Sarımsak (Allium Sativum) ve Soğan (Allium Cepa)
Synopsis
Allium bitkileri, özellikle sarımsak ve soğan, geleneksel tıpta uzun bir geçmişe sahip olup modern araştırmalarla sağlık açısından potansiyel faydaları desteklenmektedir. Bu bitkilerin kanserle mücadeledeki etkileri üzerine yapılan çalışmalar, özellikle mide kanseri riskini azaltma potansiyeline odaklanmaktadır. Sarımsak, içerdiği allicin ve diğer biyoaktif bileşikler sayesinde antioksidan, antikanser, ve anti-inflamatuar etkiler gösterdiği bilinmektedir. Özellikle allicin'in, serviks kanseri, meme kanseri, kolorektal kanser ve diğer tümör hücreleri üzerinde antitümör etkileri araştırılmıştır. Ancak, bu olumlu etkilerin kesinliği için randomize kontrollü faz 3 çalışmalara ihtiyaç duyulmaktadır. Bununla birlikte, sarımsak ve soğanın tüketimi sırasında potansiyel yan etkiler ve ilaç etkileşimleri de göz önünde bulundurulmalıdır. Örneğin, kan şekeri düzeyinin kontrolü, alerji durumları, antidiyabetik ilaçlarla etkileşim ve kanama riski gibi konular dikkate alınmalıdır. Sarımsak özellikle sitokrom P450 enzimi üzerindeki etkisi nedeniyle birçok ilaçla etkileşim gösterebilir. Sonuç olarak, Allium bitkileri sağlık açısından birçok potansiyel fayda sunsa da, bu faydaların ve etkilerin netleştirilmesi için daha kapsamlı araştırmalara ve dikkatli tüketim alışkanlıklarına ihtiyaç vardır.
Allium plants, like garlic and onions, have a rich history in traditional medicine, and modern research supports their potential health benefits. Studies examining their role in fighting cancer, particularly stomach cancer, have gained attention. Garlic, in particular, is known for its antioxidant, anticancer, and anti-inflammatory properties, attributed to compounds like allicin. Researchers have explored allicin's potential antitumor effects on cervical cancer, breast cancer, colorectal cancer, and other tumor cells. However, confirming these positive effects requires randomized controlled phase 3 studies. It's crucial to be mindful of potential side effects and interactions with medications when consuming garlic and onions. Factors such as blood sugar control, allergies, interactions with antidiabetic drugs, and bleeding risk should be considered. Garlic can interact with various drugs, affecting the cytochrome P450 enzyme. In conclusion, while Allium plants show promise for health benefits, more extensive research and careful consumption are essential to fully understand and confirm these effects.
References
World Cancer Research Fund / American Institute for Cancer Research. Food, Nutrition, Physical Activity, and the Prevention of Cancer: a Global Perspective. Washington DC: AICR; 2007.
Zaid H, Rayan A, Said O, Saad B. Cancer treatment by Greco-Arab and Islamic herbal medicine. The Open Nutraceuticals Journal. 2010;3(1).
Drogosis A, Mamoulakis C, Chrysos E et al. Medicinal plants in the treatment of urinary tract malignancies during the Araboislamic period (7th- 14th century AD). Arab J Urol. 2022;20(4):219-223.
Vimal V, Devaki T. Hepatoprotective effect of allicin on tissue defense system in galactosamine/endotoxin challenged rats. J Ethnopharmacol. 2004;90(1):151-4.
Pan Y, Zheng YM, Ho WS. Effect of quercetin glucosides from Allium extracts on HepG2, PC-3 and HT-29 cancer cell lines. Oncol Lett. 2018;15(4):4657-4661
Duke JA. Handbook of medicinal herbs. CRC press; 2002 Jun 27.
Corzo-Martínez M, Corzo N, Villamiel M. Biological properties of onions and garlic. Trends in food science & technology. 2007 Dec 1;18(12):609-25.5.
Shang A, Cao SY, Xu XY
et al. Bioactive compounds and biological functions of garlic (Allium sativum L.). Foods. 2019;8(7):246.
Banerjee SK, Maulik SK. Effect of garlic on cardiovascular disorders: a review. Nutrition journal. 2002;1(1):1-4.
Ota A, Ulrih NP. An overview of herbal products and secondary metabolites used for management of type two diabetes. Frontiers in pharmacology. 2017;8:436.
Isbilen O., Volkan E. Allium Species in the Fight Against Cancer. MedDocs Publisher LLC; Reno, NV, USA: 2020.
