances in Modern Surgery. Eur J Dent. Mayıs 2019;13(02):280-6.
Mourão CF de AB, Valiense H, Melo ER, Mourão NBMF, Maia MDC. Obtention of injectable platelets rich-fibrin (i-PRF) and its polymerization with bone graft: technical note. Rev Col Bras Cir. 2015;42(6):421-3.
Miron RJ, Fujioka-Kobayashi M, Hernandez M, Kandalam U, Zhang Y, Ghanaati S, vd. Injectable platelet rich fibrin (i-PRF): opportunities in regenerative dentistry? Clin Oral Investig. Kasım 2017;21(8):2619-27.
Karde PA, Sethi KS, Mahale SA, Khedkar SU, Patil AG, Joshi CP. Comparative evaluation of platelet count and antimicrobial efficacy of injectable platelet-rich fibrin with other platelet concentrates: An in vitro study. J Indian Soc Periodontol. 2017;21(2):97-101.
Braccini F, Dohan DM. [The relevance of Choukroun’s platelet rich fibrin (PRF) during facial aesthetic lipostructure (Coleman’s technique): preliminary results]. Rev Laryngol - Otol - Rhinol. 2007;128(4):255-60.
Arıkan F, Özçaka Ö, Bıçakçı N. Comparison of Platelet-Rich Plasma and Combine Use of Platelet-Rich Plasma with DFDBA Bone Grafting in the Treatment of Narrow Intrabony Defects. J Ege Univ Sch Dent. 2007;28(2):151-61.
Schulz A, Schiefer JL, Fuchs PC, Kanho CH, Nourah N, Heitzmann W. Does Platelet-Rich Fibrin Enhance Healing Of Burn Wounds? Our First Experiences And Main Pitfalls. Ann Burns Fire Disasters. 31 Mart 2021;34(1):42-52.
O’Connell SM, Impeduglia T, Hessler K, Wang X, Carroll RJ, Dardik H. Autologous platelet‐rich fibrin matrix as cell therapy in the healing of chronic lower‐extremity ulcers. Wound Repair Regen. Kasım 2008;16(6):749-56.
Thorat M, Pradeep AR, Pallavi B. Clinical effect of autologous platelet-rich fibrin in the treatment of intra-bony defects: a controlled clinical trial: Platelet-rich fibrin and periodontal regeneration. J Clin Periodontol. Ekim 2011;38(10):925-32.
Choukroun J, Diss A, Simonpieri A, Girard MO, Schoeffler C, Dohan SL, vd. Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part IV: clinical effects on tissue healing. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. Mart 2006;101(3):e56-60.
Lee HJ, Choi BH, Jung JH, Zhu SJ, Lee SH, Huh JY, vd. Maxillary sinus floor augmentation using autogenous bone grafts and platelet-enriched fibrin glue with simultaneous implant placement. Oral Surg Oral Med Oral Pathol Oral Radiol Endodontology. Mart 2007;103(3):329-33.
Aroca S, Keglevich T, Barbieri B, Gera I, Etienne D. Clinical Evaluation of a Modified Coronally Advanced Flap Alone or in Combination With a Platelet‐Rich Fibrin Membrane for the Treatment of Adjacent Multiple Gingival Recessions: A 6‐Month Study. J Periodontol. Şubat 2009;80(2):244-52.
Sharma A, Pradeep AR. Autologous platelet-rich fibrin in the treatment of mandibular degree II furcation defects: a randomized clinical trial. J Periodontol. Ekim 2011;82(10):1396-403.
Dohan DM, Choukroun J, Diss A, Dohan SL, Dohan AJJ, Mouhyi J, vd. Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part I: technological concepts and evolution. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. Mart 2006;101(3):e37-44.
Altuntaş, Z., Gündeşlioğlu, A. Ö., İnce, B., Dadacı, M., vd. (2014). Trombositten Zengin Plazma, Trombositten Fakir Plazma, Trombositten Zengin Fibrin Kavramları, Yara İyileşmesindeki Biyolojik Rolleri ve Plastik Cerrahide Kullanım Alanları. Türk Plastik Rekonstrüktif ve Estetik Cerrahi Dergisi, 22(2), 49-53.
Conley CL. Conley CL. Hemostasis. In V. B. Mountcastle (Ed.), Medical Physiology. St. Louis: Mosby, 2004; 1137–46. 2004.
Bithell T. Bithell T. Wintrobe’s Clinical Hematology: Disorders of hemostasis and coagulation. Lea & Febiger; 1993. 1138 s. 1993.
Heldin CH, Westermark B. Mechanism of Action and In Vivo Role of Platelet-Derived Growth Factor. Physiol Rev. 10 Ocak 1999;79(4):1283-316.
