Diyabetik Ayak Ülserleri Tedavisinde Büyüme Faktörlerinin Rolü
References
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Full article: Becaplermin gel in the treatment of diabetic neuropathic foot ulcers [İnternet]. [a.yer 21 Şubat 2023]. Erişim adresi: https://www.tandfonline.com/doi/full/10.2147/cia.s1106
Park JW, Hwang SR, Yoon IS. Advanced Growth Factor Delivery Systems in Wound Management and Skin Regeneration. Molecules. Ağustos 2017;22(8):1259.
Diagnosis and Classification of Diabetes Mellitus | Diabetes Care | American Diabetes Association [İnternet]. [a.yer 21 Şubat 2023]. Erişim adresi: https://diabetesjournals.org/care/article/37/Supplement_1/S81/37753/Diagnosis-and-Classification-of-Diabetes-Mellitus
Kharroubi AT, Darwish HM. Diabetes mellitus: The epidemic of the century. World J Diabetes. 25 Haziran 2015;6(6):850-67.
Prevalence of diabetic foot syndrome and its risk factors in the UK | Journal of Wound Care [İnternet]. [a.yer 21 Şubat 2023]. Erişim adresi: https://www.magonlinelibrary.com/doi/abs/10.12968/jowc.2010.19.8.77711
Risk Factors for Plantar Foot Ulcer Recurrence in Neuropathic Diabetic Patients | Diabetes Care | American Diabetes Association [İnternet]. [a.yer 21 Şubat 2023]. Erişim adresi: https://diabetesjournals.org/care/article/37/6/1697/29712/Risk-Factors-for-Plantar-Foot-Ulcer-Recurrence-in
Edmonds ME, Foster AVM. ABC of wound healing: Diabetic foot ulcers. BMJ. 01 Mayıs 2006;332(Suppl S5):0605190.
Anacardic Acid Inhibits the Catalytic Activity of Matrix Metalloproteinase-2 and Matrix Metalloproteinase-9 | Molecular Pharmacology [İnternet]. [a.yer 21 Şubat 2023]. Erişim adresi: https://molpharm.aspetjournals.org/content/82/4/614.short
Zubair M. Diabetic Foot Ulcer: A Review. Am J Intern Med. 2015;3(2):28.
Tesfaye S, Stevens LK, Stephenson JM, Fuller JH, Plater M, Ionescu-Tirgoviste C, vd. Prevalence of diabetic peripheral neuropathy and its relation to glycaemic control and potential risk factors: the EURODIAB IDDM Complications Study. Diabetologia. 01 Ekim 1996;39(11):1377-84.
Avogaro A, Fadini GP. Microvascular complications in diabetes: A growing concern for cardiologists. Int J Cardiol. 15 Eylül 2019;291:29-35.
Ja D. Management of peripheral arterial disease (PAD). TASC Working Group. TransAtlantic Inter‐Society Consensus (TASC). J Vasc Surg. 2000;31:S1-296.
Prompers L, Huijberts M, Apelqvist J, Jude E, Piaggesi A, Bakker K, vd. High prevalence of ischaemia, infection and serious comorbidity in patients with diabetic foot disease in Europe. Baseline results from the Eurodiale study. Diabetologia. 01 Ocak 2007;50(1):18-25.
Benotmane A, Mohammedi F, Ayad F, Kadi K, Azzouz A. Diabetic foot lesions: etiologic and prognostic factors. Diabetes Metab. 01 Nisan 2000;26(2):113-7.
Armstrong DG, Boulton AJM, Bus SA. Diabetic Foot Ulcers and Their Recurrence. N Engl J Med. 15 Haziran 2017;376(24):2367-75.
JCI - Stimulation of granulation tissue formation by platelet-derived growth factor in normal and diabetic rats. [İnternet]. [a.yer 21 Şubat 2023]. Erişim adresi: https://www.jci.org/articles/view/112243
Buckley A, Davidson JM, Kamerath CD, Woodward SC. Epidermal growth factor increases granulation tissue formation dose dependently. J Surg Res. 01 Ekim 1987;43(4):322-8.