D’Argenio G, Mazzone G, Ribecco MT et al. Garlic extract attenuating rat liver fibrosis by inhibiting TGF-β1. Clinical Nutrition. 2013;32(2):252-8.
Pârvu M, Moţ CA, Pârvu AE et al. Allium sativum extract chemical composition, antioxidant activity and antifungal effect against Meyerozyma guilliermondii and Rhodotorula mucilaginosa causing onychomycosis. Molecules. 2019;24(21):3958.
Iciek M, Kwiecień I, Włodek L. Biological properties of garlic and garlic‐derived organosulfur compounds. Environmental and molecular mutagenesis. 2009;50(3):247-65.
Țigu AB, Toma VA, Moț AC et al. The synergistic antitumor effect of 5-fluorouracil combined with allicin against lung and colorectal carcinoma cells. Molecules. 2020;25(8):1947.
Rosas‐González VC, Téllez‐Bañuelos MC, Hernández‐Flores G et al. Differential effects of alliin and allicin on apoptosis and senescence in luminal A and triple‐negative breast cancer: Caspase, ΔΨm, and pro‐apoptotic gene involvement. Fundamental & Clinical Pharmacology. 2020;34(6):671-86.
Choi YH, Park HS. Apoptosis induction of U937 human leukemia cells by diallyl trisulfide induces through generation of reactive oxygen species. Journal of biomedical science. 2012;19:1-1.
Trio PZ, You S, He X et al. Chemopreventive functions and molecular mechanisms of garlic organosulfur compounds. Food & function. 2014;5(5):833-44.
Zimta AA, Cenariu D, Irimie A et al. Berindan-Neagoe I. The role of Nrf2 activity in cancer development and progression. Cancers. 2019;11(11):1755.
Sobolewska D, Michalska K, Podolak I et al. Steroidal saponins from the genus Allium. Phytochemistry Reviews. 2016;15:1-35.
Kothari D, Lee WD, Kim SK. Allium flavonols: Health benefits, molecular targets, and bioavailability. Antioxidants. 2020;9(9):888.
Toma VA, Tigu AB, Farcaș AD et al. New aspects towards a molecular understanding of the allicin immunostimulatory mechanism via Colec12, MARCO, and SCARB1 receptors. International Journal of Molecular Sciences. 2019;20(15):3627.
Gruhlke MC, Nicco C, Batteux F, Slusarenko AJ. The effects of allicin, a reactive sulfur species from garlic, on a selection of mammalian cell lines. Antioxidants. 2016 Dec 26;6(1):1.
Huang L, Song Y, Lian J et al. Allicin inhibits the invasion of lung adenocarcinoma cells by altering tissue inhibitor of metalloproteinase/matrix metalloproteinase balance via reducing the activity of phosphoinositide 3-kinase/AKT signaling. Oncology letters. 2017;14(1):468-74.
Chen H, Zhu B, Zhao L, Liu Y, Zhao F, Feng J, Jin Y, Sun J, Geng R, Wei Y et all. Allicin inhibits proliferation and invasion in vitro and in vivo via SHP-1-mediated STAT3 signaling in cholangiocarcinoma. Cellular Physiology and Biochemistry. 2018 Jun 18;47(2):641-53
Hirsch K., Danilenko M., Giat J. Et al. Effect of purified allicin, the major ingredient of freshly crushed garlic, on cancer cell proliferation. Nutr. Cancer. 2000;38:245–254.
Oommen S., Anto R.J., Srinivas G., Karunagaran D at al. Allicin (from garlic) induces caspase-mediated apoptosis in cancer cells. Eur.J.Pharm. 2004;485:97–103.
Bat-Chen W, Golan T, Peri I et al. Allicin purified from fresh garlic cloves induces apoptosis in colon cancer cells via Nrf2. Nutrition and cancer. 2010;62(7):947-57
Zhang W, Ha M, Gong Y, Xu Y, Dong N, Yuan Y. Allicin induces apoptosis in gastric cancer cells through activation of both extrinsic and intrinsic pathways. Oncology reports. 2010;24(6):1585-92.
Ha M.W., Yuan Y et all. Allicin induced cell cycle arrest in human gastric cancer cell lines. Zhonghua Zhong Liu Za Zhi Chin. J. Oncol. 2004;26:585–589.
