Vitamin B12 Eksikliği ile Takip Edilen Çocuk Hastaların Retrospektif İncelenmesi
Synopsis
Bu çalışmada, hastanemiz hematoloji polikliniğinde vitamin B12 eksikliği tanısıyla takipli hastaların sıklığı, demografik özellikleri, eksiklik nedenleri, eşlik eden hastalıkları, klinik ve laboratuar özelliklerinin incelenmesi ve tedavi sonuçlarının değerlendirilmesi amaçlanmıştır.
Hematoloji polikliniğinde vitamin B12 eksikliği tanısıyla takip ve tedavi edilen 0-18 yaş grubu hastaların dosyası geriye dönük olarak incelenerek literatürle karşılaştırma yapılmıştır.
Bu çalışmada vitamin B12 eksikliğinin infant çağında yoğunlaşması bu yaş grubunun risk altında olduğuna işaret etmektedir. Yine emilim bozukluğuna yol açan gastrit gibi hastalıkların çocuklarda vitamin B12 eksikliğine yol açabileceği gözlenmiştir.
References
Smith AD, Warren MJ, Refsum H. Vitamin B(12). Adv Food Nutr Res. 2018;83:215-79.
Rasmussen SA, Fernhoff PM, Scanlon KS. Vitamin B12 deficiency in children and adolescents. J Pediatr. 2001;138(1):10-7.
Cuevas-Nasu L, Mundo-Rosas V, Shamah-Levy T, Méndez-Gómez Humaran I, Avila-Arcos MA, Rebollar-Campos Mdel R, et al. Prevalence of folate and vitamin B12 deficiency in Mexican children aged 1 to 6 years in a population-based survey. Salud Publica Mex. 2012;54(2):116-24.
Langan RC, Goodbred AJ. Vitamin B12 Deficiency: Recognition and Management. Am Fam Physician. 2017;96(6):384-9.
Hunt A, Harrington D, Robinson S. Vitamin B12 deficiency. Bmj. 2014;349:g5226.
Aguirre JA, Donato ML, Buscio M, Ceballos V, Armeno M, Aizpurúa L, et al. [Serious neurological compromise due to vitamin B12 deficiency in infants of vegan and vegetarian mothers]. Arch Argent Pediatr. 2019;117(4):e420-e4.
Boran P, Yildirim S, Karakoc-Aydiner E, Ogulur I, Ozen A, Haklar G, et al. Vitamin B12 deficiency among asymptomatic healthy infants: its impact on the immune system. Minerva Pediatr (Torino). 2021;73(1):59-66.
Tanner SM, Li Z, Perko JD, Oner C, Cetin M, Altay C, et al. Hereditary juvenile cobalamin deficiency caused by mutations in the intrinsic factor gene. Proc Natl Acad Sci U S A. 2005;102(11):4130-3.
Finkelstein JL, Fothergill A, Krisher JT, Thomas T, Kurpad AV, Dwarkanath P. Maternal vitamin B12 deficiency and perinatal outcomes in southern India. PLoS One. 2021;16(4):e0248145.
Goraya JS, Kaur S. Vitamin B(12) deficiency in mothers and children: risk of neuro-regression. Paediatr Int Child Health. 2023;43(4):50-6.
Tangney CC, Tang Y, Evans DA, Morris MC. Biochemical indicators of vitamin B12 and folate insufficiency and cognitive decline. Neurology. 2009;72(4):361-7.
Serin HM, Arslan EA. Neurological symptoms of vitamin B12 deficiency: analysis of pediatric patients. Acta Clin Croat. 2019;58(2):295-302.
Arıcan P, Bozkurt O, Cavusoglu D, Gencpınar P, Haspolat S, Duman O, et al. Various Neurological Symptoms with Vitamin B12 Deficiency and Posttreatment Evaluation. J Pediatr Neurosci. 2020;15(4):365-9.
Hasbaoui BE, Mebrouk N, Saghir S, Yajouri AE, Abilkassem R, Agadr A. Vitamin B12 deficiency: case report and review of literature. Pan Afr Med J. 2021;38:237.
Silva LL, Fawzi WW, Cardoso MA. Serum folate and vitamin B12 status in young Brazilian children. Public Health Nutr. 2019;22(7):1223-31.
Stopeck A. Links between Helicobacter pylori infection, cobalamin deficiency, and pernicious anemia. Arch Intern Med. 2000;160(9):1229-30.
Santambrogio E, Orsucci L. Helicobacter pylori and hematological disorders. Minerva Gastroenterol Dietol. 2019;65(3):204-13.
Yakoob J, Jafri W, Abid S. Helicobacter pylori infection and micronutrient deficiencies. World J Gastroenterol. 2003;9(10):2137-9.
