Diyabet Periodontitis İlişkisi ve Güncel Tedavi Yaklaşımları
References
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Tsai C, Hayes C, Taylor GW. Glycemic control of type 2 diabetes and severe periodontal disease in the US adult population. Community Dent Oral Epidemiol. 2002 Jun;30(3):182–92.
Mealey BL, Ocampo GL. Diabetes mellitus and periodontal disease. Periodontol 2000. 2007 Jun;44(1):127–53.
Hodge PJ, Robertson D, Paterson K, Smith GLF, Creanor S, Sherriff A. Periodontitis in non-smoking type 1 diabetic adults: a cross-sectional study. J Clin Periodontol. 2012 Jan;39(1):20–9.
Lappin DF, Robertson D, Hodge P, Treagus D, Awang RA, Ramage G, et al. The Influence of Glycated Hemoglobin on the Cross Susceptibility Between Type 1 Diabetes Mellitus and Periodontal Disease. J Periodontol. 2015 Nov;86(11):1249–59.
Meenawat A, Punn K, Srivastava V, Meenawat AS, Dolas RS, Govila V. Periodontal disease and type I diabetes mellitus: Associations with glycemic control and complications. J Indian Soc Periodontol. 2013 Sep;17(5):597–600.
Winning L, Patterson CC, Neville CE, Kee F, Linden GJ. Periodontitis and incident type 2 diabetes: a prospective cohort study. J Clin Periodontol. 2017 Mar 1;44(3):266–74.
Polak D, Shapira L. An update on the evidence for pathogenic mechanisms that may link periodontitis and diabetes. J Clin Periodontol. 2018 Feb 1;45(2):150–66.
Bastos AS, Graves DT, Loureiro APDM, Júnior CR, Abdalla DSP, Faulin TDES, et al. Lipid peroxidation is associated with the severity of periodontal disease and local inflammatory markers in patients with type 2 diabetes. J Clin Endocrinol Metab. 2012 Aug;97(8).
Southerland JH, Taylor GW, Offenbacher S. Diabetes and periodontal infection: making the connection. Clinical Diabetes. 2005 Sep 22;23(4):171–9.
Salvi GE, Yalda B, Collins JG, Jones BH, Smith FW, Arnold RR, et al. Inflammatory mediator response as a potential risk marker for periodontal diseases in insulin-dependent diabetes mellitus patients. J Periodontol. 1997 Feb;68(2):127–35.
Salvi GE, Beck JD, Offenbacher S. PGE2, IL-1 beta, and TNF-alpha responses in diabetics as modifiers of periodontal disease expression. Ann Periodontol. 1998;3(1):40–50.
Graves DT, Ding Z, Yang Y. The impact of diabetes on periodontal diseases. Periodontol 2000. 2020 Feb 1;82(1):214–24.
Lalla E, Lamster IB, Feit M, Huang L, Spessot A, Qu W, et al. Blockade of RAGE suppresses periodontitis-associated bone loss in diabetic mice. J Clin Invest. 2000;105(8):1117–24.
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Sarkar PD, Choudhury AB. Relationship of serum osteocalcin levels with blood glucose, insulin resistance and lipid profile in central Indian men with type 2 diabetes. Arch Physiol Biochem. 2012 Dec;118(5):260–4.
Acharya AB, Thakur S, Muddapur M V., Kulkarni RD. Cytokine ratios in chronic periodontitis and type 2 diabetes mellitus. Diabetes Metab Syndr. 2017 Oct 1;11(4):277–8.
Van Dyke TE. Pro-resolving mediators in the regulation of periodontal disease. Mol Aspects Med. 2017 Dec 1;58:21–36.
Andriankaja OM, Galicia J, Dong G, Xiao W, Alawi F, Graves DT. Gene expression dynamics during diabetic periodontitis. J Dent Res. 2012 Dec;91(12):1160–5.
Groeger SE, Meyle J. Epithelial barrier and oral bacterial infection. Periodontol 2000. 2015 Oct 1;69(1):46–67.
Bartold PM, Walsh LJ, Narayanan AS. Molecular and cell biology of the gingiva. Periodontol 2000. 2000 Oct 1;24(1):28–55.