Zhang ZM, Yang XY, Deng SH et al. Anti-tumor effects of polybutylcyanoacrylate nanoparticles of diallyl trisulfide on orthotopic transplantation tumor model of hepatocellular carcinoma in BALB/c nude mice. Chinese medical journal. 2007;120(15):1336-42.
Park SY, Cho SJ, Kwon HC et al. Caspase-independent cell death by allicin in human epithelial carcinoma cells: involvement of PKA. Cancer Letters. 2005;224(1):123-32.
Cha J.H., Choi Y.J., Cha S.H. et al. Allicin inhibits cell growth and induces apoptosis in U87MG human glioblastoma cells through an ERK-dependent pathway. Oncol. Rep. 2012;28:41–48.
Arditti FD, Rabinkov A, Miron T et al. Apoptotic killing of B-chronic lymphocytic leukemia tumor cells by allicin generated in situ using a rituximab-alliinase conjugate. Molecular cancer therapeutics. 2005;4(2):325-32.
Miron T, Wilchek M, Sharp A et al. Allicin inhibits cell growth and induces apoptosis through the mitochondrial pathway in HL60 and U937 cells. The Journal of Nutritional Biochemistry. 2008;19(8):524-35.
Vemuri SK, Banala RR, Subbaiah GP et al. Apoptotic efficiency of aqueous extracts of turmeric, garlic and their active compounds in combination with Tamoxifen in lung and oral cancers: A comparative study. Beni-Suef University Journal of Basic and Applied Sciences. 2018;7(2):184-97.
Khazaei S, Abdul Hamid R, Ramachandran V et al. Cytotoxicity and proapoptotic effects of allium atroviolaceum flower extract by modulating cell cycle arrest and caspase-dependent and p53-independent pathway in breast cancer cell lines. Evidence-Based Complementary and Alternative Medicine. 2017;2017.
Khazaei S, Esa NM, Ramachandran V et al. In vitro antiproliferative and apoptosis inducing effect of Allium atroviolaceum bulb extract on breast, cervical, and liver cancer cells. Frontiers in pharmacology. 2017;8:5.
Gholipour N, Mashjoor S, Naderi M et al. In vitro cytotoxic and apoptotic activities of Allium paradoxum (M. Bieb.)2018; G. Don extract on human breast cancer cell line.
Isbilen O, Rizaner N, Volkan E. Anti-proliferative and cytotoxic activities of Allium autumnale PH Davis (Amaryllidaceae) on human breast cancer cell lines MCF-7 and MDA-MB-231. BMC complementary and alternative medicine. 2018;18:1-3.
Perez-Ortiz JM, Galan-Moya EM, de la Cruz-Morcillo MA et al. Cost effective use of a thiosulfinate-enriched Allium sativum extract in combination with chemotherapy in colon cancer. International Journal of Molecular Sciences. 2020 Apr;21(8):2766.
Jasamai M, Hui CS, Azmi N et al. Effect of Allium sativum (garlic) methanol extract on viability and apoptosis of human leukemic cell lines. Tropical Journal of Pharmaceutical Research. 2016;15(7):1479-85.
Szychowski KA, Binduga UE, Rybczyńska-Tkaczyk K et al. Cytotoxic effects of two extracts from garlic (Allium sativum L.) cultivars on the human squamous carcinoma cell line SCC-15. Saudi Journal of Biological Sciences. 2018;25(8):1703-12.
Ohkubo S, Dalla Via L, Grancara S et al. The antioxidant, aged garlic extract, exerts cytotoxic effects on wild-type and multidrug-resistant human cancer cells by altering mitochondrial permeability. International Journal of Oncology. 2018;53(3):1257-68.
Vlase L, Parvu M, Parvu EA et al. Phytochemical analysis of Allium fistulosum L. and A. ursinum L. Digest Journal of Nanomaterials & Biostructures (DJNB). 2013;8(1).
Park HS, Choi EJ, Lee JH et al. Evaluation of Allium vegetables for anti-Adipogenic, anti-Cancer, and anti-inflammatory activities InVitro. Journal of Life Sciences. 2013;5(2):127-32.
Țigu AB, Moldovan CS, Toma VA et al. Phytochemical analysis and in vitro effects of Allium fistulosum L. and Allium sativum L. extracts on human normal and tumor cell lines: A comparative study. Molecules. 2021;26(3):574.
Yuan P, Lin L, Zheng K et al. Risk factors for gastric cancer and related serological levels in Fujian, China: hospital-based case–control study. BMJ open. 2020;10(9):e042341.