Kurekci AE, Atay AA, Sarici SU, Yesilkaya E, Senses Z, Okutan V, et al. Is there a relationship between childhood Helicobacter pylori infection and iron deficiency anemia? J Trop Pediatr. 2005;51(3):166-9.
Jensen CF. Vitamin B12 levels in children and adolescents on plant-based diets: a systematic review and meta-analysis. Nutr Rev. 2023;81(8):951-66.
Elgormus Y, Okuyan O, Dumur S, Sayili U, Uzun H. The Epidemiology of Deficiency of Vitamin B12 in Preschool Children in Turkey. Medicina (Kaunas). 2023;59(10).
Wong E, Molina-Cruz R, Rose C, Bailey L, Kauwell GPA, Rosenthal J. Prevalence and Disparities in Folate and Vitamin B12 Deficiency Among Preschool Children in Guatemala. Matern Child Health J. 2022;26(1):156-67.
Altuntaş N, Soylu K, Suskan E, Akar N. Homocysteine levels in Turkish children. Turk J Haematol. 2004;21(2):79-82.
P L. Manual of Pediatric Hematology and Oncology. . 5th ed. New York Academic Press; 2011. 28 p.
Biancheri R, Cerone R, Schiaffino MC, Caruso U, Veneselli E, Perrone MV, et al. Cobalamin (Cbl) C/D deficiency: clinical, neurophysiological and neuroradiologic findings in 14 cases. Neuropediatrics. 2001;32(1):14-22.
Tandon R, Thacker J, Pandya U, Patel M, Tandon K. Parenteral vs Oral Vitamin B12 in Children With Nutritional Macrocytic Anemia: A Randomized Controlled Trial. Indian Pediatr. 2022;59(9):683-7.
Siekmann JH, Allen LH, Bwibo NO, Demment MW, Murphy SP, Neumann CG. Kenyan school children have multiple micronutrient deficiencies, but increased plasma vitamin B-12 is the only detectable micronutrient response to meat or milk supplementation. J Nutr. 2003;133(11 Suppl 2):3972s-80s.
Akcaboy M, Malbora B, Zorlu P, Altınel E, Oguz MM, Senel S. Vitamin B12 Deficiency in Infants. Indian J Pediatr. 2015;82(7):619-24.
Cetinkaya F, Yildirmak Y, Kutluk G, Erdem E. Nutritional vitamin B12 deficiency in hospitalized young children. Pediatr Hematol Oncol. 2007;24(1):15-21.
Açkurt F, Wetherilt H, Löker M, Hacibekiroğlu M. Biochemical assessment of nutritional status in pre- and post-natal Turkish women and outcome of pregnancy. Eur J Clin Nutr. 1995;49(8):613-22.
Snow CF. Laboratory diagnosis of vitamin B12 and folate deficiency: a guide for the primary care physician. Arch Intern Med. 1999;159(12):1289-98.
Mills AE. Megaloblastic anaemia with normal mean cell volume. Cent Afr J Med. 1981;27(1):11-2.
Savage DG, Lindenbaum J, Stabler SP, Allen RH. Sensitivity of serum methylmalonic acid and total homocysteine determinations for diagnosing cobalamin and folate deficiencies. Am J Med. 1994;96(3):239-46.
Bay A, Öner AF, Nalbantoğlu Ö, Demirtaş M, Açıkgöz M. Megaloblastik anemili 45 olgunun klinik ve hematolojik yönden değerlendirilmesi. Van Tıp Dergisi. 2006;13(2):46-8.
Taskesen M, Okur N, Katar S, Okur N, Soker M. Nutritional megaloblastic anemia during childhood: Demographical, clinical and laboratory features of 134 patients from southeastern part of Turkey. e-SPEN, the European e-Journal of Clinical Nutrition and Metabolism. 2009;4(3):e152-e4.
Sezgin Evim M, Erdöl Ş, Özdemir Ö, Baytan B, Güneş AM. Long-term outcome in children with nutritional vitamin B12 deficiency. Turk J Haematol. 2011;28(4):286-93.
Zengin E, Sarper N, Caki Kiliç S. Clinical manifestations of infants with nutritional vitamin B deficiency due to maternal dietary deficiency. Acta Paediatr. 2009;98(1):98-102.
Akcam M, Ozdem S, Yilmaz A, Gultekin M, Artan R. Serum ferritin, vitamin B(12), folate, and zinc levels in children infected with Helicobacter pylori. Dig Dis Sci. 2007;52(2):405-10.
Chandelia S, Chandra J, Narayan S, Aneja S, Chawla HM, Sharma S, et al. Addition of cobalamin to iron and folic acid improves hemoglobin rise in nutritional anemia. Indian J Pediatr. 2012;79(12):1592-6.