Açikgoz G, Devrim İ, Özdamar Ş. Comparison of keratinocyte proliferation in diabetic and non-diabetic inflamed gingiva. J Periodontol. 2004 Jul;75(7):989–94.
Lim JC, Ko KI, Mattos M, Fang M, Zhang C, Feinberg D, et al. TNFα contributes to diabetes impaired angiogenesis in fracture healing. Bone. 2017 Jun 1;99:26–38.
Zheng J, Chen S, Albiero ML, Vieira GHA, Wang J, Feng JQ, et al. Diabetes Activates Periodontal Ligament Fibroblasts via NF-κB In Vivo. J Dent Res. 2018 May 1;97(5):580–8.
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Coughlan MT, Sharma K. Challenging the dogma of mitochondrial reactive oxygen species overproduction in diabetic kidney disease. Kidney Int. 2016 Aug 1;90(2):272–9.
Susztak K, Raff AC, Schiffer M, Böttinger EP. Glucose-Induced Reactive Oxygen Species Cause Apoptosis of Podocytes and Podocyte Depletion at the Onset of Diabetic Nephropathy. Diabetes. 2006 Jan 1;55(1):225–33.
Yang X, Gandhi C, Rahman MDM, Appleford M, Sun LW, Wang X. Age-Related Effects of Advanced Glycation End Products (Ages) in Bone Matrix on Osteoclastic Resorption. Calcif Tissue Int. 2015 Jul 24;97(6):592–601.
Sun X, Mao Y, Dai P, Li X, Gu W, Wang H, et al. Mitochondrial dysfunction is involved in the aggravation of periodontitis by diabetes. J Clin Periodontol. 2017 May 1;44(5):463–71.
Shaker O, Ghallab NA, Hamdy E, Sayed S. Inducible nitric oxide synthase (iNOS) in gingival tissues of chronic periodontitis with and without diabetes: immunohistochemistry and RT-PCR study. Arch Oral Biol. 2013;58(10):1397–406.
Patil VS, Patil VP, Gokhale N, Acharya A, Kangokar P. Chronic Periodontitis in Type 2 Diabetes Mellitus: Oxidative Stress as a Common Factor in Periodontal Tissue Injury. J Clin Diagn Res. 2016 Apr 1;10(4):BC12–6.
Napoli N, Chandran M, Pierroz DD, Abrahamsen B, Schwartz A V., Ferrari SL. Mechanisms of diabetes mellitus-induced bone fragility. Nat Rev Endocrinol. 2017 Apr 1;13(4):208–19.
Kanazawa I, Sugimoto T. Diabetes Mellitus-induced Bone Fragility. Intern Med. 2018;57(19):2773–85.
Singh VP, Bali A, Singh N, Jaggi AS. Advanced glycation end products and diabetic complications. Korean J Physiol Pharmacol. 2014;18(1):1–14.
Lalla E, Lamster IB, Feit M, Huang L, Schmidt AM. A murine model of accelerated periodontal disease in diabetes. J Periodontal Res. 1998;33(7):387–99.
Nonaka K, Kajiura Y, Bando M, Sakamoto E, Inagaki Y, Lew JH, et al. Advanced glycation end-products increase IL-6 and ICAM-1 expression via RAGE, MAPK and NF-κB pathways in human gingival fibroblasts. J Periodontal Res. 2018 Jun 1;53(3):334–44.
Lalla E, Lamster IB, Hofmann MA, Bucciarelli L, Jerud AP, Tucker S, et al. Oral infection with a periodontal pathogen accelerates early atherosclerosis in apolipoprotein E-null mice. Arterioscler Thromb Vasc Biol. 2003 Aug 1;23(8):1405–11.
Karima M, Kantarci A, Ohira T, Hasturk H, Jones VL, Nam BH, et al. Enhanced superoxide release and elevated protein kinase C activity in neutrophils from diabetic patients: association with periodontitis. J Leukoc Biol. 2005 Aug 4;78(4):862–70.
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Tsai C, Hayes C, Taylor GW. Glycemic control of type 2 diabetes and severe periodontal disease in the US adult population. Community Dent Oral Epidemiol. 2002 Jun;30(3):182–92.
Mealey BL, Ocampo GL. Diabetes mellitus and periodontal disease. Periodontol 2000. 2007 Jun;44(1):127–53.
