Post-Operatif Dirençli Ventriküler Taşikardi Sonrası Tanı Konan Geç Prezentasyonlu Uzun QT Sendromu
Synopsis
Uzun QT sendromu (UQTS), kardiyak repolarizasyon bozukluğuyla karakterize kalp hastalığıdır ve ani kardiyak ölümlere yol açabilir. Bu olguda asemptomatik bir erişkin hastada uzun QT sendromu nedeniyle nadir bir Torsades de pointes vakası sunulmuştur. Hasta özefagus ca nedeni ile opere olmuştur ve pos-operatif amiadarone’a dirençli ventriküler taşikardi gelişmiştir. Hasta, elektrokardiyografi (EKG), aile öyküsü ve genetik inceleme sonrasında uzun QT sendromu tanısı almıştır ve ICD takılması planlanmıştır.
References
Schwartz PJ. 1970-2020: 50 years of research on the long QT syndrome-from almost zero knowledge to precision medicine. Eur Heart J. 2021;42(11):1063-72.
Johnson JN, Ackerman MJ. QTc: how long is too long? Br J Sports Med. 2009;43(9):657-62.
Indraratna P, Tardo D, Delves M, Szirt R, Ng B. Measurement and Management of QT Interval Prolongation for General Physicians. J Gen Intern Med. 2020;35(3):865-73.
Ayad RF, Assar MD, Simpson L, Garner JB, Schussler JM. Causes and management of drug-induced long QT syndrome. Proc (Bayl Univ Med Cent). 2010;23(3):250-5.
Toft E, Aaroe J, Jensen BT, Christiansen M, Fog L, Thomsen PE, et al. Long QT syndrome patients may faint due to neurocardiogenic syncope. Europace. 2003;5(4):367-70.
Viskin S. Long QT syndromes and torsade de pointes. Lancet. 1999;354(9190):1625-33.
Cho Y. Management of Patients with Long QT Syndrome. Korean Circ J. 2016;46(6):747-52.
Fazio G, Vernuccio F, Grutta G, Re GL. Drugs to be avoided in patients with long QT syndrome: Focus on the anaesthesiological management. World J Cardiol. 2013;5(4):87-93.
Riuro H, Campuzano O, Berne P, Arbelo E, Iglesias A, Perez-Serra A, et al. Genetic analysis, in silico prediction, and family segregation in long QT syndrome. Eur J Hum Genet. 2015;23(1):79-85.
Wallace E, Howard L, Liu M, O'Brien T, Ward D, Shen S, et al. Long QT Syndrome: Genetics and Future Perspective. Pediatr Cardiol. 2019;40(7):1419-30.
Shah SR, Park K, Alweis R. Long QT Syndrome: A Comprehensive Review of the Literature and Current Evidence. Curr Probl Cardiol. 2019;44(3):92-106.
Belardinelli L, Giles WR, Rajamani S, Karagueuzian HS, Shryock JC. Cardiac late Na(+) current: proarrhythmic effects, roles in long QT syndromes, and pathological relationship to CaMKII and oxidative stress. Heart Rhythm. 2015;12(2):440-8.
Van Langen IM, Birnie E, Alders M, Jongbloed RJ, Le Marec H, Wilde AA. The use of genotype-phenotype correlations in mutation analysis for the long QT syndrome. J Med Genet. 2003;40(2):141-5.
Wilde AAM, Amin AS, Postema PG. Diagnosis, management and therapeutic strategies for congenital long QT syndrome. Heart. 2022;108(5):332-8.
Gordon SS, Hollowed J, Hayase J, Macias C, Wang J, Middlekauff HR. Acquired Long QT Syndrome after Acute Myocardial Infarction: A Rare but Potentially Fatal Entity. Tex Heart Inst J. 2020;47(2):163-4.
Pacia SV, Devinsky O, Luciano DJ, Vazquez B. The prolonged QT syndrome presenting as epilepsy: a report of two cases and literature review. Neurology. 1994;44(8):1408-10.
Sundaram MB, McMeekin JD, Gulamhusein S. Cardiac tachyarrhythmias in hereditary long QT syndromes presenting as a seizure disorder. Can J Neurol Sci. 1986;13(3):262-3.
Friedman MJ, Mull CC, Sharieff GQ, Tsarouhas N. Prolonged QT syndrome in children: an uncommon but potentially fatal entity. J Emerg Med. 2003;24(2):173-9.