Sezer RG, Bozaykut A, Akoğlu HA, Özdemir GN. The Efficacy of Oral Vitamin B12 Replacement for Nutritional Vitamin B12 Deficiency. J Pediatr Hematol Oncol. 2018;40(2):e69-e72.
Rasmussen SA, Fernhoff PM, Scanlon KS. Vitamin B12 deficiency in children and adolescents. J Pediatr. 2001;138(1):10-7.
Cuevas-Nasu L, Mundo-Rosas V, Shamah-Levy T, Méndez-Gómez Humaran I, Avila-Arcos MA, Rebollar-Campos Mdel R, et al. Prevalence of folate and vitamin B12 deficiency in Mexican children aged 1 to 6 years in a population-based survey. Salud Publica Mex. 2012;54(2):116-24.
Langan RC, Goodbred AJ. Vitamin B12 Deficiency: Recognition and Management. Am Fam Physician. 2017;96(6):384-9.
Hunt A, Harrington D, Robinson S. Vitamin B12 deficiency. Bmj. 2014;349:g5226.
Aguirre JA, Donato ML, Buscio M, Ceballos V, Armeno M, Aizpurúa L, et al. [Serious neurological compromise due to vitamin B12 deficiency in infants of vegan and vegetarian mothers]. Arch Argent Pediatr. 2019;117(4):e420-e4.
Boran P, Yildirim S, Karakoc-Aydiner E, Ogulur I, Ozen A, Haklar G, et al. Vitamin B12 deficiency among asymptomatic healthy infants: its impact on the immune system. Minerva Pediatr (Torino). 2021;73(1):59-66.
Tanner SM, Li Z, Perko JD, Oner C, Cetin M, Altay C, et al. Hereditary juvenile cobalamin deficiency caused by mutations in the intrinsic factor gene. Proc Natl Acad Sci U S A. 2005;102(11):4130-3.
Finkelstein JL, Fothergill A, Krisher JT, Thomas T, Kurpad AV, Dwarkanath P. Maternal vitamin B12 deficiency and perinatal outcomes in southern India. PLoS One. 2021;16(4):e0248145.
Goraya JS, Kaur S. Vitamin B(12) deficiency in mothers and children: risk of neuro-regression. Paediatr Int Child Health. 2023;43(4):50-6.
Tangney CC, Tang Y, Evans DA, Morris MC. Biochemical indicators of vitamin B12 and folate insufficiency and cognitive decline. Neurology. 2009;72(4):361-7.
Serin HM, Arslan EA. Neurological symptoms of vitamin B12 deficiency: analysis of pediatric patients. Acta Clin Croat. 2019;58(2):295-302.
Arıcan P, Bozkurt O, Cavusoglu D, Gencpınar P, Haspolat S, Duman O, et al. Various Neurological Symptoms with Vitamin B12 Deficiency and Posttreatment Evaluation. J Pediatr Neurosci. 2020;15(4):365-9.
Hasbaoui BE, Mebrouk N, Saghir S, Yajouri AE, Abilkassem R, Agadr A. Vitamin B12 deficiency: case report and review of literature. Pan Afr Med J. 2021;38:237.
Silva LL, Fawzi WW, Cardoso MA. Serum folate and vitamin B12 status in young Brazilian children. Public Health Nutr. 2019;22(7):1223-31.
Stopeck A. Links between Helicobacter pylori infection, cobalamin deficiency, and pernicious anemia. Arch Intern Med. 2000;160(9):1229-30.
Santambrogio E, Orsucci L. Helicobacter pylori and hematological disorders. Minerva Gastroenterol Dietol. 2019;65(3):204-13.
Yakoob J, Jafri W, Abid S. Helicobacter pylori infection and micronutrient deficiencies. World J Gastroenterol. 2003;9(10):2137-9.
Kurekci AE, Atay AA, Sarici SU, Yesilkaya E, Senses Z, Okutan V, et al. Is there a relationship between childhood Helicobacter pylori infection and iron deficiency anemia? J Trop Pediatr. 2005;51(3):166-9.
Jensen CF. Vitamin B12 levels in children and adolescents on plant-based diets: a systematic review and meta-analysis. Nutr Rev. 2023;81(8):951-66.
Elgormus Y, Okuyan O, Dumur S, Sayili U, Uzun H. The Epidemiology of Deficiency of Vitamin B12 in Preschool Children in Turkey. Medicina (Kaunas). 2023;59(10).
Wong E, Molina-Cruz R, Rose C, Bailey L, Kauwell GPA, Rosenthal J. Prevalence and Disparities in Folate and Vitamin B12 Deficiency Among Preschool Children in Guatemala. Matern Child Health J. 2022;26(1):156-67.