Hodge PJ, Robertson D, Paterson K, Smith GLF, Creanor S, Sherriff A. Periodontitis in non-smoking type 1 diabetic adults: a cross-sectional study. J Clin Periodontol. 2012 Jan;39(1):20–9.
Lappin DF, Robertson D, Hodge P, Treagus D, Awang RA, Ramage G, et al. The Influence of Glycated Hemoglobin on the Cross Susceptibility Between Type 1 Diabetes Mellitus and Periodontal Disease. J Periodontol. 2015 Nov;86(11):1249–59.
Meenawat A, Punn K, Srivastava V, Meenawat AS, Dolas RS, Govila V. Periodontal disease and type I diabetes mellitus: Associations with glycemic control and complications. J Indian Soc Periodontol. 2013 Sep;17(5):597–600.
Winning L, Patterson CC, Neville CE, Kee F, Linden GJ. Periodontitis and incident type 2 diabetes: a prospective cohort study. J Clin Periodontol. 2017 Mar 1;44(3):266–74.
Polak D, Shapira L. An update on the evidence for pathogenic mechanisms that may link periodontitis and diabetes. J Clin Periodontol. 2018 Feb 1;45(2):150–66.
Bastos AS, Graves DT, Loureiro APDM, Júnior CR, Abdalla DSP, Faulin TDES, et al. Lipid peroxidation is associated with the severity of periodontal disease and local inflammatory markers in patients with type 2 diabetes. J Clin Endocrinol Metab. 2012 Aug;97(8).
Southerland JH, Taylor GW, Offenbacher S. Diabetes and periodontal infection: making the connection. Clinical Diabetes. 2005 Sep 22;23(4):171–9.
Salvi GE, Yalda B, Collins JG, Jones BH, Smith FW, Arnold RR, et al. Inflammatory mediator response as a potential risk marker for periodontal diseases in insulin-dependent diabetes mellitus patients. J Periodontol. 1997 Feb;68(2):127–35.
Salvi GE, Beck JD, Offenbacher S. PGE2, IL-1 beta, and TNF-alpha responses in diabetics as modifiers of periodontal disease expression. Ann Periodontol. 1998;3(1):40–50.
Graves DT, Ding Z, Yang Y. The impact of diabetes on periodontal diseases. Periodontol 2000. 2020 Feb 1;82(1):214–24.
Lalla E, Lamster IB, Feit M, Huang L, Spessot A, Qu W, et al. Blockade of RAGE suppresses periodontitis-associated bone loss in diabetic mice. J Clin Invest. 2000;105(8):1117–24.
Pacios S, Andriankaja O, Kang J, Alnammary M, Bae J, De Brito Bezerra B, et al. Bacterial infection increases periodontal bone loss in diabetic rats through enhanced apoptosis. Am J Pathol. 2013 Dec;183(6):1928–35.
Pacios S, Kang J, Galicia J, Gluck K, Patel H, Ovaydi‐Mandel A, et al. Diabetes aggravates periodontitis by limiting repair through enhanced inflammation. FASEB J. 2012 Apr;26(4):1423–30.
Xiao W, Wang Y, Pacios S, Li S, Graves DT. Cellular and Molecular Aspects of Bone Remodeling. Front Oral Biol. 2016;18:9–16.
Sarkar PD, Choudhury AB. Relationship of serum osteocalcin levels with blood glucose, insulin resistance and lipid profile in central Indian men with type 2 diabetes. Arch Physiol Biochem. 2012 Dec;118(5):260–4.
Acharya AB, Thakur S, Muddapur M V., Kulkarni RD. Cytokine ratios in chronic periodontitis and type 2 diabetes mellitus. Diabetes Metab Syndr. 2017 Oct 1;11(4):277–8.
Van Dyke TE. Pro-resolving mediators in the regulation of periodontal disease. Mol Aspects Med. 2017 Dec 1;58:21–36.
Andriankaja OM, Galicia J, Dong G, Xiao W, Alawi F, Graves DT. Gene expression dynamics during diabetic periodontitis. J Dent Res. 2012 Dec;91(12):1160–5.
Groeger SE, Meyle J. Epithelial barrier and oral bacterial infection. Periodontol 2000. 2015 Oct 1;69(1):46–67.
Bartold PM, Walsh LJ, Narayanan AS. Molecular and cell biology of the gingiva. Periodontol 2000. 2000 Oct 1;24(1):28–55.
