Transplante Hastaya Yaklaşım
Synopsis
Organ nakilli hastalar değişen anatomi, denerve allograft ve immünosupresyonuna bağlı olarak sıklıkla transplantasyon ilişkili sebeplerden ötürü acil servislere başvurmaktadır. Bu hastalar transplantasyon ilişkisiz sebeplerden ötürü başvursalar dahi tedavileri planlanırken, bu hastaların farklılıklarını, verilecek olası ilaçların hastalardaki etkilerini bilmek ve olası ilaç etkileşimlerine karşı farkındalığın yüksek olması gerekir. Bu hastalarda en korkulan iki sorun enfeksiyon ve rejeksiyondur. Şüphe eşiğini düşük tutmak gerekir ve ihtiyaç halinde mutlaka transplantasyon ekibiyle ve enfeksiyon hastalıklarlarıyla beraber süreç multidisipliner olarak yürütülmelidir.
References
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Long B, Koyfman A. The emergency medicine approach to transplant complications. Am J Emerg Med. 2016;34(11):2200-8.
Gökçe ON, Alkan S. Contribution of Turkey in Liver Transplant Research: A Scopus Database Search. Experimental and Clinical Transplantation: Official Journal of the Middle East Society for Organ Transplantation. 2022.
Organ Procurement & Transplantation Network. 2022 organ transplants again set annual records. (30.09.2023 tarihinde https://optn.transplant.hrsa.gov/news/2022-organ-transplants-again-set-annual-records-organ-donation-from-deceased-donors-continues-12-year-record-setting-trend/ adresinden ulaşılmıştır).
Long B. The Transplant Patient. Tintinalli JE (ed.) Tintinalli's Emergency Medicine: A Comprehensive Study Guide, 9e içinde. McGraw Hill; 2019: p. 1984-1994.
Chhabra D et al. Assesment and Management of the Kidney Transplant Patient. (30.09.2023 tarihinde https://emedicine.medscape.com/article/429314-overview#a1 adresinden ulaşılmıştır).
Fishman JA. Infection in solid-organ transplant recipients. N Engl J Med. 2007;357(25):2601-14.
Fishman JA, Rubin RH. Infection in organ-transplant recipients. N Engl J Med. 1998;338(24):1741-51.
Green M. Introduction: infections in solid organ transplantation. Am J Transplant. 2013;13:3-8.
Fishman JA. Infection in Organ Transplantation. Am J Transplant. 2017;17(4):856-79.
Cimino FM, Snyder KA. Primary Care of the Solid Organ Transplant Recipient. Am Fam Physician. 2016;93(3):203-10.
Ramachandran V, Kolli SS, Strowd LC. Review of Graft-Versus-Host Disease. Dermatol Clin. 2019;37(4):569-82.
Ferrara JL, Levine JE, Reddy P, Holler E. Graft-versus-host disease. The Lancet. 2009;373(9674):1550-61.
Rühl H, Bein G, Sachs UJ. Transfusion-associated graft-versus-host disease. Transfus Med Rev. 2009;23(1):62-71.
Vincenti F. Immunosuppression minimization: current and future trends in transplant immunosuppression. J Am Soc Nephrol. 2003;14(7):1940-8.
Cozzi E, Colpo A, De Silvestro G. The mechanisms of rejection in solid organ transplantation. Transfus Apher Sci. 2017;56(4):498-505.
Suthanthiran M, Strom TB. Renal transplantation. N Engl J Med. 1994;331(6):365-76.
Venkat K, Venkat A. Care of the renal transplant recipient in the emergency department. Ann Emerg Med. 2004;44(4):330-41.
Unterman S, Zimmerman M, Tyo C, Sterk E, Gehm L, Edison M, et al. A descriptive analysis of 1251 solid organ transplant visits to the emergency department. West J Emerg Med. 2009;10(1):48.
Chapman JR, O'Connell PJ, Nankivell BJ. Chronic renal allograft dysfunction. J Am Soc Nephrol. 2005;16(10):3015-26.
Savitsky EA, Votey SR, Mebust DP, Schwartz E, Uner AB, McCain S. A descriptive analysis of 290 liver transplant patient visits to an emergency department. Acad Emerg Med. 2000;7(8):898-905.
Gür A, Oguzturk H, Kose A, Turtay MG, Ersan V, Bayindir Y, et al. Prognostic Value of Procalcitonin, CRP, Serum Amyloid A, Lactate and IL-6 Markers in Liver Transplant Patients Admitted to ED with Suspected Infection. In Vivo. 2017;31(6):1179-85.
Mohseni MM, Li Z, Simon LV. Emergency department visits among lung transplant patients: a 4-year experience. The Journal of Emergency Medicine. 2021;60(2):150-7.
Dabbs ADV, Hoffman LA, Iacono AT, Zullo TG, McCurry KR, Dauber JH. Are symptom reports useful for differentiating between acute rejection and pulmonary infection after lung transplantation? Heart Lung. 2004;33(6):372-80.
Mancini D, Lietz K. Selection of cardiac transplantation candidates in 2010. Circulation. 2010;122(2):173-83.
Awad M, Czer LS, Hou M, Golshani SS, Goltche M, De Robertis M, et al. Early Denervation and Later Reinnervation of the Heart Following Cardiac Transplantation: A Review. J Am Heart Assoc. 2016;5(11).
McCartney SL, Patel C, Del Rio JM. Long-term outcomes and management of the heart transplant recipient. Best Pract Res Clin Anaesthesiol. 2017;31(2):237-48.
Singh R, Gupta N, Vanathi M, Tandon R. Corneal transplantation in the modern era. The Indian journal of medical research. 2019;150(1):7.
