Meyan kökü (Glyctrrhiza Uralensis)
Synopsis
Meyan kökü, Çin geleneksel tıpının en eski bitkisel ilaçlarından biridir. Bu bölümde konuyla ilgili güncel literatür gözden geçirilmektedir ve Meyan kökünün meme, yumurtalık, serviks, özofagus, mide, karaciğer, kolorektal, prostat, lösemi ve lenfoma, baş-boyun, cilt ve akciğer kanseri hücreleri üzerindeki etkisi tartışılmaktadır. Ek olarak, bölümün sonunda bitki-ilaç etkileşimleri vurgulanmıştır.
Her ne kadar pre-klinik çalışmalar anti-kanserojenik etkiyi kanıtlasa da, klinik çalışmalarn olmayışı güvenli sonuca varmaya engel oluyor. Meyan kökünün kanser tedavisinde rutin kullanımı ile ilgili geniş kapsamlı klinik çalışmalara ihtiyaç vardır.
Chinese Licorice is one of the oldest herbal medicines of Chinese traditional medicine. This chapter reviews the current literature on the topic and discusses the effect of Chinese Licorice on the breast, ovary, cervical, esophagus, stomach, liver, colorectal, prostate, leukemia and lymphoma, oral cavity, skin, and lung cancer cells. In addition, herb-drug interactions are also mentioned at the end of the chapter.
Although preclinical studies may prove the anti-cancerogenic effect, absence of the clinical studies prevents reaching a reliable conclusion. There is a need for large-scale clinical studies to determine the Chinese Licorice’s routine use in cancer treatment.
References
Zhi Y. Wang & Daniel W. Nixon (2001) Licorice and Cancer, Nutrition and Cancer, 39:1, 1-11, DOI: 10.1207/S15327914nc391_1
Jiangshu New Medical School: Cyclopedia of Chinese Traditional Medicine. Shanghai: Shanghai Science and Technology Press, 1979.
Gibson, MR: Glycyrrhiza in old and new perspectives. Lloydia 41, 348–354, 1978.
Reid, D: A Handbook of Chinese Healing Herbs. Boston: Shambhala, 1995, pp 149–152.
Chen X, Liu Z, Meng R, Shi C, Guo N. Antioxidative and anticancer properties of Licochalcone A from licorice. J Ethnopharmacol. 2017;198:331-337. doi:10.1016/j.jep.2017.01.028
Lin SC, Chu PY, Liao WT, et al. Glycyrrhizic acid induces human MDA-MB-231 breast cancer cell death and autophagy via the ROS-mitochondrial pathway. Oncol Rep. 2018;39(2):703-710. doi:10.3892/or.2017.6123
Hsu YC, Hsieh WC, Chen SH, et al. 18β-glycyrrhetinic Acid Modulated Autophagy is Cytotoxic to Breast Cancer Cells. Int J Med Sci. 2023;20(4):444-454. Published 2023 Feb 13. doi:10.7150/ijms.80302
Jo EH, Hong HD, Ahn NC, et al. Modulations of the Bcl-2/Bax family were involved in the chemopreventive effects of licorice root (Glycyrrhiza uralensis Fisch) in MCF-7 human breast cancer cell. J Agric Food Chem. 2004;52(6):1715-1719. doi:10.1021/jf035012t
Liu J, Viswanadhapalli S, Garcia L, et al. Therapeutic utility of natural estrogen receptor beta agonists on ovarian cancer. Oncotarget. 2017;8(30):50002-50014. doi:10.18632/oncotarget.18442
Chen C, Huang S, Chen CL, Su SB, Fang DD. Isoliquiritigenin Inhibits Ovarian Cancer Metastasis by Reversing Epithelial-to-Mesenchymal Transition. Molecules. 2019;24(20):3725. Published 2019 Oct 16. doi:10.3390/molecules24203725
Hirchaud F, Hermetet F, Ablise M, et al. Isoliquiritigenin induces caspase-dependent apoptosis via downregulation of HPV16 E6 expression in cervical cancer Ca Ski cells. Planta Med. 2013;79(17):1628-1635. doi:10.1055/s-0033-1350956
Ye L, Zhang J, Zhang Y, Gu B, Zhu H, Mao X. Isoliquiritigenin Suppressed Esophageal Squamous Carcinoma Growth by Blocking EGFR Activation and Inducing Cell Cycle Arrest. Biomed Res Int. 2020;2020:9259852. Published 2020 Mar 8. doi:10.1155/2020/9259852