Broadley KN, Aquino AM, Hicks B, Ditesheim JA, McGee GS, Demetriou AA, vd. Growth factors bFGF and TGB beta accelerate the rate of wound repair in normal and in diabetic rats. Int J Tissue React. 01 Ocak 1988;10(6):345-53.
Role of PDGF in fibrotic diseases and systemic sclerosis | Rheumatology | Oxford Academic [İnternet]. [a.yer 21 Şubat 2023]. Erişim adresi: https://academic.oup.com/rheumatology/article/47/suppl_5/v2/1784746
Fredriksson L, Li H, Eriksson U. The PDGF family: four gene products form five dimeric isoforms. Cytokine Growth Factor Rev. 01 Ağustos 2004;15(4):197-204.
Heldin CH, Eriksson U, Östman A. New Members of the Platelet-Derived Growth Factor Family of Mitogens. Arch Biochem Biophys. 15 Şubat 2002;398(2):284-90.
Regulation of Wound Healing by Growth Factors and Cytokines | Physiological Reviews [İnternet]. [a.yer 21 Şubat 2023]. Erişim adresi: https://journals.physiology.org/doi/full/10.1152/physrev.2003.83.3.835
Pierce GF, Mustoe TA, Altrock BW, Deuel TF, Thomason A. Role of platelet-derived growth factor in wound healing. J Cell Biochem. 1991;45(4):319-26.
Heldin CH, Rönnstrand L. The Platelet-Derived Growth Factor Receptor. İçinde: Receptor Phosphorylation. CRC Press; 1989.
Steed DL, Study Group the DU. Clinical evaluation of recombinant human platelet – derived growth factor for the treatment of lower extremity diabetic ulcers. J Vasc Surg. 01 Ocak 1995;21(1):71-81.
Bennett SP, Griffiths GD, Schor AM, Leese GP, Schor SL. Growth factors in the treatment of diabetic foot ulcers. Br J Surg. 01 Şubat 2003;90(2):133-46.
Mandial V, Gupta M, Sharma R. Evaluation of recombinant human platelet derived growth factor-BB in healing of chronic diabetic foot ulcers. Int J Contemp Med Res. 2017;4:1607-10.
Das S, Majid M, Baker AB. Syndecan-4 enhances PDGF-BB activity in diabetic wound healing. Acta Biomater. 15 Eylül 2016;42:56-65.
Rangaswamy P, Rubby SA, Prasanth K. Prospective study of platelet derived growth factor in wound healing of diabetic foot ulcers in Indian population. Int Surg J. 2017;4(1):194-9.
Becaplermin: recombinant platelet derived growth factor, a new treatment for healing diabetic foot ulcers: Expert Opinion on Biological Therapy: Vol 2, No 2 [İnternet]. [a.yer 21 Şubat 2023]. Erişim adresi: https://www.tandfonline.com/doi/abs/10.1517/14712598.2.2.211
Kantor J, Margolis DJ. Treatment Options for Diabetic Neuropathic Foot Ulcers: A Cost-Effectiveness Analysis. Dermatol Surg. 2001;27(4):347-51.
Servold SA. Growth factor impact on wound healing. Clin Podiatr Med Surg. 01 Ekim 1991;8(4):937-53.
Human Epidermal Growth Factor Enhances Healing of Diabetic Foot Ulcers | Diabetes Care | American Diabetes Association [İnternet]. [a.yer 21 Şubat 2023]. Erişim adresi: https://diabetesjournals.org/care/article/26/6/1856/26382/Human-Epidermal-Growth-Factor-Enhances-Healing-of
Singla S, Garg R, Kumar A, Gill C. Efficacy of topical application of beta urogastrone (recombinant human epidermal growth factor) in Wagner’s Grade 1 and 2 diabetic foot ulcers: Comparative analysis of 50 patients. J Nat Sci Biol Med. 2014;5(2):273-7.
Gomez-Villa R, Aguilar-Rebolledo F, Lozano-Platonoff A, Teran-Soto JM, Fabian-Victoriano MR, Kresch-Tronik NS, vd. Efficacy of intralesional recombinant human epidermal growth factor in diabetic foot ulcers in Mexican patients: A randomized double-blinded controlled trial. Wound Repair Regen. 2014;22(4):497-503.