Altuntaş N, Soylu K, Suskan E, Akar N. Homocysteine levels in Turkish children. Turk J Haematol. 2004;21(2):79-82.
P L. Manual of Pediatric Hematology and Oncology. . 5th ed. New York Academic Press; 2011. 28 p.
Biancheri R, Cerone R, Schiaffino MC, Caruso U, Veneselli E, Perrone MV, et al. Cobalamin (Cbl) C/D deficiency: clinical, neurophysiological and neuroradiologic findings in 14 cases. Neuropediatrics. 2001;32(1):14-22.
Tandon R, Thacker J, Pandya U, Patel M, Tandon K. Parenteral vs Oral Vitamin B12 in Children With Nutritional Macrocytic Anemia: A Randomized Controlled Trial. Indian Pediatr. 2022;59(9):683-7.
Siekmann JH, Allen LH, Bwibo NO, Demment MW, Murphy SP, Neumann CG. Kenyan school children have multiple micronutrient deficiencies, but increased plasma vitamin B-12 is the only detectable micronutrient response to meat or milk supplementation. J Nutr. 2003;133(11 Suppl 2):3972s-80s.
Akcaboy M, Malbora B, Zorlu P, Altınel E, Oguz MM, Senel S. Vitamin B12 Deficiency in Infants. Indian J Pediatr. 2015;82(7):619-24.
Cetinkaya F, Yildirmak Y, Kutluk G, Erdem E. Nutritional vitamin B12 deficiency in hospitalized young children. Pediatr Hematol Oncol. 2007;24(1):15-21.
Açkurt F, Wetherilt H, Löker M, Hacibekiroğlu M. Biochemical assessment of nutritional status in pre- and post-natal Turkish women and outcome of pregnancy. Eur J Clin Nutr. 1995;49(8):613-22.
Snow CF. Laboratory diagnosis of vitamin B12 and folate deficiency: a guide for the primary care physician. Arch Intern Med. 1999;159(12):1289-98.
Mills AE. Megaloblastic anaemia with normal mean cell volume. Cent Afr J Med. 1981;27(1):11-2.
Savage DG, Lindenbaum J, Stabler SP, Allen RH. Sensitivity of serum methylmalonic acid and total homocysteine determinations for diagnosing cobalamin and folate deficiencies. Am J Med. 1994;96(3):239-46.
Bay A, Öner AF, Nalbantoğlu Ö, Demirtaş M, Açıkgöz M. Megaloblastik anemili 45 olgunun klinik ve hematolojik yönden değerlendirilmesi. Van Tıp Dergisi. 2006;13(2):46-8.
Taskesen M, Okur N, Katar S, Okur N, Soker M. Nutritional megaloblastic anemia during childhood: Demographical, clinical and laboratory features of 134 patients from southeastern part of Turkey. e-SPEN, the European e-Journal of Clinical Nutrition and Metabolism. 2009;4(3):e152-e4.
Sezgin Evim M, Erdöl Ş, Özdemir Ö, Baytan B, Güneş AM. Long-term outcome in children with nutritional vitamin B12 deficiency. Turk J Haematol. 2011;28(4):286-93.
Zengin E, Sarper N, Caki Kiliç S. Clinical manifestations of infants with nutritional vitamin B deficiency due to maternal dietary deficiency. Acta Paediatr. 2009;98(1):98-102.
Akcam M, Ozdem S, Yilmaz A, Gultekin M, Artan R. Serum ferritin, vitamin B(12), folate, and zinc levels in children infected with Helicobacter pylori. Dig Dis Sci. 2007;52(2):405-10.
Chandelia S, Chandra J, Narayan S, Aneja S, Chawla HM, Sharma S, et al. Addition of cobalamin to iron and folic acid improves hemoglobin rise in nutritional anemia. Indian J Pediatr. 2012;79(12):1592-6.
Sezer RG, Bozaykut A, Akoğlu HA, Özdemir GN. The Efficacy of Oral Vitamin B12 Replacement for Nutritional Vitamin B12 Deficiency. J Pediatr Hematol Oncol. 2018;40(2):e69-e72.
Pages
79-93
Published
April 29, 2024
Copyright (c) 2024 Academician Publishing Book Portal
License
LicenseHow to Cite
1.
Duman D, Uslu G, Malbora B. Vitamin B12 Eksikliği ile Takip Edilen Çocuk Hastaların Retrospektif İncelenmesi. In: Alabaz D, editor. Güncel Çocuk Sağlığı ve Hastalıkları VII (Bahar) [Internet]. Türkiye: Academician Publishing Book DOI Portal; 2024 [cited 2026 Jul. 13]. pp. 79-93. Available from: https://omp35.books.akademisyen.net/index.php/akya/catalog/book/3072/chapter/13349