Dalmartello M, Turati F, Zhang ZF et al. Allium vegetables intake and the risk of gastric cancer in the Stomach cancer Pooling (StoP) Project. British journal of cancer. 2022;126(12):1755-64.
Malagoli C, Malavolti M, Farnetani F et al. Food and beverage consumption and melanoma risk: A population-based case-control study in northern Italy. Nutrients. 2019;11(9):2206.
Wan Q, Li N, Du L et al. Allium vegetable consumption and health: An umbrella review of meta‐analyses of multiple health outcomes. Food science & nutrition. 2019;7(8):2451-70.
Galeone C, Pelucchi C, Levi F et al. Onion and garlic use and human cancer. The American journal of clinical nutrition. 2006;84(5):1027-32.
Desai G, Schelske-Santos M, Nazario CM et al. Onion and garlic intake and breast cancer, a case-control study in Puerto Rico. Nutrition and cancer. 2020;72(5):791-800.
Zhang Y, Liu X, Ruan J et al. Phytochemicals of garlic: Promising candidates for cancer therapy. Biomed Pharmacother. 2020;123:109730.
Zaid H, Rayan A, Said O, Saad B. Cancer treatment by Greco-Arab and Islamic herbal medicine. The Open Nutraceuticals Journal. 2010;3(1).
Drogosis A, Mamoulakis C, Chrysos E et al. Medicinal plants in the treatment of urinary tract malignancies during the Araboislamic period (7th- 14th century AD). Arab J Urol. 2022;20(4):219-223.
Vimal V, Devaki T. Hepatoprotective effect of allicin on tissue defense system in galactosamine/endotoxin challenged rats. J Ethnopharmacol. 2004;90(1):151-4.
Pan Y, Zheng YM, Ho WS. Effect of quercetin glucosides from Allium extracts on HepG2, PC-3 and HT-29 cancer cell lines. Oncol Lett. 2018;15(4):4657-4661
Duke JA. Handbook of medicinal herbs. CRC press; 2002 Jun 27.
Corzo-Martínez M, Corzo N, Villamiel M. Biological properties of onions and garlic. Trends in food science & technology. 2007 Dec 1;18(12):609-25.5.
Shang A, Cao SY, Xu XY
et al. Bioactive compounds and biological functions of garlic (Allium sativum L.). Foods. 2019;8(7):246.
Banerjee SK, Maulik SK. Effect of garlic on cardiovascular disorders: a review. Nutrition journal. 2002;1(1):1-4.
Ota A, Ulrih NP. An overview of herbal products and secondary metabolites used for management of type two diabetes. Frontiers in pharmacology. 2017;8:436.
Isbilen O., Volkan E. Allium Species in the Fight Against Cancer. MedDocs Publisher LLC; Reno, NV, USA: 2020.
D’Argenio G, Mazzone G, Ribecco MT et al. Garlic extract attenuating rat liver fibrosis by inhibiting TGF-β1. Clinical Nutrition. 2013;32(2):252-8.
Pârvu M, Moţ CA, Pârvu AE et al. Allium sativum extract chemical composition, antioxidant activity and antifungal effect against Meyerozyma guilliermondii and Rhodotorula mucilaginosa causing onychomycosis. Molecules. 2019;24(21):3958.
Iciek M, Kwiecień I, Włodek L. Biological properties of garlic and garlic‐derived organosulfur compounds. Environmental and molecular mutagenesis. 2009;50(3):247-65.
Țigu AB, Toma VA, Moț AC et al. The synergistic antitumor effect of 5-fluorouracil combined with allicin against lung and colorectal carcinoma cells. Molecules. 2020;25(8):1947.
Rosas‐González VC, Téllez‐Bañuelos MC, Hernández‐Flores G et al. Differential effects of alliin and allicin on apoptosis and senescence in luminal A and triple‐negative breast cancer: Caspase, ΔΨm, and pro‐apoptotic gene involvement. Fundamental & Clinical Pharmacology. 2020;34(6):671-86.
Choi YH, Park HS. Apoptosis induction of U937 human leukemia cells by diallyl trisulfide induces through generation of reactive oxygen species. Journal of biomedical science. 2012;19:1-1.
Trio PZ, You S, He X et al. Chemopreventive functions and molecular mechanisms of garlic organosulfur compounds. Food & function. 2014;5(5):833-44.
Zimta AA, Cenariu D, Irimie A et al. Berindan-Neagoe I. The role of Nrf2 activity in cancer development and progression. Cancers. 2019;11(11):1755.