Dumantepe M, Fazliogullari O, Seren M, Uyar I, Basar F. Efficacy of intralesional recombinant human epidermal growth factor in chronic diabetic foot ulcers. Growth Factors. 04 Mart 2015;33(2):128-32.
Efficacy of Topical Recombinant Human Epidermal Growth Factor for Treatment of Diabetic Foot Ulcer: A Systematic Review and Meta-Analysis - Shaowei Yang, Zhijun Geng, Kui Ma, Xiaoyan Sun, Xiaobing Fu, 2016 [İnternet]. [a.yer 21 Şubat 2023]. Erişim adresi: https://journals.sagepub.com/doi/abs/10.1177/1534734616645444?journalCode=ijla
Hong JP, Jung HD, Kim YW. Recombinant Human Epidermal Growth Factor (EGF) to Enhance Healing for Diabetic Foot Ulcers. Ann Plast Surg. Nisan 2006;56(4):394.
Manoharan DrGV, Venkatesh DrG, Shanmugam DrS. A Comparative Study on Wound Healing with Topical Application of Human Epidermal Growth Factor verses Application of Povidone-Iodine in Diabetic Wounds. Sch J Appl Med Sci. Haziran 2016;4(6):2302-6.
Mohan VK. Recombinant human epidermal growth factor (REGEN-DTM 150): Effect on healing of diabetic foot ulcers. Diabetes Res Clin Pract. 01 Aralık 2007;78(3):405-11.
The efficacy and safety of epidermal growth factor in treatment of diabetic foot ulcers: the preliminary results - Tuyet - 2009 - International Wound Journal - Wiley Online Library [İnternet]. [a.yer 21 Şubat 2023]. Erişim adresi: https://onlinelibrary.wiley.com/doi/full/10.1111/j.1742-481X.2009.00594.x
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Full article: Becaplermin gel in the treatment of diabetic neuropathic foot ulcers [İnternet]. [a.yer 21 Şubat 2023]. Erişim adresi: https://www.tandfonline.com/doi/full/10.2147/cia.s1106
Park JW, Hwang SR, Yoon IS. Advanced Growth Factor Delivery Systems in Wound Management and Skin Regeneration. Molecules. Ağustos 2017;22(8):1259.
Diagnosis and Classification of Diabetes Mellitus | Diabetes Care | American Diabetes Association [İnternet]. [a.yer 21 Şubat 2023]. Erişim adresi: https://diabetesjournals.org/care/article/37/Supplement_1/S81/37753/Diagnosis-and-Classification-of-Diabetes-Mellitus
Kharroubi AT, Darwish HM. Diabetes mellitus: The epidemic of the century. World J Diabetes. 25 Haziran 2015;6(6):850-67.
Prevalence of diabetic foot syndrome and its risk factors in the UK | Journal of Wound Care [İnternet]. [a.yer 21 Şubat 2023]. Erişim adresi: https://www.magonlinelibrary.com/doi/abs/10.12968/jowc.2010.19.8.77711
Risk Factors for Plantar Foot Ulcer Recurrence in Neuropathic Diabetic Patients | Diabetes Care | American Diabetes Association [İnternet]. [a.yer 21 Şubat 2023]. Erişim adresi: https://diabetesjournals.org/care/article/37/6/1697/29712/Risk-Factors-for-Plantar-Foot-Ulcer-Recurrence-in
Edmonds ME, Foster AVM. ABC of wound healing: Diabetic foot ulcers. BMJ. 01 Mayıs 2006;332(Suppl S5):0605190.
Anacardic Acid Inhibits the Catalytic Activity of Matrix Metalloproteinase-2 and Matrix Metalloproteinase-9 | Molecular Pharmacology [İnternet]. [a.yer 21 Şubat 2023]. Erişim adresi: https://molpharm.aspetjournals.org/content/82/4/614.short
Zubair M. Diabetic Foot Ulcer: A Review. Am J Intern Med. 2015;3(2):28.
