Aloe Vera

Synopsis

Kanser hastalığında kemoterapi, immunoterapi ve radyoterapi tedavinin bel kemiğini oluşturur ve profesyonel ekiplerce kanıta dayalı tıp esasları ile yönetilir. Bu tedavilerinin etkinliğini arttırmak ve yan etkilerini azaltmak için pek çok yöntem mevcuttur ve alternatif tıpta kullanılan ajanların kanser tedavisine olumlu veya olumsuz etkileri hakkındaki bilgilerimiz gün geçtikçe artmaktadır. Bu bölümde alternatif tıpta oldukça fazla kullanılan aloe vera bitkisinin kanser hastalığı tedavi yönetimindeki yeri, kullanılabileceği alanlar ve kullanılmaması gereken alanlar kanıta dayalı tıp esasları gözetilerek derlenmiştir.

Chemotherapy, immunotherapy and radiotherapy form the backbone of treatment in cancer and are managed by professional teams on the basis of evidence-based medicine. There are many methods available to increase the effectiveness of these treatments and reduce their side effects, and our knowledge about the positive or negative effects of agents used in alternative medicine on cancer treatment is increasing day by day. In this section, the place of the aloe vera plant, which is widely used in alternative medicine, in cancer treatment management, the areas where it can be used and the areas where it should not be used have been compiled, taking into account the principles of evidence-based medicine.

References

Vogler BK, Ernst E. Aloe vera: a systematic review of its clinical effectiveness. Br J Gen Pract. 1999 Oct;49(447):823–8.
Gao Y, Kuok KI, Jin Y, Wang R. Biomedical applications of Aloe vera. Crit Rev Food Sci Nutr. 2019;59(sup1):S244–56.
Farrugia CJE, Burke ES, Haley ME, Bedi KT, Gandhi MA. The use of aloe vera in cancer radiation: An updated comprehensive review. Vol. 35, Complementary Therapies in Clinical Practice. Churchill Livingstone; 2019. p. 126–30.
Sahebnasagh A, Ghasemi A, Akbari J, Alipour A, Lashkardoost H, Ala S, et al. Successful Treatment of Acute Radiation Proctitis with Aloe Vera: A Preliminary Randomized Controlled Clinical Trial. J Altern Complement Med. 2017 Nov;23(11):858–65.
Chaput G, Regnier L. Radiotherapy: Clinical pearls for primary care. Can Fam Physician. 2021 Oct;67(10):753–7.
Ahmadloo N, Kadkhodaei B, Omidvari S, Mosalaei A, Ansari M, Nasrollahi H, et al. Lack of Prophylactic Effects of Aloe Vera Gel on Radiation Induced Dermatitis in Breast Cancer Patients. Asian Pac J Cancer Prev. 2017 Apr 1;18(4):1139–43.
Haddad P, Amouzgar-Hashemi F, Samsami S, Chinichian S, Oghabian MA. Aloe vera for prevention of radiation-induced dermatitis: a self-controlled clinical trial. Curr Oncol. 2013 Aug;20(4):e345-8.
Hoopfer D, Holloway C, Gabos Z, Alidrisi M, Chafe S, Krause B, et al. Three-Arm Randomized Phase III Trial: Quality Aloe and Placebo Cream Versus Powder as Skin Treatment During Breast Cancer Radiation Therapy. Clin Breast Cancer. 2015 Jun;15(3):181-90.e1-4.
Heggie S, Bryant GP, Tripcony L, Keller J, Rose P, Glendenning M, et al. A Phase III study on the efficacy of topical aloe vera gel on irradiated breast tissue. Cancer Nurs. 2002 Dec;25(6):442–51.
Nyström J, Svensk AC, Lindholm-Sethson B, Geladi P, Larson J, Franzén L. Comparison of three instrumental methods for the objective evaluation of radiotherapy induced erythema in breast cancer patients and a study of the effect of skin lotions. Acta Oncol. 2007;46(7):893–9.
Djuv A, Nilsen OG. Aloe vera juice: IC₅₀ and dual mechanistic inhibition of CYP3A4 and CYP2D6. Phytother Res. 2012 Mar;26(3):445–51.
Lissoni P, Rovelli F, Brivio F, Zago R, Colciago M, Messina G, et al. A randomized study of chemotherapy versus biochemotherapy with chemotherapy plus Aloe arborescens in patients with metastatic cancer. In Vivo. 2009;23(1):171–5.
Ünlü A, Nayir E, Ay H, Kirca Ö, Özdoğan M. Aloe vera and cancer. Vol. 31, Turk Onkoloji Dergisi. Istanbul Tip Fakultesi; 2016. p. 68–72.
Boudreau MD, Beland FA, Nichols JA, Pogribna M. Toxicology and carcinogenesis studies of a nondecolorized [corrected] whole leaf extract of Aloe barbadensis Miller (Aloe vera) in F344/N rats and B6C3F1 mice (drinking water study). Natl Toxicol Program Tech Rep Ser. 2013 Aug;(577):1–266.

Published

March 11, 2024

License

License

How to Cite

1.
Kahraman EG. Aloe Vera. In: Sakin A, editor. Kanser Hastalarının Başvurduğu Geleneksel ve Tamamlayıcı Tedaviler - Tıbbi Onkolog Gözü ile Bakış ve Onkolojik İlaçlarla Etkileşim [Internet]. Türkiye: Academician Publishing Book DOI Portal; 2024 [cited 2026 Jul. 13]. pp. 233-6. Available from: https://omp35.books.akademisyen.net/index.php/akya/catalog/book/2380/chapter/13922