Sobolewska D, Michalska K, Podolak I et al. Steroidal saponins from the genus Allium. Phytochemistry Reviews. 2016;15:1-35.
Kothari D, Lee WD, Kim SK. Allium flavonols: Health benefits, molecular targets, and bioavailability. Antioxidants. 2020;9(9):888.
Toma VA, Tigu AB, Farcaș AD et al. New aspects towards a molecular understanding of the allicin immunostimulatory mechanism via Colec12, MARCO, and SCARB1 receptors. International Journal of Molecular Sciences. 2019;20(15):3627.
Gruhlke MC, Nicco C, Batteux F, Slusarenko AJ. The effects of allicin, a reactive sulfur species from garlic, on a selection of mammalian cell lines. Antioxidants. 2016 Dec 26;6(1):1.
Huang L, Song Y, Lian J et al. Allicin inhibits the invasion of lung adenocarcinoma cells by altering tissue inhibitor of metalloproteinase/matrix metalloproteinase balance via reducing the activity of phosphoinositide 3-kinase/AKT signaling. Oncology letters. 2017;14(1):468-74.
Chen H, Zhu B, Zhao L, Liu Y, Zhao F, Feng J, Jin Y, Sun J, Geng R, Wei Y et all. Allicin inhibits proliferation and invasion in vitro and in vivo via SHP-1-mediated STAT3 signaling in cholangiocarcinoma. Cellular Physiology and Biochemistry. 2018 Jun 18;47(2):641-53
Hirsch K., Danilenko M., Giat J. Et al. Effect of purified allicin, the major ingredient of freshly crushed garlic, on cancer cell proliferation. Nutr. Cancer. 2000;38:245–254.
Oommen S., Anto R.J., Srinivas G., Karunagaran D at al. Allicin (from garlic) induces caspase-mediated apoptosis in cancer cells. Eur.J.Pharm. 2004;485:97–103.
Bat-Chen W, Golan T, Peri I et al. Allicin purified from fresh garlic cloves induces apoptosis in colon cancer cells via Nrf2. Nutrition and cancer. 2010;62(7):947-57
Zhang W, Ha M, Gong Y, Xu Y, Dong N, Yuan Y. Allicin induces apoptosis in gastric cancer cells through activation of both extrinsic and intrinsic pathways. Oncology reports. 2010;24(6):1585-92.
Ha M.W., Yuan Y et all. Allicin induced cell cycle arrest in human gastric cancer cell lines. Zhonghua Zhong Liu Za Zhi Chin. J. Oncol. 2004;26:585–589.
Zhang ZM, Yang XY, Deng SH et al. Anti-tumor effects of polybutylcyanoacrylate nanoparticles of diallyl trisulfide on orthotopic transplantation tumor model of hepatocellular carcinoma in BALB/c nude mice. Chinese medical journal. 2007;120(15):1336-42.
Park SY, Cho SJ, Kwon HC et al. Caspase-independent cell death by allicin in human epithelial carcinoma cells: involvement of PKA. Cancer Letters. 2005;224(1):123-32.
Cha J.H., Choi Y.J., Cha S.H. et al. Allicin inhibits cell growth and induces apoptosis in U87MG human glioblastoma cells through an ERK-dependent pathway. Oncol. Rep. 2012;28:41–48.
Arditti FD, Rabinkov A, Miron T et al. Apoptotic killing of B-chronic lymphocytic leukemia tumor cells by allicin generated in situ using a rituximab-alliinase conjugate. Molecular cancer therapeutics. 2005;4(2):325-32.
Miron T, Wilchek M, Sharp A et al. Allicin inhibits cell growth and induces apoptosis through the mitochondrial pathway in HL60 and U937 cells. The Journal of Nutritional Biochemistry. 2008;19(8):524-35.
Vemuri SK, Banala RR, Subbaiah GP et al. Apoptotic efficiency of aqueous extracts of turmeric, garlic and their active compounds in combination with Tamoxifen in lung and oral cancers: A comparative study. Beni-Suef University Journal of Basic and Applied Sciences. 2018;7(2):184-97.
Khazaei S, Abdul Hamid R, Ramachandran V et al. Cytotoxicity and proapoptotic effects of allium atroviolaceum flower extract by modulating cell cycle arrest and caspase-dependent and p53-independent pathway in breast cancer cell lines. Evidence-Based Complementary and Alternative Medicine. 2017;2017.