Tesfaye S, Stevens LK, Stephenson JM, Fuller JH, Plater M, Ionescu-Tirgoviste C, vd. Prevalence of diabetic peripheral neuropathy and its relation to glycaemic control and potential risk factors: the EURODIAB IDDM Complications Study. Diabetologia. 01 Ekim 1996;39(11):1377-84.
Avogaro A, Fadini GP. Microvascular complications in diabetes: A growing concern for cardiologists. Int J Cardiol. 15 Eylül 2019;291:29-35.
Ja D. Management of peripheral arterial disease (PAD). TASC Working Group. TransAtlantic Inter‐Society Consensus (TASC). J Vasc Surg. 2000;31:S1-296.
Prompers L, Huijberts M, Apelqvist J, Jude E, Piaggesi A, Bakker K, vd. High prevalence of ischaemia, infection and serious comorbidity in patients with diabetic foot disease in Europe. Baseline results from the Eurodiale study. Diabetologia. 01 Ocak 2007;50(1):18-25.
Benotmane A, Mohammedi F, Ayad F, Kadi K, Azzouz A. Diabetic foot lesions: etiologic and prognostic factors. Diabetes Metab. 01 Nisan 2000;26(2):113-7.
Armstrong DG, Boulton AJM, Bus SA. Diabetic Foot Ulcers and Their Recurrence. N Engl J Med. 15 Haziran 2017;376(24):2367-75.
JCI - Stimulation of granulation tissue formation by platelet-derived growth factor in normal and diabetic rats. [İnternet]. [a.yer 21 Şubat 2023]. Erişim adresi: https://www.jci.org/articles/view/112243
Buckley A, Davidson JM, Kamerath CD, Woodward SC. Epidermal growth factor increases granulation tissue formation dose dependently. J Surg Res. 01 Ekim 1987;43(4):322-8.
Broadley KN, Aquino AM, Hicks B, Ditesheim JA, McGee GS, Demetriou AA, vd. Growth factors bFGF and TGB beta accelerate the rate of wound repair in normal and in diabetic rats. Int J Tissue React. 01 Ocak 1988;10(6):345-53.
Role of PDGF in fibrotic diseases and systemic sclerosis | Rheumatology | Oxford Academic [İnternet]. [a.yer 21 Şubat 2023]. Erişim adresi: https://academic.oup.com/rheumatology/article/47/suppl_5/v2/1784746
Fredriksson L, Li H, Eriksson U. The PDGF family: four gene products form five dimeric isoforms. Cytokine Growth Factor Rev. 01 Ağustos 2004;15(4):197-204.
Heldin CH, Eriksson U, Östman A. New Members of the Platelet-Derived Growth Factor Family of Mitogens. Arch Biochem Biophys. 15 Şubat 2002;398(2):284-90.
Regulation of Wound Healing by Growth Factors and Cytokines | Physiological Reviews [İnternet]. [a.yer 21 Şubat 2023]. Erişim adresi: https://journals.physiology.org/doi/full/10.1152/physrev.2003.83.3.835
Pierce GF, Mustoe TA, Altrock BW, Deuel TF, Thomason A. Role of platelet-derived growth factor in wound healing. J Cell Biochem. 1991;45(4):319-26.
Heldin CH, Rönnstrand L. The Platelet-Derived Growth Factor Receptor. İçinde: Receptor Phosphorylation. CRC Press; 1989.
Steed DL, Study Group the DU. Clinical evaluation of recombinant human platelet – derived growth factor for the treatment of lower extremity diabetic ulcers. J Vasc Surg. 01 Ocak 1995;21(1):71-81.
Bennett SP, Griffiths GD, Schor AM, Leese GP, Schor SL. Growth factors in the treatment of diabetic foot ulcers. Br J Surg. 01 Şubat 2003;90(2):133-46.
Mandial V, Gupta M, Sharma R. Evaluation of recombinant human platelet derived growth factor-BB in healing of chronic diabetic foot ulcers. Int J Contemp Med Res. 2017;4:1607-10.
Das S, Majid M, Baker AB. Syndecan-4 enhances PDGF-BB activity in diabetic wound healing. Acta Biomater. 15 Eylül 2016;42:56-65.