Açikgoz G, Devrim İ, Özdamar Ş. Comparison of keratinocyte proliferation in diabetic and non-diabetic inflamed gingiva. J Periodontol. 2004 Jul;75(7):989–94.
Lim JC, Ko KI, Mattos M, Fang M, Zhang C, Feinberg D, et al. TNFα contributes to diabetes impaired angiogenesis in fracture healing. Bone. 2017 Jun 1;99:26–38.
Zheng J, Chen S, Albiero ML, Vieira GHA, Wang J, Feng JQ, et al. Diabetes Activates Periodontal Ligament Fibroblasts via NF-κB In Vivo. J Dent Res. 2018 May 1;97(5):580–8.
Fakhruddin S, Alanazi W, Jackson KE. Diabetes-Induced Reactive Oxygen Species: Mechanism of Their Generation and Role in Renal Injury. J Diabetes Res. 2017;2017.
Coughlan MT, Sharma K. Challenging the dogma of mitochondrial reactive oxygen species overproduction in diabetic kidney disease. Kidney Int. 2016 Aug 1;90(2):272–9.
Susztak K, Raff AC, Schiffer M, Böttinger EP. Glucose-Induced Reactive Oxygen Species Cause Apoptosis of Podocytes and Podocyte Depletion at the Onset of Diabetic Nephropathy. Diabetes. 2006 Jan 1;55(1):225–33.
Yang X, Gandhi C, Rahman MDM, Appleford M, Sun LW, Wang X. Age-Related Effects of Advanced Glycation End Products (Ages) in Bone Matrix on Osteoclastic Resorption. Calcif Tissue Int. 2015 Jul 24;97(6):592–601.
Sun X, Mao Y, Dai P, Li X, Gu W, Wang H, et al. Mitochondrial dysfunction is involved in the aggravation of periodontitis by diabetes. J Clin Periodontol. 2017 May 1;44(5):463–71.
Shaker O, Ghallab NA, Hamdy E, Sayed S. Inducible nitric oxide synthase (iNOS) in gingival tissues of chronic periodontitis with and without diabetes: immunohistochemistry and RT-PCR study. Arch Oral Biol. 2013;58(10):1397–406.
Patil VS, Patil VP, Gokhale N, Acharya A, Kangokar P. Chronic Periodontitis in Type 2 Diabetes Mellitus: Oxidative Stress as a Common Factor in Periodontal Tissue Injury. J Clin Diagn Res. 2016 Apr 1;10(4):BC12–6.
Napoli N, Chandran M, Pierroz DD, Abrahamsen B, Schwartz A V., Ferrari SL. Mechanisms of diabetes mellitus-induced bone fragility. Nat Rev Endocrinol. 2017 Apr 1;13(4):208–19.
Kanazawa I, Sugimoto T. Diabetes Mellitus-induced Bone Fragility. Intern Med. 2018;57(19):2773–85.
Singh VP, Bali A, Singh N, Jaggi AS. Advanced glycation end products and diabetic complications. Korean J Physiol Pharmacol. 2014;18(1):1–14.
Lalla E, Lamster IB, Feit M, Huang L, Schmidt AM. A murine model of accelerated periodontal disease in diabetes. J Periodontal Res. 1998;33(7):387–99.
Nonaka K, Kajiura Y, Bando M, Sakamoto E, Inagaki Y, Lew JH, et al. Advanced glycation end-products increase IL-6 and ICAM-1 expression via RAGE, MAPK and NF-κB pathways in human gingival fibroblasts. J Periodontal Res. 2018 Jun 1;53(3):334–44.
Lalla E, Lamster IB, Hofmann MA, Bucciarelli L, Jerud AP, Tucker S, et al. Oral infection with a periodontal pathogen accelerates early atherosclerosis in apolipoprotein E-null mice. Arterioscler Thromb Vasc Biol. 2003 Aug 1;23(8):1405–11.
Karima M, Kantarci A, Ohira T, Hasturk H, Jones VL, Nam BH, et al. Enhanced superoxide release and elevated protein kinase C activity in neutrophils from diabetic patients: association with periodontitis. J Leukoc Biol. 2005 Aug 4;78(4):862–70.
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Published
January 17, 2025
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