Khazaei S, Esa NM, Ramachandran V et al. In vitro antiproliferative and apoptosis inducing effect of Allium atroviolaceum bulb extract on breast, cervical, and liver cancer cells. Frontiers in pharmacology. 2017;8:5.
Gholipour N, Mashjoor S, Naderi M et al. In vitro cytotoxic and apoptotic activities of Allium paradoxum (M. Bieb.)2018; G. Don extract on human breast cancer cell line.
Isbilen O, Rizaner N, Volkan E. Anti-proliferative and cytotoxic activities of Allium autumnale PH Davis (Amaryllidaceae) on human breast cancer cell lines MCF-7 and MDA-MB-231. BMC complementary and alternative medicine. 2018;18:1-3.
Perez-Ortiz JM, Galan-Moya EM, de la Cruz-Morcillo MA et al. Cost effective use of a thiosulfinate-enriched Allium sativum extract in combination with chemotherapy in colon cancer. International Journal of Molecular Sciences. 2020 Apr;21(8):2766.
Jasamai M, Hui CS, Azmi N et al. Effect of Allium sativum (garlic) methanol extract on viability and apoptosis of human leukemic cell lines. Tropical Journal of Pharmaceutical Research. 2016;15(7):1479-85.
Szychowski KA, Binduga UE, Rybczyńska-Tkaczyk K et al. Cytotoxic effects of two extracts from garlic (Allium sativum L.) cultivars on the human squamous carcinoma cell line SCC-15. Saudi Journal of Biological Sciences. 2018;25(8):1703-12.
Ohkubo S, Dalla Via L, Grancara S et al. The antioxidant, aged garlic extract, exerts cytotoxic effects on wild-type and multidrug-resistant human cancer cells by altering mitochondrial permeability. International Journal of Oncology. 2018;53(3):1257-68.
Vlase L, Parvu M, Parvu EA et al. Phytochemical analysis of Allium fistulosum L. and A. ursinum L. Digest Journal of Nanomaterials & Biostructures (DJNB). 2013;8(1).
Park HS, Choi EJ, Lee JH et al. Evaluation of Allium vegetables for anti-Adipogenic, anti-Cancer, and anti-inflammatory activities InVitro. Journal of Life Sciences. 2013;5(2):127-32.
Țigu AB, Moldovan CS, Toma VA et al. Phytochemical analysis and in vitro effects of Allium fistulosum L. and Allium sativum L. extracts on human normal and tumor cell lines: A comparative study. Molecules. 2021;26(3):574.
Yuan P, Lin L, Zheng K et al. Risk factors for gastric cancer and related serological levels in Fujian, China: hospital-based case–control study. BMJ open. 2020;10(9):e042341.
Dalmartello M, Turati F, Zhang ZF et al. Allium vegetables intake and the risk of gastric cancer in the Stomach cancer Pooling (StoP) Project. British journal of cancer. 2022;126(12):1755-64.
Malagoli C, Malavolti M, Farnetani F et al. Food and beverage consumption and melanoma risk: A population-based case-control study in northern Italy. Nutrients. 2019;11(9):2206.
Wan Q, Li N, Du L et al. Allium vegetable consumption and health: An umbrella review of meta‐analyses of multiple health outcomes. Food science & nutrition. 2019;7(8):2451-70.
Galeone C, Pelucchi C, Levi F et al. Onion and garlic use and human cancer. The American journal of clinical nutrition. 2006;84(5):1027-32.
Desai G, Schelske-Santos M, Nazario CM et al. Onion and garlic intake and breast cancer, a case-control study in Puerto Rico. Nutrition and cancer. 2020;72(5):791-800.
Zhang Y, Liu X, Ruan J et al. Phytochemicals of garlic: Promising candidates for cancer therapy. Biomed Pharmacother. 2020;123:109730.
Pages
193-198
Published
March 11, 2024
Copyright (c) 2024 Academician Publishing Book Portal
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Aydın A, Göktaş Aydın S. Sarımsak (Allium Sativum) ve Soğan (Allium Cepa). In: Sakin A, editor. Kanser Hastalarının Başvurduğu Geleneksel ve Tamamlayıcı Tedaviler - Tıbbi Onkolog Gözü ile Bakış ve Onkolojik İlaçlarla Etkileşim [Internet]. Türkiye: Academician Publishing Book DOI Portal; 2024 [cited 2026 Jul. 13]. pp. 193-8. Available from: https://omp35.books.akademisyen.net/index.php/akya/catalog/book/2380/chapter/13916