Schwartz PJ, Moss AJ, Vincent GM, Crampton RS. Diagnostic criteria for the long QT syndrome. An update. Circulation. 1993;88(2):782-4.
Schwartz PJ, Crotti L. QTc behavior during exercise and genetic testing for the long-QT syndrome. Circulation. 2011;124(20):2181-4.
Ackerman MJ, Priori SG, Dubin AM, Kowey P, Linker NJ, Slotwiner D, et al. Beta-blocker therapy for long QT syndrome and catecholaminergic polymorphic ventricular tachycardia: Are all beta-blockers equivalent? Heart Rhythm. 2017;14(1):e41-e4.
Han L, Liu F, Li Q, Qing T, Zhai Z, Xia Z, et al. The Efficacy of Beta-Blockers in Patients With Long QT Syndrome 1-3 According to Individuals' Gender, Age, and QTc Intervals: A Network Meta-analysis. Front Pharmacol. 2020;11:579525.
Schwartz PJ, Spazzolini C, Priori SG, Crotti L, Vicentini A, Landolina M, et al. Who are the long-QT syndrome patients who receive an implantable cardioverter-defibrillator and what happens to them?: data from the European Long-QT Syndrome Implantable Cardioverter-Defibrillator (LQTS ICD) Registry. Circulation. 2010;122(13):1272-82.
Antonopoulos A, Lawrence D, Patrini D, Scarci M, George R, Hayward M, et al. The role of sympathectomy in long QT syndrome. J Thorac Dis. 2017;9(9):3394-7.
Khatib R, Sabir FRN, Omari C, Pepper C, Tayebjee MH. Managing drug-induced QT prolongation in clinical practice. Postgrad Med J. 2021;97(1149):452-8.
Torres V, Tepper D, Flowers D, Wynn J, Lam S, Keefe D, et al. QT prolongation and the antiarrhythmic efficacy of amiodarone. J Am Coll Cardiol. 1986;7(1):142-7.
Duchatelet S, Crotti L, Peat RA, Denjoy I, Itoh H, Berthet M, et al. Identification of a KCNQ1 polymorphism acting as a protective modifier against arrhythmic risk in long-QT syndrome. Circ Cardiovasc Genet. 2013;6(4):354-61.
Goldman AM, Glasscock E, Yoo J, Chen TT, Klassen TL, Noebels JL. Arrhythmia in heart and brain: KCNQ1 mutations link epilepsy and sudden unexplained death. Sci Transl Med. 2009;1(2):2ra6.
Johnson JN, Ackerman MJ. QTc: how long is too long? Br J Sports Med. 2009;43(9):657-62.
Indraratna P, Tardo D, Delves M, Szirt R, Ng B. Measurement and Management of QT Interval Prolongation for General Physicians. J Gen Intern Med. 2020;35(3):865-73.
Ayad RF, Assar MD, Simpson L, Garner JB, Schussler JM. Causes and management of drug-induced long QT syndrome. Proc (Bayl Univ Med Cent). 2010;23(3):250-5.
Toft E, Aaroe J, Jensen BT, Christiansen M, Fog L, Thomsen PE, et al. Long QT syndrome patients may faint due to neurocardiogenic syncope. Europace. 2003;5(4):367-70.
Viskin S. Long QT syndromes and torsade de pointes. Lancet. 1999;354(9190):1625-33.
Cho Y. Management of Patients with Long QT Syndrome. Korean Circ J. 2016;46(6):747-52.
Fazio G, Vernuccio F, Grutta G, Re GL. Drugs to be avoided in patients with long QT syndrome: Focus on the anaesthesiological management. World J Cardiol. 2013;5(4):87-93.
Riuro H, Campuzano O, Berne P, Arbelo E, Iglesias A, Perez-Serra A, et al. Genetic analysis, in silico prediction, and family segregation in long QT syndrome. Eur J Hum Genet. 2015;23(1):79-85.
Wallace E, Howard L, Liu M, O'Brien T, Ward D, Shen S, et al. Long QT Syndrome: Genetics and Future Perspective. Pediatr Cardiol. 2019;40(7):1419-30.
Shah SR, Park K, Alweis R. Long QT Syndrome: A Comprehensive Review of the Literature and Current Evidence. Curr Probl Cardiol. 2019;44(3):92-106.
Belardinelli L, Giles WR, Rajamani S, Karagueuzian HS, Shryock JC. Cardiac late Na(+) current: proarrhythmic effects, roles in long QT syndromes, and pathological relationship to CaMKII and oxidative stress. Heart Rhythm. 2015;12(2):440-8.