Ma J, Fu NY, Pang DB, Wu WY, Xu AL. Apoptosis induced by isoliquiritigenin in human gastric cancer MGC-803 cells. Planta Med. 2001;67(8):754-757. doi:10.1055/s-2001-18361
Zhang XR, Wang SY, Sun W, Wei C. Isoliquiritigenin inhibits proliferation and metastasis of MKN28 gastric cancer cells by suppressing the PI3K/AKT/mTOR signaling pathway. Mol Med Rep. 2018;18(3):3429-3436. doi:10.3892/mmr.2018.9318
Tang ZH, Li T, Chang LL, et al. Glycyrrhetinic Acid triggers a protective autophagy by activation of extracellular regulated protein kinases in hepatocellular carcinoma cells. J Agric Food Chem. 2014;62(49):11910-11916. doi:10.1021/jf503968k
Cai Y, Xu Y, Chan HF, Fang X, He C, Chen M. Glycyrrhetinic Acid Mediated Drug Delivery Carriers for Hepatocellular Carcinoma Therapy. Mol Pharm. 2016;13(3):699-709. doi:10.1021/acs.molpharmaceut.5b00677
Wang G, Hiramoto K, Ma N, et al. Glycyrrhizin Attenuates Carcinogenesis by Inhibiting the Inflammatory Response in a Murine Model of Colorectal Cancer. Int J Mol Sci. 2021;22(5):2609. Published 2021 Mar 5. doi:10.3390/ijms22052609
Chen C, Shao R, Li B, et al. Neoisoliquiritin exerts tumor suppressive effects on prostate cancer by repressing androgen receptor activity. Phytomedicine. 2021;85:153514. doi:10.1016/j.phymed.2021.153514
Cao ZX, Wen Y, He JL, et al. Isoliquiritigenin, an Orally Available Natural FLT3 Inhibitor from Licorice, Exhibits Selective Anti-Acute Myeloid Leukemia Efficacy In Vitro and In Vivo. Mol Pharmacol. 2019;96(5):589-599. doi:10.1124/mol.119.116129
Shen H, Zeng G, Sun B, et al. A polysaccharide from Glycyrrhiza inflata Licorice inhibits proliferation of human oral cancer cells by inducing apoptosis via mitochondrial pathway. Tumour Biol. 2015;36(6):4825-4831. doi:10.1007/s13277-015-3135-6
Shen H, Zeng G, Tang G, et al. Antimetastatic effects of licochalcone A on oral cancer via regulating metastasis-associated proteases. Tumour Biol. 2014;35(8):7467-7474. doi:10.1007/s13277-014-1985-y
Kang TH, Yoon G, Kang IA, Oh HN, Chae JI, Shim JH. Natural Compound Licochalcone B Induced Extrinsic and Intrinsic Apoptosis in Human Skin Melanoma (A375) and Squamous Cell Carcinoma (A431) Cells. Phytother Res. 2017;31(12):1858-1867. doi:10.1002/ptr.5928
Qiu C, Zhang T, Zhang W, et al. Licochalcone A Inhibits the Proliferation of Human Lung Cancer Cell Lines A549 and H460 by Inducing G2/M Cell Cycle Arrest and ER Stress. Int J Mol Sci. 2017;18(8):1761. Published 2017 Aug 12. doi:10.3390/ijms18081761
Chen C, Shenoy AK, Padia R, et al. Suppression of lung cancer progression by isoliquiritigenin through its metabolite 2, 4, 2', 4'-Tetrahydroxychalcone. J Exp Clin Cancer Res. 2018;37(1):243. Published 2018 Oct 3. doi:10.1186/s13046-018-0902-4
Wang X, Zhang H, Chen L, Shan L, Fan G, Gao X. Liquorice, a unique "guide drug" of traditional Chinese medicine: a review of its role in drug interactions. J Ethnopharmacol. 2013 Dec 12;150(3):781-90. doi: 10.1016/j.jep.2013.09.055. Epub 2013 Nov 5. PMID: 24201019.
Satoh T, Watanabe Y, Ikarashi N, Ito K, Sugiyama K. Effects of Kampo medicines on P-glycoprotein. Biol Pharm Bull. 2009 Dec;32(12):2018-21. doi: 10.1248/bpb.32.2018. PMID: 19952421.
Hou YC, Lin SP, Chao PD. Liquorice reduced cyclosporine bioavailability by activating P-glycoprotein and CYP 3A. Food Chem. 2012 Dec 15;135(4):2307-12. doi: 10.1016/j.foodchem.2012.07.061. Epub 2012 Jul 20. PMID: 22980806.
Huang BB, Li GF, Ren F, Tang ZK, Ma HF, Sun YB, Chen LJ, Yang L. [Effect of Glycyrrhiza inflata and Daphne genkwa on permeabilities of rhodamine 123, a P-glycoprotein substrate across rat jejunum membranes in vitro]. Zhongguo Zhong Yao Za Zhi. 2008 Nov;33(21):2521-6. Chinese. PMID: 19149264.