Rangaswamy P, Rubby SA, Prasanth K. Prospective study of platelet derived growth factor in wound healing of diabetic foot ulcers in Indian population. Int Surg J. 2017;4(1):194-9.
Becaplermin: recombinant platelet derived growth factor, a new treatment for healing diabetic foot ulcers: Expert Opinion on Biological Therapy: Vol 2, No 2 [İnternet]. [a.yer 21 Şubat 2023]. Erişim adresi: https://www.tandfonline.com/doi/abs/10.1517/14712598.2.2.211
Kantor J, Margolis DJ. Treatment Options for Diabetic Neuropathic Foot Ulcers: A Cost-Effectiveness Analysis. Dermatol Surg. 2001;27(4):347-51.
Servold SA. Growth factor impact on wound healing. Clin Podiatr Med Surg. 01 Ekim 1991;8(4):937-53.
Human Epidermal Growth Factor Enhances Healing of Diabetic Foot Ulcers | Diabetes Care | American Diabetes Association [İnternet]. [a.yer 21 Şubat 2023]. Erişim adresi: https://diabetesjournals.org/care/article/26/6/1856/26382/Human-Epidermal-Growth-Factor-Enhances-Healing-of
Singla S, Garg R, Kumar A, Gill C. Efficacy of topical application of beta urogastrone (recombinant human epidermal growth factor) in Wagner’s Grade 1 and 2 diabetic foot ulcers: Comparative analysis of 50 patients. J Nat Sci Biol Med. 2014;5(2):273-7.
Gomez-Villa R, Aguilar-Rebolledo F, Lozano-Platonoff A, Teran-Soto JM, Fabian-Victoriano MR, Kresch-Tronik NS, vd. Efficacy of intralesional recombinant human epidermal growth factor in diabetic foot ulcers in Mexican patients: A randomized double-blinded controlled trial. Wound Repair Regen. 2014;22(4):497-503.
Dumantepe M, Fazliogullari O, Seren M, Uyar I, Basar F. Efficacy of intralesional recombinant human epidermal growth factor in chronic diabetic foot ulcers. Growth Factors. 04 Mart 2015;33(2):128-32.
Efficacy of Topical Recombinant Human Epidermal Growth Factor for Treatment of Diabetic Foot Ulcer: A Systematic Review and Meta-Analysis - Shaowei Yang, Zhijun Geng, Kui Ma, Xiaoyan Sun, Xiaobing Fu, 2016 [İnternet]. [a.yer 21 Şubat 2023]. Erişim adresi: https://journals.sagepub.com/doi/abs/10.1177/1534734616645444?journalCode=ijla
Hong JP, Jung HD, Kim YW. Recombinant Human Epidermal Growth Factor (EGF) to Enhance Healing for Diabetic Foot Ulcers. Ann Plast Surg. Nisan 2006;56(4):394.
Manoharan DrGV, Venkatesh DrG, Shanmugam DrS. A Comparative Study on Wound Healing with Topical Application of Human Epidermal Growth Factor verses Application of Povidone-Iodine in Diabetic Wounds. Sch J Appl Med Sci. Haziran 2016;4(6):2302-6.
Mohan VK. Recombinant human epidermal growth factor (REGEN-DTM 150): Effect on healing of diabetic foot ulcers. Diabetes Res Clin Pract. 01 Aralık 2007;78(3):405-11.
The efficacy and safety of epidermal growth factor in treatment of diabetic foot ulcers: the preliminary results - Tuyet - 2009 - International Wound Journal - Wiley Online Library [İnternet]. [a.yer 21 Şubat 2023]. Erişim adresi: https://onlinelibrary.wiley.com/doi/full/10.1111/j.1742-481X.2009.00594.x
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115-132
Published
April 5, 2023
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Soydan AT, Kurt M, Alkan S. Diyabetik Ayak Ülserleri Tedavisinde Büyüme Faktörlerinin Rolü. In: Alabaz Ö, editor. Güncel Genel Cerrahi Çalışmaları IV [Internet]. Türkiye: Academician Publishing Book DOI Portal; 2023 [cited 2026 Jul. 15]. pp. 115-32. Available from: https://omp35.books.akademisyen.net/index.php/akya/catalog/book/2553/chapter/12759