Ghanaati S, Herrera-Vizcaino C, Al-Maawi S, Lorenz J, Miron RJ, Nelson K, vd. Fifteen Years of Platelet Rich Fibrin in Dentistry and Oromaxillofacial Surgery: How High is the Level of Scientific Evidence? J Oral Implantol. Aralık 2018;44(6):471-92.
Fujioka-Kobayashi M, Miron RJ, Hernandez M, Kandalam U, Zhang Y, Choukroun J. Optimized Platelet-Rich Fibrin With the Low-Speed Concept: Growth Factor Release, Biocompatibility, and Cellular Response. J Periodontol. Ocak 2017;88(1):112-21.
Toffler M. Toffler M, Toscano N, Holtzclaw D, Corso M, Dohan D (2009) Introducing Choukroun’s platelet rich fibrin (PRF) to the reconstructive surgery milieu. J Implant Adv Clin Dent 1:22–31. 2009;
Choukroun J. Choukroun J, Adda F, Schoeffler C, Vervelle A (2001) Une opportunité en paro-implantologie: le PRF. Implantodontie 42:e62. 2001.
Sammartino G, Tia M, Marenzi G, Espedito Di Lauro A, D’Agostino E, Claudio PP. Use of Autologous Platelet-Rich Plasma (PRP) in Periodontal Defect Treatment After Extraction of Impacted Mandibular Third Molars. J Oral Maxillofac Surg. Haziran 2005;63(6):766-70.
Taşkaldıran A, Koçyiğit İD, Tüz H, Tekin U, Atıl F. ve Trombositten Zengin Fibrinin Ağız, Çene ve Yüz Cerrahisinde Kullanım Alanı. J Clin. 2011;
Choukroun J, Diss A, Simonpieri A, Girard MO, Schoeffler C, Dohan SL, vd. Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part IV: clinical effects on tissue healing. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. Mart 2006;101(3):e56-60.
Choukroun J, Ghanaati S. Reduction of relative centrifugation force within injectable platelet-rich-fibrin (PRF) concentrates advances patients’ own inflammatory cells, platelets and growth factors: the first introduction to the low speed centrifugation concept. Eur J Trauma Emerg Surg Off Publ Eur Trauma Soc. Şubat 2018;44(1):87-95.
Kumar RV, Shubhashini N. Platelet rich fibrin: a new paradigm in periodontal regeneration. Cell Tissue Bank. Eylül 2013;14(3):453-63.
Pavlovic V, Ciric M, Jovanovic V, Trandafilovic M, Stojanovic P. Platelet-rich fibrin: Basics of biological actions and protocol modifications. Open Med. 22 Mart 2021;16(1):446-54.
Miron RJ, Chai J, Fujioka-Kobayashi M, Sculean A, Zhang Y. Evaluation of 24 protocols for the production of platelet-rich fibrin. BMC Oral Health. 07 Kasım 2020;20(1):310.
Pinto N, Quirynen M, et al. Letter to the editor regarding Fujioka- Kobayashi et al. 2017 (JOP-16-0443.R1). J Periodontol. 2018. 2017;
Miron RJ, Choukroun J, Ghanaati S. Reply from authors: RE: Optimized platelet-rich fibrin with the low-speed concept: Growth factor release, biocompatibility, and cellular response: Necessity for standardization of relative centrifugal force values in studies on platelet-rich fibrin. J Periodontol. Şubat 2019;90(2):122-5.
Choukroun J, Diss A, Simonpieri A, Girard MO, Schoeffler C, Dohan SL, vd. Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part V: histologic evaluations of PRF effects on bone allograft maturation in sinus lift. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. Mart 2006;101(3):299-303.
Dohan DM, Choukroun J, Diss A, Dohan SL, Dohan AJJ, Mouhyi J, vd. Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part III: leucocyte activation: a new feature for platelet concentrates? Oral Surg Oral Med Oral Pathol Oral Radiol Endod. Mart 2006;101(3):e51-55.
Dohan Ehrenfest DM, De Peppo GM, Doglioli P, Sammartino G. Slow release of growth factors and thrombospondin-1 in Choukroun’s platelet-rich fibrin (PRF): a gold standard to achieve for all surgical platelet concentrates technologies. Growth Factors. Ocak 2009;27(1):63-9.
Miron RJ, Chai J, Zheng S, Feng M, Sculean A, Zhang Y. A novel method for evaluating and quantifying cell types in platelet rich fibrin and an introduction to horizontal centrifugation. J Biomed Mater Res A. Ekim 2019;107(10):2257-71.