Ha Y, Wang T, Li J, Li J, Lu R, Li J, Chen L, Gan P. Herb-Drug Interaction Potential of Licorice Extract and Paclitaxel: A Pharmacokinetic Study in Rats. Eur J Drug Metab Pharmacokinet. 2020 Apr;45(2):257-264. doi: 10.1007/s13318-019-00593-5. PMID: 31820303.
Feng X, Ding L, Qiu F. Potential drug interactions associated with glycyrrhizin and glycyrrhetinic acid. Drug Metab Rev. 2015 May;47(2):229-38. doi: 10.3109/03602532.2015.1029634. Epub 2015 Mar 31. PMID: 25825801.
Jiangshu New Medical School: Cyclopedia of Chinese Traditional Medicine. Shanghai: Shanghai Science and Technology Press, 1979.
Gibson, MR: Glycyrrhiza in old and new perspectives. Lloydia 41, 348–354, 1978.
Reid, D: A Handbook of Chinese Healing Herbs. Boston: Shambhala, 1995, pp 149–152.
Chen X, Liu Z, Meng R, Shi C, Guo N. Antioxidative and anticancer properties of Licochalcone A from licorice. J Ethnopharmacol. 2017;198:331-337. doi:10.1016/j.jep.2017.01.028
Lin SC, Chu PY, Liao WT, et al. Glycyrrhizic acid induces human MDA-MB-231 breast cancer cell death and autophagy via the ROS-mitochondrial pathway. Oncol Rep. 2018;39(2):703-710. doi:10.3892/or.2017.6123
Hsu YC, Hsieh WC, Chen SH, et al. 18β-glycyrrhetinic Acid Modulated Autophagy is Cytotoxic to Breast Cancer Cells. Int J Med Sci. 2023;20(4):444-454. Published 2023 Feb 13. doi:10.7150/ijms.80302
Jo EH, Hong HD, Ahn NC, et al. Modulations of the Bcl-2/Bax family were involved in the chemopreventive effects of licorice root (Glycyrrhiza uralensis Fisch) in MCF-7 human breast cancer cell. J Agric Food Chem. 2004;52(6):1715-1719. doi:10.1021/jf035012t
Liu J, Viswanadhapalli S, Garcia L, et al. Therapeutic utility of natural estrogen receptor beta agonists on ovarian cancer. Oncotarget. 2017;8(30):50002-50014. doi:10.18632/oncotarget.18442
Chen C, Huang S, Chen CL, Su SB, Fang DD. Isoliquiritigenin Inhibits Ovarian Cancer Metastasis by Reversing Epithelial-to-Mesenchymal Transition. Molecules. 2019;24(20):3725. Published 2019 Oct 16. doi:10.3390/molecules24203725
Hirchaud F, Hermetet F, Ablise M, et al. Isoliquiritigenin induces caspase-dependent apoptosis via downregulation of HPV16 E6 expression in cervical cancer Ca Ski cells. Planta Med. 2013;79(17):1628-1635. doi:10.1055/s-0033-1350956
Ye L, Zhang J, Zhang Y, Gu B, Zhu H, Mao X. Isoliquiritigenin Suppressed Esophageal Squamous Carcinoma Growth by Blocking EGFR Activation and Inducing Cell Cycle Arrest. Biomed Res Int. 2020;2020:9259852. Published 2020 Mar 8. doi:10.1155/2020/9259852
Ma J, Fu NY, Pang DB, Wu WY, Xu AL. Apoptosis induced by isoliquiritigenin in human gastric cancer MGC-803 cells. Planta Med. 2001;67(8):754-757. doi:10.1055/s-2001-18361
Zhang XR, Wang SY, Sun W, Wei C. Isoliquiritigenin inhibits proliferation and metastasis of MKN28 gastric cancer cells by suppressing the PI3K/AKT/mTOR signaling pathway. Mol Med Rep. 2018;18(3):3429-3436. doi:10.3892/mmr.2018.9318
Tang ZH, Li T, Chang LL, et al. Glycyrrhetinic Acid triggers a protective autophagy by activation of extracellular regulated protein kinases in hepatocellular carcinoma cells. J Agric Food Chem. 2014;62(49):11910-11916. doi:10.1021/jf503968k
Cai Y, Xu Y, Chan HF, Fang X, He C, Chen M. Glycyrrhetinic Acid Mediated Drug Delivery Carriers for Hepatocellular Carcinoma Therapy. Mol Pharm. 2016;13(3):699-709. doi:10.1021/acs.molpharmaceut.5b00677
Wang G, Hiramoto K, Ma N, et al. Glycyrrhizin Attenuates Carcinogenesis by Inhibiting the Inflammatory Response in a Murine Model of Colorectal Cancer. Int J Mol Sci. 2021;22(5):2609. Published 2021 Mar 5. doi:10.3390/ijms22052609