Azevedo Magalhaes O, Shalaby Bardan A, Zarei-Ghanavati M, Liu C. Literature review and suggested protocol for prevention and treatment of corneal graft rejection. Eye. 2020;34(3):442-50.
Long B, Koyfman A. The emergency medicine approach to transplant complications. Am J Emerg Med. 2016;34(11):2200-8.
Gökçe ON, Alkan S. Contribution of Turkey in Liver Transplant Research: A Scopus Database Search. Experimental and Clinical Transplantation: Official Journal of the Middle East Society for Organ Transplantation. 2022.
Organ Procurement & Transplantation Network. 2022 organ transplants again set annual records. (30.09.2023 tarihinde https://optn.transplant.hrsa.gov/news/2022-organ-transplants-again-set-annual-records-organ-donation-from-deceased-donors-continues-12-year-record-setting-trend/ adresinden ulaşılmıştır).
Long B. The Transplant Patient. Tintinalli JE (ed.) Tintinalli's Emergency Medicine: A Comprehensive Study Guide, 9e içinde. McGraw Hill; 2019: p. 1984-1994.
Chhabra D et al. Assesment and Management of the Kidney Transplant Patient. (30.09.2023 tarihinde https://emedicine.medscape.com/article/429314-overview#a1 adresinden ulaşılmıştır).
Fishman JA. Infection in solid-organ transplant recipients. N Engl J Med. 2007;357(25):2601-14.
Fishman JA, Rubin RH. Infection in organ-transplant recipients. N Engl J Med. 1998;338(24):1741-51.
Green M. Introduction: infections in solid organ transplantation. Am J Transplant. 2013;13:3-8.
Fishman JA. Infection in Organ Transplantation. Am J Transplant. 2017;17(4):856-79.
Cimino FM, Snyder KA. Primary Care of the Solid Organ Transplant Recipient. Am Fam Physician. 2016;93(3):203-10.
Ramachandran V, Kolli SS, Strowd LC. Review of Graft-Versus-Host Disease. Dermatol Clin. 2019;37(4):569-82.
Ferrara JL, Levine JE, Reddy P, Holler E. Graft-versus-host disease. The Lancet. 2009;373(9674):1550-61.
Rühl H, Bein G, Sachs UJ. Transfusion-associated graft-versus-host disease. Transfus Med Rev. 2009;23(1):62-71.
Vincenti F. Immunosuppression minimization: current and future trends in transplant immunosuppression. J Am Soc Nephrol. 2003;14(7):1940-8.
Cozzi E, Colpo A, De Silvestro G. The mechanisms of rejection in solid organ transplantation. Transfus Apher Sci. 2017;56(4):498-505.
Suthanthiran M, Strom TB. Renal transplantation. N Engl J Med. 1994;331(6):365-76.
Venkat K, Venkat A. Care of the renal transplant recipient in the emergency department. Ann Emerg Med. 2004;44(4):330-41.
Unterman S, Zimmerman M, Tyo C, Sterk E, Gehm L, Edison M, et al. A descriptive analysis of 1251 solid organ transplant visits to the emergency department. West J Emerg Med. 2009;10(1):48.
Chapman JR, O'Connell PJ, Nankivell BJ. Chronic renal allograft dysfunction. J Am Soc Nephrol. 2005;16(10):3015-26.
Savitsky EA, Votey SR, Mebust DP, Schwartz E, Uner AB, McCain S. A descriptive analysis of 290 liver transplant patient visits to an emergency department. Acad Emerg Med. 2000;7(8):898-905.
Gür A, Oguzturk H, Kose A, Turtay MG, Ersan V, Bayindir Y, et al. Prognostic Value of Procalcitonin, CRP, Serum Amyloid A, Lactate and IL-6 Markers in Liver Transplant Patients Admitted to ED with Suspected Infection. In Vivo. 2017;31(6):1179-85.
Mohseni MM, Li Z, Simon LV. Emergency department visits among lung transplant patients: a 4-year experience. The Journal of Emergency Medicine. 2021;60(2):150-7.
Dabbs ADV, Hoffman LA, Iacono AT, Zullo TG, McCurry KR, Dauber JH. Are symptom reports useful for differentiating between acute rejection and pulmonary infection after lung transplantation? Heart Lung. 2004;33(6):372-80.
Mancini D, Lietz K. Selection of cardiac transplantation candidates in 2010. Circulation. 2010;122(2):173-83.
Awad M, Czer LS, Hou M, Golshani SS, Goltche M, De Robertis M, et al. Early Denervation and Later Reinnervation of the Heart Following Cardiac Transplantation: A Review. J Am Heart Assoc. 2016;5(11).
McCartney SL, Patel C, Del Rio JM. Long-term outcomes and management of the heart transplant recipient. Best Pract Res Clin Anaesthesiol. 2017;31(2):237-48.
Singh R, Gupta N, Vanathi M, Tandon R. Corneal transplantation in the modern era. The Indian journal of medical research. 2019;150(1):7.
Azevedo Magalhaes O, Shalaby Bardan A, Zarei-Ghanavati M, Liu C. Literature review and suggested protocol for prevention and treatment of corneal graft rejection. Eye. 2020;34(3):442-50.
Volume
Pages
377-386
Published
May 3, 2024
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1.
Kudu E. Transplante Hastaya Yaklaşım. In: Akman C, Karcıoğlu Ö, editors. Dahili Aciller [Internet]. Türkiye: Academician Publishing Book DOI Portal; 2024 [cited 2026 Jul. 13]. pp. 377-86. Available from: https://omp35.books.akademisyen.net/index.php/akya/catalog/book/3074/chapter/13188