Kubesch A, Barbeck M, Al-Maawi S, Orlowska A, Booms PF, Sader RA, vd. A low-speed centrifugation concept leads to cell accumulation and vascularization of solid platelet-rich fibrin: an experimental study in vivo. Platelets. 03 Nisan 2019;30(3):329-40.
Feng M, Wang Y, Zhang P, Zhao Q, Yu S, Shen K, vd. Antibacterial effects of platelet-rich fibrin produced by horizontal centrifugation. Int J Oral Sci. 26 Kasım 2020;12(1):1-8.
Fujioka-Kobayashi M, Kono M, Katagiri H, Schaller B, Zhang Y, Sculean A, vd. Histological comparison of Platelet rich fibrin clots prepared by fixed-angle versus horizontal centrifugation. Platelets. 03 Nisan 2021;32(3):413-9.
Caruana A, Savina D, Macedo JP, Soares SC. From Platelet-Rich Plasma to Advanced Platelet-Rich Fibrin: Biological Achievements and Clinical Advances in Modern Surgery. Eur J Dent. Mayıs 2019;13(02):280-6.
Mourão CF de AB, Valiense H, Melo ER, Mourão NBMF, Maia MDC. Obtention of injectable platelets rich-fibrin (i-PRF) and its polymerization with bone graft: technical note. Rev Col Bras Cir. 2015;42(6):421-3.
Miron RJ, Fujioka-Kobayashi M, Hernandez M, Kandalam U, Zhang Y, Ghanaati S, vd. Injectable platelet rich fibrin (i-PRF): opportunities in regenerative dentistry? Clin Oral Investig. Kasım 2017;21(8):2619-27.
Karde PA, Sethi KS, Mahale SA, Khedkar SU, Patil AG, Joshi CP. Comparative evaluation of platelet count and antimicrobial efficacy of injectable platelet-rich fibrin with other platelet concentrates: An in vitro study. J Indian Soc Periodontol. 2017;21(2):97-101.
Braccini F, Dohan DM. [The relevance of Choukroun’s platelet rich fibrin (PRF) during facial aesthetic lipostructure (Coleman’s technique): preliminary results]. Rev Laryngol - Otol - Rhinol. 2007;128(4):255-60.
Arıkan F, Özçaka Ö, Bıçakçı N. Comparison of Platelet-Rich Plasma and Combine Use of Platelet-Rich Plasma with DFDBA Bone Grafting in the Treatment of Narrow Intrabony Defects. J Ege Univ Sch Dent. 2007;28(2):151-61.
Schulz A, Schiefer JL, Fuchs PC, Kanho CH, Nourah N, Heitzmann W. Does Platelet-Rich Fibrin Enhance Healing Of Burn Wounds? Our First Experiences And Main Pitfalls. Ann Burns Fire Disasters. 31 Mart 2021;34(1):42-52.
O’Connell SM, Impeduglia T, Hessler K, Wang X, Carroll RJ, Dardik H. Autologous platelet‐rich fibrin matrix as cell therapy in the healing of chronic lower‐extremity ulcers. Wound Repair Regen. Kasım 2008;16(6):749-56.
Thorat M, Pradeep AR, Pallavi B. Clinical effect of autologous platelet-rich fibrin in the treatment of intra-bony defects: a controlled clinical trial: Platelet-rich fibrin and periodontal regeneration. J Clin Periodontol. Ekim 2011;38(10):925-32.
Choukroun J, Diss A, Simonpieri A, Girard MO, Schoeffler C, Dohan SL, vd. Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part IV: clinical effects on tissue healing. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. Mart 2006;101(3):e56-60.
Lee HJ, Choi BH, Jung JH, Zhu SJ, Lee SH, Huh JY, vd. Maxillary sinus floor augmentation using autogenous bone grafts and platelet-enriched fibrin glue with simultaneous implant placement. Oral Surg Oral Med Oral Pathol Oral Radiol Endodontology. Mart 2007;103(3):329-33.
Aroca S, Keglevich T, Barbieri B, Gera I, Etienne D. Clinical Evaluation of a Modified Coronally Advanced Flap Alone or in Combination With a Platelet‐Rich Fibrin Membrane for the Treatment of Adjacent Multiple Gingival Recessions: A 6‐Month Study. J Periodontol. Şubat 2009;80(2):244-52.
Sharma A, Pradeep AR. Autologous platelet-rich fibrin in the treatment of mandibular degree II furcation defects: a randomized clinical trial. J Periodontol. Ekim 2011;82(10):1396-403.
Pages
71-80
Published
January 20, 2025
Copyright (c) 2025 Academician Publishing Book Portal