Chen C, Shao R, Li B, et al. Neoisoliquiritin exerts tumor suppressive effects on prostate cancer by repressing androgen receptor activity. Phytomedicine. 2021;85:153514. doi:10.1016/j.phymed.2021.153514
Cao ZX, Wen Y, He JL, et al. Isoliquiritigenin, an Orally Available Natural FLT3 Inhibitor from Licorice, Exhibits Selective Anti-Acute Myeloid Leukemia Efficacy In Vitro and In Vivo. Mol Pharmacol. 2019;96(5):589-599. doi:10.1124/mol.119.116129
Shen H, Zeng G, Sun B, et al. A polysaccharide from Glycyrrhiza inflata Licorice inhibits proliferation of human oral cancer cells by inducing apoptosis via mitochondrial pathway. Tumour Biol. 2015;36(6):4825-4831. doi:10.1007/s13277-015-3135-6
Shen H, Zeng G, Tang G, et al. Antimetastatic effects of licochalcone A on oral cancer via regulating metastasis-associated proteases. Tumour Biol. 2014;35(8):7467-7474. doi:10.1007/s13277-014-1985-y
Kang TH, Yoon G, Kang IA, Oh HN, Chae JI, Shim JH. Natural Compound Licochalcone B Induced Extrinsic and Intrinsic Apoptosis in Human Skin Melanoma (A375) and Squamous Cell Carcinoma (A431) Cells. Phytother Res. 2017;31(12):1858-1867. doi:10.1002/ptr.5928
Qiu C, Zhang T, Zhang W, et al. Licochalcone A Inhibits the Proliferation of Human Lung Cancer Cell Lines A549 and H460 by Inducing G2/M Cell Cycle Arrest and ER Stress. Int J Mol Sci. 2017;18(8):1761. Published 2017 Aug 12. doi:10.3390/ijms18081761
Chen C, Shenoy AK, Padia R, et al. Suppression of lung cancer progression by isoliquiritigenin through its metabolite 2, 4, 2', 4'-Tetrahydroxychalcone. J Exp Clin Cancer Res. 2018;37(1):243. Published 2018 Oct 3. doi:10.1186/s13046-018-0902-4
Wang X, Zhang H, Chen L, Shan L, Fan G, Gao X. Liquorice, a unique "guide drug" of traditional Chinese medicine: a review of its role in drug interactions. J Ethnopharmacol. 2013 Dec 12;150(3):781-90. doi: 10.1016/j.jep.2013.09.055. Epub 2013 Nov 5. PMID: 24201019.
Satoh T, Watanabe Y, Ikarashi N, Ito K, Sugiyama K. Effects of Kampo medicines on P-glycoprotein. Biol Pharm Bull. 2009 Dec;32(12):2018-21. doi: 10.1248/bpb.32.2018. PMID: 19952421.
Hou YC, Lin SP, Chao PD. Liquorice reduced cyclosporine bioavailability by activating P-glycoprotein and CYP 3A. Food Chem. 2012 Dec 15;135(4):2307-12. doi: 10.1016/j.foodchem.2012.07.061. Epub 2012 Jul 20. PMID: 22980806.
Huang BB, Li GF, Ren F, Tang ZK, Ma HF, Sun YB, Chen LJ, Yang L. [Effect of Glycyrrhiza inflata and Daphne genkwa on permeabilities of rhodamine 123, a P-glycoprotein substrate across rat jejunum membranes in vitro]. Zhongguo Zhong Yao Za Zhi. 2008 Nov;33(21):2521-6. Chinese. PMID: 19149264.
Ha Y, Wang T, Li J, Li J, Lu R, Li J, Chen L, Gan P. Herb-Drug Interaction Potential of Licorice Extract and Paclitaxel: A Pharmacokinetic Study in Rats. Eur J Drug Metab Pharmacokinet. 2020 Apr;45(2):257-264. doi: 10.1007/s13318-019-00593-5. PMID: 31820303.
Feng X, Ding L, Qiu F. Potential drug interactions associated with glycyrrhizin and glycyrrhetinic acid. Drug Metab Rev. 2015 May;47(2):229-38. doi: 10.3109/03602532.2015.1029634. Epub 2015 Mar 31. PMID: 25825801.
Pages
209-216
Published
March 11, 2024
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1.
Aliyev A. Meyan kökü (Glyctrrhiza Uralensis). In: Sakin A, editor. Kanser Hastalarının Başvurduğu Geleneksel ve Tamamlayıcı Tedaviler - Tıbbi Onkolog Gözü ile Bakış ve Onkolojik İlaçlarla Etkileşim [Internet]. Türkiye: Academician Publishing Book DOI Portal; 2024 [cited 2026 Jul. 13]. pp. 209-16. Available from: https://omp35.books.akademisyen.net/index.php/akya/catalog/book/2380/chapter/13918