Van Langen IM, Birnie E, Alders M, Jongbloed RJ, Le Marec H, Wilde AA. The use of genotype-phenotype correlations in mutation analysis for the long QT syndrome. J Med Genet. 2003;40(2):141-5.
Wilde AAM, Amin AS, Postema PG. Diagnosis, management and therapeutic strategies for congenital long QT syndrome. Heart. 2022;108(5):332-8.
Gordon SS, Hollowed J, Hayase J, Macias C, Wang J, Middlekauff HR. Acquired Long QT Syndrome after Acute Myocardial Infarction: A Rare but Potentially Fatal Entity. Tex Heart Inst J. 2020;47(2):163-4.
Pacia SV, Devinsky O, Luciano DJ, Vazquez B. The prolonged QT syndrome presenting as epilepsy: a report of two cases and literature review. Neurology. 1994;44(8):1408-10.
Sundaram MB, McMeekin JD, Gulamhusein S. Cardiac tachyarrhythmias in hereditary long QT syndromes presenting as a seizure disorder. Can J Neurol Sci. 1986;13(3):262-3.
Friedman MJ, Mull CC, Sharieff GQ, Tsarouhas N. Prolonged QT syndrome in children: an uncommon but potentially fatal entity. J Emerg Med. 2003;24(2):173-9.
Schwartz PJ, Moss AJ, Vincent GM, Crampton RS. Diagnostic criteria for the long QT syndrome. An update. Circulation. 1993;88(2):782-4.
Schwartz PJ, Crotti L. QTc behavior during exercise and genetic testing for the long-QT syndrome. Circulation. 2011;124(20):2181-4.
Ackerman MJ, Priori SG, Dubin AM, Kowey P, Linker NJ, Slotwiner D, et al. Beta-blocker therapy for long QT syndrome and catecholaminergic polymorphic ventricular tachycardia: Are all beta-blockers equivalent? Heart Rhythm. 2017;14(1):e41-e4.
Han L, Liu F, Li Q, Qing T, Zhai Z, Xia Z, et al. The Efficacy of Beta-Blockers in Patients With Long QT Syndrome 1-3 According to Individuals' Gender, Age, and QTc Intervals: A Network Meta-analysis. Front Pharmacol. 2020;11:579525.
Schwartz PJ, Spazzolini C, Priori SG, Crotti L, Vicentini A, Landolina M, et al. Who are the long-QT syndrome patients who receive an implantable cardioverter-defibrillator and what happens to them?: data from the European Long-QT Syndrome Implantable Cardioverter-Defibrillator (LQTS ICD) Registry. Circulation. 2010;122(13):1272-82.
Antonopoulos A, Lawrence D, Patrini D, Scarci M, George R, Hayward M, et al. The role of sympathectomy in long QT syndrome. J Thorac Dis. 2017;9(9):3394-7.
Khatib R, Sabir FRN, Omari C, Pepper C, Tayebjee MH. Managing drug-induced QT prolongation in clinical practice. Postgrad Med J. 2021;97(1149):452-8.
Torres V, Tepper D, Flowers D, Wynn J, Lam S, Keefe D, et al. QT prolongation and the antiarrhythmic efficacy of amiodarone. J Am Coll Cardiol. 1986;7(1):142-7.
Duchatelet S, Crotti L, Peat RA, Denjoy I, Itoh H, Berthet M, et al. Identification of a KCNQ1 polymorphism acting as a protective modifier against arrhythmic risk in long-QT syndrome. Circ Cardiovasc Genet. 2013;6(4):354-61.
Goldman AM, Glasscock E, Yoo J, Chen TT, Klassen TL, Noebels JL. Arrhythmia in heart and brain: KCNQ1 mutations link epilepsy and sudden unexplained death. Sci Transl Med. 2009;1(2):2ra6.
Pages
91-100
Published
May 2, 2024
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1.
Demirci M. Post-Operatif Dirençli Ventriküler Taşikardi Sonrası Tanı Konan Geç Prezentasyonlu Uzun QT Sendromu. In: Erol Ç, editor. Olgular Eşliğinde Kardiyoloji II [Internet]. Türkiye: Academician Publishing Book DOI Portal; 2024 [cited 2026 Jul. 13]. pp. 91-100. Available from: https://omp35.books.akademisyen.net/index.php/akya/catalog/book/3007/chapter/13235
